SIMILAR PATTERNS OF AMINO ACIDS FOR 3PS9_A_SAMA670_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 336
GLY A 387
THR A 329
LEU A 328
 None
 0.77A 3ps9A-1bf2A:
undetectable		 3ps9A-1bf2A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A1300
THR A1301
LEU A1298
ASP A1328
 None
 0.86A 3ps9A-1fnfA:
undetectable		 3ps9A-1fnfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 TYR A  22
GLY A  56
GLU A  77
ASP A  52
 None
 1.04A 3ps9A-1i4wA:
6.8		 3ps9A-1i4wA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 GLY A 381
THR A 382
LEU A 383
ASP A 534
 None
 1.00A 3ps9A-1mhsA:
undetectable		 3ps9A-1mhsA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or8 PROTEIN ARGININE
N-METHYLTRANSFERASE
1

(Rattus
norvegicus) 		PF13649
(Methyltransf_25) 		4 GLY A  80
THR A  81
GLU A 100
ASP A  76
 SAH  A 354 (-3.6A)
SAH  A 354 ( 4.8A)
SAH  A 354 (-2.5A)
SAH  A 354 ( 3.9A)
 0.84A 3ps9A-1or8A:
5.6		 3ps9A-1or8A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		4 GLY A  59
THR A  60
GLU A  79
ASP A  55
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.6A)
SAH  A1001 (-2.8A)
SAH  A1001 ( 4.5A)
 0.89A 3ps9A-1wy7A:
10.4		 3ps9A-1wy7A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 GLY A 158
THR A 159
LEU A 155
ASP A  43
 None
 0.98A 3ps9A-1xi8A:
4.1		 3ps9A-1xi8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		4 GLY A  55
THR A  54
LEU A  59
ASP A 286
 None
 0.99A 3ps9A-1xp8A:
2.3		 3ps9A-1xp8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yna ENDO-1,4-BETA-XYLANA
SE

(Thermomyces
lanuginosus) 		PF00457
(Glyco_hydro_11) 		4 GLY A  33
THR A  34
LEU A  30
ASP A  11
 None
 0.87A 3ps9A-1ynaA:
undetectable		 3ps9A-1ynaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq6 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		4 TYR A 207
GLY A 212
THR A 211
LEU A 231
 None
 0.97A 3ps9A-1yq6A:
undetectable		 3ps9A-1yq6A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq8 MINOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF08949
(DUF1860) 		4 TYR A 207
GLY A 212
THR A 211
LEU A 231
 None
 0.93A 3ps9A-1yq8A:
undetectable		 3ps9A-1yq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 221
THR A 230
LEU A 194
GLU A 157
 None
 0.88A 3ps9A-2gksA:
undetectable		 3ps9A-2gksA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npl COXSACKIEVIRUS AND
ADENOVIRUS RECEPTOR

(Homo sapiens) 		PF13927
(Ig_3) 		4 GLY X  69
THR X  70
LEU X  39
ASP X  41
 None
 0.74A 3ps9A-2nplX:
undetectable		 3ps9A-2nplX:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		4 GLY A 103
THR A 104
LEU A 101
GLU A 106
 None
 1.00A 3ps9A-2om6A:
undetectable		 3ps9A-2om6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 GLY A 388
THR A 389
LEU A 385
ASP A 377
 None
 0.99A 3ps9A-2pg6A:
undetectable		 3ps9A-2pg6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 296
THR A 297
LEU A 299
ASP A 293
 None
 1.04A 3ps9A-2qddA:
undetectable		 3ps9A-2qddA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy6 UPF0209 PROTEIN YFCK

