SIMILAR PATTERNS OF AMINO ACIDS FOR 3PYY_A_STIA3_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 VAL A 346
VAL A 371
ILE A 319
ARG A 339
 None
 1.02A 3pyyA-1bxdA:
undetectable		 3pyyA-1bxdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehw NUCLEOSIDE
DIPHOSPHATE KINASE

(Homo sapiens) 		PF00334
(NDK) 		4 VAL A   9
VAL A  36
ILE A 130
ARG A  31
 None
 1.10A 3pyyA-1ehwA:
undetectable		 3pyyA-1ehwA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 TYR B  71
VAL B  30
VAL B  94
ILE B  57
 None
 1.09A 3pyyA-1ep2B:
undetectable		 3pyyA-1ep2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exz STEM CELL FACTOR

(Homo sapiens) 		PF02404
(SCF) 		4 VAL A  15
VAL A  83
ILE A  76
ARG A 117
 None
 0.91A 3pyyA-1exzA:
undetectable		 3pyyA-1exzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 TYR A 306
VAL A 276
VAL A 314
ILE A 362
 None
 1.10A 3pyyA-1fcdA:
undetectable		 3pyyA-1fcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 VAL A 316
VAL A 325
ILE A 303
ARG A 285
 None
 0.93A 3pyyA-1gq1A:
undetectable		 3pyyA-1gq1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxt HYDROGENASE
MATURATION PROTEIN
HYPF

(Escherichia
coli) 		PF00708
(Acylphosphatase) 		4 VAL A  26
VAL A  20
ILE A  71
ARG A  91
 None
SO4  A1093 (-3.7A)
None
None
 1.00A 3pyyA-1gxtA:
undetectable		 3pyyA-1gxtA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzv NITRITE REDUCTASE

(Pseudomonas
aeruginosa) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		4 VAL A 298
VAL A 307
ILE A 285
ARG A 267
 None
 0.91A 3pyyA-1hzvA:
undetectable		 3pyyA-1hzvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 VAL A  89
VAL A 371
ILE A  13
ARG A  30
 None
 1.01A 3pyyA-1jaeA:
undetectable		 3pyyA-1jaeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 VAL A  91
VAL A 390
ILE A  13
ARG A  30
 None
 1.03A 3pyyA-1jxkA:
undetectable		 3pyyA-1jxkA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		4 VAL A  54
VAL A  15
ILE A  69
ARG A 149
 None
 0.94A 3pyyA-1k1eA:
undetectable		 3pyyA-1k1eA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.39A 3pyyA-1k9aA:
31.0		 3pyyA-1k9aA:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 TYR A  11
VAL A  40
VAL A 155
ILE A  18
 None
 1.09A 3pyyA-1kq3A:
undetectable		 3pyyA-1kq3A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6r HYPOTHETICAL PROTEIN
TA0175

(Thermoplasma
acidophilum) 		PF08282
(Hydrolase_3) 		4 TYR A 208
VAL A  38
ILE A 172
ARG A  29
 None
 1.00A 3pyyA-1l6rA:
undetectable		 3pyyA-1l6rA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbq JUNCTIONAL ADHESION
MOLECULE 1

(Homo sapiens) 		PF07686
(V-set)
PF13927
(Ig_3) 		4 LYS A  47
VAL A  60
VAL A 122
ILE A  94
 None
 1.10A 3pyyA-1nbqA:
undetectable		 3pyyA-1nbqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  93
VAL A 118
ILE A 136
ARG A 185
 STU  A 401 ( 4.5A)
None
None
None
 1.08A 3pyyA-1nxkA:
19.4		 3pyyA-1nxkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		4 VAL A 193
VAL A 154
ILE A 210
ARG A 181
 None
 1.05A 3pyyA-1o9gA:
undetectable		 3pyyA-1o9gA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 290
VAL A 318
ILE A 332
ARG A 381
 P16  A   2 (-4.5A)
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
None
 1.02A 3pyyA-1opkA:
34.3		 3pyyA-1opkA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 TYR A 272
LYS A 290
VAL A 308
VAL A 318
ILE A 332
 P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
 0.92A 3pyyA-1opkA:
34.3		 3pyyA-1opkA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 TYR A 449
VAL A 401
ILE A 427
ARG A 392
 None
 1.11A 3pyyA-1oseA:
undetectable		 3pyyA-1oseA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ose PORCINE
ALPHA-AMYLASE

