SIMILAR PATTERNS OF AMINO ACIDS FOR 3PRS_A_RITA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens)
PF00191
(Annexin)
5 ILE A 145
LEU A 100
THR A 149
ILE A 244
THR A 122
None
1.00A 3prsA-1axnA:
undetectable
3prsA-1axnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)


(Geobacillus
stearothermophilus)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 ASP A 267
ILE A 184
ILE A 121
THR A  90
ILE A 150
None
None
None
CA  A3001 (-4.0A)
None
1.19A 3prsA-1brwA:
0.0
3prsA-1brwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)


(Clostridium
pasteurianum)
PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4)
5 ILE A 268
ASP A 267
ALA A 230
ILE A 198
ILE A 522
HC1  A 580 ( 4.8A)
None
HC1  A 580 (-3.1A)
None
None
1.16A 3prsA-1fehA:
undetectable
3prsA-1fehA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN


(Homo sapiens)
PF01857
(RB_B)
PF01858
(RB_A)
5 ALA B 734
ILE B 680
LEU B 665
ILE B 753
THR B 738
None
1.09A 3prsA-1gh6B:
undetectable
3prsA-1gh6B:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
6 ILE A  72
TYR A  74
LEU A 120
THR A 130
ILE A 212
THR A 218
None
0.38A 3prsA-1ibqA:
49.0
3prsA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
7 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 212
THR A 218
ILE A 293
None
0.43A 3prsA-1izeA:
49.9
3prsA-1izeA:
58.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk4 HYPOTHETICAL PROTEIN
YQJY


(Bacillus
subtilis)
PF00583
(Acetyltransf_1)
5 ALA A 117
ILE A  84
THR A  53
ILE A  70
ILE A  93
None
1.19A 3prsA-1mk4A:
0.0
3prsA-1mk4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni3 YCHF GTP-BINDING
PROTEIN


(Schizosaccharomyces
pombe)
PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C)
5 ALA A 125
TYR A 229
LEU A 144
ILE A  25
ILE A 297
None
1.08A 3prsA-1ni3A:
undetectable
3prsA-1ni3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE


(Desulfovibrio
vulgaris)
PF03063
(Prismane)
5 ALA A  73
ILE A  84
ILE A 152
THR A  71
ILE A 136
None
None
None
SF4  A1554 (-3.1A)
None
1.25A 3prsA-1oa1A:
0.0
3prsA-1oa1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA A 567
ILE A 321
LEU A 577
ILE A 300
ILE A 311
None
0.90A 3prsA-1qhgA:
undetectable
3prsA-1qhgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA D 567
ILE B 321
LEU D 577
ILE B 300
ILE B 311
None
0.97A 3prsA-1qhhD:
undetectable
3prsA-1qhhD:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Zymomonas
mobilis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 ILE A 315
LEU A 228
THR A 273
ILE A 102
ILE A 208
None
None
None
NDP  A 400 ( 4.9A)
None
1.22A 3prsA-1r0lA:
undetectable
3prsA-1r0lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori)
PF01264
(Chorismate_synt)
5 ILE A  83
ASP A  61
ALA A 130
LEU A  10
ILE A 206
None
1.14A 3prsA-1umfA:
undetectable
3prsA-1umfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE


(Cellvibrio
japonicus)
PF00331
(Glyco_hydro_10)
PF03426
(CBM_15)
5 ILE A 476
ALA A 536
LEU A 498
THR A 293
THR A 540
None
1.22A 3prsA-1us2A:
undetectable
3prsA-1us2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3i 2-KETO-3-DEOXY
GLUCONATE ALDOLASE


(Sulfolobus
solfataricus)
PF00701
(DHDPS)
5 ALA A 135
ILE A   9
LEU A 242
THR A 249
ILE A  70
None
None
GOL  A1296 (-3.4A)
None
None
1.16A 3prsA-1w3iA:
undetectable
3prsA-1w3iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE


(Sulfolobus
solfataricus)
PF14681
(UPRTase)
5 ILE A  75
ALA A 139
LEU A  32
THR A  23
ILE A 203
None
None
None
None
U5P  A1250 (-4.1A)
1.22A 3prsA-1xttA:
undetectable
3prsA-1xttA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040


(Bacillus
subtilis)
PF01476
(LysM)
PF03734
(YkuD)
5 ILE A  15
ASP A  10
ILE A  54
LEU A  48
ILE A 122
None
1.09A 3prsA-1y7mA:
undetectable
3prsA-1y7mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
5 ILE A1156
ALA A1153
TYR A1080
THR A1268
ILE A1190
None
1.24A 3prsA-2b39A:
undetectable
3prsA-2b39A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ALA A 154
TYR A  84
LEU A 135
ILE A  79
ILE A1068
None
1.11A 3prsA-2b5mA:
undetectable
3prsA-2b5mA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Desulfovibrio
africanus)
PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II)
5 ILE A 559
ASP A 428
LEU A 613
ILE A 534
ILE A 504
None
1.20A 3prsA-2c3oA:
undetectable
3prsA-2c3oA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli)
PF02525
(Flavodoxin_2)
5 ILE A 100
ALA A  93
LEU A 160
ILE A 197
THR A 138
None
1.21A 3prsA-2d5iA:
undetectable
3prsA-2d5iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B


(Bacillus
subtilis)
PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB)
5 ILE A 138
ALA A 126
LEU A 148
THR A 314
ILE A 179
None
1.07A 3prsA-2d7dA:
undetectable
3prsA-2d7dA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6)
PF01593
(Amino_oxidase)
5 ILE A  48
ILE A  98
LEU A 336
ILE A 348
ILE A  63
None
FAD  A 801 (-4.8A)
None
None
None
1.23A 3prsA-2e1mA:
undetectable
3prsA-2e1mA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN


(Sulfurisphaera
tokodaii)
PF05694
(SBP56)
5 ILE A  60
ALA A  46
THR A  11
ILE A  99
ILE A 123
None
1.18A 3prsA-2eceA:
undetectable
3prsA-2eceA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT


(Stenotrophomonas
maltophilia)
PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4)
5 ALA A 493
THR A 367
ILE A 256
THR A 491
ILE A 266
None
1.15A 3prsA-2gahA:
undetectable
3prsA-2gahA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Pyrococcus
furiosus)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 ILE A 153
ILE A  12
THR A  17
ILE A  91
ILE A 359
None
1.17A 3prsA-2i14A:
undetectable
3prsA-2i14A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iaf HYPOTHETICAL PROTEIN
SDHL


