SIMILAR PATTERNS OF AMINO ACIDS FOR 3Q70_A_RITA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ILE A  30
ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE A 300
 None
 0.37A 3q70A-1am5A:
10.3		 3q70A-1am5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
 None
 0.47A 3q70A-1am5A:
10.3		 3q70A-1am5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		6 ILE A 213
ASP A 215
GLY A 217
GLU A  13
ASP A  32
ILE A 120
 None
 0.80A 3q70A-1am5A:
10.3		 3q70A-1am5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		7 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE B 300
 None
 0.41A 3q70A-1b5fA:
23.3		 3q70A-1b5fA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		6 ILE A 120
ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE B 300
 None
 1.17A 3q70A-1b5fA:
23.3		 3q70A-1b5fA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		6 ILE A 120
ASP A  32
ILE A  73
ASP A 215
THR A 218
ILE B 300
 None
 1.29A 3q70A-1b5fA:
23.3		 3q70A-1b5fA:
25.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		7 ILE E 120
ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
 None
 1.30A 3q70A-1cziE:
13.0		 3q70A-1cziE:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 ILE E 213
ASP E 215
GLY E 217
GLY E  76
ASP E  32
 None
 0.59A 3q70A-1cziE:
13.0		 3q70A-1cziE:
31.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ILE A  30
ASP A  32
GLY A  34
ASP A 215
ILE A 300
 None
 0.60A 3q70A-1g0vA:
35.0		 3q70A-1g0vA:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		5 ILE A  30
ASP A  32
GLY A  34
ASP A 215
THR A 218
 None
 0.68A 3q70A-1g0vA:
35.0		 3q70A-1g0vA:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens) 		PF00026
(Asp) 		5 ASP B  32
GLY B  34
ASP B 217
THR B 220
ILE B 303
 None
 0.50A 3q70A-1htrB:
12.7		 3q70A-1htrB:
31.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
GLY A  49
ASP A  25
ILE A  84
 A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 ( 3.7A)
A79  A 800 (-2.8A)
A79  A 800 (-3.8A)
 0.55A 3q70A-1hvcA:
10.0		 3q70A-1hvcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ASP A  25
GLY A  27
GLY A  49
ASP A  25
ILE A  84
 A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
A79  A 800 (-3.4A)
A79  A 800 (-2.7A)
A79  A 800 (-3.6A)
 0.61A 3q70A-1hvcA:
10.0		 3q70A-1hvcA:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
GLY A  75
ASP A 214
THR A 217
ILE A 299
 ZN  A1457 (-1.9A)
ZN  A1457 (-3.6A)
None
ZN  A1457 (-1.9A)
None
None
 0.42A 3q70A-1ibqA:
13.1		 3q70A-1ibqA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		5 ILE A 212
ASP A 214
GLY A 216
GLY A  75
ASP A  32
 None
ZN  A1457 (-1.9A)
ZN  A1457 ( 3.7A)
None
ZN  A1457 (-1.9A)
 0.64A 3q70A-1ibqA:
13.1		 3q70A-1ibqA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		6 ASP A  33
GLY A  35
GLY A  76
ASP A 214
THR A 217
ILE A 297
 None
 0.26A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		6 ILE A 212
ASP A 214
GLY A 216
ILE A 293
GLU A  16
ASP A  33
 None
 0.79A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		8 ASP A  32
GLY A  34
GLY A  85
GLU A 194
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 0.49A 3q70A-1j71A:
50.5		 3q70A-1j71A:
62.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		8 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 1.12A 3q70A-1j71A:
50.5		 3q70A-1j71A:
62.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
GLY A  76
ASN A 128
ASP A 215
THR A 218
ILE A 300
 None
 0.30A 3q70A-1mppA:
11.1		 3q70A-1mppA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ILE A  34
ASP A  36
GLY A  38
ASP A 223
ILE A 312
 None
 0.55A 3q70A-1qdmA:
8.0		 3q70A-1qdmA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ILE A  34
ASP A  36
GLY A  38
ASP A 223
THR A 226
 None
 0.65A 3q70A-1qdmA:
8.0		 3q70A-1qdmA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 ILE A 221
ASP A 223
GLY A 225
ASP A  36
ILE A 125
 None
 0.67A 3q70A-1qdmA:
8.0		 3q70A-1qdmA:
27.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		6 ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
 HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 0.31A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		6 ILE E 120
ASP E  32
GLY E  34
ASP E 215
THR E 218
ILE E 300
 None
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 1.21A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		6 ILE E 120
ASP E  32
ILE E  73
ASP E 215
THR E 218
ILE E 300
 None
HH0  E 327 (-2.7A)
None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
 1.33A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		6 ILE E 213
ASP E 215
GLY E 217
GLY E  76
ASP E  32
ILE E 120
 None
HH0  E 327 (-2.5A)
HH0  E 327 (-3.5A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.7A)
None
 0.74A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		7 ILE A  32
ASP A  34
GLY A  36
GLY A  78
ASP A 214
THR A 217
ILE A 300
 None
 0.38A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		6 ILE A 123
ASP A  34
GLY A  36
ASP A 214
THR A 217
ILE A 300
 None
 1.15A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		6 ILE A 123
ASP A  34
ILE A  75
ASP A 214
THR A 217
ILE A 300
 None
 1.37A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		5 ILE A 212
ASP A 214
GLY A 216
GLY A  78
ASP A  34
 None
 0.70A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		6 ILE A 212
ASP A 214
GLY A 216
ILE A 294
ASP A  34
ILE A 123
 None
 0.84A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
 None
 0.57A 3q70A-1smrA:
10.8		 3q70A-1smrA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		6 ILE A  41
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
 None
 0.32A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		6 ILE A 131
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
 None
 1.16A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		6 ILE A 226
ASP A 228
GLY A 230
ILE A 307
ASP A  43
ILE A 131
 None
 0.73A 3q70A-1tzsA:
11.8		 3q70A-1tzsA:
31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		6 ASP A  35
GLY A  37
GLY A  78
ASP A 218
THR A 221
ILE A 298
 None
 0.37A 3q70A-1uh9A:
38.2		 3q70A-1uh9A:
33.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		5 ILE A 216
ASP A 218
GLY A 220
GLY A  78
ASP A  35
 None
 0.69A 3q70A-1uh9A:
38.2		 3q70A-1uh9A:
33.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
GLY A  64
ASP A 212
THR A 215
ILE A 307
 None
 0.30A 3q70A-1wkrA:
34.2		 3q70A-1wkrA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 ILE A 210
ASP A 212
GLY A 214
ASP A  32
ILE A 104
 None
 0.60A 3q70A-1wkrA:
34.2		 3q70A-1wkrA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 ILE A 210
ASP A 212
GLY A 214
GLY A  64
ASP A  32
 None
 0.65A 3q70A-1wkrA:
34.2		 3q70A-1wkrA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		12 ILE A  30
ASP A  32
GLY A  34
GLY A  85
SER A  88
ILE A 119
ASN A 131