(Escherichia
coli) 		PF05430
(Methyltransf_30) 		6 TYR A  48
GLY A  88
THR A  89
LEU A  91
GLU A 121
ASP A 198
 None
 0.40A 3ps9A-2qy6A:
38.0		 3ps9A-2qy6A:
43.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w01 ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803) 		PF00211
(Guanylate_cyc) 		4 GLY A 484
THR A 485
LEU A 497
ASP A 507
 None
 1.01A 3ps9A-2w01A:
undetectable		 3ps9A-2w01A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		4 GLY A 258
THR A 259
LEU A 263
ASP A 271
 None
 1.04A 3ps9A-2ylnA:
undetectable		 3ps9A-2ylnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 GLY A  92
THR A  91
LEU A  96
ASP A 321
 None
 1.00A 3ps9A-2zucA:
2.6		 3ps9A-2zucA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 TYR A 193
GLY A 192
LEU A 194
ASP A 189
 None
 0.96A 3ps9A-3a74A:
undetectable		 3ps9A-3a74A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 GLY A 205
THR A 207
LEU A 211
GLU A  73
 None
 1.02A 3ps9A-3eqxA:
undetectable		 3ps9A-3eqxA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 191
LEU A 193
GLU A  77
ASP A 198
 None
 0.93A 3ps9A-3fahA:
undetectable		 3ps9A-3fahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 203
THR A 202
GLU A 198
ASP A 142
 None
NAD  A 601 (-3.8A)
None
None
 1.01A 3ps9A-3glqA:
3.7		 3ps9A-3glqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 GLY A 173
LEU A 163
GLU A   3
ASP A 178
 None
 0.94A 3ps9A-3gpuA:
undetectable		 3ps9A-3gpuA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2b SAM-DEPENDENT
METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13649
(Methyltransf_25) 		4 GLY A 108
THR A 109
GLU A 127
ASP A 104
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-2.6A)
SAH  A 301 ( 4.4A)
 0.94A 3ps9A-3h2bA:
5.1		 3ps9A-3h2bA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 159
THR A 158
GLU A 154
ASP A 133
 None
NAD  A 438 (-3.6A)
None
None
 0.91A 3ps9A-3h9uA:
5.3		 3ps9A-3h9uA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis) 		PF07063
(DUF1338) 		4 THR A 188
LEU A 187
GLU A  36
ASP A 184
 PGE  A 344 ( 4.9A)
None
None
PGE  A 344 ( 3.9A)
 1.04A 3ps9A-3iuzA:
undetectable		 3ps9A-3iuzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1469
LEU A1100
GLU A1471
ASP A1467
 None
 0.96A 3ps9A-3k9bA:
undetectable		 3ps9A-3k9bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhk PUTATIVE DNA BINDING
PROTEIN MJ0014

(Methanocaldococcus
jannaschii) 		PF00239
(Resolvase) 		4 GLY A 106
THR A 138
LEU A 137
ASP A 102
 None
 0.96A 3ps9A-3lhkA:
2.6		 3ps9A-3lhkA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsp DEST

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 GLY A 117
LEU A 119
GLU A 113
ASP A  57
 None
 0.91A 3ps9A-3lspA:
undetectable		 3ps9A-3lspA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 GLY A 372
THR A 373
LEU A 374
ASP A 586
 PHD  A 369 ( 4.9A)
PHD  A 369 ( 3.3A)
PHD  A 369 ( 3.9A)
None
 0.98A 3ps9A-3n23A:
undetectable		 3ps9A-3n23A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n29 CARBOXYNORSPERMIDINE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF00278
(Orn_DAP_Arg_deC) 		4 TYR A 378
GLY A 352
THR A 349
LEU A 355
 None
 0.96A 3ps9A-3n29A:
undetectable		 3ps9A-3n29A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n58 ADENOSYLHOMOCYSTEINA
SE

(Brucella
abortus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 196
THR A 195
GLU A 191
ASP A 135
 None
NAD  A 550 (-3.7A)
None
None
 1.01A 3ps9A-3n58A:
3.2		 3ps9A-3n58A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 TYR B 279
GLY B 302
LEU B 300
GLU B 303
 None
 0.84A 3ps9A-3ohmB:
undetectable		 3ps9A-3ohmB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3one ADENOSYLHOMOCYSTEINA
SE

