SIMILAR PATTERNS OF AMINO ACIDS FOR 3PWR_A_ROCA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A 267
VAL A 189
THR A 169
 None
 0.76A 3pwrA-1a5zA:
0.0		 3pwrA-1a5zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 246
VAL A 255
THR A 230
 None
 0.81A 3pwrA-1akmA:
0.0		 3pwrA-1akmA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		3 ARG B 266
VAL B 323
THR B  61
 None
 0.83A 3pwrA-1ccwB:
0.0		 3pwrA-1ccwB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		3 ARG A 272
VAL A 313
THR A 358
 None
 0.82A 3pwrA-1cg4A:
undetectable		 3pwrA-1cg4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 ARG A 185
VAL A 303
THR A 218
 None
 0.79A 3pwrA-1flgA:
0.0		 3pwrA-1flgA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		3 ARG A 185
VAL A  68
THR A  79
 A3P  A 400 (-2.8A)
None
None
 0.82A 3pwrA-1fmlA:
0.0		 3pwrA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fml RETINOL DEHYDRATASE

(Spodoptera
frugiperda) 		PF00685
(Sulfotransfer_1) 		3 ARG A 312
VAL A 293
THR A  77
 A3P  A 400 (-3.7A)
None
A3P  A 400 (-3.6A)
 0.76A 3pwrA-1fmlA:
0.0		 3pwrA-1fmlA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		3 ARG A 394
VAL A 464
THR A 399
 None
 0.67A 3pwrA-1fohA:
0.0		 3pwrA-1fohA:
9.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
VAL A  32
THR A  80
 A79  A 800 (-3.4A)
A79  A 800 ( 4.4A)
None
 0.47A 3pwrA-1hvcA:
14.2		 3pwrA-1hvcA:
46.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
VAL A  32
THR A  80
 A79  A 800 (-3.6A)
A79  A 800 ( 4.3A)
None
 0.50A 3pwrA-1hvcA:
14.2		 3pwrA-1hvcA:
46.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 ARG A 500
VAL A 455
THR A 564
 None
 0.87A 3pwrA-1ikpA:
0.0		 3pwrA-1ikpA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		3 ARG A 172
VAL A 155
THR A 178
 None
 0.78A 3pwrA-1iu9A:
undetectable		 3pwrA-1iu9A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfl ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		3 ARG A 172
VAL A 155
THR A 178
 None
 0.83A 3pwrA-1jflA:
undetectable		 3pwrA-1jflA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		3 ARG A 637
VAL A 175
THR A 180
 None
 0.81A 3pwrA-1kehA:
undetectable		 3pwrA-1kehA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1505
VAL A1829
THR A1844
 None
 0.85A 3pwrA-1larA:
undetectable		 3pwrA-1larA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9) 		3 ARG A 176
VAL A 147
THR A 149
 None
 0.84A 3pwrA-1m4iA:
undetectable		 3pwrA-1m4iA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 ARG A 120
VAL A  51
THR A  30
 None
 0.83A 3pwrA-1mb9A:
undetectable		 3pwrA-1mb9A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mlz 7,8-DIAMINO-PELARGON
IC ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 ARG A 221
VAL A 154
THR A 139
 None
 0.73A 3pwrA-1mlzA:
undetectable		 3pwrA-1mlzA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		3 ARG A 266
VAL A 247
THR A  71
 None
 0.59A 3pwrA-1n9bA:
undetectable		 3pwrA-1n9bA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		3 ARG A 425
VAL A 457
THR A 451
 None
 0.84A 3pwrA-1obbA:
undetectable		 3pwrA-1obbA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ort ORNITHINE
TRANSCARBAMOYLASE

(Pseudomonas
aeruginosa) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 246
VAL A 255
THR A 230
 None
 0.73A 3pwrA-1ortA:
undetectable		 3pwrA-1ortA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IG ALPHA-1 CHAIN C
REGION

