SIMILAR PATTERNS OF AMINO ACIDS FOR 3PWW_A_ROCA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayz UBIQUITIN-CONJUGATIN
G ENZYME RAD6

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 ILE A  91
TYR A 100
ASP A 101
SER A 104
 None
 0.77A 3pwwA-1ayzA:
undetectable		 3pwwA-1ayzA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)

(Saccharomyces
cerevisiae) 		PF00080
(Sod_Cu) 		4 GLY A 138
SER A 134
ASP A  76
ASP A 124
 None
 0.84A 3pwwA-1b4tA:
undetectable		 3pwwA-1b4tA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		5 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A 215
 None
 0.37A 3pwwA-1b5fA:
24.9		 3pwwA-1b5fA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 GLY E  34
SER E  35
ILE E  73
TYR E  75
ASP E 215
 None
 0.33A 3pwwA-1cziE:
39.5		 3pwwA-1cziE:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		4 GLY A 130
ILE A 158
ASP A  20
THR A  13
 None
 0.66A 3pwwA-1ggpA:
undetectable		 3pwwA-1ggpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 GLY A 547
ILE A 543
ASP A 663
THR A 573
 None
 0.82A 3pwwA-1h7wA:
undetectable		 3pwwA-1h7wA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  72
TYR A  74
ASP A 214
THR A 218
 ZN  A1457 (-3.6A)
None
None
None
ZN  A1457 (-1.9A)
None
 0.31A 3pwwA-1ibqA:
49.0		 3pwwA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  72
TYR A  74
SER A  78
ASP A 214
 ZN  A1457 (-3.6A)
None
None
None
None
ZN  A1457 (-1.9A)
 0.39A 3pwwA-1ibqA:
49.0		 3pwwA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 ILE A  72
TYR A  74
ASP A  76
SER A  78
 None
 0.53A 3pwwA-1ibqA:
49.0		 3pwwA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		8 GLY A  35
SER A  36
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 214
THR A 218
 None
 0.45A 3pwwA-1izeA:
49.8		 3pwwA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A  86
THR A 222
 None
 0.55A 3pwwA-1j71A:
36.3		 3pwwA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A 218
THR A 222
 None
 0.22A 3pwwA-1j71A:
36.3		 3pwwA-1j71A:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lyb CATHEPSIN D

(Homo sapiens) 		PF00026
(Asp) 		4 GLY A  35
SER A  36
ILE A  76
TYR A  78
 None
 0.36A 3pwwA-1lybA:
9.0		 3pwwA-1lybA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		5 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A 215
 None
 0.36A 3pwwA-1mppA:
37.6		 3pwwA-1mppA:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdm PROPHYTEPSIN

(Hordeum vulgare) 		PF00026
(Asp)
PF03489
(SapB_2)
PF05184
(SapB_1) 		5 GLY A  38
SER A  39
ILE A  78
TYR A  80
ASP A 223
 None
 0.68A 3pwwA-1qdmA:
37.1		 3pwwA-1qdmA:
25.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		5 GLY E  34
SER E  35
ILE E  73
TYR E  75
ASP E 215
 HH0  E 327 (-4.1A)
HH0  E 327 (-4.1A)
None
HH0  E 327 (-4.5A)
HH0  E 327 (-2.5A)
 0.34A 3pwwA-1qrpE:
38.7		 3pwwA-1qrpE:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		6 GLY A  36
SER A  37
ILE A  75
TYR A  77
ASP A 214
THR A 218
 None
 0.54A 3pwwA-1qs8A:
35.9		 3pwwA-1qs8A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 GLY A 267
SER A 266
ILE A  82
SER A  72
 None
 0.84A 3pwwA-1r6xA:
undetectable		 3pwwA-1r6xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus) 		PF00026
(Asp) 		5 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A 215
 None
 0.26A 3pwwA-1smrA:
37.7		 3pwwA-1smrA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tr1 BETA-GLUCOSIDASE A