(Lupinus luteus) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 209
THR A 208
GLU A 204
ASP A 142
 None
NAD  A 501 (-3.7A)
None
None
 1.01A 3ps9A-3oneA:
undetectable		 3ps9A-3oneA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 TYR A 890
GLY A 888
LEU A 880
GLU A 887
 None
 1.01A 3ps9A-3pihA:
3.0		 3ps9A-3pihA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		6 TYR A  28
GLY A  68
THR A  69
LEU A  71
GLU A 101
ASP A 178
 SAM  A 670 (-4.5A)
SAM  A 670 (-3.2A)
SAM  A 670 (-3.6A)
SAM  A 670 (-3.8A)
SAM  A 670 (-2.6A)
SAM  A 670 (-3.4A)
 0.03A 3ps9A-3ps9A:
67.7		 3ps9A-3ps9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pvc TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Yersinia pestis) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 GLY A  68
THR A  69
LEU A  71
GLU A 101
ASP A 178
 None
 0.47A 3ps9A-3pvcA:
58.8		 3ps9A-3pvcA:
60.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		4 GLY A  60
THR A  61
GLU A  79
ASP A  56
 SAH  A 263 (-3.3A)
None
SAH  A 263 (-2.7A)
None
 1.01A 3ps9A-3px2A:
9.7		 3ps9A-3px2A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 GLY A 202
THR A 204
LEU A 208
ASP A 213
 None
 1.03A 3ps9A-3ro2A:
undetectable		 3ps9A-3ro2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		4 GLY A  28
THR A  29
LEU A  33
ASP A  25
 None
 0.95A 3ps9A-3ro8A:
undetectable		 3ps9A-3ro8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A1422
THR A1423
LEU A1420
ASP A1450
 None
 0.81A 3ps9A-3t1wA:
undetectable		 3ps9A-3t1wA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 GLY A 405
THR A 454
LEU A 402
ASP A 342
 None
 1.02A 3ps9A-3v4oA:
2.8		 3ps9A-3v4oA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		4 GLY A 196
THR A  26
GLU A 203
ASP A 222
 None
None
None
NA  A 502 (-2.9A)
 0.91A 3ps9A-3vdgA:
undetectable		 3ps9A-3vdgA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 TYR A  67
GLY A 106
GLU A 133
ASP A 193
 SAM  A 501 (-4.5A)
SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
SAM  A 501 (-3.8A)
 0.35A 3ps9A-3vywA:
22.3		 3ps9A-3vywA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		5 GLY A  74
THR A  75
LEU A  77
GLU A  94
ASP A  70
 SAH  A 701 ( 3.8A)
None
None
SAH  A 701 (-2.7A)
SAH  A 701 ( 4.4A)
 1.27A 3ps9A-3wstA:
4.4		 3ps9A-3wstA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLY A 151
THR A 152
LEU A 147
ASP A 149
 None
 0.84A 3ps9A-3zcwA:
undetectable		 3ps9A-3zcwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zty MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Thermus
thermophilus) 		PF08282
(Hydrolase_3) 		4 GLY A   9
THR A  10
LEU A  11
GLU A  14
 GD  A 262 ( 4.4A)
None
None
GD  A 262 (-3.0A)
 0.87A 3ps9A-3ztyA:
undetectable		 3ps9A-3ztyA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 GLY A  74
THR A  75
LEU A  77
GLU A  94
ASP A  70
 SAH  A1689 ( 3.7A)
SAH  A1689 ( 4.7A)
SAH  A1689 ( 4.5A)
SAH  A1689 (-2.6A)
SAH  A1689 ( 4.4A)
 1.18A 3ps9A-4c4aA:
6.2		 3ps9A-4c4aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 TYR A  35
GLY A  74
THR A  75
LEU A  77
GLU A  94
 SAH  A1689 (-4.5A)
SAH  A1689 ( 3.7A)
SAH  A1689 ( 4.7A)
SAH  A1689 ( 4.5A)
SAH  A1689 (-2.6A)
 0.82A 3ps9A-4c4aA:
6.2		 3ps9A-4c4aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 TYR A 467
GLY A 469
THR A 468
LEU A 477
 TYR  A 467 ( 1.3A)
GLY  A 469 ( 0.0A)
THR  A 468 ( 0.8A)
LEU  A 477 ( 0.6A)
 0.96A 3ps9A-4g9kA:
5.9		 3ps9A-4g9kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 TYR B 279
GLY B 302
LEU B 300
GLU B 303
 None
 0.97A 3ps9A-4gnkB:
undetectable		 3ps9A-4gnkB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwg UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Rickettsia
bellii) 		PF02350
(Epimerase_2) 		4 GLY A 283
THR A 284
GLU A 304
ASP A 281
 None
 0.98A 3ps9A-4hwgA:
2.3		 3ps9A-4hwgA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		4 TYR A 122
GLY A 124
THR A 125
LEU A 121
 SO4  A 502 (-4.5A)
None
None
None
 1.01A 3ps9A-4kamA:
undetectable		 3ps9A-4kamA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		4 TYR A  50
GLY A  75
THR A  78
LEU A  82
 None
 1.03A 3ps9A-4kyiA:
3.1		 3ps9A-4kyiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 240
THR A 239
LEU A 216
ASP A 243
 None
 0.96A 3ps9A-4lg8A:
undetectable		 3ps9A-4lg8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 201
THR A 200
GLU A 196
ASP A 138
 None
GOL  A 504 ( 2.9A)
None
None
 1.01A 3ps9A-4lvcA:
3.4		 3ps9A-4lvcA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 GLY B  64
THR B  65
GLU B  84
ASP B  60
 None
 0.94A 3ps9A-4lwoB:
5.6		 3ps9A-4lwoB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		4 GLY A 199
THR A 202
GLU A 200
ASP A 196
 None
 1.04A 3ps9A-4mnrA:
undetectable		 3ps9A-4mnrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk2 HEMOGLOBIN-LIKE
PROTEIN

