SIMILAR PATTERNS OF AMINO ACIDS FOR 3PRS_A_RITA1001
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1axn | ANNEXIN III (Homo sapiens) |
PF00191(Annexin) | 5 | ILE A 145LEU A 100THR A 149ILE A 244THR A 122 | None | 1.00A | 3prsA-1axnA:undetectable | 3prsA-1axnA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1brw | PROTEIN (PYRIMIDINENUCLEOSIDEPHOSPHORYLASE) (Geobacillusstearothermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | ASP A 267ILE A 184ILE A 121THR A 90ILE A 150 | NoneNoneNone CA A3001 (-4.0A)None | 1.19A | 3prsA-1brwA:0.0 | 3prsA-1brwA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1feh | PROTEIN (PERIPLASMICHYDROGENASE 1) (Clostridiumpasteurianum) |
PF02256(Fe_hyd_SSU)PF02906(Fe_hyd_lg_C)PF12838(Fer4_7)PF13510(Fer2_4) | 5 | ILE A 268ASP A 267ALA A 230ILE A 198ILE A 522 | HC1 A 580 ( 4.8A)NoneHC1 A 580 (-3.1A)NoneNone | 1.16A | 3prsA-1fehA:undetectable | 3prsA-1fehA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gh6 | RETINOBLASTOMA-ASSOCIATED PROTEIN (Homo sapiens) |
PF01857(RB_B)PF01858(RB_A) | 5 | ALA B 734ILE B 680LEU B 665ILE B 753THR B 738 | None | 1.09A | 3prsA-1gh6B:undetectable | 3prsA-1gh6B:19.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 6 | ILE A 72TYR A 74LEU A 120THR A 130ILE A 212THR A 218 | None | 0.38A | 3prsA-1ibqA:49.0 | 3prsA-1ibqA:56.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 7 | ILE A 73TYR A 75LEU A 121THR A 131ILE A 212THR A 218ILE A 293 | None | 0.43A | 3prsA-1izeA:49.9 | 3prsA-1izeA:58.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mk4 | HYPOTHETICAL PROTEINYQJY (Bacillussubtilis) |
PF00583(Acetyltransf_1) | 5 | ALA A 117ILE A 84THR A 53ILE A 70ILE A 93 | None | 1.19A | 3prsA-1mk4A:0.0 | 3prsA-1mk4A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ni3 | YCHF GTP-BINDINGPROTEIN (Schizosaccharomycespombe) |
PF01926(MMR_HSR1)PF06071(YchF-GTPase_C) | 5 | ALA A 125TYR A 229LEU A 144ILE A 25ILE A 297 | None | 1.08A | 3prsA-1ni3A:undetectable | 3prsA-1ni3A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oa1 | HYDROXYLAMINEREDUCTASE (Desulfovibriovulgaris) |
PF03063(Prismane) | 5 | ALA A 73ILE A 84ILE A 152THR A 71ILE A 136 | NoneNoneNoneSF4 A1554 (-3.1A)None | 1.25A | 3prsA-1oa1A:0.0 | 3prsA-1oa1A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 567ILE A 321LEU A 577ILE A 300ILE A 311 | None | 0.90A | 3prsA-1qhgA:undetectable | 3prsA-1qhgA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhh | PROTEIN (PCRA(SUBUNIT)) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA D 567ILE B 321LEU D 577ILE B 300ILE B 311 | None | 0.97A | 3prsA-1qhhD:undetectable | 3prsA-1qhhD:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r0l | 1-DEOXY-D-XYLULOSE5-PHOSPHATEREDUCTOISOMERASE (Zymomonasmobilis) |
PF02670(DXP_reductoisom)PF08436(DXP_redisom_C)PF13288(DXPR_C) | 5 | ILE A 315LEU A 228THR A 273ILE A 102ILE A 208 | NoneNoneNoneNDP A 400 ( 4.9A)None | 1.22A | 3prsA-1r0lA:undetectable | 3prsA-1r0lA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umf | CHORISMATE SYNTHASE (Helicobacterpylori) |
PF01264(Chorismate_synt) | 5 | ILE A 83ASP A 61ALA A 130LEU A 10ILE A 206 | None | 1.14A | 3prsA-1umfA:undetectable | 3prsA-1umfA:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1us2 | ENDO-BETA-1,4-XYLANASE (Cellvibriojaponicus) |
PF00331(Glyco_hydro_10)PF03426(CBM_15) | 5 | ILE A 476ALA A 536LEU A 498THR A 293THR A 540 | None | 1.22A | 3prsA-1us2A:undetectable | 3prsA-1us2A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3i | 2-KETO-3-DEOXYGLUCONATE ALDOLASE (Sulfolobussolfataricus) |
PF00701(DHDPS) | 5 | ALA A 135ILE A 9LEU A 242THR A 249ILE A 70 | NoneNoneGOL A1296 (-3.4A)NoneNone | 1.16A | 3prsA-1w3iA:undetectable | 3prsA-1w3iA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xtt | PROBABLE URACILPHOSPHORIBOSYLTRANSFERASE (Sulfolobussolfataricus) |
PF14681(UPRTase) | 5 | ILE A 75ALA A 139LEU A 32THR A 23ILE A 203 | NoneNoneNoneNoneU5P A1250 (-4.1A) | 1.22A | 3prsA-1xttA:undetectable | 3prsA-1xttA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7m | HYPOTHETICAL PROTEINBSU14040 (Bacillussubtilis) |
PF01476(LysM)PF03734(YkuD) | 5 | ILE A 15ASP A 10ILE A 54LEU A 48ILE A 122 | None | 1.09A | 3prsA-1y7mA:undetectable | 3prsA-1y7mA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 5 | ILE A1156ALA A1153TYR A1080THR A1268ILE A1190 | None | 1.24A | 3prsA-2b39A:undetectable | 3prsA-2b39A:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5m | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ALA A 154TYR A 84LEU A 135ILE A 79ILE A1068 | None | 1.11A | 3prsA-2b5mA:undetectable | 3prsA-2b5mA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c3o | PYRUVATE-FERREDOXINOXIDOREDUCTASE (Desulfovibrioafricanus) |