(Sus scrofa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 VAL A  91
VAL A 395
ILE A  13
ARG A  30
 None
 1.10A 3pyyA-1oseA:
undetectable		 3pyyA-1oseA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 VAL A 106
VAL A 200
ILE A 101
ARG A 136
 None
 1.10A 3pyyA-1otkA:
undetectable		 3pyyA-1otkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmj BETA-1,4-MANNANASE

(Caldicellulosiruptor
saccharolyticus) 		PF09212
(CBM27) 		4 TYR X 105
VAL X  16
VAL X 178
ARG X  49
 None
 1.05A 3pyyA-1pmjX:
undetectable		 3pyyA-1pmjX:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 VAL A 282
VAL A 512
ILE A 241
ARG A 324
 None
 0.95A 3pyyA-1qhbA:
undetectable		 3pyyA-1qhbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		4 TYR A 194
VAL A 205
VAL A 201
ILE A 175
 None
 1.06A 3pyyA-1qnlA:
undetectable		 3pyyA-1qnlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens) 		PF00089
(Trypsin) 		4 TYR A 614
VAL A 630
VAL A 577
ILE A 633
 None
 1.08A 3pyyA-1qrzA:
undetectable		 3pyyA-1qrzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2w SORTASE

(Staphylococcus
aureus) 		PF04203
(Sortase) 		4 TYR A 153
VAL A  87
ILE A  83
ARG A 197
 None
None
None
GLU  A 333 ( 3.8A)
 0.92A 3pyyA-1t2wA:
undetectable		 3pyyA-1t2wA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vaj HYPOTHETICAL PROTEIN
PH0010

(Pyrococcus
horikoshii) 		PF01871
(AMMECR1) 		4 LYS A 203
VAL A  14
ILE A 190
ARG A  53
 None
 0.91A 3pyyA-1vajA:
undetectable		 3pyyA-1vajA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 VAL 1 348
VAL 1 445
ILE 1 267
ARG 1 470
 None
 1.08A 3pyyA-1wao1:
undetectable		 3pyyA-1wao1:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS013

(Pyrococcus
horikoshii) 		PF05016
(ParE_toxin) 		4 TYR A  35
VAL A  66
VAL A   5
ARG A  25
 None
 1.11A 3pyyA-1wmiA:
undetectable		 3pyyA-1wmiA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB

(Mycobacterium
tuberculosis) 		PF13350
(Y_phosphatase3) 		4 VAL A 178
VAL A 170
ILE A 262
ARG A  26
 None
 0.96A 3pyyA-1ywfA:
undetectable		 3pyyA-1ywfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e18 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Pyrococcus
horikoshii) 		PF02540
(NAD_synthase) 		4 TYR A  40
VAL A 126
VAL A  51
ARG A 111
 None
 1.02A 3pyyA-2e18A:
undetectable		 3pyyA-2e18A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		4 VAL A 171
VAL A 163
ILE A 204
ARG A 244
 None
 1.05A 3pyyA-2e87A:
undetectable		 3pyyA-2e87A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 273
VAL A 291
VAL A 301
ILE A 314
ARG A 363
 1BM  A 499 (-3.8A)
None
None
1BM  A 499 (-3.9A)
None
 1.13A 3pyyA-2hk5A:
27.6		 3pyyA-2hk5A:
45.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 289
VAL A 299
ILE A 313
ARG A 362
 None
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
None
 1.07A 3pyyA-2hz0A:
34.0		 3pyyA-2hz0A:
95.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 162
VAL A 137
ILE A 102
ARG A 152
 None
 1.01A 3pyyA-2q27A:
undetectable		 3pyyA-2q27A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 VAL A 214
VAL A 139
ILE A 115
ARG A 150
 None
 1.01A 3pyyA-2y5wA:
undetectable		 3pyyA-2y5wA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 VAL A 328
VAL A 351
ILE A 331
ARG A 385
 None
None
None
SO4  A 656 (-3.9A)
 1.09A 3pyyA-3af5A:
undetectable		 3pyyA-3af5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz8 PUTATIVE
SPORULATION-SPECIFIC
GLYCOSYLASE YDHD