(Legionella
pneumophila)
PF03315
(SDH_beta)
5 ILE A 140
ALA A  13
LEU A  37
ILE A  78
ILE A  92
None
1.16A 3prsA-2iafA:
undetectable
3prsA-2iafA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae)
PF08596
(Lgl_C)
5 ILE A 357
ALA A 332
ILE A 408
ILE A 368
ILE A 287
None
1.25A 3prsA-2oajA:
undetectable
3prsA-2oajA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA B 567
ILE A 321
LEU B 577
ILE A 300
ILE A 311
None
0.97A 3prsA-2pjrB:
undetectable
3prsA-2pjrB:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptg ENOYL-ACYL CARRIER
REDUCTASE


(Eimeria tenella)
PF13561
(adh_short_C2)
5 ILE A 211
ASP A 188
ALA A 185
ILE A 118
ILE A 284
None
1.20A 3prsA-2ptgA:
undetectable
3prsA-2ptgA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE


(Desulfitobacterium
hafniense)
PF06253
(MTTB)
5 ILE A  23
ALA A 249
LEU A 300
THR A 338
ILE A 225
None
1.17A 3prsA-2qneA:
undetectable
3prsA-2qneA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT


(Bacillus phage
SPP1)
PF17288
(Terminase_3C)
5 ILE A 328
ALA A 320
LEU A 274
ILE A 373
ILE A 291
None
1.14A 3prsA-2wbnA:
undetectable
3prsA-2wbnA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
6 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
ILE A 293
None
PP6  A 327 (-3.8A)
None
None
None
None
0.88A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
6 ILE A  73
TYR A  75
LEU A 121
THR A 131
ILE A 211
THR A 217
None
PP6  A 327 (-3.8A)
None
None
None
PP6  A 327 (-4.5A)
0.40A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME


(Candida
albicans)
PF09084
(NMT1)
5 ASP A 225
ALA A 227
THR A 185
ILE A  58
ILE A 255
None
1.15A 3prsA-2x7qA:
undetectable
3prsA-2x7qA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE


(Bacillus
subtilis)
PF01008
(IF-2B)
5 ALA A  68
ILE A 131
LEU A 107
ILE A  45
ILE A  20
None
1.04A 3prsA-2yrfA:
undetectable
3prsA-2yrfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxd PROBABLE
COBALT-PRECORRIN-6Y
C(15)-METHYLTRANSFER
ASE
[DECARBOXYLATING]


(Methanocaldococcus
jannaschii)
PF13847
(Methyltransf_31)
5 ILE A  87
ALA A  62
LEU A  99
ILE A 127
ILE A 112
None
1.11A 3prsA-2yxdA:
undetectable
3prsA-2yxdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli)
PF00595
(PDZ)
PF13365
(Trypsin_2)
5 ILE A 154
ALA A 196
LEU A 176
THR A 111
ILE A  19
None
1.11A 3prsA-2zleA:
undetectable
3prsA-2zleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE


(Selenomonas
ruminantium)
PF04616
(Glyco_hydro_43)
PF07081
(DUF1349)
5 ILE A 294
ALA A 262
ILE A 111
ILE A  87
ILE A  72
None
1.09A 3prsA-3c2uA:
undetectable
3prsA-3c2uA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 ALA A  35
ILE A  19
THR A 363
THR A 171
ILE A   5
FAD  A 500 (-3.6A)
None
None
None
None
1.21A 3prsA-3dmeA:
undetectable
3prsA-3dmeA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
5 ASP A   8
ILE A  73
TYR A  75
ILE A 299
THR A 219
None
1.18A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
7 ASP A   8
ILE A  73
TYR A  75
LEU A 120
ILE A 213
THR A 219
ILE A 297
None
0.56A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia4 DIHYDROFOLATE
REDUCTASE


(Moritella
profunda)
PF00186
(DHFR_1)
5 ILE A  15
ALA A   7
LEU A 106
ILE A   2
ILE A 138
NDP  A 163 (-3.7A)
NDP  A 163 ( 3.9A)
None
None
None
1.16A 3prsA-3ia4A:
undetectable
3prsA-3ia4A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH


(Escherichia
coli)
PF00294
(PfkB)
5 ILE A  73
ALA A  12
ILE A 267
ILE A 142
ILE A 156
None
1.00A 3prsA-3in1A:
undetectable
3prsA-3in1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE


(Thermoplasma
acidophilum)
PF01676
(Metalloenzyme)
PF10143
(PhosphMutase)
5 ILE A  42
ASP A 365
LEU A 391
ILE A 278
ILE A 317
None
1.23A 3prsA-3kd8A:
undetectable
3prsA-3kd8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula)
PF14765
(PS-DH)
5 ILE A1034
ALA A1006
LEU A1238
ILE A1148
ILE A1204
None
1.11A 3prsA-3kg9A:
undetectable
3prsA-3kg9A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A  66
ALA A 101
ILE A  54
ILE A 290
ILE A 277
None
None
TYR  A 356 (-4.5A)
None
None
1.11A 3prsA-3kumA:
undetectable
3prsA-3kumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ILE A 297
TYR A 600
LEU A 308
ILE A 318
ILE A 572
None
1.04A 3prsA-3lfuA:
undetectable
3prsA-3lfuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN


(Bos taurus)
PF10409
(PTEN_C2)
5 ILE A 170
ALA A 132
ILE A 327
THR A 331
ILE A 261
None
0.92A 3prsA-3n0aA:
undetectable
3prsA-3n0aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
5 ALA A 374
ILE A  91
THR A  76
ILE A 226
ILE A 245
None
1.07A 3prsA-3ng0A:
undetectable
3prsA-3ng0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qha PUTATIVE
OXIDOREDUCTASE


(Mycobacterium
avium)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 ALA A  88
ILE A 103
LEU A 111
THR A 174
ILE A 153
None
1.24A 3prsA-3qhaA:
undetectable
3prsA-3qhaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgg PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, PURE
PROTEIN


(Treponema
denticola)
PF00731
(AIRC)
5 ALA A  39
TYR A  62
LEU A  50
ILE A  34
ILE A  21
None
0.93A 3prsA-3rggA:
undetectable
3prsA-3rggA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl1 ARGINASE