PF01558(POR)PF01855(POR_N)PF02775(TPP_enzyme_C)PF10371(EKR)PF13484(Fer4_16)PF17147(PFOR_II) | 5 | ILE A 559ASP A 428LEU A 613ILE A 534ILE A 504 | None | 1.20A | 3prsA-2c3oA:undetectable | 3prsA-2c3oA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5i | AZO REDUCTASE (Escherichiacoli) |
PF02525(Flavodoxin_2) | 5 | ILE A 100ALA A 93LEU A 160ILE A 197THR A 138 | None | 1.21A | 3prsA-2d5iA:undetectable | 3prsA-2d5iA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7d | UVRABC SYSTEMPROTEIN B (Bacillussubtilis) |
PF00271(Helicase_C)PF02151(UVR)PF04851(ResIII)PF12344(UvrB) | 5 | ILE A 138ALA A 126LEU A 148THR A 314ILE A 179 | None | 1.07A | 3prsA-2d7dA:undetectable | 3prsA-2d7dA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e1m | L-GLUTAMATE OXIDASE (Streptomycessp. X-119-6) |
PF01593(Amino_oxidase) | 5 | ILE A 48ILE A 98LEU A 336ILE A 348ILE A 63 | NoneFAD A 801 (-4.8A)NoneNoneNone | 1.23A | 3prsA-2e1mA:undetectable | 3prsA-2e1mA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ece | 462AA LONGHYPOTHETICALSELENIUM-BINDINGPROTEIN (Sulfurisphaeratokodaii) |
PF05694(SBP56) | 5 | ILE A 60ALA A 46THR A 11ILE A 99ILE A 123 | None | 1.18A | 3prsA-2eceA:undetectable | 3prsA-2eceA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 5 | ALA A 493THR A 367ILE A 256THR A 491ILE A 266 | None | 1.15A | 3prsA-2gahA:undetectable | 3prsA-2gahA:15.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i14 | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Pyrococcusfuriosus) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | ILE A 153ILE A 12THR A 17ILE A 91ILE A 359 | None | 1.17A | 3prsA-2i14A:undetectable | 3prsA-2i14A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iaf | HYPOTHETICAL PROTEINSDHL (Legionellapneumophila) |
PF03315(SDH_beta) | 5 | ILE A 140ALA A 13LEU A 37ILE A 78ILE A 92 | None | 1.16A | 3prsA-2iafA:undetectable | 3prsA-2iafA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oaj | PROTEIN SNI1 (Saccharomycescerevisiae) |
PF08596(Lgl_C) | 5 | ILE A 357ALA A 332ILE A 408ILE A 368ILE A 287 | None | 1.25A | 3prsA-2oajA:undetectable | 3prsA-2oajA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjr | PROTEIN (HELICASEPCRA) (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA B 567ILE A 321LEU B 577ILE A 300ILE A 311 | None | 0.97A | 3prsA-2pjrB:undetectable | 3prsA-2pjrB:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ptg | ENOYL-ACYL CARRIERREDUCTASE (Eimeria tenella) |
PF13561(adh_short_C2) | 5 | ILE A 211ASP A 188ALA A 185ILE A 118ILE A 284 | None | 1.20A | 3prsA-2ptgA:undetectable | 3prsA-2ptgA:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qne | PUTATIVEMETHYLTRANSFERASE (Desulfitobacteriumhafniense) |
PF06253(MTTB) | 5 | ILE A 23ALA A 249LEU A 300THR A 338ILE A 225 | None | 1.17A | 3prsA-2qneA:undetectable | 3prsA-2qneA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wbn | TERMINASE LARGESUBUNIT (Bacillus phageSPP1) |
PF17288(Terminase_3C) | 5 | ILE A 328ALA A 320LEU A 274ILE A 373ILE A 291 | None | 1.14A | 3prsA-2wbnA:undetectable | 3prsA-2wbnA:18.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 6 | ILE A 73TYR A 75LEU A 121THR A 131ILE A 211ILE A 293 | NonePP6 A 327 (-3.8A)NoneNoneNoneNone | 0.88A | 3prsA-2wedA:47.9 | 3prsA-2wedA:54.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 6 | ILE A 73TYR A 75LEU A 121THR A 131ILE A 211THR A 217 | NonePP6 A 327 (-3.8A)NoneNoneNonePP6 A 327 (-4.5A) | 0.40A | 3prsA-2wedA:47.9 | 3prsA-2wedA:54.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x7q | POSSIBLE THIAMINEBIOSYNTHESIS ENZYME (Candidaalbicans) |
PF09084(NMT1) | 5 | ASP A 225ALA A 227THR A 185ILE A 58ILE A 255 | None | 1.15A | 3prsA-2x7qA:undetectable | 3prsA-2x7qA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrf | METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Bacillussubtilis) |
PF01008(IF-2B) | 5 | ALA A 68ILE A 131LEU A 107ILE A 45ILE A 20 | None | 1.04A | 3prsA-2yrfA:undetectable | 3prsA-2yrfA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxd | PROBABLECOBALT-PRECORRIN-6YC(15)-METHYLTRANSFERASE[DECARBOXYLATING] (Methanocaldococcusjannaschii) |
PF13847(Methyltransf_31) | 5 | ILE A 87ALA A 62LEU A 99ILE A 127ILE A 112 | None | 1.11A | 3prsA-2yxdA:undetectable | 3prsA-2yxdA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zle | PROTEASE DO (Escherichiacoli) |
PF00595(PDZ)PF13365(Trypsin_2) | 5 | ILE A 154ALA A 196LEU A 176THR A 111ILE A 19 | None | 1.11A | 3prsA-2zleA:undetectable | 3prsA-2zleA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c2u | XYLOSIDASE/ARABINOSIDASE (Selenomonasruminantium) |