(Homo sapiens) 		PF00047
(ig)
PF07654
(C1-set) 		3 ARG A 401
VAL A 381
THR A 397
 None
 0.79A 3pwrA-1ow0A:
undetectable		 3pwrA-1ow0A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		3 ARG D  94
VAL E 276
THR D 192
 None
 0.77A 3pwrA-1qgeD:
undetectable		 3pwrA-1qgeD:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A 139
VAL A 105
THR A 159
 None
 0.81A 3pwrA-1qlbA:
undetectable		 3pwrA-1qlbA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8t HEPARAN SULFATE
D-GLUCOSAMINYL
3-O-SULFOTRANSFERASE
3A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 ARG A 248
VAL A 379
THR A 270
 None
 0.64A 3pwrA-1t8tA:
undetectable		 3pwrA-1t8tA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 3 ARG B  94
VAL B 276
THR B 192
 None
 0.80A 3pwrA-1tahB:
undetectable		 3pwrA-1tahB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		3 ARG A 768
VAL A 418
THR A 469
 None
 0.77A 3pwrA-1ulvA:
undetectable		 3pwrA-1ulvA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ARG A 185
VAL A  72
THR A 148
 None
 0.78A 3pwrA-1v9lA:
undetectable		 3pwrA-1v9lA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		3 ARG A  38
VAL A 427
THR A  76
 CAO  A 429 (-3.1A)
None
None
 0.80A 3pwrA-1vgqA:
undetectable		 3pwrA-1vgqA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj7 BIFUNCTIONAL
RELA/SPOT

(Streptococcus
dysgalactiae) 		PF04607
(RelA_SpoT)
PF13328
(HD_4) 		3 ARG A 290
VAL A 282
THR A 313
 None
 0.61A 3pwrA-1vj7A:
undetectable		 3pwrA-1vj7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wio T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set)
PF09191
(CD4-extracel) 		3 ARG A 329
VAL A 305
THR A 309
 None
 0.82A 3pwrA-1wioA:
undetectable		 3pwrA-1wioA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkk NUCLEOSIDE
DIPHOSPHATE KINASE

(Thermus
thermophilus) 		PF00334
(NDK) 		3 ARG A  31
VAL A  84
THR A   4
 None
 0.77A 3pwrA-1wkkA:
undetectable		 3pwrA-1wkkA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wko TERMINAL FLOWER 1
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		3 ARG A 122
VAL A  71
THR A 148
 None
 0.84A 3pwrA-1wkoA:
undetectable		 3pwrA-1wkoA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		3 ARG A 195
VAL A 175
THR A 179
 None
 0.87A 3pwrA-1xqpA:
undetectable		 3pwrA-1xqpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A  12
VAL A  73
THR A  98
 None
 0.58A 3pwrA-1yb5A:
undetectable		 3pwrA-1yb5A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 ARG A 101
VAL A 479
THR A 429
 None
 0.84A 3pwrA-1yr2A:
undetectable		 3pwrA-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Plasmodium
falciparum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ARG O  16
VAL O 290
THR O 242
 None
 0.68A 3pwrA-1ywgO:
undetectable		 3pwrA-1ywgO:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Escherichia
coli) 		PF02233
(PNTB) 		3 ARG C  58
VAL C 109
THR C 106
 None
 0.72A 3pwrA-2bruC:
undetectable		 3pwrA-2bruC:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5s PROBABLE THIAMINE
BIOSYNTHESIS PROTEIN
THII

(Bacillus
anthracis) 		PF02568
(ThiI)
PF02926
(THUMP) 		3 ARG A 314
VAL A 207
THR A 272
 None
 0.73A 3pwrA-2c5sA:
undetectable		 3pwrA-2c5sA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2col BIFUNCTIONAL
HEMOLYSIN-ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF03497
(Anthrax_toxA) 		3 ARG A  15
VAL A  43
THR A  48
 None
 0.62A 3pwrA-2colA:
undetectable		 3pwrA-2colA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		3 ARG A 226
VAL A 222
THR A 131
 None
 0.78A 3pwrA-2dpwA:
undetectable		 3pwrA-2dpwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT

(Homo sapiens) 		PF00620
(RhoGAP) 		3 ARG A 147
VAL A  80
THR A  41
 None
 0.87A 3pwrA-2ee4A:
undetectable		 3pwrA-2ee4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egg SHIKIMATE
5-DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 ARG A 173
VAL A 146
THR A 211
 None
 0.81A 3pwrA-2eggA:
undetectable		 3pwrA-2eggA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		3 ARG A 439
VAL A 387
THR A 452
 None
 0.82A 3pwrA-2eidA:
undetectable		 3pwrA-2eidA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		3 ARG A  42
VAL A 245
THR A 268
 None
 0.76A 3pwrA-2ek8A:
undetectable		 3pwrA-2ek8A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 ARG A 335
VAL A 264
THR A 237
 None
 0.87A 3pwrA-2fvmA:
undetectable		 3pwrA-2fvmA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 184
VAL A 155
THR A 152
 None
 0.77A 3pwrA-2g5tA:
undetectable		 3pwrA-2g5tA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		3 ARG A 422
VAL A 246
THR A 435
 None
 0.83A 3pwrA-2gahA:
undetectable		 3pwrA-2gahA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		3 ARG A 385
VAL A 612
THR A 620
 None
 0.86A 3pwrA-2gh8A:
undetectable		 3pwrA-2gh8A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h7g DNA TOPOISOMERASE 1

(Variola virus) 		PF01028
(Topoisom_I)
PF09266
(VirDNA-topo-I_N) 		3 ARG X  86
VAL X 304
THR X 278
 None
 0.74A 3pwrA-2h7gX:
undetectable		 3pwrA-2h7gX:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 229
VAL A  62
THR A  94
 None
 0.81A 3pwrA-2ihtA:
undetectable		 3pwrA-2ihtA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		3 ARG A  91
VAL A  95
THR A 115
 None
 0.85A 3pwrA-2iuyA:
undetectable		 3pwrA-2iuyA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		3 ARG A  44
VAL A  17
THR A 292
 FAD  A1489 (-3.9A)
None
FAD  A1489 ( 4.7A)
 0.85A 3pwrA-2jb1A:
undetectable		 3pwrA-2jb1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzd REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		3 ARG A 625
VAL A 635
THR A 528
 None
 0.86A 3pwrA-2jzdA:
undetectable		 3pwrA-2jzdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lc0 PUTATIVE
UNCHARACTERIZED
PROTEIN TB39.8

(Mycobacterium
tuberculosis) 		PF12401
(DUF3662) 		3 ARG A  10
VAL A 125
THR A 100
 None
 0.87A 3pwrA-2lc0A:
undetectable		 3pwrA-2lc0A:
29.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ng1 SIGNAL SEQUENCE
RECOGNITION PROTEIN
FFH

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 ARG A  36
VAL A  43
THR A  48
 None
 0.81A 3pwrA-2ng1A:
undetectable		 3pwrA-2ng1A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		3 ARG A  80
VAL A  52
THR A  50
 None
 0.78A 3pwrA-2nwqA:
undetectable		 3pwrA-2nwqA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN

(Archaeoglobus
fulgidus) 		PF00437
(T2SSE) 		3 ARG 1 409
VAL 1 265
THR 1 276
 None
 0.85A 3pwrA-2oap1:
undetectable		 3pwrA-2oap1:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C

(Neurospora
crassa) 		PF00225
(Kinesin) 		3 ARG A 294
VAL A  40
THR A 415
 None
 0.58A 3pwrA-2owmA:
undetectable		 3pwrA-2owmA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		3 ARG A  83
VAL A  77
THR A 293
 None
 0.64A 3pwrA-2qpqA:
undetectable		 3pwrA-2qpqA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9g AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C) 		3 ARG A 278
VAL A 320
THR A 298
 None
 0.73A 3pwrA-2r9gA:
undetectable		 3pwrA-2r9gA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rc3 CBS DOMAIN