(Plasmodium
falciparum)
PF00491
(Arginase)
5 ALA A 332
ILE A 320
LEU A 401
ILE A 294
ILE A 270
None
1.15A 3prsA-3sl1A:
undetectable
3prsA-3sl1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
PG4  A 372 ( 4.9A)
None
None
None
None
1.16A 3prsA-3tcsA:
undetectable
3prsA-3tcsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ASP A 292
ALA A 296
ILE A 256
LEU A 270
THR A 131
None
1.08A 3prsA-3tl2A:
undetectable
3prsA-3tl2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF00092
(VWA)
5 ALA A 353
ILE A 427
TYR A 391
THR A 388
ILE A 509
ACT  A 702 (-4.4A)
None
None
ACT  A 702 (-2.9A)
None
1.22A 3prsA-3tw0A:
undetectable
3prsA-3tw0A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ILE A 334
ALA A 339
THR A 232
ILE A 303
ILE A 265
None
1.25A 3prsA-3u4fA:
undetectable
3prsA-3u4fA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vx6 E1

(Kluyveromyces
marxianus)
PF16420
(ATG7_N)
5 ILE A 150
ALA A 241
ILE A 117
ILE A 181
THR A 228
None
1.18A 3prsA-3vx6A:
undetectable
3prsA-3vx6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
5 ILE A 311
ALA A 556
ILE A 281
TYR A 283
ILE A 286
None
1.13A 3prsA-3welA:
undetectable
3prsA-3welA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus)
PF00141
(peroxidase)
5 ILE A  34
ASP A  31
LEU A 103
THR A 128
ILE A 140
None
1.24A 3prsA-4a5gA:
undetectable
3prsA-4a5gA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE


(Lachnoclostridium
phytofermentans)
PF00171
(Aldedh)
5 ILE A 250
ALA A 248
ILE A 406
TYR A 402
THR A 408
SO4  A1467 (-4.2A)
None
None
None
None
1.00A 3prsA-4c3sA:
undetectable
3prsA-4c3sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE


(Clostridioides
difficile)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A  42
ILE A  89
LEU A  58
ILE A 107
ILE A 280
None
1.16A 3prsA-4dd5A:
undetectable
3prsA-4dd5A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eze HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Salmonella
enterica)
PF12710
(HAD)
5 ILE A 165
ILE A   3
TYR A   5
LEU A 295
ILE A  12
None
1.18A 3prsA-4ezeA:
undetectable
3prsA-4ezeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I


(Hordeum vulgare)
PF00161
(RIP)
5 ALA A 141
ILE A 202
LEU A 133
ILE A  31
ILE A  86
None
1.24A 3prsA-4fbhA:
undetectable
3prsA-4fbhA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE


(Shewanella
oneidensis)
PF01048
(PNP_UDP_1)
5 ALA A 109
ILE A  88
LEU A 200
THR A 127
ILE A 194
None
1.16A 3prsA-4lkrA:
undetectable
3prsA-4lkrA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 ILE A 258
ALA A 246
ILE A 171
TYR A 167
THR A 175
None
1.25A 3prsA-4lobA:
undetectable
3prsA-4lobA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 ALA A 566
ILE A 519
TYR A 520
ILE A 537
THR A 564
None
0.97A 3prsA-4rbnA:
undetectable
3prsA-4rbnA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 ASP A 302
ALA A 305
LEU A 412
ILE A  23
ILE A 672
None
1.19A 3prsA-4uozA:
undetectable
3prsA-4uozA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL


(Trypanosoma
brucei)
PF00155
(Aminotran_1_2)
5 ALA A 169
ILE A 251
LEU A 229
ILE A 113
ILE A 126
None
1.04A 3prsA-4w5kA:
undetectable
3prsA-4w5kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 ALA A 289
ILE A 278
THR A 227
THR A 250
ILE A   2
ANP  A 401 (-3.5A)
None
None
None
None
1.21A 3prsA-4wjmA:
undetectable
3prsA-4wjmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA


(Escherichia
coli)
PF07804
(HipA_C)
PF13657
(Couple_hipA)
5 ILE D 149
ASP D  96
LEU D 129
ILE D 184
ILE D 334
None
1.13A 3prsA-4yg7D:
undetectable
3prsA-4yg7D:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium)
PF03243
(MerB)
5 ILE A  29
ALA A  79
TYR A  11
LEU A 204
ILE A 168
None
None
None
None
DTV  A 303 ( 4.9A)
1.24A 3prsA-5c17A:
undetectable
3prsA-5c17A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR


(Mycolicibacterium
smegmatis)
PF00440
(TetR_N)
5 ILE A 173
ALA A 118
LEU A 125
THR A  35
ILE A  47
None
0.91A 3prsA-5e57A:
undetectable
3prsA-5e57A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE


(Trypanosoma
brucei)
PF06325
(PrmA)
5 ALA A 333
ILE A 281
LEU A 369
THR A 176
ILE A 173
None
None
None
None
SAH  A 401 ( 4.4A)
1.20A 3prsA-5ekuA:
undetectable
3prsA-5ekuA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1


(Homo sapiens)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 ALA A 154
TYR A  84
LEU A 135
ILE A  79
ILE A1068
None
1.15A 3prsA-5fqdA:
undetectable
3prsA-5fqdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL


(Oryctolagus
cuniculus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 ASP A 384
ALA A 386
LEU A 429
ILE A 351
ILE A 291
None
1.20A 3prsA-5h53A:
undetectable
3prsA-5h53A:
17.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
10 ILE A  10
ASP A  11
ALA A  16
ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 217
THR A 223
ILE A 300
None
None
None
None
61P  A 406 (-4.3A)
None
None
None
PG4  A 408 (-3.8A)
61P  A 406 (-4.0A)
0.25A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 302
None
61P  A 406 (-4.3A)
None
None
None
0.99A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiw CYTOCHROME P450
CYP260B1


(Sorangium
cellulosum)
PF00067
(p450)
5 ALA A 344
ILE A 203
LEU A  91
THR A 233
ILE A 154
HEM  A 401 (-3.5A)
None
None
HEM  A 401 (-4.5A)
None
1.19A 3prsA-5hiwA:
undetectable
3prsA-5hiwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING


(Caenorhabditis
elegans)
PF03828
(PAP_assoc)
no annotation
5 ILE E 193
ILE A 653
LEU A 628
THR A 614
ILE A 677
None
1.08A 3prsA-5jnbE:
undetectable
3prsA-5jnbE:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1