PF04616(Glyco_hydro_43)PF07081(DUF1349) | 5 | ILE A 294ALA A 262ILE A 111ILE A 87ILE A 72 | None | 1.09A | 3prsA-3c2uA:undetectable | 3prsA-3c2uA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dme | CONSERVED EXPORTEDPROTEIN (Bordetellapertussis) |
PF01266(DAO) | 5 | ALA A 35ILE A 19THR A 363THR A 171ILE A 5 | FAD A 500 (-3.6A)NoneNoneNoneNone | 1.21A | 3prsA-3dmeA:undetectable | 3prsA-3dmeA:22.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 5 | ASP A 8ILE A 73TYR A 75ILE A 299THR A 219 | None | 1.18A | 3prsA-3emyA:51.8 | 3prsA-3emyA:60.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 7 | ASP A 8ILE A 73TYR A 75LEU A 120ILE A 213THR A 219ILE A 297 | None | 0.56A | 3prsA-3emyA:51.8 | 3prsA-3emyA:60.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 5 | ILE A 15ALA A 7LEU A 106ILE A 2ILE A 138 | NDP A 163 (-3.7A)NDP A 163 ( 3.9A)NoneNoneNone | 1.16A | 3prsA-3ia4A:undetectable | 3prsA-3ia4A:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 5 | ILE A 73ALA A 12ILE A 267ILE A 142ILE A 156 | None | 1.00A | 3prsA-3in1A:undetectable | 3prsA-3in1A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd8 | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Thermoplasmaacidophilum) |
PF01676(Metalloenzyme)PF10143(PhosphMutase) | 5 | ILE A 42ASP A 365LEU A 391ILE A 278ILE A 317 | None | 1.23A | 3prsA-3kd8A:undetectable | 3prsA-3kd8A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg9 | CURK (Lyngbyamajuscula) |
PF14765(PS-DH) | 5 | ILE A1034ALA A1006LEU A1238ILE A1148ILE A1204 | None | 1.11A | 3prsA-3kg9A:undetectable | 3prsA-3kg9A:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kum | DIPEPTIDE EPIMERASE (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 66ALA A 101ILE A 54ILE A 290ILE A 277 | NoneNoneTYR A 356 (-4.5A)NoneNone | 1.11A | 3prsA-3kumA:undetectable | 3prsA-3kumA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lfu | DNA HELICASE II (Escherichiacoli) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ILE A 297TYR A 600LEU A 308ILE A 318ILE A 572 | None | 1.04A | 3prsA-3lfuA:undetectable | 3prsA-3lfuA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0a | TYROSINE-PROTEINPHOSPHATASE AUXILIN (Bos taurus) |
PF10409(PTEN_C2) | 5 | ILE A 170ALA A 132ILE A 327THR A 331ILE A 261 | None | 0.92A | 3prsA-3n0aA:undetectable | 3prsA-3n0aA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ng0 | GLUTAMINE SYNTHETASE (Synechocystissp. PCC 6803) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | ALA A 374ILE A 91THR A 76ILE A 226ILE A 245 | None | 1.07A | 3prsA-3ng0A:undetectable | 3prsA-3ng0A:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qha | PUTATIVEOXIDOREDUCTASE (Mycobacteriumavium) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | ALA A 88ILE A 103LEU A 111THR A 174ILE A 153 | None | 1.24A | 3prsA-3qhaA:undetectable | 3prsA-3qhaA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgg | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, PUREPROTEIN (Treponemadenticola) |
PF00731(AIRC) | 5 | ALA A 39TYR A 62LEU A 50ILE A 34ILE A 21 | None | 0.93A | 3prsA-3rggA:undetectable | 3prsA-3rggA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl1 | ARGINASE (Plasmodiumfalciparum) |
PF00491(Arginase) | 5 | ALA A 332ILE A 320LEU A 401ILE A 294ILE A 270 | None | 1.15A | 3prsA-3sl1A:undetectable | 3prsA-3sl1A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tcs | RACEMASE, PUTATIVE (Roseobacterdenitrificans) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 334ALA A 339THR A 232ILE A 303ILE A 265 | PG4 A 372 ( 4.9A)NoneNoneNoneNone | 1.16A | 3prsA-3tcsA:undetectable | 3prsA-3tcsA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl2 | MALATE DEHYDROGENASE (Bacillusanthracis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASP A 292ALA A 296ILE A 256LEU A 270THR A 131 | None | 1.08A | 3prsA-3tl2A:undetectable | 3prsA-3tl2A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tw0 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcusagalactiae) |
PF00092(VWA) | 5 | ALA A 353ILE A 427TYR A 391THR A 388ILE A 509 | ACT A 702 (-4.4A)NoneNoneACT A 702 (-2.9A)None | 1.22A | 3prsA-3tw0A:undetectable | 3prsA-3tw0A:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4f | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 334ALA A 339THR A 232ILE A 303ILE A 265 | None | 1.25A | 3prsA-3u4fA:undetectable | 3prsA-3u4fA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vx6 | E1 (Kluyveromycesmarxianus) |
PF16420(ATG7_N) | 5 | ILE A 150ALA A 241ILE A 117ILE A 181THR A 228 | None | 1.18A | 3prsA-3vx6A:undetectable | 3prsA-3vx6A:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wel | ALPHA-GLUCOSIDASE (Beta vulgaris) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 5 | ILE A 311ALA A 556ILE A 281TYR A 283ILE A 286 | None | 1.13A | 3prsA-3welA:undetectable | 3prsA-3welA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5g | ANIONIC PEROXIDASE (Raphanussativus) |