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 A70  A 500 (-4.3A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 ( 4.2A)
A70  A 500 (-3.9A)
A70  A 500 (-3.8A)
A70  A 500 (-4.4A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 0.48A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		10 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ILE A 119
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 A70  A 500 (-4.8A)
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.9A)
A70  A 500 (-4.4A)
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
 1.19A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ASP A 214
GLY A 216
GLY A  78
ILE A 294
ASP A  34
ILE A 123
 JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
JE2  A3151 (-3.6A)
JE2  A3151 ( 4.8A)
JE2  A3151 (-3.0A)
None
 0.83A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ILE A  32
ASP A  34
GLY A  36
GLY A  78
ASP A 214
ILE A 300
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 ( 4.5A)
 0.48A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ILE A  32
ASP A  34
GLY A  36
GLY A  78
ASP A 214
THR A 217
 None
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
JE2  A3151 (-2.6A)
 0.52A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		6 ILE A 212
ASP A 214
GLY A 216
GLY A  78
ILE A 294
ASP A  34
 None
JE2  A3151 (-2.5A)
JE2  A3151 ( 3.9A)
JE2  A3151 (-3.6A)
JE2  A3151 ( 4.8A)
JE2  A3151 (-3.0A)
 0.74A 3q70A-2anlA:
11.5		 3q70A-2anlA:
30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		6 ILE A  32
ASP A  34
GLY A  36
ASP A 214
THR A 217
ILE A 300
 IH4  A1330 (-4.1A)
IH4  A1330 (-4.2A)
IH4  A1330 ( 4.6A)
IH4  A1330 (-3.3A)
IH4  A1331 ( 4.1A)
IH4  A1330 (-4.5A)
 0.29A 3q70A-2bjuA:
11.4		 3q70A-2bjuA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		9 ILE A 123
ASP A  32
GLY A  34
GLY A  85
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 1.14A 3q70A-2h6tA:
50.9		 3q70A-2h6tA:
73.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		7 GLY A  85
SER A  88
ILE A 119
GLU A 193
THR A 221
TYR A 225
ILE A 305
 None
 0.92A 3q70A-2qzwA:
52.3		 3q70A-2qzwA:
73.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		11 ILE A  30
ASP A  32
GLY A  34
GLY A  85
ILE A 119
ASN A 131
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 0.50A 3q70A-2qzwA:
52.3		 3q70A-2qzwA:
73.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		10 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ILE A 119
GLU A 193
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 1.29A 3q70A-2qzwA:
52.3		 3q70A-2qzwA:
73.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		8 ILE A  30
ASP A  32
GLY A  34
GLY A  85
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 0.41A 3q70A-2qzxA:
50.4		 3q70A-2qzxA:
56.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		6 ILE A 123
ASP A  32
ASP A 218
THR A 221
TYR A 225
ILE A 305
 None
 1.12A 3q70A-2qzxA:
50.4		 3q70A-2qzxA:
56.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		6 ILE A 123
ASP A  32
ILE A  82
ASP A 218
TYR A 225
ILE A 305
 None
 1.39A 3q70A-2qzxA:
50.4		 3q70A-2qzxA:
56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		7 ASP A  38
GLY A  40
GLY A  83
ASN A 140
ASP A 237
THR A 240
ILE A 329
 None
 0.34A 3q70A-2rmpA:
12.1		 3q70A-2rmpA:
29.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		6 ASP A  33
GLY A  35
GLY A  76
ASP A 213
THR A 216
ILE A 297
 PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.2A)
 0.39A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 ILE A 211
ASP A 213
GLY A 215
GLY A  76
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-3.5A)
PP6  A 327 ( 2.7A)
 0.64A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		5 ILE A 211
ASP A 213
GLY A 215
ILE A 293
ASP A  33
 None
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
None
PP6  A 327 ( 2.7A)
 0.65A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE A 301
 None
 0.28A 3q70A-3emyA:
11.3		 3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		6 ASP A  32
GLY A  34
ILE A 117
ASP A 215
THR A 218
ILE A 301
 None
 1.13A 3q70A-3emyA:
11.3		 3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		6 ILE A 213
ASP A 215
GLY A 217
ILE A 297
GLU A  13
ASP A  32
 None
 1.21A 3q70A-3emyA:
11.3		 3q70A-3emyA:
29.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		9 ILE A  30
ASP A  32
GLY A  34
GLY A  79
ASN A 125
ASP A 220
THR A 223
TYR A 227
ILE A 303
 None
None
None
GOL  A 341 (-4.5A)
None
None
None
GOL  A 341 ( 4.6A)
None
 0.37A 3q70A-3fv3A:
13.9		 3q70A-3fv3A:
51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		6 ILE A  30
ASP A  32
GLY A  34
SER A  84
ASN A 125
ASP A 220
 None
 1.43A 3q70A-3fv3A:
13.9		 3q70A-3fv3A:
51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		8 ILE A 117
ASP A  32
GLY A  34
GLY A  79
ASP A 220
THR A 223
TYR A 227
ILE A 303
 None
None
None
GOL  A 341 (-4.5A)
None
None
GOL  A 341 ( 4.6A)
None
 1.20A 3q70A-3fv3A:
13.9		 3q70A-3fv3A:
51.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ILE A  30
ASP A  32
GLY A  34
ASP A 215
ILE A 300
 None
 0.49A 3q70A-3psgA:
7.9		 3q70A-3psgA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ILE A  30
ASP A  32
GLY A  34
ASP A 215
THR A 218
 None
 0.65A 3q70A-3psgA:
7.9		 3q70A-3psgA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		6 ILE A 213
ASP A 215
GLY A 217
SER A  35
ASP A  32
ILE A 120
 None
 1.16A 3q70A-3psgA:
7.9		 3q70A-3psgA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		6 ILE A  30
ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE A 300
 006  A 330 ( 4.4A)
006  A 330 (-2.8A)
006  A 330 (-3.2A)
006  A 330 (-2.8A)
006  A 330 (-3.5A)
None
 0.32A 3q70A-3qs1A:
9.9		 3q70A-3qs1A:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		5 ASP A  34
GLY A  36
ASP A 216
THR A 219
ILE A 297
 None
None
GOL  A1334 (-3.5A)
None
GOL  A1334 (-4.2A)
 0.36A 3q70A-4aa9A:
11.8		 3q70A-4aa9A:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		5 ILE A 214
ASP A 216
GLY A 218
ASP A  34
ILE A 122
 None
GOL  A1334 (-3.5A)
None
None
None
 0.61A 3q70A-4aa9A:
11.8		 3q70A-4aa9A:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 ILE A 226
ASP A 228
GLY A 230
ASP A  32
ILE A 118
 None
3LL  A 501 (-2.6A)
3LL  A 501 (-3.0A)
3LL  A 501 (-2.8A)
3LL  A 501 (-4.6A)
 0.65A 3q70A-4rcdA:
8.9		 3q70A-4rcdA:
25.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		7 ASP A  32
GLY A  34
GLY A  78
ASP A 211
THR A 214
TYR A 218
ILE A 298
 None
 0.41A 3q70A-4y9wA:
46.9		 3q70A-4y9wA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		7 ILE A 116
ASP A  32
GLY A  78
ASP A 211
THR A 214
TYR A 218
ILE A 298
 None
 1.22A 3q70A-4y9wA:
46.9		 3q70A-4y9wA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		7 ASP A  35
GLY A  37
GLY A  80
ASP A 219
THR A 222
TYR A 226
ILE A 304
 61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
61P  A 406 (-4.1A)