(Hyoscyamus
muticus)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A  90
ALA A  83
TYR A 222
LEU A 232
ILE A 553
None
1.14A 3prsA-5jo7A:
undetectable
3prsA-5jo7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
5 ILE A 172
ILE A 242
TYR A 244
LEU A 199
ILE A 298
None
1.24A 3prsA-5l56A:
undetectable
3prsA-5l56A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-)
no annotation 5 ILE A 122
ALA A 115
LEU A  37
THR A  42
ILE A  80
None
1.05A 3prsA-5mxpA:
undetectable
3prsA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN


(Chaetomium
thermophilum)
PF12569
(NARP1)
PF13432
(TPR_16)
5 ILE A 672
ALA A 698
TYR A 682
ILE A 734
ILE A 718
None
1.05A 3prsA-5nnpA:
undetectable
3prsA-5nnpA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN


(Chaetomium
thermophilum)
PF12569
(NARP1)
PF13432
(TPR_16)
5 ILE A 672
ALA A 698
TYR A 682
LEU A 665
ILE A 734
None
0.98A 3prsA-5nnpA:
undetectable
3prsA-5nnpA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
10 ILE A  10
ASP A  11
ALA A  16
ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 217
THR A 223
ILE A 300
None
0.31A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 302
None
1.03A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
5 ILE A  77
TYR A  79
THR A 135
ILE A 302
THR A 223
None
0.96A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B


(Methanothermobacter
sp. CaT2)
PF00384
(Molybdopterin)
5 ILE B 341
ASP B 414
ALA B 342
THR B 257
ILE B  37
None
MGD  B 503 (-3.0A)
MGD  B 503 (-3.4A)
None
SF4  B 501 (-4.5A)
1.16A 3prsA-5t5iB:
undetectable
3prsA-5t5iB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugj 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE


(Neisseria
meningitidis)
no annotation 5 ILE A   6
LEU A  19
THR A  29
THR A 100
ILE A 120
None
1.09A 3prsA-5ugjA:
undetectable
3prsA-5ugjA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Campylobacter
jejuni)
PF00275
(EPSP_synthase)
5 ILE A 137
ALA A 135
ILE A  33
THR A  75
ILE A 214
None
1.10A 3prsA-5ujsA:
undetectable
3prsA-5ujsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE


(Citrus sinensis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 ILE A 124
ALA A 117
TYR A 257
LEU A 267
ILE A 590
None
1.23A 3prsA-5uv2A:
undetectable
3prsA-5uv2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v52 T-CELL
IMMUNORECEPTOR WITH
IG AND ITIM DOMAINS


(Homo sapiens)
PF07686
(V-set)
5 ILE A  77
ALA A  67
ILE A  33
LEU A  95
ILE A  27
None
1.19A 3prsA-5v52A:
undetectable
3prsA-5v52A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens)
no annotation 5 ASP A 538
ILE A 593
LEU A 650
THR A 856
ILE A 575
None
1.22A 3prsA-5vm9A:
undetectable
3prsA-5vm9A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA


(Chaetomium
thermophilum)
no annotation 5 ILE B2580
ILE B 510
ILE B 865
THR B 827
ILE B 891
None
1.08A 3prsA-5wfcB:
undetectable
3prsA-5wfcB:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa)
PF00348
(polyprenyl_synt)
5 ILE A 223
TYR A 219
LEU A 296
ILE A 201
ILE A 213
None
1.20A 3prsA-5xn6A:
undetectable
3prsA-5xn6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN


(Lactobacillus
rhamnosus)
no annotation 5 ILE A 409
ALA A 392
ILE A 475
LEU A 443
THR A 419
None
1.25A 3prsA-5yxgA:
undetectable
3prsA-5yxgA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 5 ILE A1504
ILE A1449
LEU A1481
THR A1447
ILE A1342
None
1.19A 3prsA-6bhuA:
undetectable
3prsA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 5 ASP A 779
LEU A 765
ILE A 863
THR A 803
ILE A 883
None
1.05A 3prsA-6eojA:
undetectable
3prsA-6eojA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE


(Staphylococcus
hominis)
no annotation 5 ILE A 243
ILE A  88
THR A  93
ILE A 106
ILE A  78
None
None
OLC  A 512 (-4.7A)
None
None
1.19A 3prsA-6exsA:
undetectable
3prsA-6exsA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes)
PF01261
(AP_endonuc_2)
5 ASP A 331
GLY A 139
GLY A 180
PHE A  99
TYR A  96
None
1.09A 3prsA-1a0cA:
undetectable
3prsA-1a0cA:
21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1am5 PEPSIN

(Gadus morhua)
PF00026
(Asp)
5 ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE A 300
None
0.42A 3prsA-1am5A:
37.5
3prsA-1am5A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus)
PF00026
(Asp)
6 ASP A  32
GLY A  34
ASP A   9
ASP A 215
THR A 218
ILE B 300
None
1.22A 3prsA-1b5fA:
25.0
3prsA-1b5fA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus)
PF00026
(Asp)
6 ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE B 300
None
0.43A 3prsA-1b5fA:
25.0
3prsA-1b5fA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus)
PF00026
(Asp)
6 ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
None
0.41A 3prsA-1cziE:
39.5
3prsA-1cziE:
28.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1htr GASTRICSIN

(Homo sapiens)
PF00026
(Asp)
5 ASP B  32
GLY B  34
ASP B 217
THR B 220
ILE B 303
None
0.56A 3prsA-1htrB:
31.4
3prsA-1htrB:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
GLY A  27
GLY A  49
ASP A  25
ILE A  84
A79  A 800 (-2.7A)
A79  A 800 (-3.0A)
A79  A 800 ( 3.7A)
A79  A 800 (-2.8A)
A79  A 800 (-3.8A)
0.59A 3prsA-1hvcA:
10.6
3prsA-1hvcA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
GLY A  27
GLY A  49
ASP A  25
ILE A  84
A79  A 800 (-2.8A)
A79  A 800 (-3.0A)
A79  A 800 (-3.4A)
A79  A 800 (-2.7A)
A79  A 800 (-3.6A)
0.65A 3prsA-1hvcA:
10.6
3prsA-1hvcA:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis)
PF00026
(Asp)
8 ASP A  30
ASP A  32
GLY A  34
GLY A  75
ASP A 114
ASP A 214
THR A 217
ILE A 299
None
ZN  A1457 (-1.9A)
ZN  A1457 (-3.6A)
None
None
ZN  A1457 (-1.9A)
None
None
0.58A 3prsA-1ibqA:
49.0
3prsA-1ibqA:
56.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
5 ASP A  14
ASP A  33
GLY A  35
PHE A 190
ASP A 214
None
1.14A 3prsA-1izeA:
49.9
3prsA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae)
PF00026
(Asp)
10 ASP A  31
ASP A  33
GLY A  35
GLY A  76
ASP A  77
ASP A 115
PHE A 190
ASP A 214
THR A 217
ILE A 297
None
0.39A 3prsA-1izeA:
49.9
3prsA-1izeA:
58.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis)
PF00026
(Asp)
7 ASP A  32
GLY A  34
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 298
None
None
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
0.55A 3prsA-1j71A:
36.5
3prsA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 298
None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
0.42A 3prsA-1j71A:
36.5
3prsA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mpp PEPSIN