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		4 GLY A 344
ILE A 291
ASP A 248
SER A 247
 None
 0.71A 3pwwA-1tr1A:
undetectable		 3pwwA-1tr1A:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		4 GLY A  45
SER A  46
TYR A  86
ASP A 228
 None
 0.41A 3pwwA-1tzsA:
8.9		 3pwwA-1tzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		7 GLY A  37
SER A  38
ILE A  75
TYR A  77
SER A  81
ASP A 218
THR A 222
 None
 0.37A 3pwwA-1uh9A:
42.5		 3pwwA-1uh9A:
40.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus) 		PF00026
(Asp) 		6 SER A  38
ILE A  75
TYR A  77
ASP A  79
SER A  81
THR A 222
 None
 0.67A 3pwwA-1uh9A:
42.5		 3pwwA-1uh9A:
40.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 GLY A 216
SER A 305
ASP A 296
SER A 298
 None
None
PYC  A 700 (-3.3A)
PYC  A 700 ( 4.3A)
 0.84A 3pwwA-1w61A:
undetectable		 3pwwA-1w61A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		5 GLY A  34
SER A  35
TYR A  63
ASP A 212
THR A 216
 None
 0.34A 3pwwA-1wkrA:
35.5		 3pwwA-1wkrA:
33.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xso COPPER,ZINC
SUPEROXIDE DISMUTASE

(Xenopus laevis) 		PF00080
(Sod_Cu) 		4 GLY A 136
SER A 132
ASP A  74
ASP A 122
 None
 0.85A 3pwwA-1xsoA:
undetectable		 3pwwA-1xsoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		7 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A  86
ASP A 218
THR A 222
 A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
None
A70  A 500 (-3.8A)
A70  A 500 (-3.1A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.0A)
 0.33A 3pwwA-1zapA:
36.2		 3pwwA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		7 GLY A  34
SER A  35
TYR A  84
ASP A  86
SER A  88
ASP A 218
THR A 222
 A70  A 500 (-3.8A)
A70  A 500 ( 4.5A)
A70  A 500 (-3.8A)
A70  A 500 (-3.1A)
A70  A 500 ( 4.2A)
A70  A 500 ( 2.3A)
A70  A 500 (-4.0A)
 0.48A 3pwwA-1zapA:
36.2		 3pwwA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		5 GLY A 138
SER A 139
SER A  49
ASP A 136
THR A 134
 None
None
PO4  A 362 (-2.5A)
None
None
 1.29A 3pwwA-2amlA:
undetectable		 3pwwA-2amlA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anl PLASMEPSIN IV