61P  A 406 (-2.9A)
61P  A 406 ( 3.5A)
61P  A 406 (-4.0A)
None
 0.43A 3q70A-5hctA:
11.2		 3q70A-5hctA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		7 ASP A  35
GLY A  37
ILE A 122
ASP A 219
THR A 222
TYR A 226
ILE A 304
 61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
None
61P  A 406 (-2.9A)
61P  A 406 ( 3.5A)
61P  A 406 (-4.0A)
None
 1.05A 3q70A-5hctA:
11.2		 3q70A-5hctA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 6 ASP B 214
GLY B 216
GLY B  78
ILE B 294
ASP B  34
ILE B 123
 None
 0.83A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 7 ILE B  32
ASP B  34
GLY B  36
GLY B  78
ASP B 214
THR B 217
ILE B 300
 None
 0.44A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 6 ILE B 123
ASP B  34
GLY B  36
ASP B 214
THR B 217
ILE B 300
 None
 1.13A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 6 ILE A  26
GLY A 101
GLY A  67
ILE A  22
GLU A 139
THR A  36
 None
 1.18A 3q70A-5lw3A:
undetectable		 3q70A-5lw3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ILE A  79
ASP A  81
GLY A  83
GLY A 127
ASP A 266
THR A 269
 None
 0.82A 3q70A-5mlgA:
9.6		 3q70A-5mlgA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 6 ILE A  79
ASP A  81
GLY A  83
SER A 128
ASP A 266
THR A 269
 None
 0.74A 3q70A-5mlgA:
9.6		 3q70A-5mlgA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 7 ILE A  34
ASP A  36
GLY A  38
GLY A  80
ASP A 227
THR A 230
ILE A 313
 None
 0.38A 3q70A-5n7qA:
36.1		 3q70A-5n7qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 6 ILE A 124
ASP A  36
GLY A  38
ASP A 227
THR A 230
ILE A 313
 None
 1.22A 3q70A-5n7qA:
36.1		 3q70A-5n7qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 6 ILE A 124
ASP A  36
ILE A  77
ASP A 227
THR A 230
ILE A 313
 None
 1.38A 3q70A-5n7qA:
36.1		 3q70A-5n7qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 6 ILE A 225
ASP A 227
GLY A 229
GLY A  80
ASP A  36
ILE A 124
 None
 0.80A 3q70A-5n7qA:
36.1		 3q70A-5n7qA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 6 ILE A  78
ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
 None
 0.59A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 6 ILE A 169
ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
 None
 1.26A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 ILE A 265
ASP A 267
GLY A 269
ILE A 348
ASP A  80
 None
 0.71A 3q70A-5nfgA:
35.0		 3q70A-5nfgA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		7 ASP A  35
GLY A  37
GLY A  80
ASP A 219
THR A 222
TYR A 226
ILE A 304
 None
 0.42A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		7 ASP A  35
GLY A  37
ILE A 122
ASP A 219
THR A 222
TYR A 226
ILE A 304
 None
 1.05A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		7 ILE A  30
ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE A 301
 None
 0.45A 3q70A-5pepA:
12.8		 3q70A-5pepA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		5 ILE A 213
ASP A 215
GLY A 217
ASP A  32
ILE A 120
 None
 0.57A 3q70A-5pepA:
12.8		 3q70A-5pepA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		5 ILE A 213
ASP A 215
GLY A 217
GLY A  76
ASP A  32
 None
 0.57A 3q70A-5pepA:
12.8		 3q70A-5pepA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		6 ILE A 793
GLY A 747
GLY A 609
THR A 798
TYR A 612
ILE A 626
 None
 1.47A 3q70A-5ucgA:
undetectable		 3q70A-5ucgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 5 ASP A  33
GLY A  35
ASP A 226
THR A 229
ILE A 315
 3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 (-2.4A)
3UT  A 404 ( 4.8A)
None
 0.25A 3q70A-5ux4A:
10.4		 3q70A-5ux4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus) 		no annotation 6 ILE A 224
ASP A 226
GLY A 228
ILE A 306
ASP A  33
ILE A 129
 None
3UT  A 404 (-2.4A)
3UT  A 404 (-3.1A)
None
3UT  A 404 (-2.9A)
None
 0.60A 3q70A-5ux4A:
10.4		 3q70A-5ux4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 6 ILE A  34
ASP A  36
GLY A  38
ASP A 216
THR A 219
ILE A 302
 K95  A 401 ( 4.0A)
K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
NA  A 403 ( 1.9A)
K95  A 401 (-3.8A)
None
 0.34A 3q70A-5yidA:
9.7		 3q70A-5yidA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 6 ILE A  78
ASP A  80
GLY A  82
SER A 143
ASP A 313
ILE A 439
 EQG  A 504 ( 3.8A)
EQG  A 504 (-2.5A)
EQG  A 504 (-3.0A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-4.3A)
 0.45A 3q70A-6c4gA:
8.7		 3q70A-6c4gA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 ILE A 635
ASP A 637
GLY A 639
ASP A 441
ILE A 527
 None
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-2.9A)
B7E  A 901 (-4.4A)
 0.65A 3q70A-6ej2A:
31.9		 3q70A-6ej2A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 SER A  35
ILE A  73
TYR A  75
ASP A 118
 None
 0.93A 3q70A-1b5fA:
23.3		 3q70A-1b5fA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 THR A 138
SER A  95
ASP A 144
THR A 107
 None
 1.08A 3q70A-1dgfA:
undetectable		 3q70A-1dgfA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 SER A 268
ILE A 106
TYR A 108
ASP A 210
 None
None
None
PLP  A1201 (-2.7A)
 0.85A 3q70A-1fc4A:
undetectable		 3q70A-1fc4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 THR A  49
SER A  45
ILE A 125
THR A 119
 None
 1.02A 3q70A-1fjjA:
undetectable		 3q70A-1fjjA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 SER A 394
TYR A 398
ASP A 419
THR A 370
 None
 1.06A 3q70A-1hn0A:
undetectable		 3q70A-1hn0A:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		5 SER A  35
ILE A  72
TYR A  74
ASP A 114
THR A 218
 None
 0.83A 3q70A-1ibqA:
13.1		 3q70A-1ibqA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		4 SER A  36
ILE A  73
TYR A  75
THR A 218
 None
 0.24A 3q70A-1izeA:
12.8		 3q70A-1izeA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		4 SER A  35
ILE A  82
TYR A  84
THR A 222
 None
 0.18A 3q70A-1j71A:
50.5		 3q70A-1j71A:
62.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 THR A 755
SER A 128
ASP A 758
THR A 753
 None
 1.02A 3q70A-1k32A:
undetectable		 3q70A-1k32A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A1844
ILE A1809
TYR A1683
THR A1847
 None
 0.97A 3q70A-1larA:
undetectable		 3q70A-1larA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 SER A  37
ILE A  75
TYR A  77
ASP A 121
 None
 1.06A 3q70A-1miqA:
9.4		 3q70A-1miqA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		4 SER E  35
ILE E  73
TYR E  75
ASP E 118
 HH0  E 327 (-4.1A)
None
HH0  E 327 (-4.5A)
None
 0.98A 3q70A-1qrpE:
13.1		 3q70A-1qrpE:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 SER A  37
ILE A  75
TYR A  77
THR A 218
 None
 0.54A 3q70A-1qs8A:
12.0		 3q70A-1qs8A:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		4 SER A 330
ILE A 320
TYR A 290
ASP A   9
 None
 1.09A 3q70A-1qyiA:
undetectable		 3q70A-1qyiA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txj TRANSLATIONALLY
CONTROLLED
TUMOUR-ASSOCIATED
PROTEIN (TCTP) FROM
PLASMODIUM KNOWLESI,
PKN_PFE0545C