(Bacillus
subtilis) 		PF00704
(Glyco_hydro_18) 		4 VAL A 192
VAL A 181
ILE A 165
ARG A 227
 None
 1.11A 3pyyA-3cz8A:
undetectable		 3pyyA-3cz8A:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 222
VAL A 239
VAL A 249
ILE A 264
ARG A 313
 None
 1.39A 3pyyA-3d7uA:
27.1		 3pyyA-3d7uA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 VAL C1602
VAL C1647
ILE C1582
ARG C1632
 None
 0.84A 3pyyA-3dqvC:
undetectable		 3pyyA-3dqvC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffs INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		4 LYS A 180
VAL A 161
VAL A 153
ILE A 179
 None
 1.11A 3pyyA-3ffsA:
undetectable		 3pyyA-3ffsA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkh PUTATIVE
PYRIDOXAMINE
5'-PHOSPHATE OXIDASE

(Corynebacterium
glutamicum) 		PF12900
(Pyridox_ox_2) 		4 TYR A 115
VAL A  27
VAL A  38
ILE A 118
 None
 1.09A 3pyyA-3fkhA:
undetectable		 3pyyA-3fkhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5j PUTATIVE ATP/GTP
BINDING PROTEIN

(Clostridioides
difficile) 		PF00581
(Rhodanese) 		4 TYR A 124
VAL A 114
VAL A  15
ILE A   4
 None
 0.92A 3pyyA-3g5jA:
undetectable		 3pyyA-3g5jA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gku PROBABLE RNA-BINDING
PROTEIN

([Clostridium]
symbiosum) 		PF01424
(R3H)
PF13083
(KH_4)
PF14804
(Jag_N) 		4 VAL A 201
VAL A 188
ILE A 154
ARG A 176
 None
 0.93A 3pyyA-3gkuA:
undetectable		 3pyyA-3gkuA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpm PRKCA-BINDING
PROTEIN,9-MER
PEPTIDE OF THE GLUR2
SUBUNIT

(Rattus
norvegicus;
synthetic
construct) 		PF00595
(PDZ) 		4 TYR A  48
VAL A  97
ILE A  35
ARG A  76
 None
 1.08A 3pyyA-3hpmA:
undetectable		 3pyyA-3hpmA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 VAL X 253
VAL X 291
ILE X 222
ARG X 314
 None
 1.03A 3pyyA-3j8gX:
undetectable		 3pyyA-3j8gX:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		4 VAL A  69
VAL A  24
ILE A 131
ARG A  64
 None
 1.09A 3pyyA-3kq5A:
undetectable		 3pyyA-3kq5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 VAL A 199
VAL A 174
ILE A 115
ARG A 230
 None
 0.95A 3pyyA-3mcxA:
undetectable		 3pyyA-3mcxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 VAL A 291
VAL A 315
ILE A 308
ARG A 330
 None
 1.01A 3pyyA-3nowA:
undetectable		 3pyyA-3nowA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		4 TYR A 245
VAL A  51
VAL A  24
ILE A  35
 None
 1.04A 3pyyA-3nz4A:
undetectable		 3pyyA-3nz4A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
VAL A 609
ILE A 623
ARG A 675
 STU  A   1 (-3.5A)
None
None
SEP  A 710 ( 3.6A)
 0.87A 3pyyA-3ppzA:
28.6		 3pyyA-3ppzA:
36.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdt BOLETUS EDULIS
LECTIN

(Boletus edulis) 		PF07367
(FB_lectin) 		4 TYR A  96
VAL A 130
VAL A 125
ILE A   4
 None
 1.04A 3pyyA-3qdtA:
undetectable		 3pyyA-3qdtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  73
VAL A  98
ILE A 116
ARG A 165
 I85  A 350 (-2.8A)
None
None
None
 1.07A 3pyyA-3sheA:
18.6		 3pyyA-3sheA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 TYR X 124
VAL X 186
ILE X 236
ARG X 181
 None
 1.11A 3pyyA-3ss7X:
undetectable		 3pyyA-3ss7X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1p ALPHA-1-ANTITRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 TYR A  38
VAL A 333
VAL A 302
ILE A  57
 None
 1.02A 3pyyA-3t1pA:
undetectable		 3pyyA-3t1pA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 VAL A 608
VAL A 771
ILE A 557
ARG A 694
 None
 1.10A 3pyyA-3wajA:
undetectable		 3pyyA-3wajA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 TYR A 149
VAL A  41
ILE A  96
ARG A  73
 None
 1.04A 3pyyA-3zbmA:
undetectable		 3pyyA-3zbmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5p PROTEIN MXIA