(Rhizomucor
pusillus)
PF00026
(Asp)
7 ASP A  32
GLY A  34
GLY A  76
PHE A 189
ASP A 215
THR A 218
ILE A 300
None
0.42A 3prsA-1mppA:
37.8
3prsA-1mppA:
31.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 ASP A 161
ASP A 162
GLY A 166
TYR A 209
ILE A 206
None
1.10A 3prsA-1qhoA:
undetectable
3prsA-1qhoA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrp PEPSIN 3A

(Homo sapiens)
PF00026
(Asp)
6 ASP E  32
GLY E  34
GLY E  76
ASP E 215
THR E 218
ILE E 300
HH0  E 327 (-2.7A)
HH0  E 327 (-4.1A)
HH0  E 327 (-3.2A)
HH0  E 327 (-2.5A)
HH0  E 327 (-3.7A)
None
0.42A 3prsA-1qrpE:
38.8
3prsA-1qrpE:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax)
PF00026
(Asp)
6 ASP A  34
GLY A  36
GLY A  78
ASP A 214
THR A 217
ILE A 300
None
0.40A 3prsA-1qs8A:
36.1
3prsA-1qs8A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B


(Streptomyces
griseus)
PF00089
(Trypsin)
6 ASP E  60
ASP E 102
GLY E 197
GLY E 193
ASP E 175
ILE E  31
None
1.30A 3prsA-1sgqE:
undetectable
3prsA-1sgqE:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sl8 AEQUORIN 1

(Aequorea
victoria)
PF13202
(EF-hand_5)
5 GLY A 173
ASP A 155
PHE A  67
THR A 168
TYR A  99
None
CA  A 669 (-3.2A)
None
None
None
1.02A 3prsA-1sl8A:
undetectable
3prsA-1sl8A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tzs CATHEPSIN E

(Homo sapiens)
PF00026
(Asp)
6 ASP A  22
ASP A  43
GLY A  45
ASP A 228
THR A 231
ILE A 316
None
0.84A 3prsA-1tzsA:
8.6
3prsA-1tzsA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uh9 HIZOPUSPEPSIN I

(Rhizopus
microsporus)
PF00026
(Asp)
8 ASP A  33
ASP A  35
GLY A  37
GLY A  78
ASP A  79
ASP A 218
THR A 221
ILE A 298
None
0.44A 3prsA-1uh9A:
42.5
3prsA-1uh9A:
40.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 ASP A 549
GLY A 573
GLY A 557
PHE A 618
THR A 567
None
1.06A 3prsA-1v7vA:
undetectable
3prsA-1v7vA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus)
PF00026
(Asp)
6 ASP A  32
GLY A  34
GLY A  64
ASP A 212
THR A 215
ILE A 307
None
0.49A 3prsA-1wkrA:
35.6
3prsA-1wkrA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wkr POLYPOROPEPSIN

(Irpex lacteus)
PF00026
(Asp)
5 ASP A 111
ASP A 212
GLY A 214
ASP A  32
ILE A 104
None
1.11A 3prsA-1wkrA:
35.6
3prsA-1wkrA:
33.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR


(Homo sapiens)
PF00089
(Trypsin)
5 GLY A 541
GLY A 621
ASP A 597
TYR A 631
ILE A 616
None
1.10A 3prsA-1ybwA:
undetectable
3prsA-1ybwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE


(Candida
albicans)
PF00026
(Asp)
9 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 305
A70  A 500 ( 2.7A)
A70  A 500 (-3.8A)
A70  A 500 (-3.5A)
A70  A 500 (-3.1A)
None
A70  A 500 ( 2.3A)
A70  A 500 (-3.6A)
A70  A 500 ( 4.0A)
A70  A 500 (-4.8A)
0.83A 3prsA-1zapA:
36.4
3prsA-1zapA:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anl PLASMEPSIN IV

(Plasmodium
malariae)
PF00026
(Asp)
7 ASP A  34
GLY A  36
GLY A  78
PHE A 192
ASP A 214
THR A 217
ILE A 300
JE2  A3151 (-3.0A)
JE2  A3151 (-2.7A)
JE2  A3151 (-3.6A)
JE2  A3151 (-4.6A)
JE2  A3151 (-2.5A)
JE2  A3151 (-2.6A)
JE2  A3151 ( 4.5A)
0.70A 3prsA-2anlA:
35.4
3prsA-2anlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum)
PF00026
(Asp)
5 ASP A  34
GLY A  36
ASP A 214
THR A 217
ILE A 300
IH4  A1330 (-4.2A)
IH4  A1330 ( 4.6A)
IH4  A1330 (-3.3A)
IH4  A1331 ( 4.1A)
IH4  A1330 (-4.5A)
0.20A 3prsA-2bjuA:
35.4
3prsA-2bjuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4x ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF00801
(PKD)
5 ASP A  21
GLY A  46
ASP A  47
PHE A  11
ILE A  88
None
1.09A 3prsA-2c4xA:
undetectable
3prsA-2c4xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa)
PF03309
(Pan_kinase)
5 ASP A 129
GLY A 140
GLY A  99
THR A 127
ILE A 142
None
1.13A 3prsA-2f9tA:
undetectable
3prsA-2f9tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans)
PF00026
(Asp)
7 ASP A  32
GLY A  34
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 305
None
0.79A 3prsA-2h6tA:
35.2
3prsA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 305
None
0.48A 3prsA-2h6tA:
35.2
3prsA-2h6tA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6t CANDIDAPEPSIN-3

(Candida
albicans)
PF00026
(Asp)
5 ASP A 308
GLY A  34
ASP A 120
THR A 221
ILE A 305
None
1.11A 3prsA-2h6tA:
35.2
3prsA-2h6tA:
27.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qzw CANDIDAPEPSIN-1