PF00141(peroxidase) | 5 | ILE A 34ASP A 31LEU A 103THR A 128ILE A 140 | None | 1.24A | 3prsA-4a5gA:undetectable | 3prsA-4a5gA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3s | ALDEHYDEDEHYDROGENASE (Lachnoclostridiumphytofermentans) |
PF00171(Aldedh) | 5 | ILE A 250ALA A 248ILE A 406TYR A 402THR A 408 | SO4 A1467 (-4.2A)NoneNoneNoneNone | 1.00A | 3prsA-4c3sA:undetectable | 3prsA-4c3sA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dd5 | ACETYL-COAACETYLTRANSFERASE (Clostridioidesdifficile) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 42ILE A 89LEU A 58ILE A 107ILE A 280 | None | 1.16A | 3prsA-4dd5A:undetectable | 3prsA-4dd5A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eze | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Salmonellaenterica) |
PF12710(HAD) | 5 | ILE A 165ILE A 3TYR A 5LEU A 295ILE A 12 | None | 1.18A | 3prsA-4ezeA:undetectable | 3prsA-4ezeA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbh | PROTEIN SYNTHESISINHIBITOR I (Hordeum vulgare) |
PF00161(RIP) | 5 | ALA A 141ILE A 202LEU A 133ILE A 31ILE A 86 | None | 1.24A | 3prsA-4fbhA:undetectable | 3prsA-4fbhA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lkr | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Shewanellaoneidensis) |
PF01048(PNP_UDP_1) | 5 | ALA A 109ILE A 88LEU A 200THR A 127ILE A 194 | None | 1.16A | 3prsA-4lkrA:undetectable | 3prsA-4lkrA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lob | POLYPRENYLSYNTHETASE (Acinetobacterbaumannii) |
PF00348(polyprenyl_synt) | 5 | ILE A 258ALA A 246ILE A 171TYR A 167THR A 175 | None | 1.25A | 3prsA-4lobA:undetectable | 3prsA-4lobA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | ALA A 566ILE A 519TYR A 520ILE A 537THR A 564 | None | 0.97A | 3prsA-4rbnA:undetectable | 3prsA-4rbnA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoz | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | ASP A 302ALA A 305LEU A 412ILE A 23ILE A 672 | None | 1.19A | 3prsA-4uozA:undetectable | 3prsA-4uozA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w5k | ASPARTATEAMINOTRANSFERASE,MITOCHONDRIAL (Trypanosomabrucei) |
PF00155(Aminotran_1_2) | 5 | ALA A 169ILE A 251LEU A 229ILE A 113ILE A 126 | None | 1.04A | 3prsA-4w5kA:undetectable | 3prsA-4w5kA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | ALA A 289ILE A 278THR A 227THR A 250ILE A 2 | ANP A 401 (-3.5A)NoneNoneNoneNone | 1.21A | 3prsA-4wjmA:undetectable | 3prsA-4wjmA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yg7 | SERINE/THREONINE-PROTEIN KINASE HIPA (Escherichiacoli) |
PF07804(HipA_C)PF13657(Couple_hipA) | 5 | ILE D 149ASP D 96LEU D 129ILE D 184ILE D 334 | None | 1.13A | 3prsA-4yg7D:undetectable | 3prsA-4yg7D:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c17 | MERB2 (Bacillusmegaterium) |
PF03243(MerB) | 5 | ILE A 29ALA A 79TYR A 11LEU A 204ILE A 168 | NoneNoneNoneNoneDTV A 303 ( 4.9A) | 1.24A | 3prsA-5c17A:undetectable | 3prsA-5c17A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e57 | TRANSCRIPTIONREGULATOR AMTR (Mycolicibacteriumsmegmatis) |
PF00440(TetR_N) | 5 | ILE A 173ALA A 118LEU A 125THR A 35ILE A 47 | None | 0.91A | 3prsA-5e57A:undetectable | 3prsA-5e57A:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eku | ARGININEN-METHYLTRANSFERASE,PUTATIVE (Trypanosomabrucei) |
PF06325(PrmA) | 5 | ALA A 333ILE A 281LEU A 369THR A 176ILE A 173 | NoneNoneNoneNoneSAH A 401 ( 4.4A) | 1.20A | 3prsA-5ekuA:undetectable | 3prsA-5ekuA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ALA A 154TYR A 84LEU A 135ILE A 79ILE A1068 | None | 1.15A | 3prsA-5fqdA:undetectable | 3prsA-5fqdA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h53 | SKELETAL MUSCLEMYOSIN HEAVY CHAINMYHC-EO/IIL (Oryctolaguscuniculus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ASP A 384ALA A 386LEU A 429ILE A 351ILE A 291 | None | 1.20A | 3prsA-5h53A:undetectable | 3prsA-5h53A:17.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 10 | ILE A 10ASP A 11ALA A 16ILE A 77TYR A 79LEU A 125THR A 135ILE A 217THR A 223ILE A 300 | NoneNoneNoneNone61P A 406 (-4.3A)NoneNoneNonePG4 A 408 (-3.8A)61P A 406 (-4.0A) | 0.25A | 3prsA-5hctA:58.2 | 3prsA-5hctA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | ILE A 77TYR A 79LEU A 125THR A 135ILE A 302 | None61P A 406 (-4.3A)NoneNoneNone | 0.99A | 3prsA-5hctA:58.2 | 3prsA-5hctA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hiw | CYTOCHROME P450CYP260B1 (Sorangiumcellulosum) |