(Plasmodium
malariae) 		PF00026
(Asp) 		5 GLY A  36
SER A  37
ILE A  75
TYR A  77
ASP A 214
 JE2  A3151 (-2.7A)
None
None
JE2  A3151 (-3.6A)
JE2  A3151 (-2.5A)
 0.51A 3pwwA-2anlA:
35.2		 3pwwA-2anlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		4 GLY A 142
SER A 138
ASP A  80
ASP A 128
 None
 0.82A 3pwwA-2e47A:
undetectable		 3pwwA-2e47A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 GLY A  50
SER A  51
TYR A  87
ASP A 241
THR A 245
 DBO  A1001 (-3.7A)
DBO  A1001 (-4.1A)
DBO  A1001 (-3.8A)
DBO  A1001 (-3.2A)
DBO  A1001 (-3.8A)
 0.29A 3pwwA-2ewyA:
5.1		 3pwwA-2ewyA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		4 GLY A  35
SER A  36
TYR A  78
ASP A 221
 4IG  A 885 (-3.5A)
4IG  A 885 ( 4.8A)
4IG  A 885 (-4.0A)
4IG  A 885 (-2.6A)
 0.22A 3pwwA-2g1sA:
37.8		 3pwwA-2g1sA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		4 SER A 299
ILE A 422
SER A 340
ASP A 107
 None
 0.71A 3pwwA-2gljA:
undetectable		 3pwwA-2gljA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A  86
ASP A 218
 None
 0.51A 3pwwA-2h6tA:
35.1		 3pwwA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans) 		PF00026
(Asp) 		6 GLY A  34
SER A  35
ILE A  82
TYR A  84
ASP A 218
THR A 222
 None
 0.31A 3pwwA-2h6tA:
35.1		 3pwwA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 GLY A 248
SER A 249
ASP A  28
THR A 334
 None
None
None
MG  A1347 (-4.7A)
 0.75A 3pwwA-2j1nA:
undetectable		 3pwwA-2j1nA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		7 GLY A  34
SER A  35
ILE A  82
TYR A  84
SER A  88
ASP A 218
THR A 222
 None
 0.38A 3pwwA-2qzwA:
36.0		 3pwwA-2qzwA:
30.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A  82
TYR A  84
ASP A  86
SER A  88
THR A 222
 None
 0.67A 3pwwA-2qzwA:
36.0		 3pwwA-2qzwA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		7 GLY A  34
SER A  35
ILE A  82
TYR A  84
SER A  88
ASP A 218
THR A 222
 None
 0.34A 3pwwA-2qzxA:
35.9		 3pwwA-2qzxA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		7 SER A  35
ILE A  82
TYR A  84
ASP A  86
SER A  88
ASP A 218
THR A 222
 None
 0.57A 3pwwA-2qzxA:
35.9		 3pwwA-2qzxA:
29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		5 GLY A  40
SER A  41
ILE A  80
TYR A  82
ASP A 237
 None
 0.42A 3pwwA-2rmpA:
37.6		 3pwwA-2rmpA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum) 		PF00026
(Asp) 		8 GLY A  35
SER A  36
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 213
THR A 217
 PP6  A 327 (-4.0A)
PP6  A 327 ( 4.0A)
None
PP6  A 327 (-3.8A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.4A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-4.5A)
 0.29A 3pwwA-2wedA:
48.0		 3pwwA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ILE A 699
TYR A 701
ASP A 703
SER A 705
 None
 0.42A 3pwwA-2xsgA:
undetectable		 3pwwA-2xsgA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  77
TYR H  79
SER H  70
THR H  17
 None
 0.56A 3pwwA-2zpkH:
undetectable		 3pwwA-2zpkH:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE

(Trichoderma
reesei) 		PF00026
(Asp) 		8 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A  77
SER A  79
ASP A 215
THR A 219
 None
 0.56A 3pwwA-3emyA:
51.6		 3pwwA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
innocua) 		PF06838
(Met_gamma_lyase) 		4 SER A 167
SER A 370
ASP A 200
THR A  86
 LLP  A 226 ( 4.1A)
LLP  A 226 ( 4.2A)
LLP  A 226 ( 2.8A)
LLP  A 226 ( 3.6A)
 0.81A 3pwwA-3fd0A:
undetectable		 3pwwA-3fd0A:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1

(Candida
parapsilosis) 		PF00026
(Asp) 		8 GLY A  34
SER A  35
ILE A  76
TYR A  78
ASP A  80
SER A  82
ASP A 220
THR A 224
 None
 0.55A 3pwwA-3fv3A:
36.8		 3pwwA-3fv3A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 GLY A 621
ILE A 646
ASP A 625
SER A 640
 None
 0.63A 3pwwA-3gq9A:
undetectable		 3pwwA-3gq9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 GLY A 235
SER A 236
TYR A 293
THR A 229
 None
 0.76A 3pwwA-3h2iA:
undetectable		 3pwwA-3h2iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		4 SER A 184
SER A 387
ASP A 217
THR A 100
 None
TLA  A 427 ( 4.9A)
None
TLA  A 427 (-3.8A)
 0.77A 3pwwA-3i16A:
undetectable		 3pwwA-3i16A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE

(Listeria
monocytogenes) 		PF06838
(Met_gamma_lyase) 		4 SER A 167
SER A 370
ASP A 200
THR A  86
 LLP  A 226 ( 4.1A)
LLP  A 226 ( 3.0A)
LLP  A 226 ( 2.8A)
LLP  A 226 ( 3.4A)
 0.78A 3pwwA-3jzlA:
undetectable		 3pwwA-3jzlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbe RICIN B-LIKE LECTIN

(Clitocybe
nebularis) 		PF14200
(RicinB_lectin_2) 		4 GLY A  81
ASP A 132
SER A 135
ASP A  80
 None
 0.84A 3pwwA-3nbeA:
undetectable		 3pwwA-3nbeA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 GLY A  34
SER A  35
TYR A  75
ASP A 215
 None
 0.43A 3pwwA-3psgA:
34.7		 3pwwA-3psgA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLY A 145
ILE A  52
SER A  10
THR A 148
 None
 0.82A 3pwwA-3qfkA:
undetectable		 3pwwA-3qfkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 GLY A  34
SER A  35
TYR A  75
ASP A 215
 006  A 330 (-3.2A)
006  A 330 (-4.5A)
006  A 330 (-4.3A)
006  A 330 (-2.8A)
 0.45A 3pwwA-3qs1A:
35.9		 3pwwA-3qs1A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 GLY A 621
ILE A 646
ASP A 625
SER A 640
 None
 0.67A 3pwwA-3sucA:
undetectable		 3pwwA-3sucA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 GLY A 275
ILE A  17
SER A 115
ASP A 278
 ADN  A 353 (-3.7A)
None
ADN  A 353 ( 4.0A)
ADN  A 353 (-3.3A)
 0.82A 3pwwA-3uboA:
undetectable		 3pwwA-3uboA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		4 GLY A  27
ILE A  92
ASP A  98
SER A 101
 None
 0.73A 3pwwA-3uitA:
undetectable		 3pwwA-3uitA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpp CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 GLY A 269
SER A 268
SER A 367
THR A 285
 None
 0.67A 3pwwA-3zppA:
undetectable		 3pwwA-3zppA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0j PROBABLE HYDROLYTIC
ENZYME

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 GLY A 274
ILE A 245
ASP A 190
SER A 238
 EDO  A 405 (-3.3A)
None
None
None
 0.72A 3pwwA-4f0jA:
undetectable		 3pwwA-4f0jA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN

(Homo sapiens) 		PF01019
(G_glu_transpept) 		4 GLY A 140
ILE A  93
ASP A  66
SER A  63
 None
None
None
NAG  A 401 ( 4.0A)
 0.83A 3pwwA-4gg2A:
undetectable		 3pwwA-4gg2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjc ENVELOPE
GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		PF07245
(Phlebovirus_G2) 		4 GLY A 886
ILE A 863
ASP A 867
SER A 869
 None
 0.73A 3pwwA-4hjcA:
undetectable		 3pwwA-4hjcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		4 GLY A 160
SER A 241
ASP A 232
SER A 234
 None
None
PYC  A 402 (-3.6A)
PYC  A 402 ( 4.4A)
 0.83A 3pwwA-4j9wA:
undetectable		 3pwwA-4j9wA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		4 GLY A 160
SER A 241
ASP A 232
SER A 234
 None
 0.84A 3pwwA-4jbdA:
undetectable		 3pwwA-4jbdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 GLY B 170
SER B 261
ASP B 252
SER B 254
 None
None
PYC  B 904 (-3.2A)
PYC  B 904 ( 3.9A)
 0.82A 3pwwA-4k7gB:
undetectable		 3pwwA-4k7gB:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A3316
ASP A3157
SER A3634
THR A3415
 None
 0.83A 3pwwA-4kc5A:
undetectable		 3pwwA-4kc5A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 GLY A 280
SER A 279
SER A 378
THR A 256
 None
 0.77A 3pwwA-4mr0A:
undetectable		 3pwwA-4mr0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mr0 PLASMIN AND
FIBRONECTIN-BINDING
PROTEIN A