(Plasmodium
knowlesi) 		PF00838
(TCTP) 		4 ILE A  98
TYR A  94
ASP A  11
THR A  80
 None
 1.12A 3q70A-1txjA:
undetectable		 3q70A-1txjA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		4 SER A  38
ILE A  75
TYR A  77
THR A 222
 None
 0.23A 3q70A-1uh9A:
38.2		 3q70A-1uh9A:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh) 		4 THR A  78
SER A  88
ILE A 168
TYR A 170
 None
 0.87A 3q70A-1w85A:
undetectable		 3q70A-1w85A:
23.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		4 SER A  35
TYR A  63
ASP A  99
THR A 216
 None
None
SO4  A 905 ( 4.4A)
None
 0.97A 3q70A-1wkrA:
34.2		 3q70A-1wkrA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		6 THR A  13
SER A  35
ILE A  82
TYR A  84
ASP A 120
THR A 222
 A70  A 500 (-3.5A)
A70  A 500 ( 4.5A)
None
A70  A 500 (-3.8A)
None
A70  A 500 (-4.0A)
 0.34A 3q70A-1zapA:
54.1		 3q70A-1zapA:
97.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		4 SER A  37
ILE A  75
TYR A  77
ASP A 121
 None
None
JE2  A3151 (-3.6A)
None
 0.99A 3q70A-2anlA:
11.9		 3q70A-2anlA:
30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 THR A 310
SER A 102
ILE A 140
THR A  65
 None
 1.12A 3q70A-2c4kA:
undetectable		 3q70A-2c4kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3u HYPOTHETICAL PROTEIN
PH1566

