SIMILAR PATTERNS OF AMINO ACIDS FOR 3PRS_A_RITA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens)
PF00191
(Annexin)
5 ILE A 145
LEU A 100
THR A 149
ILE A 244
THR A 122
None
1.00A 3prsA-1axnA:
undetectable
3prsA-1axnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)


(Geobacillus
stearothermophilus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 ASP A 267
ILE A 184
ILE A 121
THR A  90
ILE A 150
None
None
None
CA  A3001 (-4.0A)
None
1.19A 3prsA-1brwA:
0.0
3prsA-1brwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)


(Clostridium
pasteurianum)
PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4)
5 ILE A 268
ASP A 267
ALA A 230
ILE A 198
ILE A 522
HC1  A 580 ( 4.8A)
None
HC1  A 580 (-3.1A)
None
None
1.16A 3prsA-1fehA:
undetectable
3prsA-1fehA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
5 ALA B 734
ILE B 680
LEU B 665
ILE B 753
THR B 738
None
1.09A 3prsA-1gh6B:
undetectable
3prsA-1gh6B:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
6 ILE A  72
TYR A  74
LEU A 120
THR A 130
ILE A 212
THR A 218
None
0.38A 3prsA-1ibqA:
49.0
3prsA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
7 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 212
THR A 218
ILE A 293
None
0.43A 3prsA-1izeA:
49.9
3prsA-1izeA:
58.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk4 HYPOTHETICAL PROTEIN
YQJY


(Bacillus
subtilis)
PF00583
(Acetyltransf_1)
5 ALA A 117
ILE A  84
THR A  53
ILE A  70
ILE A  93
None
1.19A 3prsA-1mk4A:
0.0
3prsA-1mk4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN


(Schizosaccharomyces
pombe)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 ALA A 125
TYR A 229
LEU A 144
ILE A  25
ILE A 297
None
1.08A 3prsA-1ni3A:
undetectable
3prsA-1ni3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE


(Desulfovibrio
vulgaris)
PF03063
(Prismane)
5 ALA A  73
ILE A  84
ILE A 152
THR A  71
ILE A 136
None
None
None
SF4  A1554 (-3.1A)
None
1.25A 3prsA-1oa1A:
0.0
3prsA-1oa1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA A 567
ILE A 321
LEU A 577
ILE A 300
ILE A 311
None
0.90A 3prsA-1qhgA:
undetectable
3prsA-1qhgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA D 567
ILE B 321
LEU D 577
ILE B 300
ILE B 311
None
0.97A 3prsA-1qhhD:
undetectable
3prsA-1qhhD:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Zymomonas
mobilis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 ILE A 315
LEU A 228
THR A 273
ILE A 102
ILE A 208
None
None
None
NDP  A 400 ( 4.9A)
None
1.22A 3prsA-1r0lA:
undetectable
3prsA-1r0lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori)
PF01264
(Chorismate_synt)
5 ILE A  83
ASP A  61
ALA A 130
LEU A  10
ILE A 206
None
1.14A 3prsA-1umfA:
undetectable
3prsA-1umfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE


(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
PF03426
(CBM_15)
5 ILE A 476
ALA A 536
LEU A 498
THR A 293
THR A 540
None
1.22A 3prsA-1us2A:
undetectable
3prsA-1us2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE


(Sulfolobus
solfataricus)
PF00701
(DHDPS)
5 ALA A 135
ILE A   9
LEU A 242
THR A 249
ILE A  70
None
None
GOL  A1296 (-3.4A)
None
None
1.16A 3prsA-1w3iA:
undetectable
3prsA-1w3iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF14681
(UPRTase)
5 ILE A  75
ALA A 139
LEU A  32
THR A  23
ILE A 203
None
None
None
None
U5P  A1250 (-4.1A)
1.22A 3prsA-1xttA:
undetectable
3prsA-1xttA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040