PF00067(p450) | 5 | ALA A 344ILE A 203LEU A 91THR A 233ILE A 154 | HEM A 401 (-3.5A)NoneNoneHEM A 401 (-4.5A)None | 1.19A | 3prsA-5hiwA:undetectable | 3prsA-5hiwA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jnb | POLY(A) RNAPOLYMERASE GLD-2RNP (RRM RNA BINDINGDOMAIN) CONTAINING (Caenorhabditiselegans) |
PF03828(PAP_assoc)no annotation | 5 | ILE E 193ILE A 653LEU A 628THR A 614ILE A 677 | None | 1.08A | 3prsA-5jnbE:undetectable | 3prsA-5jnbE:12.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jo7 | VETISPIRADIENESYNTHASE 1 (Hyoscyamusmuticus) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | ILE A 90ALA A 83TYR A 222LEU A 232ILE A 553 | None | 1.14A | 3prsA-5jo7A:undetectable | 3prsA-5jo7A:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l56 | PLEXIN-A1 (Mus musculus) |
PF01403(Sema)PF01437(PSI)PF01833(TIG) | 5 | ILE A 172ILE A 242TYR A 244LEU A 199ILE A 298 | None | 1.24A | 3prsA-5l56A:undetectable | 3prsA-5l56A:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mxp | - (-) |
no annotation | 5 | ILE A 122ALA A 115LEU A 37THR A 42ILE A 80 | None | 1.05A | 3prsA-5mxpA:undetectable | 3prsA-5mxpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnp | N-TERMINALACETYLTRANSFERASE-LIKE PROTEIN (Chaetomiumthermophilum) |
PF12569(NARP1)PF13432(TPR_16) | 5 | ILE A 672ALA A 698TYR A 682ILE A 734ILE A 718 | None | 1.05A | 3prsA-5nnpA:undetectable | 3prsA-5nnpA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnp | N-TERMINALACETYLTRANSFERASE-LIKE PROTEIN (Chaetomiumthermophilum) |
PF12569(NARP1)PF13432(TPR_16) | 5 | ILE A 672ALA A 698TYR A 682LEU A 665ILE A 734 | None | 0.98A | 3prsA-5nnpA:undetectable | 3prsA-5nnpA:16.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 10 | ILE A 10ASP A 11ALA A 16ILE A 77TYR A 79LEU A 125THR A 135ILE A 217THR A 223ILE A 300 | None | 0.31A | 3prsA-5p60A:58.1 | 3prsA-5p60A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | ILE A 77TYR A 79LEU A 125THR A 135ILE A 302 | None | 1.03A | 3prsA-5p60A:58.1 | 3prsA-5p60A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | ILE A 77TYR A 79THR A 135ILE A 302THR A 223 | None | 0.96A | 3prsA-5p60A:58.1 | 3prsA-5p60A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT B (Methanothermobactersp. CaT2) |
PF00384(Molybdopterin) | 5 | ILE B 341ASP B 414ALA B 342THR B 257ILE B 37 | NoneMGD B 503 (-3.0A)MGD B 503 (-3.4A)NoneSF4 B 501 (-4.5A) | 1.16A | 3prsA-5t5iB:undetectable | 3prsA-5t5iB:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ugj | 4-HYDROXY-TETRAHYDRODIPICOLINATEREDUCTASE (Neisseriameningitidis) |
no annotation | 5 | ILE A 6LEU A 19THR A 29THR A 100ILE A 120 | None | 1.09A | 3prsA-5ugjA:undetectable | 3prsA-5ugjA:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ujs | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Campylobacterjejuni) |
PF00275(EPSP_synthase) | 5 | ILE A 137ALA A 135ILE A 33THR A 75ILE A 214 | None | 1.10A | 3prsA-5ujsA:undetectable | 3prsA-5ujsA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uv2 | (+)-LIMONENESYNTHASE (Citrus sinensis) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 5 | ILE A 124ALA A 117TYR A 257LEU A 267ILE A 590 | None | 1.23A | 3prsA-5uv2A:undetectable | 3prsA-5uv2A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v52 | T-CELLIMMUNORECEPTOR WITHIG AND ITIM DOMAINS (Homo sapiens) |
PF07686(V-set) | 5 | ILE A 77ALA A 67ILE A 33LEU A 95ILE A 27 | None | 1.19A | 3prsA-5v52A:undetectable | 3prsA-5v52A:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm9 | PROTEIN ARGONAUTE-3 (Homo sapiens) |
no annotation | 5 | ASP A 538ILE A 593LEU A 650THR A 856ILE A 575 | None | 1.22A | 3prsA-5vm9A:undetectable | 3prsA-5vm9A:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wfc | HISTONE-LYSINE-N-METHYLTRANSFERASE EZH2,POLYCOMB PROTEINSUZ12 CHIMERA (Chaetomiumthermophilum) |
no annotation | 5 | ILE B2580ILE B 510ILE B 865THR B 827ILE B 891 | None | 1.08A | 3prsA-5wfcB:undetectable | 3prsA-5wfcB:10.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xn6 | OS07G0580900 PROTEIN (Oryza sativa) |
PF00348(polyprenyl_synt) | 5 | ILE A 223TYR A 219LEU A 296ILE A 201ILE A 213 | None | 1.20A | 3prsA-5xn6A:undetectable | 3prsA-5xn6A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yxg | PILUS ASSEMBLYPROTEIN (Lactobacillusrhamnosus) |
no annotation | 5 | ILE A 409ALA A 392ILE A 475LEU A 443THR A 419 | None | 1.25A | 3prsA-5yxgA:undetectable | 3prsA-5yxgA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhu | MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
no annotation | 5 | ILE A1504ILE A1449LEU A1481THR A1447ILE A1342 | None | 1.19A | 3prsA-6bhuA:undetectable | 3prsA-6bhuA:0.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | PROTEIN CFT1 (Saccharomycescerevisiae) |