(Pyrococcus
horikoshii) 		PF00013
(KH_1) 		4 THR A  63
ILE A  69
ASP A  95
THR A  84
 None
 1.08A 3q70A-2e3uA:
undetectable		 3q70A-2e3uA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		4 SER A  98
ILE A  35
ASP A 162
THR A 152
 None
 1.05A 3q70A-2g5cA:
undetectable		 3q70A-2g5cA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 THR A  59
ILE A  75
ASP A  85
THR A  53
 None
 1.10A 3q70A-2gr9A:
undetectable		 3q70A-2gr9A:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		5 SER A  35
ILE A  82
TYR A  84
ASP A 120
THR A 222
 None
 0.68A 3q70A-2h6tA:
50.9		 3q70A-2h6tA:
73.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 SER A 430
ILE A 394
ASP A 408
THR A 466
 None
 1.05A 3q70A-2hpiA:
undetectable		 3q70A-2hpiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 THR A 323
SER A 114
ILE A 152
THR A  77
 None
 1.08A 3q70A-2ji4A:
undetectable		 3q70A-2ji4A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		4 SER A  35
ILE A  82
TYR A  84
THR A 222
 None
 0.25A 3q70A-2qzwA:
52.3		 3q70A-2qzwA:
73.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 THR A  13
SER A  35
ILE A  82
TYR A  84
THR A 222
 None
 0.30A 3q70A-2qzxA:
50.4		 3q70A-2qzxA:
56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 SER A  36
ILE A  73
TYR A  75
ASP A 115
 PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
None
 0.88A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		4 SER A  36
ILE A  73
TYR A  75
THR A 217
 PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
PP6  A 327 (-4.5A)
 0.23A 3q70A-2wedA:
10.6		 3q70A-2wedA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 THR A 385
SER A 374
ILE A 242
THR A 378
 None
 0.90A 3q70A-3cqfA:
undetectable		 3q70A-3cqfA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 SER A  35
ILE A  73
TYR A  75
ASP A 114
 None
 1.00A 3q70A-3emyA:
11.3		 3q70A-3emyA:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		4 SER A  35
ILE A  73
TYR A  75
THR A 219
 None
 0.36A 3q70A-3emyA:
11.3		 3q70A-3emyA:
29.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		5 SER A  35
ILE A  76
TYR A  78
ASP A 114
THR A 224
 None
 0.45A 3q70A-3fv3A:
13.9		 3q70A-3fv3A:
51.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		no annotation 4 SER D  98
ILE D  35
ASP D 162
THR D 152
 None
 1.06A 3q70A-3gggD:
undetectable		 3q70A-3gggD:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		4 THR X  95
SER X  82
ILE X 150
THR X  93
 None
 1.12A 3q70A-3i2mX:
undetectable		 3q70A-3i2mX:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A 487
ILE A 491
ASP A 571
THR A 464
 None
 0.88A 3q70A-3ogrA:
undetectable		 3q70A-3ogrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		4 THR A 466
ILE A  46
TYR A 389
ASP A 403
 None
 0.91A 3q70A-3om5A:
undetectable		 3q70A-3om5A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 ILE A   7
TYR A  16
ASP A  36
THR A  46
 None
 1.03A 3q70A-3oosA:
undetectable		 3q70A-3oosA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oug ASPARTATE
1-DECARBOXYLASE