(Streptococcus
pneumoniae) 		PF12708
(Pectate_lyase_3)
PF13229
(Beta_helix) 		4 GLY A 280
SER A 279
SER A 378
THR A 296
 None
 0.67A 3pwwA-4mr0A:
undetectable		 3pwwA-4mr0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 GLY A 153
TYR A  90
ASP A  86
SER A  89
 None
 0.85A 3pwwA-4p9nA:
undetectable		 3pwwA-4p9nA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris) 		PF12697
(Abhydrolase_6) 		5 GLY A 270
SER A 189
ILE A 191
SER A  55
ASP A 243
 None
 1.41A 3pwwA-4psuA:
undetectable		 3pwwA-4psuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		4 GLY A 173
SER A 260
ASP A 251
SER A 253
 None
None
CSO  A 255 (-3.5A)
CSO  A 255 ( 3.0A)
 0.84A 3pwwA-4q2hA:
undetectable		 3pwwA-4q2hA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		4 GLY A  34
SER A  35
ASP A 228
THR A 232
 3LL  A 501 ( 3.9A)
3LL  A 501 ( 4.3A)
3LL  A 501 (-2.6A)
GOL  A 506 ( 4.3A)
 0.24A 3pwwA-4rcdA:
32.4		 3pwwA-4rcdA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unr THYMIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF02223
(Thymidylate_kin) 		4 GLY A  83
TYR A  88
ASP A  89
SER A  30
 None
 0.76A 3pwwA-4unrA:
undetectable		 3pwwA-4unrA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2

(Candida
parapsilosis) 		PF00026
(Asp) 		8 GLY A  34
SER A  35
ILE A  75
TYR A  77
ASP A  79
SER A  81
ASP A 211
THR A 215
 None
 0.50A 3pwwA-4y9wA:
36.5		 3pwwA-4y9wA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 GLY D  37
SER D 100
ILE D  62
TYR D  58
 None
 0.68A 3pwwA-4ymwD:
undetectable		 3pwwA-4ymwD:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 GLY A 254
SER A 255
ILE A 173
ASP A 201
 EDO  A1578 (-3.5A)
None
None
None
 0.73A 3pwwA-5a29A:
undetectable		 3pwwA-5a29A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLY A 719
ILE A 216
SER A 219
ASP A 701
 None
 0.77A 3pwwA-5fr8A:
undetectable		 3pwwA-5fr8A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 238
SER A 237
ASP A 131
THR A 153
 None
 0.82A 3pwwA-5gndA:
undetectable		 3pwwA-5gndA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		7 GLY A  37
SER A  38
ILE A  77
TYR A  79
SER A  83
ASP A 219
THR A 223
 61P  A 406 ( 4.0A)
None
None
61P  A 406 (-4.3A)
61P  A 406 (-3.0A)
61P  A 406 (-2.9A)
PG4  A 408 (-3.8A)
 0.27A 3pwwA-5hctA:
57.6		 3pwwA-5hctA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		6 SER A  38
ILE A  77
TYR A  79
ASP A  81
SER A  83
THR A 223
 None
None
61P  A 406 (-4.3A)
61P  A 406 ( 2.8A)
61P  A 406 (-3.0A)
PG4  A 408 (-3.8A)
 0.52A 3pwwA-5hctA:
57.6		 3pwwA-5hctA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 5 GLY B  36
SER B  37
ILE B  75
TYR B  77
ASP B 214
 None
 0.59A 3pwwA-5i70B:
36.3		 3pwwA-5i70B:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kiq PLATELET-BINDING
GLYCOPROTEIN

(Streptococcus
sanguinis) 		no annotation 4 ILE A 426
TYR A 428
ASP A 430
SER A 432
 None
 0.39A 3pwwA-5kiqA:
undetectable		 3pwwA-5kiqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 GLY B 119
ILE B 167
ASP B 171
SER B 173
 None
 0.65A 3pwwA-5kswB:
undetectable		 3pwwA-5kswB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE

(Pseudomonas
stutzeri) 		no annotation 4 GLY H 187
SER H  46
ASP H 297
THR H 252
 None
None
MG  H 401 (-3.0A)
None
 0.78A 3pwwA-5mgyH:
undetectable		 3pwwA-5mgyH:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkt RENIN-1

(Mus musculus) 		no annotation 4 GLY A  83
SER A  84
ILE A 124
ASP A 266
 None
 0.50A 3pwwA-5mktA:
32.0		 3pwwA-5mktA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 4 GLY A  83
SER A  84
ILE A 124
ASP A 266
 None
 0.41A 3pwwA-5mlgA:
36.3		 3pwwA-5mlgA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 GLY A  38
SER A  39
ILE A  77
TYR A  79
ASP A 227
 None
 0.33A 3pwwA-5n7qA:
39.7		 3pwwA-5n7qA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 4 GLY A  82
SER A  83
ILE A 122
ASP A 267
 None
 0.35A 3pwwA-5nfgA:
38.2		 3pwwA-5nfgA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 GLY A  65
ILE A 166
TYR A  39
ASP A  37
 None
 0.78A 3pwwA-5njfA:
undetectable		 3pwwA-5njfA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 4 GLY A 100
ILE A  27
ASP A  31
SER A  33
 None
 0.80A 3pwwA-5nzbA:
undetectable		 3pwwA-5nzbA:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		8 GLY A  37
SER A  38
ILE A  77
TYR A  79
ASP A  81
SER A  83
ASP A 219
THR A 223
 None
 0.45A 3pwwA-5p60A:
57.9		 3pwwA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa) 		PF00026
(Asp) 		5 GLY A  34
SER A  35
ILE A  73
TYR A  75
ASP A 215
 None
 0.46A 3pwwA-5pepA:
38.4		 3pwwA-5pepA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uff RBC36

(Petromyzon
marinus) 		no annotation 4 GLY A  81
SER A  82
ASP A 152
ASP A 103
 None
8B7  A 300 ( 4.2A)
8B7  A 300 (-3.0A)
8B7  A 300 (-3.2A)
 0.73A 3pwwA-5uffA:
undetectable		 3pwwA-5uffA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ILE A  77
TYR A  79
SER A  70
THR A  17
 None
 0.49A 3pwwA-5xctA:
undetectable		 3pwwA-5xctA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 ILE A 343
TYR A 345
ASP A 347
SER A 349
 None
 0.61A 3pwwA-5xnrA:
undetectable		 3pwwA-5xnrA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 GLY A  82
SER A  83
TYR A 139
ASP A 313
THR A 317
 EQG  A 504 (-3.0A)
EQG  A 504 (-4.3A)
EQG  A 504 (-3.2A)
EQG  A 504 (-2.1A)
EQG  A 504 (-2.9A)
 0.19A 3pwwA-6c4gA:
32.0		 3pwwA-6c4gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 5 GLY A  82
TYR A 139
SER A 143
ASP A 313
THR A 317
 EQG  A 504 (-3.0A)
EQG  A 504 (-3.2A)
EQG  A 504 ( 4.3A)
EQG  A 504 (-2.1A)
EQG  A 504 (-2.9A)
 0.49A 3pwwA-6c4gA:
32.0		 3pwwA-6c4gA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus) 		no annotation 4 GLY A 365
SER A 361
TYR A 400
SER A 348
 None
 0.84A 3pwwA-6cv0A:
undetectable		 3pwwA-6cv0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 4 GLY A 443
SER A 444
ASP A 637
THR A 641
 B7E  A 901 ( 3.8A)
B7E  A 901 ( 3.7A)
B7E  A 901 (-2.6A)
None
 0.30A 3pwwA-6ej2A:
9.0		 3pwwA-6ej2A:
13.18