(Bacillus
subtilis)
PF01476
(LysM)
PF03734
(YkuD)
5 ILE A  15
ASP A  10
ILE A  54
LEU A  48
ILE A 122
None
1.09A 3prsA-1y7mA:
undetectable
3prsA-1y7mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
5 ILE A1156
ALA A1153
TYR A1080
THR A1268
ILE A1190
None
1.24A 3prsA-2b39A:
undetectable
3prsA-2b39A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ALA A 154
TYR A  84
LEU A 135
ILE A  79
ILE A1068
None
1.11A 3prsA-2b5mA:
undetectable
3prsA-2b5mA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
5 ILE A 559
ASP A 428
LEU A 613
ILE A 534
ILE A 504
None
1.20A 3prsA-2c3oA:
undetectable
3prsA-2c3oA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli)
PF02525
(Flavodoxin_2)
5 ILE A 100
ALA A  93
LEU A 160
ILE A 197
THR A 138
None
1.21A 3prsA-2d5iA:
undetectable
3prsA-2d5iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
5 ILE A 138
ALA A 126
LEU A 148
THR A 314
ILE A 179
None
1.07A 3prsA-2d7dA:
undetectable
3prsA-2d7dA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6)
PF01593
(Amino_oxidase)
5 ILE A  48
ILE A  98
LEU A 336
ILE A 348
ILE A  63
None
FAD  A 801 (-4.8A)
None
None
None
1.23A 3prsA-2e1mA:
undetectable
3prsA-2e1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN


(Sulfurisphaera
tokodaii)
PF05694
(SBP56)
5 ILE A  60
ALA A  46
THR A  11
ILE A  99
ILE A 123
None
1.18A 3prsA-2eceA:
undetectable
3prsA-2eceA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT


(Stenotrophomonas
maltophilia)
PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4)
5 ALA A 493
THR A 367
ILE A 256
THR A 491
ILE A 266
None
1.15A 3prsA-2gahA:
undetectable
3prsA-2gahA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ILE A 153
ILE A  12
THR A  17
ILE A  91
ILE A 359
None
1.17A 3prsA-2i14A:
undetectable
3prsA-2i14A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaf HYPOTHETICAL PROTEIN
SDHL


(Legionella
pneumophila)
PF03315
(SDH_beta)
5 ILE A 140
ALA A  13
LEU A  37
ILE A  78
ILE A  92
None
1.16A 3prsA-2iafA:
undetectable
3prsA-2iafA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae)
PF08596
(Lgl_C)
5 ILE A 357
ALA A 332
ILE A 408
ILE A 368
ILE A 287
None
1.25A 3prsA-2oajA:
undetectable
3prsA-2oajA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA B 567
ILE A 321
LEU B 577
ILE A 300
ILE A 311
None
0.97A 3prsA-2pjrB:
undetectable
3prsA-2pjrB:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptg ENOYL-ACYL CARRIER
REDUCTASE


(Eimeria tenella)
PF13561
(adh_short_C2)
5 ILE A 211
ASP A 188
ALA A 185
ILE A 118
ILE A 284
None
1.20A 3prsA-2ptgA:
undetectable
3prsA-2ptgA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE


(Desulfitobacterium
hafniense)
PF06253
(MTTB)
5 ILE A  23
ALA A 249
LEU A 300
THR A 338
ILE A 225
None
1.17A 3prsA-2qneA:
undetectable
3prsA-2qneA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT


(Bacillus phage
SPP1)
PF17288
(Terminase_3C)
5 ILE A 328
ALA A 320
LEU A 274
ILE A 373
ILE A 291
None
1.14A 3prsA-2wbnA:
undetectable
3prsA-2wbnA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
6 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
ILE A 293
None
PP6  A 327 (-3.8A)
None
None
None
None
0.88A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
6 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
THR A 217
None
PP6  A 327 (-3.8A)
None
None
None
PP6  A 327 (-4.5A)
0.40A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME


(Candida
albicans)
PF09084
(NMT1)
5 ASP A 225
ALA A 227
THR A 185
ILE A  58
ILE A 255
None
1.15A 3prsA-2x7qA:
undetectable
3prsA-2x7qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Bacillus
subtilis)
PF01008
(IF-2B)
5 ALA A  68
ILE A 131
LEU A 107
ILE A  45
ILE A  20
None
1.04A 3prsA-2yrfA:
undetectable
3prsA-2yrfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]


(Methanocaldococcus
jannaschii)
PF13847
(Methyltransf_31)
5 ILE A  87
ALA A  62
LEU A  99
ILE A 127
ILE A 112
None
1.11A 3prsA-2yxdA:
undetectable
3prsA-2yxdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli)
PF00595
(PDZ)
PF13365
(Trypsin_2)
5 ILE A 154
ALA A 196
LEU A 176
THR A 111
ILE A  19
None
1.11A 3prsA-2zleA:
undetectable
3prsA-2zleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE


(Selenomonas
ruminantium)
PF04616
(Glyco_hydro_43)
PF07081
(DUF1349)
5 ILE A 294
ALA A 262
ILE A 111
ILE A  87
ILE A  72
None
1.09A 3prsA-3c2uA:
undetectable
3prsA-3c2uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 ALA A  35
ILE A  19
THR A 363
THR A 171
ILE A   5
FAD  A 500 (-3.6A)
None
None
None
None
1.21A 3prsA-3dmeA:
undetectable
3prsA-3dmeA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
5 ASP A   8
ILE A  73
TYR A  75
ILE A 299
THR A 219
None
1.18A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
7 ASP A   8
ILE A  73
TYR A  75
LEU A 120
ILE A 213
THR A 219
ILE A 297
None
0.56A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia4 DIHYDROFOLATE
REDUCTASE


(Moritella
profunda)
PF00186
(DHFR_1)
5 ILE A  15
ALA A   7
LEU A 106
ILE A   2
ILE A 138
NDP  A 163 (-3.7A)
NDP  A 163 ( 3.9A)
None
None
None
1.16A 3prsA-3ia4A:
undetectable
3prsA-3ia4A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
5 ILE A  73
ALA A  12
ILE A 267
ILE A 142
ILE A 156
None
1.00A 3prsA-3in1A:
undetectable
3prsA-3in1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Thermoplasma
acidophilum)
PF01676
(Metalloenzyme)
PF10143
(PhosphMutase)
5 ILE A  42
ASP A 365
LEU A 391
ILE A 278
ILE A 317
None
1.23A 3prsA-3kd8A:
undetectable
3prsA-3kd8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula)
PF14765
(PS-DH)
5 ILE A1034
ALA A1006
LEU A1238
ILE A1148
ILE A1204
None
1.11A 3prsA-3kg9A:
undetectable
3prsA-3kg9A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  66
ALA A 101
ILE A  54
ILE A 290
ILE A 277
None
None
TYR  A 356 (-4.5A)
None
None
1.11A 3prsA-3kumA:
undetectable
3prsA-3kumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ILE A 297
TYR A 600
LEU A 308
ILE A 318
ILE A 572
None
1.04A 3prsA-3lfuA:
undetectable
3prsA-3lfuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN


(Bos taurus)
PF10409
(PTEN_C2)
5 ILE A 170
ALA A 132
ILE A 327
THR A 331
ILE A 261
None
0.92A 3prsA-3n0aA:
undetectable
3prsA-3n0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
5 ALA A 374
ILE A  91
THR A  76
ILE A 226
ILE A 245
None
1.07A 3prsA-3ng0A:
undetectable
3prsA-3ng0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 ALA A  88
ILE A 103
LEU A 111
THR A 174
ILE A 153
None
1.24A 3prsA-3qhaA:
undetectable
3prsA-3qhaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN


(Treponema
denticola)
PF00731
(AIRC)
5 ALA A  39
TYR A  62
LEU A  50
ILE A  34
ILE A  21
None
0.93A 3prsA-3rggA:
undetectable
3prsA-3rggA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum)
PF00491
(Arginase)
5 ALA A 332
ILE A 320
LEU A 401
ILE A 294
ILE A 270
None
1.15A 3prsA-3sl1A:
undetectable
3prsA-3sl1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
PG4  A 372 ( 4.9A)
None
None
None
None
1.16A 3prsA-3tcsA:
undetectable
3prsA-3tcsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ASP A 292
ALA A 296
ILE A 256
LEU A 270
THR A 131
None
1.08A 3prsA-3tl2A:
undetectable
3prsA-3tl2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF00092
(VWA)
5 ALA A 353
ILE A 427
TYR A 391
THR A 388
ILE A 509
ACT  A 702 (-4.4A)
None
None
ACT  A 702 (-2.9A)
None
1.22A 3prsA-3tw0A:
undetectable
3prsA-3tw0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
None
1.25A 3prsA-3u4fA:
undetectable
3prsA-3u4fA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus)
PF16420
(ATG7_N)
5 ILE A 150
ALA A 241
ILE A 117
ILE A 181
THR A 228
None
1.18A 3prsA-3vx6A:
undetectable
3prsA-3vx6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
5 ILE A 311
ALA A 556
ILE A 281
TYR A 283
ILE A 286
None
1.13A 3prsA-3welA:
undetectable
3prsA-3welA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus)
PF00141
(peroxidase)
5 ILE A  34
ASP A  31
LEU A 103
THR A 128
ILE A 140
None
1.24A 3prsA-4a5gA:
undetectable
3prsA-4a5gA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE


(Lachnoclostridium
phytofermentans)
PF00171
(Aldedh)
5 ILE A 250
ALA A 248
ILE A 406
TYR A 402
THR A 408
SO4  A1467 (-4.2A)
None
None
None
None
1.00A 3prsA-4c3sA:
undetectable
3prsA-4c3sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE


(Clostridioides
difficile)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A  42
ILE A  89
LEU A  58
ILE A 107
ILE A 280
None
1.16A 3prsA-4dd5A:
undetectable
3prsA-4dd5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Salmonella
enterica)
PF12710
(HAD)
5 ILE A 165
ILE A   3
TYR A   5
LEU A 295
ILE A  12
None
1.18A 3prsA-4ezeA:
undetectable
3prsA-4ezeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I


(Hordeum vulgare)
PF00161
(RIP)
5 ALA A 141
ILE A 202
LEU A 133
ILE A  31
ILE A  86
None
1.24A 3prsA-4fbhA:
undetectable
3prsA-4fbhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Shewanella
oneidensis)
PF01048
(PNP_UDP_1)
5 ALA A 109
ILE A  88
LEU A 200
THR A 127
ILE A 194
None
1.16A 3prsA-4lkrA:
undetectable
3prsA-4lkrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 ILE A 258
ALA A 246
ILE A 171
TYR A 167
THR A 175
None
1.25A 3prsA-4lobA:
undetectable
3prsA-4lobA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 ALA A 566
ILE A 519
TYR A 520
ILE A 537
THR A 564
None
0.97A 3prsA-4rbnA:
undetectable
3prsA-4rbnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 ASP A 302
ALA A 305
LEU A 412
ILE A  23
ILE A 672
None
1.19A 3prsA-4uozA:
undetectable
3prsA-4uozA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF00155
(Aminotran_1_2)
5 ALA A 169
ILE A 251
LEU A 229
ILE A 113
ILE A 126
None
1.04A 3prsA-4w5kA:
undetectable
3prsA-4w5kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 ALA A 289
ILE A 278
THR A 227
THR A 250
ILE A   2
ANP  A 401 (-3.5A)
None
None
None
None
1.21A 3prsA-4wjmA:
undetectable
3prsA-4wjmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA


(Escherichia
coli)
PF07804
(HipA_C)
PF13657
(Couple_hipA)
5 ILE D 149
ASP D  96
LEU D 129
ILE D 184
ILE D 334
None
1.13A 3prsA-4yg7D:
undetectable
3prsA-4yg7D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium)
PF03243
(MerB)
5 ILE A  29
ALA A  79
TYR A  11
LEU A 204
ILE A 168
None
None
None
None
DTV  A 303 ( 4.9A)
1.24A 3prsA-5c17A:
undetectable
3prsA-5c17A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR


(Mycolicibacterium
smegmatis)
PF00440
(TetR_N)
5 ILE A 173
ALA A 118
LEU A 125
THR A  35
ILE A  47
None
0.91A 3prsA-5e57A:
undetectable
3prsA-5e57A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE


(Trypanosoma
brucei)
PF06325
(PrmA)
5 ALA A 333
ILE A 281
LEU A 369
THR A 176
ILE A 173
None
None
None
None
SAH  A 401 ( 4.4A)
1.20A 3prsA-5ekuA:
undetectable
3prsA-5ekuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ALA A 154
TYR A  84
LEU A 135
ILE A  79
ILE A1068
None
1.15A 3prsA-5fqdA:
undetectable
3prsA-5fqdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL


(Oryctolagus
cuniculus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 ASP A 384
ALA A 386
LEU A 429
ILE A 351
ILE A 291
None
1.20A 3prsA-5h53A:
undetectable
3prsA-5h53A:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
10 ILE A  10
ASP A  11
ALA A  16
ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 217
THR A 223
ILE A 300
None
None
None
None
61P  A 406 (-4.3A)
None
None
None
PG4  A 408 (-3.8A)
61P  A 406 (-4.0A)
0.25A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 302
None
61P  A 406 (-4.3A)
None
None
None
0.99A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1


(Sorangium
cellulosum)
PF00067
(p450)
5 ALA A 344
ILE A 203
LEU A  91
THR A 233
ILE A 154
HEM  A 401 (-3.5A)
None
None
HEM  A 401 (-4.5A)
None
1.19A 3prsA-5hiwA:
undetectable
3prsA-5hiwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING


(Caenorhabditis
elegans)
PF03828
(PAP_assoc)
no annotation
5 ILE E 193
ILE A 653
LEU A 628
THR A 614
ILE A 677
None
1.08A 3prsA-5jnbE:
undetectable
3prsA-5jnbE:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1


(Hyoscyamus
muticus)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A  90
ALA A  83
TYR A 222
LEU A 232
ILE A 553
None
1.14A 3prsA-5jo7A:
undetectable
3prsA-5jo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
5 ILE A 172
ILE A 242
TYR A 244
LEU A 199
ILE A 298
None
1.24A 3prsA-5l56A:
undetectable
3prsA-5l56A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-)
no annotation 5 ILE A 122
ALA A 115
LEU A  37
THR A  42
ILE A  80
None
1.05A 3prsA-5mxpA:
undetectable
3prsA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN


(Chaetomium
thermophilum)
PF12569
(NARP1)
PF13432
(TPR_16)
5 ILE A 672
ALA A 698
TYR A 682
ILE A 734
ILE A 718
None
1.05A 3prsA-5nnpA:
undetectable
3prsA-5nnpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN


(Chaetomium
thermophilum)
PF12569
(NARP1)
PF13432
(TPR_16)
5 ILE A 672
ALA A 698
TYR A 682
LEU A 665
ILE A 734
None
0.98A 3prsA-5nnpA:
undetectable
3prsA-5nnpA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
10 ILE A  10
ASP A  11
ALA A  16
ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 217
THR A 223
ILE A 300
None
0.31A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 302
None
1.03A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
THR A 135
ILE A 302
THR A 223
None
0.96A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B


(Methanothermobacter
sp. CaT2)
PF00384
(Molybdopterin)
5 ILE B 341
ASP B 414
ALA B 342
THR B 257
ILE B  37
None
MGD  B 503 (-3.0A)
MGD  B 503 (-3.4A)
None
SF4  B 501 (-4.5A)
1.16A 3prsA-5t5iB:
undetectable
3prsA-5t5iB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Neisseria
meningitidis)
no annotation 5 ILE A   6
LEU A  19
THR A  29
THR A 100
ILE A 120
None
1.09A 3prsA-5ugjA:
undetectable
3prsA-5ugjA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Campylobacter
jejuni)
PF00275
(EPSP_synthase)
5 ILE A 137
ALA A 135
ILE A  33
THR A  75
ILE A 214
None
1.10A 3prsA-5ujsA:
undetectable
3prsA-5ujsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE


(Citrus sinensis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A 124
ALA A 117
TYR A 257
LEU A 267
ILE A 590
None
1.23A 3prsA-5uv2A:
undetectable
3prsA-5uv2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v52 T-CELL
IMMUNORECEPTOR WITH
IG AND ITIM DOMAINS


(Homo sapiens)
PF07686
(V-set)
5 ILE A  77
ALA A  67
ILE A  33
LEU A  95
ILE A  27
None
1.19A 3prsA-5v52A:
undetectable
3prsA-5v52A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 5 ASP A 538
ILE A 593
LEU A 650
THR A 856
ILE A 575
None
1.22A 3prsA-5vm9A:
undetectable
3prsA-5vm9A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA


(Chaetomium
thermophilum)
no annotation 5 ILE B2580
ILE B 510
ILE B 865
THR B 827
ILE B 891
None
1.08A 3prsA-5wfcB:
undetectable
3prsA-5wfcB:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa)
PF00348
(polyprenyl_synt)
5 ILE A 223
TYR A 219
LEU A 296
ILE A 201
ILE A 213
None
1.20A 3prsA-5xn6A:
undetectable
3prsA-5xn6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN


(Lactobacillus
rhamnosus)
no annotation 5 ILE A 409
ALA A 392
ILE A 475
LEU A 443
THR A 419
None
1.25A 3prsA-5yxgA:
undetectable
3prsA-5yxgA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 5 ILE A1504
ILE A1449
LEU A1481
THR A1447
ILE A1342
None
1.19A 3prsA-6bhuA:
undetectable
3prsA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 5 ASP A 779
LEU A 765
ILE A 863
THR A 803
ILE A 883
None
1.05A 3prsA-6eojA:
undetectable
3prsA-6eojA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 5 ILE A 243
ILE A  88
THR A  93
ILE A 106
ILE A  78
None
None
OLC  A 512 (-4.7A)
None
None
1.19A 3prsA-6exsA:
undetectable
3prsA-6exsA:
14.18