(Candida
albicans)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 305
None
0.49A 3prsA-2qzwA:
36.2
3prsA-2qzwA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 305
None
0.58A 3prsA-2qzxA:
36.0
3prsA-2qzxA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3)
5 ASP A 738
ASP A 741
GLY A 748
ASP A 747
ASP A 734
None
CA  A  26 (-2.3A)
None
CA  A  24 ( 3.1A)
CA  A  26 ( 2.8A)
1.01A 3prsA-2rhpA:
undetectable
3prsA-2rhpA:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei)
PF00026
(Asp)
6 ASP A  38
GLY A  40
ASP A  14
PHE A 210
THR A 240
ILE A 329
None
1.50A 3prsA-2rmpA:
37.9
3prsA-2rmpA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei)
PF00026
(Asp)
7 ASP A  38
GLY A  40
GLY A  83
PHE A 210
ASP A 237
THR A 240
ILE A 329
None
0.34A 3prsA-2rmpA:
37.9
3prsA-2rmpA:
30.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
5 ASP A  14
ASP A  33
GLY A  35
PHE A 190
ASP A 213
None
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
1.14A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
8 ASP A  33
GLY A  35
GLY A  76
ASP A  77
ASP A 115
PHE A 190
ASP A 213
THR A 216
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
PP6  A 327 (-3.5A)
None
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
0.42A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wed PENICILLOPEPSIN

(Penicillium
janthinellum)
PF00026
(Asp)
8 ASP A  33
GLY A  35
GLY A  76
ASP A 115
PHE A 190
ASP A 213
THR A 216
ILE A 297
PP6  A 327 ( 2.7A)
PP6  A 327 (-4.0A)
PP6  A 327 (-3.5A)
None
PP6  A 327 ( 4.8A)
PP6  A 327 ( 2.5A)
PP6  A 327 (-3.6A)
PP6  A 327 (-4.2A)
0.47A 3prsA-2wedA:
47.9
3prsA-2wedA:
54.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus)
PF05711
(TylF)
5 ASP A  57
ASP A 198
GLY A 197
ASP A 254
ASP A 196
None
SAH  A 301 (-4.1A)
EDO  A 551 ( 3.7A)
None
SAH  A 301 ( 3.5A)
1.11A 3prsA-2wk1A:
undetectable
3prsA-2wk1A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6p 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Aquifex
aeolicus)
PF02348
(CTP_transf_3)
5 ASP A 219
ASP A  95
GLY A  94
GLY A  73
TYR A 170
MG  A1234 ( 2.3A)
MG  A1234 ( 2.6A)
CTP  A1233 (-3.5A)
CTP  A1233 (-3.4A)
IPA  A1236 ( 4.0A)
0.92A 3prsA-2y6pA:
undetectable
3prsA-2y6pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdi UNCHARACTERIZED
PROTEIN TA0194


(Thermoplasma
acidophilum)
PF00561
(Abhydrolase_1)
PF12146
(Hydrolase_4)
6 ASP A 201
GLY A 105
GLY A 126
PHE A  32
TYR A  56
ILE A  29
None
1.37A 3prsA-3bdiA:
undetectable
3prsA-3bdiA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
6 ASP A  11
ASP A  32
GLY A  34
PHE A 189
ASP A 215
ILE A 301
None
1.19A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3emy TRICHODERMA REESEI
ASPARTIC PROTEASE


(Trichoderma
reesei)
PF00026
(Asp)
10 ASP A  30
ASP A  32
GLY A  34
GLY A  76
ASP A  77
ASP A 114
PHE A 189
ASP A 215
THR A 218
ILE A 301
None
0.43A 3prsA-3emyA:
51.8
3prsA-3emyA:
60.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN


(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
5 ASP A 466
ASP A 469
GLY A 476
ASP A 475
ASP A 462
None
CA  A 820 (-2.6A)
None
CA  A 823 ( 2.7A)
CA  A 819 ( 2.8A)
1.01A 3prsA-3fbyA:
undetectable
3prsA-3fbyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
5 GLY A 118
ASP A 125
ASP A 144
ASP A 157
ILE A  69
None
1.11A 3prsA-3fcyA:
undetectable
3prsA-3fcyA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1


(Candida
parapsilosis)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  79
ASP A  80
ASP A 220
THR A 223
TYR A 227
ILE A 303
None
None
GOL  A 341 (-4.5A)
None
None
None
GOL  A 341 ( 4.6A)
None
0.46A 3prsA-3fv3A:
36.9
3prsA-3fv3A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv3 SAPP1P-SECRETED
ASPARTIC PROTEASE 1


(Candida
parapsilosis)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  79
ASP A 114
ASP A 220
THR A 223
TYR A 227
ILE A 303
None
None
GOL  A 341 (-4.5A)
None
None
None
GOL  A 341 ( 4.6A)
None
0.87A 3prsA-3fv3A:
36.9
3prsA-3fv3A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE


(Bordetella
bronchiseptica)
PF07969
(Amidohydro_3)
5 GLY A 363
GLY A 379
ASP A 370
ASP A  64
ILE A  87
None
0.90A 3prsA-3gipA:
undetectable
3prsA-3gipA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Pyrococcus
furiosus)
PF07969
(Amidohydro_3)
5 ASP A 432
GLY A 367
GLY A 292
ASP A  97
PHE A 365
ZN  A 601 (-2.6A)
None
None
None
None
0.83A 3prsA-3icjA:
undetectable
3prsA-3icjA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ign DIGUANYLATE CYCLASE

(Marinobacter
hydrocarbonoclasticus)
PF00990
(GGDEF)
5 ASP A 158
GLY A 235
GLY A 209
TYR A 275
ILE A 194
None
1.14A 3prsA-3ignA:
undetectable
3prsA-3ignA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN


(Staphylococcus
aureus)
no annotation 5 ASP A 321
ASP A 190
GLY A  12
ASP A  10
ASP A 169
None
1.10A 3prsA-3js6A:
undetectable
3prsA-3js6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN


(Staphylococcus
aureus)
no annotation 5 ASP A 321
GLY A 192
GLY A  12
ASP A  10
ASP A 169
None
1.11A 3prsA-3js6A:
undetectable
3prsA-3js6A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei)
PF01593
(Amino_oxidase)
5 GLY A 349
GLY A 309
ASP A 352
THR A 304
TYR A  97
None
1.07A 3prsA-3ka7A:
undetectable
3prsA-3ka7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56