(Francisella
tularensis) 		PF02261
(Asp_decarbox) 		4 THR A  68
SER A  25
TYR A  22
THR A  16
 None
 1.11A 3q70A-3ougA:
undetectable		 3q70A-3ougA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 185
SER A 344
ILE A 261
ASP A 179
 None
 1.02A 3q70A-3pdkA:
undetectable		 3q70A-3pdkA:
23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 THR A  12
ILE A  73
TYR A  75
THR A 218
 None
 1.03A 3q70A-3psgA:
7.9		 3q70A-3psgA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 THR A 381
ILE A 193
TYR A 190
THR A 407
 None
 0.86A 3q70A-3t5tA:
undetectable		 3q70A-3t5tA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfj GCVT-LIKE
AMINOMETHYLTRANSFERA
SE PROTEIN

(Candidatus
Pelagibacter
ubique) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 122
ILE A 152
TYR A 206
ASP A 181
 THG  A 370 (-3.8A)
None
None
None
 0.90A 3q70A-3tfjA:
undetectable		 3q70A-3tfjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		4 THR A 341
SER A 161
ILE A 178
THR A 373
 None
FDA  A 547 (-4.8A)
None
None
 1.09A 3q70A-3v76A:
undetectable		 3q70A-3v76A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ILE A 311
TYR A 365
ASP A 329
THR A 402
 None
 0.95A 3q70A-3vr5A:
undetectable		 3q70A-3vr5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 THR A 402
SER A 433
ILE A 428
THR A 405
 None
 1.11A 3q70A-3vr5A:
undetectable		 3q70A-3vr5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0s HYGROMYCIN-B
4-O-KINASE