no annotation | 5 | ASP A 779LEU A 765ILE A 863THR A 803ILE A 883 | None | 1.05A | 3prsA-6eojA:undetectable | 3prsA-6eojA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exs | PEPTIDE ABCTRANSPORTER PERMEASE (Staphylococcushominis) |
no annotation | 5 | ILE A 243ILE A 88THR A 93ILE A 106ILE A 78 | NoneNoneOLC A 512 (-4.7A)NoneNone | 1.19A | 3prsA-6exsA:undetectable | 3prsA-6exsA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a0c | XYLOSE ISOMERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF01261(AP_endonuc_2) | 5 | ASP A 331GLY A 139GLY A 180PHE A 99TYR A 96 | None | 1.09A | 3prsA-1a0cA:undetectable | 3prsA-1a0cA:21.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1am5 | PEPSIN (Gadus morhua) |
PF00026(Asp) | 5 | ASP A 32GLY A 34ASP A 215THR A 218ILE A 300 | None | 0.42A | 3prsA-1am5A:37.5 | 3prsA-1am5A:30.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 6 | ASP A 32GLY A 34ASP A 9ASP A 215THR A 218ILE B 300 | None | 1.22A | 3prsA-1b5fA:25.0 | 3prsA-1b5fA:27.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 6 | ASP A 32GLY A 34GLY A 76ASP A 215THR A 218ILE B 300 | None | 0.43A | 3prsA-1b5fA:25.0 | 3prsA-1b5fA:27.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1czi | CHYMOSIN (Bos taurus) |
PF00026(Asp) | 6 | ASP E 32GLY E 34GLY E 76ASP E 215THR E 218ILE E 300 | None | 0.41A | 3prsA-1cziE:39.5 | 3prsA-1cziE:28.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1htr | GASTRICSIN (Homo sapiens) |
PF00026(Asp) | 5 | ASP B 32GLY B 34ASP B 217THR B 220ILE B 303 | None | 0.56A | 3prsA-1htrB:31.4 | 3prsA-1htrB:32.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27GLY A 49ASP A 25ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 ( 3.7A)A79 A 800 (-2.8A)A79 A 800 (-3.8A) | 0.59A | 3prsA-1hvcA:10.6 | 3prsA-1hvcA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27GLY A 49ASP A 25ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.4A)A79 A 800 (-2.7A)A79 A 800 (-3.6A) | 0.65A | 3prsA-1hvcA:10.6 | 3prsA-1hvcA:19.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ibq | ASPERGILLOPEPSIN (Aspergillusphoenicis) |
PF00026(Asp) | 8 | ASP A 30ASP A 32GLY A 34GLY A 75ASP A 114ASP A 214THR A 217ILE A 299 | None ZN A1457 (-1.9A) ZN A1457 (-3.6A)NoneNone ZN A1457 (-1.9A)NoneNone | 0.58A | 3prsA-1ibqA:49.0 | 3prsA-1ibqA:56.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 5 | ASP A 14ASP A 33GLY A 35PHE A 190ASP A 214 | None | 1.14A | 3prsA-1izeA:49.9 | 3prsA-1izeA:58.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ize | ASPARTIC PROTEINASE (Aspergillusoryzae) |
PF00026(Asp) | 10 | ASP A 31ASP A 33GLY A 35GLY A 76ASP A 77ASP A 115PHE A 190ASP A 214THR A 217ILE A 297 | None | 0.39A | 3prsA-1izeA:49.9 | 3prsA-1izeA:58.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j71 | ASPARTIC PROTEINASE (Candidatropicalis) |
PF00026(Asp) | 7 | ASP A 32GLY A 34ASP A 120ASP A 218THR A 221TYR A 225ILE A 298 | NoneNoneNoneNoneEOH A 575 ( 4.4A)EOH A 575 ( 4.0A)None | 0.55A | 3prsA-1j71A:36.5 | 3prsA-1j71A:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j71 | ASPARTIC PROTEINASE (Candidatropicalis) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 85ASP A 86ASP A 218THR A 221TYR A 225ILE A 298 | NoneNoneEOH A 575 (-4.0A)NoneNoneEOH A 575 ( 4.4A)EOH A 575 ( 4.0A)None | 0.42A | 3prsA-1j71A:36.5 | 3prsA-1j71A:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mpp | PEPSIN (Rhizomucorpusillus) |
PF00026(Asp) | 7 | ASP A 32GLY A 34GLY A 76PHE A 189ASP A 215THR A 218ILE A 300 | None | 0.42A | 3prsA-1mppA:37.8 | 3prsA-1mppA:31.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qho | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ASP A 161ASP A 162GLY A 166TYR A 209ILE A 206 | None | 1.10A | 3prsA-1qhoA:undetectable | 3prsA-1qhoA:20.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1qrp | PEPSIN 3A (Homo sapiens) |
PF00026(Asp) | 6 | ASP E 32GLY E 34GLY E 76ASP E 215THR E 218ILE E 300 | HH0 E 327 (-2.7A)HH0 E 327 (-4.1A)HH0 E 327 (-3.2A)HH0 E 327 (-2.5A)HH0 E 327 (-3.7A)None | 0.42A | 3prsA-1qrpE:38.8 | 3prsA-1qrpE:33.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs8 | PLASMEPSIN (Plasmodiumvivax) |
PF00026(Asp) | 6 | ASP A 34GLY A 36GLY A 78ASP A 214THR A 217ILE A 300 | None | 0.40A | 3prsA-1qs8A:36.1 | 3prsA-1qs8A:27.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgq | STREPTOMYCES GRISEUSPROTEINASE B (Streptomycesgriseus) |
PF00089(Trypsin) | 6 | ASP E 60ASP E 102GLY E 197GLY E 193ASP E 175ILE E 31 | None | 1.30A | 3prsA-1sgqE:undetectable | 3prsA-1sgqE:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sl8 | AEQUORIN 1 (Aequoreavictoria) |
PF13202(EF-hand_5) | 5 | GLY A 173ASP A 155PHE A 67THR A 168TYR A 99 | None CA A 669 (-3.2A)NoneNoneNone | 1.02A | 3prsA-1sl8A:undetectable | 3prsA-1sl8A:21.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1tzs | CATHEPSIN E (Homo sapiens) |