(Arabidopsis
thaliana)
PF00481
(PP2C)
5 GLY B 241
GLY B 260
ASP B 261
ASP B 317
ILE B 324
None
0.85A 3prsA-3kdjB:
undetectable
3prsA-3kdjB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis)
PF12697
(Abhydrolase_6)
5 ASP A  58
ASP A  72
GLY A  77
ASP A  48
THR A  50
None
0.96A 3prsA-3llcA:
undetectable
3prsA-3llcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5l BINDING PROTEIN
COMPONENT OF ABC
PHOSPHONATE
TRANSPORTER


(Pseudomonas
aeruginosa)
PF12974
(Phosphonate-bd)
5 ASP A 147
GLY A 228
ASP A 229
THR A 151
ILE A 281
None
None
UNL  A 401 ( 2.7A)
UNL  A 401 ( 3.7A)
None
0.94A 3prsA-3n5lA:
undetectable
3prsA-3n5lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Rubrobacter
xylanophilus)
PF00535
(Glycos_transf_2)
5 ASP A 137
ASP A 135
GLY A 209
GLY A 116
PHE A 211
MG  A 339 ( 2.5A)
GDD  A 340 (-3.2A)
GDD  A 340 (-3.5A)
None
None
0.83A 3prsA-3o3pA:
undetectable
3prsA-3o3pA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa)
PF00026
(Asp)
PF07966
(A1_Propeptide)
5 ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE A 300
None
0.71A 3prsA-3psgA:
34.7
3prsA-3psgA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qs1 PLASMEPSIN-1

(Plasmodium
falciparum)
PF00026
(Asp)
5 ASP A  32
GLY A  34
ASP A 215
THR A 218
ILE A 300
006  A 330 (-2.8A)
006  A 330 (-3.2A)
006  A 330 (-2.8A)
006  A 330 (-3.5A)
None
0.30A 3prsA-3qs1A:
36.0
3prsA-3qs1A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE


(Parabacteroides
distasonis)
PF04389
(Peptidase_M28)
5 ASP A 147
ASP A 146
GLY A 223
GLY A 153
ASP A 124
ZN  A 350 ( 2.3A)
None
None
None
None
1.12A 3prsA-3tc8A:
undetectable
3prsA-3tc8A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE


(Salmonella
enterica)
PF02769
(AIRS_C)
PF13507
(GATase_5)
6 ASP A 667
GLY A 334
GLY A 416
ASP A 657
THR A 386
ILE A 697
None
ADP  A2005 ( 4.2A)
None
None
ADP  A2005 (-3.8A)
None
1.36A 3prsA-3ummA:
undetectable
3prsA-3ummA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN


(Thermus
thermophilus)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
5 ASP A 452
GLY A 514
ASP A 446
ASP A 436
PHE A 563
None
1.13A 3prsA-3w3aA:
undetectable
3prsA-3w3aA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea)
no annotation 6 ASP A 219
ASP A 138
GLY A 140
GLY A 224
ASP A 223
ILE A 153
None
1.32A 3prsA-3wevA:
undetectable
3prsA-3wevA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aa9 CHYMOSIN

(Camelus
dromedarius)
PF00026
(Asp)
5 ASP A  34
GLY A  36
ASP A 216
THR A 219
ILE A 297
None
None
GOL  A1334 (-3.5A)
None
GOL  A1334 (-4.2A)
0.37A 3prsA-4aa9A:
35.8
3prsA-4aa9A:
30.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)


(Pyrococcus
furiosus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM)
5 ASP A 215
ASP A 305
GLY A 306
PHE A 308
ILE A 272
None
1.13A 3prsA-4aefA:
undetectable
3prsA-4aefA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
5 ASP A1033
ASP A1069
GLY A1066
ASP A1028
THR A 966
None
GOL  A2792 (-3.7A)
GOL  A2792 ( 3.8A)
GOL  A2792 (-3.4A)
GOL  A2792 (-3.5A)
1.07A 3prsA-4aygA:
undetectable
3prsA-4aygA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60


(Rabbit
hemorrhagic
disease virus)
PF00915
(Calici_coat)
5 ASP A 531
GLY A 488
ASP A 338
THR A 273
ILE A 443
None
1.13A 3prsA-4egtA:
undetectable
3prsA-4egtA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN


(Thermotoga
maritima;
Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
5 GLY A 209
GLY A 225
ASP A 295
TYR A 263
ILE A 262
None
1.00A 3prsA-4gxpA:
undetectable
3prsA-4gxpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp4 EAG-LIKE K[+]
CHANNEL


(Drosophila
melanogaster)
PF13426
(PAS_9)
5 GLY A  47
GLY A  24
ASP A  23
ASP A  16
ASP A  46
None
SO4  A 201 (-3.4A)
GOL  A 202 ( 2.6A)
None
None
1.13A 3prsA-4hp4A:
undetectable
3prsA-4hp4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE


(Caenorhabditis
elegans)
PF00481
(PP2C)
5 GLY A 261
GLY A 282
ASP A 283
ASP A 340
ILE A 347
None
0.99A 3prsA-4jndA:
undetectable
3prsA-4jndA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
5 ASP A 231
GLY A 217
ASP A 255
THR A 234
ILE A 238
None
0.99A 3prsA-4mo9A:
undetectable
3prsA-4mo9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
5 GLY A 507
GLY A 527
ASP A 556
TYR A 498
ILE A 484
None
0.91A 3prsA-4nsxA:
undetectable
3prsA-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE


(Caldalkalibacillus
thermarum)
PF07992
(Pyr_redox_2)
5 GLY A 220
GLY A 172
ASP A 176
PHE A 226
ILE A 194
None
0.92A 3prsA-4nwzA:
undetectable
3prsA-4nwzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic PROBABLE PROTEIN
PHOSPHATASE 2C 6


(Oryza sativa)
PF00481
(PP2C)
5 GLY B 280
GLY B 299
ASP B 300
ASP B 356
ILE B 363
None
0.85A 3prsA-4oicB:
undetectable
3prsA-4oicB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaf LIPOCALIN-1

(Homo sapiens)
PF00061
(Lipocalin)
5 GLY A 112
GLY A  27
ASP A  25
TYR A  77
ILE A  80
None
1.06A 3prsA-4qafA:
undetectable
3prsA-4qafA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r29 UNCHARACTERIZED
PROTEIN