(Escherichia
coli) 		PF01636
(APH) 		4 THR A 206
ILE A 232
ASP A 102
THR A 212
 None
 1.07A 3q70A-3w0sA:
undetectable		 3q70A-3w0sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6d LYSOZYME-LIKE
CHITINOLYTIC ENZYME

(Ralstonia sp.
A-471) 		no annotation 4 THR A 102
ILE A 207
TYR A 245
THR A 104
 None
 0.94A 3q70A-3w6dA:
undetectable		 3q70A-3w6dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 THR A 225
SER A  11
TYR A  84
THR A 227
 None
None
None
ATP  A1301 (-3.4A)
 0.84A 3q70A-3zs7A:
undetectable		 3q70A-3zs7A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a34 RBSD/FUCU TRANSPORT
PROTEIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF05025
(RbsD_FucU) 		4 THR A 102
ILE A  57
ASP A  64
THR A 104
 None
 0.94A 3q70A-4a34A:
undetectable		 3q70A-4a34A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Homo sapiens) 		PF00790
(VHS)
PF01363
(FYVE) 		4 SER A  48
TYR A  44
ASP A  39
THR A  78
 None
EDO  A1234 (-4.1A)
None
None
 1.10A 3q70A-4avxA:
undetectable		 3q70A-4avxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 ILE A 150
TYR A  84
ASP A 113
THR A 105
 None
 1.07A 3q70A-4etmA:
undetectable		 3q70A-4etmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 THR A  68
SER A 316
ASP A  95
THR A  32
 None
 1.05A 3q70A-4eudA:
undetectable		 3q70A-4eudA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 THR A 197
SER A 287
TYR A 292
ASP A 301
 None
 1.11A 3q70A-4fgwA:
undetectable		 3q70A-4fgwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		4 THR A  61
ILE A 205
ASP A 196
THR A  25
 None
 0.95A 3q70A-4izdA:
undetectable		 3q70A-4izdA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 THR A 235
TYR A 264
ASP A 244
THR A 260
 None
 0.95A 3q70A-4ksfA:
undetectable		 3q70A-4ksfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		4 SER A 195
ILE A   5
ASP A 121
THR A 335
 None
None
GOL  A1002 ( 2.2A)
None
 1.10A 3q70A-4mcaA:
undetectable		 3q70A-4mcaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 4 THR A 227
SER A 246
ASP A 257
THR A 230
 None
 1.12A 3q70A-4roeA:
undetectable		 3q70A-4roeA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyp CELLULOSOMAL
SCAFFOLDIN ANCHORING
PROTEIN C

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 THR A 114
ILE A  31
ASP A   5
THR A  38
 None
 0.84A 3q70A-4uypA:
undetectable		 3q70A-4uypA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyp CELLULOSOMAL
SCAFFOLDIN ANCHORING
PROTEIN C

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 THR A 114
ILE A  87
ASP A   5
THR A  38
 None
 0.90A 3q70A-4uypA:
undetectable		 3q70A-4uypA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0j ACYL-[ACYL-CARRIER-P
ROTEIN] DESATURASE,
CHLOROPLASTIC

(Ricinus
communis) 		PF03405
(FA_desaturase_2) 		4 THR A 110
ILE A 263
TYR A 191
THR A 113
 None
 1.11A 3q70A-4v0jA:
undetectable		 3q70A-4v0jA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ILE A  81
TYR A 161
ASP A 209
THR A 394
 None
 1.05A 3q70A-4xwtA:
undetectable		 3q70A-4xwtA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		4 SER A  35
ILE A  75
TYR A  77
THR A 215
 None
 0.14A 3q70A-4y9wA:
46.9		 3q70A-4y9wA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 SER A 101
TYR A  99
ASP A  67
THR A 123
 None
None
SAH  A 301 (-2.8A)
None
 1.11A 3q70A-5bp7A:
undetectable		 3q70A-5bp7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjp RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP2

(Homo sapiens) 		PF00616
(RasGAP) 		4 THR E 980
ILE E 919
TYR E 923
ASP E1120
 None
 1.11A 3q70A-5cjpE:
undetectable		 3q70A-5cjpE:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dth MULTIPLE PDZ DOMAIN
PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 THR A1330
ILE A1392
TYR A1394
THR A1332
 None
 0.94A 3q70A-5dthA:
undetectable		 3q70A-5dthA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		4 THR A 873
TYR A 842
ASP A 845
THR A 897
 None
 1.05A 3q70A-5e55A:
undetectable		 3q70A-5e55A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6

(Mus musculus) 		PF01663
(Phosphodiest) 		4 SER A 317
ILE A  90
TYR A 310
ASP A 357
 None
 1.07A 3q70A-5egeA:
undetectable		 3q70A-5egeA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq8 BT_2262
(UNCHARACTERISED
LIPOPROTEIN)

(Bacteroides
thetaiotaomicron) 		PF16403
(DUF5011)
PF16404
(DUF5012) 		4 ILE G  64
TYR G  86
ASP G  22
THR G 101
 None
 1.05A 3q70A-5fq8G:
undetectable		 3q70A-5fq8G:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ILE A 343
TYR A 344
ASP A 312
THR A 269
 None
 1.00A 3q70A-5gl7A:
undetectable		 3q70A-5gl7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 THR A  87
SER A 168
ASP A   4
THR A 162
 None
 1.05A 3q70A-5h04A:
undetectable		 3q70A-5h04A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
ILE A  77
TYR A  79
ASP A 119
 None
None
61P  A 406 (-4.3A)
61P  A 406 ( 4.9A)
 0.71A 3q70A-5hctA:
11.2		 3q70A-5hctA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
ILE A  77
TYR A  79
THR A 223
 None
None
61P  A 406 (-4.3A)
PG4  A 408 (-3.8A)
 0.23A 3q70A-5hctA:
11.2		 3q70A-5hctA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE GAMMA
CHAIN