PF00026(Asp) | 6 | ASP A 22ASP A 43GLY A 45ASP A 228THR A 231ILE A 316 | None | 0.84A | 3prsA-1tzsA:8.6 | 3prsA-1tzsA:33.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1uh9 | HIZOPUSPEPSIN I (Rhizopusmicrosporus) |
PF00026(Asp) | 8 | ASP A 33ASP A 35GLY A 37GLY A 78ASP A 79ASP A 218THR A 221ILE A 298 | None | 0.44A | 3prsA-1uh9A:42.5 | 3prsA-1uh9A:40.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v7v | CHITOBIOSEPHOSPHORYLASE (Vibrioproteolyticus) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 5 | ASP A 549GLY A 573GLY A 557PHE A 618THR A 567 | None | 1.06A | 3prsA-1v7vA:undetectable | 3prsA-1v7vA:18.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wkr | POLYPOROPEPSIN (Irpex lacteus) |
PF00026(Asp) | 6 | ASP A 32GLY A 34GLY A 64ASP A 212THR A 215ILE A 307 | None | 0.49A | 3prsA-1wkrA:35.6 | 3prsA-1wkrA:33.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1wkr | POLYPOROPEPSIN (Irpex lacteus) |
PF00026(Asp) | 5 | ASP A 111ASP A 212GLY A 214ASP A 32ILE A 104 | None | 1.11A | 3prsA-1wkrA:35.6 | 3prsA-1wkrA:33.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ybw | HEPATOCYTE GROWTHFACTOR ACTIVATORPRECURSOR (Homo sapiens) |
PF00089(Trypsin) | 5 | GLY A 541GLY A 621ASP A 597TYR A 631ILE A 616 | None | 1.10A | 3prsA-1ybwA:undetectable | 3prsA-1ybwA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zap | SECRETED ASPARTICPROTEINASE (Candidaalbicans) |
PF00026(Asp) | 9 | ASP A 32GLY A 34GLY A 85ASP A 86ASP A 120ASP A 218THR A 221TYR A 225ILE A 305 | A70 A 500 ( 2.7A)A70 A 500 (-3.8A)A70 A 500 (-3.5A)A70 A 500 (-3.1A)NoneA70 A 500 ( 2.3A)A70 A 500 (-3.6A)A70 A 500 ( 4.0A)A70 A 500 (-4.8A) | 0.83A | 3prsA-1zapA:36.4 | 3prsA-1zapA:29.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anl | PLASMEPSIN IV (Plasmodiummalariae) |
PF00026(Asp) | 7 | ASP A 34GLY A 36GLY A 78PHE A 192ASP A 214THR A 217ILE A 300 | JE2 A3151 (-3.0A)JE2 A3151 (-2.7A)JE2 A3151 (-3.6A)JE2 A3151 (-4.6A)JE2 A3151 (-2.5A)JE2 A3151 (-2.6A)JE2 A3151 ( 4.5A) | 0.70A | 3prsA-2anlA:35.4 | 3prsA-2anlA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bju | PLASMEPSIN II (Plasmodiumfalciparum) |
PF00026(Asp) | 5 | ASP A 34GLY A 36ASP A 214THR A 217ILE A 300 | IH4 A1330 (-4.2A)IH4 A1330 ( 4.6A)IH4 A1330 (-3.3A)IH4 A1331 ( 4.1A)IH4 A1330 (-4.5A) | 0.20A | 3prsA-2bjuA:35.4 | 3prsA-2bjuA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c4x | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF00801(PKD) | 5 | ASP A 21GLY A 46ASP A 47PHE A 11ILE A 88 | None | 1.09A | 3prsA-2c4xA:undetectable | 3prsA-2c4xA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9t | PANTOTHENATE KINASE (Pseudomonasaeruginosa) |
PF03309(Pan_kinase) | 5 | ASP A 129GLY A 140GLY A 99THR A 127ILE A 142 | None | 1.13A | 3prsA-2f9tA:undetectable | 3prsA-2f9tA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 7 | ASP A 32GLY A 34ASP A 120ASP A 218THR A 221TYR A 225ILE A 305 | None | 0.79A | 3prsA-2h6tA:35.2 | 3prsA-2h6tA:27.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 85ASP A 86ASP A 218THR A 221TYR A 225ILE A 305 | None | 0.48A | 3prsA-2h6tA:35.2 | 3prsA-2h6tA:27.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6t | CANDIDAPEPSIN-3 (Candidaalbicans) |
PF00026(Asp) | 5 | ASP A 308GLY A 34ASP A 120THR A 221ILE A 305 | None | 1.11A | 3prsA-2h6tA:35.2 | 3prsA-2h6tA:27.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qzw | CANDIDAPEPSIN-1 (Candidaalbicans) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 85ASP A 86ASP A 218THR A 221TYR A 225ILE A 305 | None | 0.49A | 3prsA-2qzwA:36.2 | 3prsA-2qzwA:30.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 85ASP A 86ASP A 218THR A 221TYR A 225ILE A 305 | None | 0.58A | 3prsA-2qzxA:36.0 | 3prsA-2qzxA:29.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 5 | ASP A 738ASP A 741GLY A 748ASP A 747ASP A 734 | None CA A 26 (-2.3A)None CA A 24 ( 3.1A) CA A 26 ( 2.8A) | 1.01A | 3prsA-2rhpA:undetectable | 3prsA-2rhpA:17.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rmp | MUCOROPEPSIN (Rhizomucormiehei) |
PF00026(Asp) | 6 | ASP A 38GLY A 40ASP A 14PHE A 210THR A 240ILE A 329 | None | 1.50A | 3prsA-2rmpA:37.9 | 3prsA-2rmpA:30.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rmp | MUCOROPEPSIN (Rhizomucormiehei) |
PF00026(Asp) | 7 | ASP A 38GLY A 40GLY A 83PHE A 210ASP A 237THR A 240ILE A 329 | None | 0.34A | 3prsA-2rmpA:37.9 | 3prsA-2rmpA:30.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 5 | ASP A 14ASP A 33GLY A 35PHE A 190ASP A 213 | NonePP6 A 327 ( 2.7A)PP6 A 327 (-4.0A)PP6 A 327 ( 4.8A)PP6 A 327 ( 2.5A) | 1.14A | 3prsA-2wedA:47.9 | 3prsA-2wedA:54.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 8 | ASP A 33GLY A 35GLY A 76ASP A 77ASP A 115PHE A 190ASP A 213THR A 216 | PP6 A 327 ( 2.7A)PP6 A 327 (-4.0A)PP6 A 327 (-3.5A)PP6 A 327 (-3.5A)NonePP6 A 327 ( 4.8A)PP6 A 327 ( 2.5A)PP6 A 327 (-3.6A) | 0.42A | 3prsA-2wedA:47.9 | 3prsA-2wedA:54.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wed | PENICILLOPEPSIN (Penicilliumjanthinellum) |