(Nitrosomonas
europaea) 		PF00571
(CBS) 		3 ARG A 124
VAL A 102
THR A  99
 BR  A 171 (-4.4A)
None
BR  A 177 ( 4.2A)
 0.85A 3pwrA-2rc3A:
undetectable		 3pwrA-2rc3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		3 ARG A  60
VAL A  92
THR A 112
 None
 0.68A 3pwrA-2uvdA:
undetectable		 3pwrA-2uvdA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w45 ALKALINE EXONUCLEASE

(Human
gammaherpesvirus
4) 		PF01771
(Herpes_alk_exo) 		3 ARG A  45
VAL A  32
THR A 454
 None
 0.74A 3pwrA-2w45A:
undetectable		 3pwrA-2w45A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3

(Homo sapiens) 		PF05645
(RNA_pol_Rpc82)
PF08221
(HTH_9) 		3 ARG A 150
VAL A 107
THR A  95
 None
 0.72A 3pwrA-2xubA:
undetectable		 3pwrA-2xubA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 ARG A 149
VAL A 298
THR A 274
 None
 0.82A 3pwrA-2ycbA:
undetectable		 3pwrA-2ycbA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ARG A 187
VAL A  73
THR A 149
 SO4  A1423 (-2.1A)
None
None
 0.74A 3pwrA-2yfqA:
undetectable		 3pwrA-2yfqA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yt0 AMYLOID BETA A4
PROTEIN AND AMYLOID
BETA A4 PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER 2

(Mus musculus) 		PF00640
(PID)
PF10515
(APP_amyloid) 		3 ARG A 127
VAL A  61
THR A  58
 None
 0.85A 3pwrA-2yt0A:
undetectable		 3pwrA-2yt0A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		3 ARG A 230
VAL A  48
THR A  43
 LLP  A 222 ( 2.8A)
None
None
 0.84A 3pwrA-2z61A:
undetectable		 3pwrA-2z61A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		3 ARG A 138
VAL A 181
THR A 393
 None
 0.77A 3pwrA-3a2qA:
undetectable		 3pwrA-3a2qA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		3 ARG A 192
VAL A 358
THR A 355
 None
 0.73A 3pwrA-3axsA:
undetectable		 3pwrA-3axsA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		3 ARG A 266
VAL A 172
THR A 158
 None
 0.87A 3pwrA-3bfnA:
undetectable		 3pwrA-3bfnA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		3 ARG A 294
VAL A 303
THR A 316
 None
 0.72A 3pwrA-3ckbA:
undetectable		 3pwrA-3ckbA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cps GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 ARG A 252
VAL A 261
THR A 169
 None
 0.82A 3pwrA-3cpsA:
undetectable		 3pwrA-3cpsA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3y UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF05193
(Peptidase_M16_C) 		3 ARG A 343
VAL A 274
THR A 350
 None
 0.82A 3pwrA-3d3yA:
undetectable		 3pwrA-3d3yA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff2 UNCHARACTERIZED
CYSTATIN FOLD
PROTEIN
(YP_497570.1) FROM
NTF2 SUPERFAMILY

(Novosphingobium
aromaticivorans) 		PF12680
(SnoaL_2) 		3 ARG A 111
VAL A  23
THR A  47
 None
 0.82A 3pwrA-3ff2A:
undetectable		 3pwrA-3ff2A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grf ORNITHINE
CARBAMOYLTRANSFERASE

(Giardia
intestinalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 255
VAL A 264
THR A 239
 None
 0.82A 3pwrA-3grfA:
undetectable		 3pwrA-3grfA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 ARG A 204
VAL A 125
THR A 147
 None
 0.74A 3pwrA-3gt5A:
undetectable		 3pwrA-3gt5A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ARG A 171
VAL A 304
THR A 488
 None
 0.82A 3pwrA-3h8fA:
undetectable		 3pwrA-3h8fA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 161
VAL A 106
THR A  68
 None
 0.82A 3pwrA-3hdxA:
undetectable		 3pwrA-3hdxA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		3 ARG A  58
VAL A 131
THR A 143
 None
 0.86A 3pwrA-3hu5A:
undetectable		 3pwrA-3hu5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ism CG4930
CG8862