(Caldalkalibacillus
thermarum) 		PF00231
(ATP-synt) 		4 THR G  82
SER G 100
TYR G 131
ASP G 124
 None
 1.04A 3q70A-5ik2G:
undetectable		 3q70A-5ik2G:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ILE A 829
TYR A 938
ASP A 756
THR A 572
 None
 1.02A 3q70A-5jm0A:
undetectable		 3q70A-5jm0A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 SER A  37
ILE A  75
TYR A  77
ASP A 121
 None
 1.03A 3q70A-5jodA:
10.1		 3q70A-5jodA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 THR A 218
ILE A 377
ASP A 447
THR A 475
 None
 1.10A 3q70A-5n6mA:
undetectable		 3q70A-5n6mA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 THR A 656
ILE A  52
TYR A  36
THR A  23
 None
 1.05A 3q70A-5nqdA:
undetectable		 3q70A-5nqdA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuq PROBABLE
PHOSPHOLIPID-BINDING
LIPOPROTEIN MLAA

(Serratia
marcescens) 		no annotation 4 SER G 139
TYR G 131
ASP G 192
THR G  22
 None
 1.11A 3q70A-5nuqG:
undetectable		 3q70A-5nuqG:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
ILE A  77
TYR A  79
ASP A 119
 None
 0.84A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A  38
ILE A  77
TYR A  79
THR A 223
 None
 0.28A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		4 SER A  35
ILE A  73
TYR A  75
ASP A 118
 None
 0.98A 3q70A-5pepA:
12.8		 3q70A-5pepA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t51 KLLA0E05809P
KLLA0F02343P

(Kluyveromyces
lactis) 		PF03980
(Nnf1)
PF05859
(Mis12) 		4 THR A  65
ILE A  52
TYR B  48
ASP A  59
 None
 1.11A 3q70A-5t51A:
undetectable		 3q70A-5t51A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN UL130

(Human
betaherpesvirus
5) 		PF11668
(Gp_UL130) 		4 SER D 103
ILE D 111
TYR D  89
THR D  54
 None
 1.00A 3q70A-5vocD:
undetectable		 3q70A-5vocD:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 THR A1276
SER A 924
TYR A 926
ASP A1273
 None
None
None
CA  A1303 (-2.3A)
 1.03A 3q70A-5x7sA:
undetectable		 3q70A-5x7sA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 SER A 195
ILE A   5
ASP A 121
THR A 335
 None
None
ZN  A 401 ( 4.1A)
None
 1.10A 3q70A-5xn8A:
undetectable		 3q70A-5xn8A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y28 -

(-) 		no annotation 4 THR A 261
SER A 166
ILE A 210
ASP A 147
 None
 1.12A 3q70A-5y28A:
undetectable		 3q70A-5y28A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A1636
TYR A1631
ASP A1967
THR A1894
 None
 1.03A 3q70A-5y29A:
undetectable		 3q70A-5y29A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 ILE A2082
TYR A2077
ASP A2404
THR A2331
 None
 1.02A 3q70A-5y2aA:
undetectable		 3q70A-5y2aA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 4 THR A 306
ILE A  32
ASP A 130
THR A 302
 None
 1.10A 3q70A-5zmyA:
undetectable		 3q70A-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT

(Homo sapiens) 		no annotation 4 SER A 286
ILE A 382
TYR A 360
THR A 350
 None
 0.99A 3q70A-6au6A:
undetectable		 3q70A-6au6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 THR A 462
SER A 473
ILE A 422
THR A 466
 None
 1.04A 3q70A-6bo6A:
undetectable		 3q70A-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6s -

(-) 		no annotation 4 SER D  84
ILE D  87
TYR D   5
THR D  68
 None
 1.11A 3q70A-6c6sD:
undetectable		 3q70A-6c6sD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0y NUCLEAR CAP-BINDING
PROTEIN SUBUNIT 2

(Homo sapiens) 		no annotation 4 SER A  63
ILE A  66
TYR A  88
ASP A 114
 None
None
None
GTA  A 201 (-2.8A)
 1.12A 3q70A-6d0yA:
undetectable		 3q70A-6d0yA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0y NUCLEAR CAP-BINDING
PROTEIN SUBUNIT 2

(Homo sapiens) 		no annotation 4 SER A  63
ILE A  66
TYR A  88
ASP A 116
 None
None
None
GTA  A 201 (-2.9A)
 1.08A 3q70A-6d0yA:
undetectable		 3q70A-6d0yA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium) 		no annotation 4 THR A 210
ILE A 171
ASP A 156
THR A 229
 None
 0.90A 3q70A-6eioA:
undetectable		 3q70A-6eioA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 4 THR B 322
SER B 227
ILE B 209
ASP B 326
 None
 1.09A 3q70A-6eqnB:
undetectable		 3q70A-6eqnB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 4 THR A 188
SER A 215
TYR A 202
ASP A 173
 None
PUT  A 401 ( 4.2A)
None
None
 1.05A 3q70A-6f9gA:
undetectable		 3q70A-6f9gA:
11.68