SIMILAR PATTERNS OF AMINO ACIDS FOR 3QLG_B_1N1B601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
ILE A 264
MET A 269
LYS A 271
 None
 1.00A 3qlgB-1k9aA:
28.1		 3qlgB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
None
None
 0.66A 3qlgB-2h8hA:
34.2		 3qlgB-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 None
 1.09A 3qlgB-2hckA:
32.6		 3qlgB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
ILE A 314
MET A 319
LYS A 321
 1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
None
None
 0.38A 3qlgB-2hk5A:
28.9		 3qlgB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 275
ILE A 317
MET A 322
LYS A 324
 None
 0.53A 3qlgB-2zv7A:
28.5		 3qlgB-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
ILE A 264
MET A 269
LYS A 271
 None
 1.00A 3qlgB-3d7uA:
28.1		 3qlgB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
None
None
 0.70A 3qlgB-4k11A:
34.0		 3qlgB-4k11A:
94.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 295
ILE A 336
MET A 341
LYS A 343
 VGG  A 601 (-3.8A)
VGG  A 601 (-4.2A)
None
None
 0.60A 3qlgB-4lggA:
37.3		 3qlgB-4lggA:
99.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 4 LYS A 219
ILE A 262
MET A 267
LYS A 269
 None
 1.21A 3qlgB-6cz4A:
21.8		 3qlgB-6cz4A:
15.95