(Drosophila
melanogaster) 		PF01223
(Endonuclease_NS)
PF08785
(Ku_PK_bind) 		3 ARG A 153
VAL C  50
THR C  55
 None
 0.83A 3pwrA-3ismA:
undetectable		 3pwrA-3ismA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 ARG A 133
VAL A 124
THR A 102
 None
 0.79A 3pwrA-3it4A:
undetectable		 3pwrA-3it4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ARG A  94
VAL A 519
THR A 148
 None
 0.85A 3pwrA-3jb9A:
undetectable		 3pwrA-3jb9A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ARG A 131
VAL A 139
THR A 106
 ADP  A 873 ( 4.6A)
None
None
 0.87A 3pwrA-3juxA:
undetectable		 3pwrA-3juxA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 3 ARG Q  15
VAL Q 284
THR Q 239
 None
 0.66A 3pwrA-3ksdQ:
undetectable		 3pwrA-3ksdQ:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6e OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Aeromonas
hydrophila) 		PF00106
(adh_short) 		3 ARG A  39
VAL A  51
THR A  20
 None
 0.86A 3pwrA-3l6eA:
undetectable		 3pwrA-3l6eA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcu DIPICOLINATE
SYNTHASE, B CHAIN

(Bacillus cereus) 		PF02441
(Flavoprotein) 		3 ARG A  37
VAL A 124
THR A 117
 None
 0.73A 3pwrA-3mcuA:
undetectable		 3pwrA-3mcuA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
VAL A  32
THR A  80
 None
 0.65A 3pwrA-3mwsA:
19.8		 3pwrA-3mwsA:
78.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens) 		PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI) 		3 ARG A 412
VAL A 404
THR A 332
 None
 0.82A 3pwrA-3ol2A:
undetectable		 3pwrA-3ol2A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ARG B 244
VAL B  38
THR B 157
 None
 0.86A 3pwrA-3pcoB:
undetectable		 3pwrA-3pcoB:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ARG A 124
VAL A 119
THR A 147
 None
 0.78A 3pwrA-3pdwA:
undetectable		 3pwrA-3pdwA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		3 ARG A 504
VAL A 473
THR A 457
 None
 0.78A 3pwrA-3r75A:
undetectable		 3pwrA-3r75A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhy N(G),N(G)-DIMETHYLAR
GININE
DIMETHYLAMINOHYDROLA
SE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		3 ARG A  85
VAL A 160
THR A 165
 HM3  A 255 ( 4.7A)
None
None
 0.78A 3pwrA-3rhyA:
undetectable		 3pwrA-3rhyA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 ARG A 440
VAL A 360
THR A  34
 None
 0.36A 3pwrA-3tsdA:
undetectable		 3pwrA-3tsdA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/DEOXYRIBONU
CLEASE SUBUNIT B

(Bacillus
subtilis) 		PF12705
(PDDEXK_1) 		3 ARG B  84
VAL B  75
THR B  79
 None
 0.84A 3pwrA-3u44B:
undetectable		 3pwrA-3u44B:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us9 SODIUM/CALCIUM
EXCHANGER 1

(Canis lupus) 		PF03160
(Calx-beta) 		3 ARG A 547
VAL A 573
THR A 541
 None
 0.85A 3pwrA-3us9A:
undetectable		 3pwrA-3us9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi3 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 ARG A 423
VAL A 369
THR A 292
 None
 0.78A 3pwrA-3vi3A:
undetectable		 3pwrA-3vi3A:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vys HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPD

(Thermococcus
kodakarensis) 		PF01924
(HypD) 		3 ARG B  84
VAL B  73
THR B 106
 None
 0.78A 3pwrA-3vysB:
undetectable		 3pwrA-3vysB:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 ARG A 122
VAL A 118
THR A  73
 SAH  A 701 (-4.0A)
None
None
 0.82A 3pwrA-3wstA:
undetectable		 3pwrA-3wstA:
11.15