(Methylacidiphilum
infernorum) 		PF01152
(Bac_globin) 		4 TYR A 111
GLY A 116
THR A 112
LEU A 113
 HEM  A 700 (-4.5A)
None
None
None
 0.99A 3ps9A-4nk2A:
undetectable		 3ps9A-4nk2A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 TYR A  76
THR A 366
LEU A 365
GLU A 508
 None
 0.94A 3ps9A-4obsA:
undetectable		 3ps9A-4obsA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 4 GLY B 328
THR B 327
LEU B 323
GLU B 345
 PEG  B 604 ( 4.1A)
None
None
None
 0.96A 3ps9A-4p37B:
undetectable		 3ps9A-4p37B:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 TYR A  79
GLY A  95
THR A  94
LEU A  87
GLU A  96
 None
None
None
None
GSH  A 301 (-3.2A)
 1.48A 3ps9A-4pqiA:
undetectable		 3ps9A-4pqiA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 TYR B 279
GLY B 302
LEU B 300
GLU B 303
 None
 0.86A 3ps9A-4qj4B:
undetectable		 3ps9A-4qj4B:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 GLY A  92
THR A  93
GLU A 112
ASP A  88
 SAH  A1000 ( 3.7A)
None
SAH  A1000 (-2.7A)
SAH  A1000 ( 4.2A)
 0.92A 3ps9A-4qppA:
5.3		 3ps9A-4qppA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 TYR A 115
GLY A  31
LEU A  36
GLU A  27
 None
 1.01A 3ps9A-4r42A:
undetectable		 3ps9A-4r42A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		4 TYR A 163
GLY A 147
THR A 144
LEU A 143
 None
 0.99A 3ps9A-4u0zA:
undetectable		 3ps9A-4u0zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 4 GLY A 328
THR A 327
LEU A 323
GLU A 345
 None
 0.96A 3ps9A-4wseA:
undetectable		 3ps9A-4wseA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 GLY A 320
THR A 321
LEU A 318
ASP A   4
 None
 0.85A 3ps9A-4xj6A:
undetectable		 3ps9A-4xj6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 GLY A 906
THR A 907
GLU A 944
ASP A 902
 None
 0.89A 3ps9A-4xqkA:
undetectable		 3ps9A-4xqkA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn0 TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
21

(Mus musculus) 		PF00020
(TNFR_c6) 		4 GLY A  52
THR A  53
LEU A  50
GLU A 100
 None
 0.98A 3ps9A-4yn0A:
undetectable		 3ps9A-4yn0A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		4 GLY A  21
THR A  22
LEU A  24
ASP A  29
 None
 1.01A 3ps9A-4yxmA:
undetectable		 3ps9A-4yxmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 GLY A 202
THR A 204
LEU A 208
ASP A 213
 None
 0.99A 3ps9A-5a6cA:
undetectable		 3ps9A-5a6cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		4 GLY A  55
THR A  56
GLU A  74
ASP A  51
 SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
SAH  A 301 ( 4.7A)
 0.99A 3ps9A-5bszA:
4.7		 3ps9A-5bszA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		4 GLY A 151
THR A 150
LEU A 115
GLU A 175
 None
 1.03A 3ps9A-5exkA:
undetectable		 3ps9A-5exkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 139
THR A 140
LEU A 137
GLU A 142
 EDO  A 502 ( 3.9A)
None
None
EDO  A 502 (-3.9A)
 0.99A 3ps9A-5fg0A:
undetectable		 3ps9A-5fg0A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 GLY A 125
THR A 126
GLU A 146
ASP A 121
 SAH  A 409 ( 3.7A)
None
SAH  A 409 (-2.6A)
SAH  A 409 ( 4.5A)
 0.92A 3ps9A-5fubA:
5.6		 3ps9A-5fubA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 GLY A 159
THR A 160
GLU A 180
ASP A 155
 SAH  A1446 ( 3.9A)
None
SAH  A1446 (-2.7A)
SAH  A1446 ( 4.5A)
 0.96A 3ps9A-5fulA:
5.7		 3ps9A-5fulA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN

(Enterococcus
faecalis) 		no annotation 4 GLY A 440
THR A 439
LEU A 431
GLU A 514
 None
 0.96A 3ps9A-5h29A:
undetectable		 3ps9A-5h29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		4 TYR A 132
GLY A 134
THR A 135
LEU A 131
 PLP  A 501 (-3.5A)
None
None
None
 0.98A 3ps9A-5ijgA:
undetectable		 3ps9A-5ijgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 TYR A 186
THR A 187
LEU A 188
GLU A 194
 None
 0.97A 3ps9A-5k04A:
undetectable		 3ps9A-5k04A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 GLY A 144
THR A 126
GLU A 151
ASP A 147
 None
 1.04A 3ps9A-5kcaA:
3.1		 3ps9A-5kcaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 GLY B 458
THR B 460
LEU B 464
ASP B 373
 None
 1.01A 3ps9A-5ltmB:
undetectable		 3ps9A-5ltmB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 GLY A 224
THR A 223
LEU A 234
GLU A 184
 None
 0.95A 3ps9A-5tu4A:
undetectable		 3ps9A-5tu4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		4 GLY A1505
LEU A1638
GLU A1509
ASP A1606
 None
 1.01A 3ps9A-5v41A:
undetectable		 3ps9A-5v41A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLY A 201
THR A 200
GLU A 196
ASP A 139
 None
NAD  A 501 (-3.6A)
None
EDO  A 512 (-3.3A)
 1.01A 3ps9A-5v96A:
3.3		 3ps9A-5v96A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 410
THR A 411
LEU A 405
ASP A 305
 None
 1.00A 3ps9A-5wrpA:
undetectable		 3ps9A-5wrpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 4 TYR A 400
GLY A 398
THR A 399
LEU A 414
 None
 0.98A 3ps9A-5yb7A:
3.7		 3ps9A-5yb7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 4 TYR A 139
GLY A 151
THR A 138
LEU A 149
 None
None
None
IOD  A 306 ( 4.4A)
 1.00A 3ps9A-5yguA:
undetectable		 3ps9A-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb PSAF

(Cyanidioschyzon
merolae) 		no annotation 4 TYR F 131
THR F 132
LEU F 129
GLU F 134
 None
None
CLA  F 301 (-3.9A)
None
 1.00A 3ps9A-5zgbF:
undetectable		 3ps9A-5zgbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 4 GLY A 139
THR A 133
LEU A 130
GLU A  69
 None
 1.03A 3ps9A-6c9kA:
undetectable		 3ps9A-6c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 4 TYR A 101
GLY A 103
THR A 104
LEU A 100
 LLP  A 199 (-3.7A)
None
None
None
 1.02A 3ps9A-6cjbA:
undetectable		 3ps9A-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 4 GLY A 110
THR A 142
LEU A 141
ASP A 106
 None
 1.00A 3ps9A-6dgcA:
2.7		 3ps9A-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 TYR A 376
GLY A 281
THR A 282
GLU A 306
 BJ8  A 501 (-4.8A)
None
BJ8  A 501 (-3.9A)
None
 0.80A 3ps9A-6enoA:
undetectable		 3ps9A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 GLY B 168
THR B 167
GLU B 163
ASP B 142
 None
NAD  B 501 (-3.8A)
None
None
 1.04A 3ps9A-6f3mB:
4.0		 3ps9A-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fht BACTERIOPHYTOCHROME,
ADENYLATE CYCLASE

(Synechocystis
sp. PCC 6803;
Deinococcus
radiodurans) 		no annotation 4 GLY A 585
THR A 586
LEU A 598
ASP A 608
 None
 0.97A 3ps9A-6fhtA:
undetectable		 3ps9A-6fhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g42 MINOR CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 4 TYR A 211
GLY A 228
THR A 227
LEU A 213
 None
 0.73A 3ps9A-6g42A:
undetectable		 3ps9A-6g42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 GLY A 163
THR A 162
GLU A 158
ASP A 137
 None
NAD  A 502 (-3.7A)
None
None
 1.00A 3ps9A-6gbnA:
4.0		 3ps9A-6gbnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 TYR A 492
THR A 486
LEU A 485
GLU A 572
 None
 0.99A 3ps9A-6gh2A:
undetectable		 3ps9A-6gh2A:
undetectable