(Shigella
flexneri) 		PF00771
(FHIPEP) 		4 TYR A 671
VAL A 644
ILE A 579
ARG A 657
 None
MLY  A 590 ( 4.3A)
None
None
 1.01A 3pyyA-4a5pA:
undetectable		 3pyyA-4a5pA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  91
VAL A 123
ILE A 137
ARG A 184
 None
9ZP  A1333 (-4.4A)
None
None
 1.08A 3pyyA-4b6lA:
22.5		 3pyyA-4b6lA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqb NEOGENIN

(Mus musculus) 		PF00041
(fn3) 		4 TYR A1060
VAL A 994
ILE A1023
ARG A1002
 None
 1.08A 3pyyA-4bqbA:
undetectable		 3pyyA-4bqbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		4 TYR A 398
VAL A 230
VAL A 413
ILE A 409
 None
 1.04A 3pyyA-4de8A:
undetectable		 3pyyA-4de8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 TYR A  56
VAL A 159
VAL A 133
ILE A  69
 None
 0.99A 3pyyA-4f0jA:
undetectable		 3pyyA-4f0jA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 317
VAL A 303
ILE A 328
ARG A 262
 None
None
None
NAP  A 502 (-3.3A)
 0.95A 3pyyA-4gi2A:
undetectable		 3pyyA-4gi2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		4 TYR A  69
VAL A  62
VAL A 117
ILE A   7
 None
 0.98A 3pyyA-4hujA:
undetectable		 3pyyA-4hujA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 450
VAL A 507
ILE A 512
ARG A 492
 None
 0.96A 3pyyA-4isbA:
undetectable		 3pyyA-4isbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iul EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02854
(MIF4G) 		4 TYR A 132
VAL A 105
VAL A  81
ILE A 115
 None
 1.09A 3pyyA-4iulA:
undetectable		 3pyyA-4iulA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 VAL A 169
VAL A 139
ILE A 221
ARG A 157
 None
SO4  A 503 (-4.8A)
None
NK  A 501 ( 4.9A)
 0.90A 3pyyA-4jz6A:
undetectable		 3pyyA-4jz6A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis) 		PF14011
(ESX-1_EspG) 		4 VAL A 115
VAL A 106
ILE A  72
ARG A  95
 None
 1.06A 3pyyA-4l4wA:
undetectable		 3pyyA-4l4wA:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 295
VAL A 313
VAL A 323
ILE A 336
 VGG  A 601 (-3.8A)
None
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
 0.88A 3pyyA-4lggA:
30.1		 3pyyA-4lggA:
45.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 TYR A 485
VAL A  86
VAL A 128
ILE A 135
 None
 1.10A 3pyyA-4lihA:
undetectable		 3pyyA-4lihA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 375
VAL A 404
ILE A 411
ARG A 444
 None
 0.92A 3pyyA-4lq1A:
undetectable		 3pyyA-4lq1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		4 VAL A 188
VAL A 177
ILE A 231
ARG A 196
 None
 1.11A 3pyyA-4mtnA:
undetectable		 3pyyA-4mtnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		4 VAL A 140
VAL A  40
ILE A  84
ARG A 151
 None
 1.11A 3pyyA-4nbwA:
undetectable		 3pyyA-4nbwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 TYR A 198
VAL A 221
ILE A  11
ARG A 215
 None
 1.06A 3pyyA-4nnbA:
undetectable		 3pyyA-4nnbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 VAL A 119
VAL A 125
ILE A 216
ARG A 105
 None
 1.06A 3pyyA-4o3sA:
undetectable		 3pyyA-4o3sA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4o PHYCOCYANOBILIN
LYASE CPCT

(Nostoc sp. PCC
7120) 		PF06206
(CpeT) 		4 VAL A  49
VAL A  53
ILE A  81
ARG A  12
 None
 1.10A 3pyyA-4o4oA:
undetectable		 3pyyA-4o4oA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 4 VAL A 286
VAL A 320
ILE A 259
ARG A 451
 None
 0.99A 3pyyA-4ru5A:
undetectable		 3pyyA-4ru5A:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LYS B 290
VAL B 308
VAL B 318
ILE B 332
 1N1  B 601 (-4.6A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
 0.97A 3pyyA-4xeyB:
29.9		 3pyyA-4xeyB:
73.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 VAL A 371
VAL A 367
ILE A 308
ARG A 243
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-4.7A)
 1.09A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE

(Streptomyces
globisporus) 		PF00668
(Condensation) 		4 VAL A 371
VAL A 367
ILE A 308
ARG A 393
 None
4T7  A 501 (-4.8A)
None
SUC  A 502 (-3.7A)
 1.05A 3pyyA-4zxwA:
undetectable		 3pyyA-4zxwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT
EPSILON

(Schizosaccharomyces
pombe) 		PF00132
(Hexapep)
PF00483
(NTP_transferase) 		4 LYS I 315
VAL I 345
ILE I 313
ARG I 323
 None
 0.97A 3pyyA-5b04I:
undetectable		 3pyyA-5b04I:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6k UNCHARACTERIZED
PROTEIN CGKR1

([Candida]
glabrata) 		PF01370
(Epimerase) 		4 TYR A 190
VAL A  12
VAL A 126
ILE A 114
 None
 0.81A 3pyyA-5b6kA:
undetectable		 3pyyA-5b6kA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 TYR A1066
VAL A 823
VAL A 765
ILE A 740
 None
 1.10A 3pyyA-5b7iA:
undetectable		 3pyyA-5b7iA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 VAL A  70
VAL A  28
ILE A 123
ARG A  41
 None
 1.02A 3pyyA-5by3A:
undetectable		 3pyyA-5by3A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A 298
VAL A 211
ILE A 205
ARG A 184
 None
 0.99A 3pyyA-5dgtA:
undetectable		 3pyyA-5dgtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlb CHAPERONE ESPG3

(Mycobacterium
marinum) 		PF14011
(ESX-1_EspG) 		4 VAL A 134
VAL A 125
ILE A  74
ARG A 102
 None
 1.09A 3pyyA-5dlbA:
undetectable		 3pyyA-5dlbA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 VAL A 101
VAL A 114
ILE A  56
ARG A 757
 None
 1.07A 3pyyA-5fkrA:
undetectable		 3pyyA-5fkrA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iql YEATS
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF03366
(YEATS) 		4 VAL A 212
VAL A 327
ILE A 247
ARG A 288
 None
 1.08A 3pyyA-5iqlA:
undetectable		 3pyyA-5iqlA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.97A 3pyyA-5k5tA:
undetectable		 3pyyA-5k5tA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzl HEME OXYGENASE

(Leptospira
interrogans) 		PF01126
(Heme_oxygenase) 		4 TYR A  45
VAL A 194
VAL A 104
ILE A 201
 None
 0.90A 3pyyA-5kzlA:
undetectable		 3pyyA-5kzlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t53 N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13878
(zf-C2H2_3)
PF13880
(Acetyltransf_13) 		4 TYR A 677
LYS A 681
VAL A 719
ILE A 685
 None
 0.97A 3pyyA-5t53A:
undetectable		 3pyyA-5t53A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 279
VAL A 234
ILE A 346
ARG A 255
 None
 1.00A 3pyyA-5weaA:
undetectable		 3pyyA-5weaA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 VAL A 304
VAL A 383
ILE A 405
ARG A 297
 None
 0.80A 3pyyA-5wlhA:
undetectable		 3pyyA-5wlhA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		4 TYR A 132
VAL A   7
VAL A  17
ILE A  65
 None
 1.11A 3pyyA-5x6sA:
undetectable		 3pyyA-5x6sA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 4 VAL C 306
VAL C  92
ILE C 222
ARG C  62
 None
 0.81A 3pyyA-5xw6C:
undetectable		 3pyyA-5xw6C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 393
VAL A 298
ILE A 387
ARG A 153
 None
None
None
C  I  58 ( 4.0A)
 1.05A 3pyyA-6asoA:
undetectable		 3pyyA-6asoA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 4 VAL A  91
VAL A  99
ILE A 149
ARG A  32
 None
 1.11A 3pyyA-6btpA:
undetectable		 3pyyA-6btpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL g 122
VAL g 118
ILE g 227
ARG g 171
 None
 1.03A 3pyyA-6fkhg:
undetectable		 3pyyA-6fkhg:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 LYS A 191
VAL A 209
VAL A 225
ILE A 239
 EAQ  A 501 (-3.2A)
None
None
None
 0.72A 3pyyA-6fyoA:
21.2		 3pyyA-6fyoA:
undetectable