(Escherichia
coli)
no annotation 5 GLY A 105
ASP A 121
PHE A  84
THR A 101
ILE A  87
None
1.11A 3prsA-4r29A:
undetectable
3prsA-4r29A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2g SURFACE PROTEIN
GP160


(Human
immunodeficiency
virus 1)
no annotation 5 ASP E 279
GLY E 472
ASP E 275
PHE E 391
THR E 455
NAG  E 512 (-4.3A)
None
None
None
None
1.14A 3prsA-4r2gE:
undetectable
3prsA-4r2gE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN B CHAIN
LINKER L1


(Glossoscolex
paulistus)
PF00042
(Globin)
PF16915
(Eryth_link_C)
5 ASP M  79
GLY M  92
GLY M  85
ASP M  84
ASP B  27
None
None
None
CA  M 301 (-3.1A)
None
1.07A 3prsA-4u8uM:
undetectable
3prsA-4u8uM:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD


(Mycolicibacterium
smegmatis)
PF10017
(Methyltransf_33)
5 ASP A  45
ASP A 115
ASP A 113
GLY A  86
PHE A 159
None
None
SAH  A 801 (-3.0A)
SAH  A 801 (-3.0A)
None
1.13A 3prsA-4uy6A:
undetectable
3prsA-4uy6A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE


(Micromonospora
griseorubida)
PF05711
(TylF)
5 ASP A  48
ASP A 191
GLY A 190
GLY A 247
ASP A 189
None
MVI  A 305 ( 2.7A)
SAH  A 301 ( 4.0A)
None
MG  A 304 (-2.5A)
1.14A 3prsA-4x81A:
undetectable
3prsA-4x81A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y9w ASPARTIC ACID
ENDOPEPTIDASE SAPP2


(Candida
parapsilosis)
PF00026
(Asp)
8 ASP A  32
GLY A  34
GLY A  78
ASP A  79
ASP A 211
THR A 214
TYR A 218
ILE A 298
None
0.45A 3prsA-4y9wA:
36.7
3prsA-4y9wA:
32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
5 ASP b 386
GLY b  89
GLY b  60
ASP b 378
ASP b  85
None
1.10A 3prsA-5gw5b:
undetectable
3prsA-5gw5b:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
10 ASP A  15
ASP A  33
ASP A  35
GLY A  37
ASP A 119
PHE A 194
ASP A 219
THR A 222
TYR A 226
ILE A 304
PG4  A 408 (-3.7A)
61P  A 406 (-4.0A)
61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
61P  A 406 ( 4.9A)
None
61P  A 406 (-2.9A)
61P  A 406 ( 3.5A)
61P  A 406 (-4.0A)
None
0.64A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
11 ASP A  15
ASP A  33
ASP A  35
GLY A  37
GLY A  80
ASP A  81
PHE A 194
ASP A 219
THR A 222
TYR A 226
ILE A 304
PG4  A 408 (-3.7A)
61P  A 406 (-4.0A)
61P  A 406 (-2.7A)
61P  A 406 ( 4.0A)
61P  A 406 (-4.1A)
61P  A 406 ( 2.8A)
None
61P  A 406 (-2.9A)
61P  A 406 ( 3.5A)
61P  A 406 (-4.0A)
None
0.34A 3prsA-5hctA:
58.2
3prsA-5hctA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum)
no annotation 6 ASP B  34
GLY B  36
GLY B  78
ASP B 214
THR B 217
ILE B 300
None
0.53A 3prsA-5i70B:
36.4
3prsA-5i70B:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
5 GLY A 202
GLY A 221
ASP A 291
TYR A 259
ILE A 258
None
1.08A 3prsA-5jbkA:
undetectable
3prsA-5jbkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus)
no annotation 6 ASP A  36
GLY A  38
GLY A  80
ASP A 227
THR A 230
ILE A 313
None
0.47A 3prsA-5n7qA:
39.9
3prsA-5n7qA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B


(Cynara
cardunculus)
no annotation 5 ASP A  80
GLY A  82
ASP A 267
THR A 270
ILE A 357
None
0.57A 3prsA-5nfgA:
38.3
3prsA-5nfgA:
26.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica)
PF00026
(Asp)
12 ASP A  15
ASP A  33
ASP A  35
GLY A  37
GLY A  80
ASP A  81
ASP A 119
PHE A 194
ASP A 219
THR A 222
TYR A 226
ILE A 304
None
0.46A 3prsA-5p60A:
58.1
3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
6 ASP A  32
GLY A  34
GLY A  76
ASP A 215
THR A 218
ILE A 301
None
0.53A 3prsA-5pepA:
38.5
3prsA-5pepA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux4 CATHEPSIN D

(Rattus
norvegicus)
no annotation 5 ASP A  33
GLY A  35
ASP A 226
THR A 229
ILE A 315
3UT  A 404 (-2.9A)
3UT  A 404 (-3.5A)
3UT  A 404 (-2.4A)
3UT  A 404 ( 4.8A)
None
0.24A 3prsA-5ux4A:
37.5
3prsA-5ux4A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans)
PF03639
(Glyco_hydro_81)
5 ASP A 678
GLY A 722
GLY A 362
ASP A 363
PHE A 738
None
1.14A 3prsA-5v1wA:
undetectable
3prsA-5v1wA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1


(Homo sapiens)
PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3)
5 ASP A 571
GLY A1533
ASP A 585
PHE A1390
TYR A1513
None
1.15A 3prsA-5xjyA:
undetectable
3prsA-5xjyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum)
no annotation 5 ASP A  36
GLY A  38
ASP A 216
THR A 219
ILE A 302
K95  A 401 ( 2.6A)
K95  A 401 ( 3.5A)
NA  A 403 ( 1.9A)
K95  A 401 (-3.8A)
None
0.38A 3prsA-5yidA:
36.1
3prsA-5yidA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bs7 ADENYLOSUCCINATE
SYNTHETASE


(Legionella
pneumophila)
no annotation 5 ASP A  27
GLY A 223
GLY A  18
ASP A  22
ILE A 266
None
1.16A 3prsA-6bs7A:
undetectable
3prsA-6bs7A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Sus scrofa)
no annotation 5 ASP B1004
ASP B 715
GLY B 997
ASP B 998
ILE B1011
None
1.12A 3prsA-6exvB:
undetectable
3prsA-6exvB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)


(Homo sapiens)
no annotation 5 GLY A 603
GLY A 429
THR A 434
TYR A 400
ILE A 408
None
1.15A 3prsA-6fn1A:
undetectable
3prsA-6fn1A:
11.18