PF00026(Asp) | 8 | ASP A 33GLY A 35GLY A 76ASP A 115PHE A 190ASP A 213THR A 216ILE A 297 | PP6 A 327 ( 2.7A)PP6 A 327 (-4.0A)PP6 A 327 (-3.5A)NonePP6 A 327 ( 4.8A)PP6 A 327 ( 2.5A)PP6 A 327 (-3.6A)PP6 A 327 (-4.2A) | 0.47A | 3prsA-2wedA:47.9 | 3prsA-2wedA:54.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk1 | NOVP (Actinoalloteichuscyanogriseus) |
PF05711(TylF) | 5 | ASP A 57ASP A 198GLY A 197ASP A 254ASP A 196 | NoneSAH A 301 (-4.1A)EDO A 551 ( 3.7A)NoneSAH A 301 ( 3.5A) | 1.11A | 3prsA-2wk1A:undetectable | 3prsA-2wk1A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y6p | 3-DEOXY-MANNO-OCTULOSONATECYTIDYLYLTRANSFERASE (Aquifexaeolicus) |
PF02348(CTP_transf_3) | 5 | ASP A 219ASP A 95GLY A 94GLY A 73TYR A 170 | MG A1234 ( 2.3A) MG A1234 ( 2.6A)CTP A1233 (-3.5A)CTP A1233 (-3.4A)IPA A1236 ( 4.0A) | 0.92A | 3prsA-2y6pA:undetectable | 3prsA-2y6pA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdi | UNCHARACTERIZEDPROTEIN TA0194 (Thermoplasmaacidophilum) |
PF00561(Abhydrolase_1)PF12146(Hydrolase_4) | 6 | ASP A 201GLY A 105GLY A 126PHE A 32TYR A 56ILE A 29 | None | 1.37A | 3prsA-3bdiA:undetectable | 3prsA-3bdiA:20.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 6 | ASP A 11ASP A 32GLY A 34PHE A 189ASP A 215ILE A 301 | None | 1.19A | 3prsA-3emyA:51.8 | 3prsA-3emyA:60.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3emy | TRICHODERMA REESEIASPARTIC PROTEASE (Trichodermareesei) |
PF00026(Asp) | 10 | ASP A 30ASP A 32GLY A 34GLY A 76ASP A 77ASP A 114PHE A 189ASP A 215THR A 218ILE A 301 | None | 0.43A | 3prsA-3emyA:51.8 | 3prsA-3emyA:60.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fby | CARTILAGE OLIGOMERICMATRIX PROTEIN (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 5 | ASP A 466ASP A 469GLY A 476ASP A 475ASP A 462 | None CA A 820 (-2.6A)None CA A 823 ( 2.7A) CA A 819 ( 2.8A) | 1.01A | 3prsA-3fbyA:undetectable | 3prsA-3fbyA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcy | XYLAN ESTERASE 1 (Thermoanaerobacteriumsaccharolyticum) |
PF05448(AXE1) | 5 | GLY A 118ASP A 125ASP A 144ASP A 157ILE A 69 | None | 1.11A | 3prsA-3fcyA:undetectable | 3prsA-3fcyA:20.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fv3 | SAPP1P-SECRETEDASPARTIC PROTEASE 1 (Candidaparapsilosis) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 79ASP A 80ASP A 220THR A 223TYR A 227ILE A 303 | NoneNoneGOL A 341 (-4.5A)NoneNoneNoneGOL A 341 ( 4.6A)None | 0.46A | 3prsA-3fv3A:36.9 | 3prsA-3fv3A:30.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fv3 | SAPP1P-SECRETEDASPARTIC PROTEASE 1 (Candidaparapsilosis) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 79ASP A 114ASP A 220THR A 223TYR A 227ILE A 303 | NoneNoneGOL A 341 (-4.5A)NoneNoneNoneGOL A 341 ( 4.6A)None | 0.87A | 3prsA-3fv3A:36.9 | 3prsA-3fv3A:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gip | N-ACYL-D-GLUTAMATEDEACYLASE (Bordetellabronchiseptica) |
PF07969(Amidohydro_3) | 5 | GLY A 363GLY A 379ASP A 370ASP A 64ILE A 87 | None | 0.90A | 3prsA-3gipA:undetectable | 3prsA-3gipA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icj | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcusfuriosus) |
PF07969(Amidohydro_3) | 5 | ASP A 432GLY A 367GLY A 292ASP A 97PHE A 365 | ZN A 601 (-2.6A)NoneNoneNoneNone | 0.83A | 3prsA-3icjA:undetectable | 3prsA-3icjA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ign | DIGUANYLATE CYCLASE (Marinobacterhydrocarbonoclasticus) |
PF00990(GGDEF) | 5 | ASP A 158GLY A 235GLY A 209TYR A 275ILE A 194 | None | 1.14A | 3prsA-3ignA:undetectable | 3prsA-3ignA:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js6 | UNCHARACTERIZED PARMPROTEIN (Staphylococcusaureus) |
no annotation | 5 | ASP A 321ASP A 190GLY A 12ASP A 10ASP A 169 | None | 1.10A | 3prsA-3js6A:undetectable | 3prsA-3js6A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js6 | UNCHARACTERIZED PARMPROTEIN (Staphylococcusaureus) |
no annotation | 5 | ASP A 321GLY A 192GLY A 12ASP A 10ASP A 169 | None | 1.11A | 3prsA-3js6A:undetectable | 3prsA-3js6A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ka7 | OXIDOREDUCTASE (Methanosarcinamazei) |
PF01593(Amino_oxidase) | 5 | GLY A 349GLY A 309ASP A 352THR A 304TYR A 97 | None | 1.07A | 3prsA-3ka7A:undetectable | 3prsA-3ka7A:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kdj | PROTEIN PHOSPHATASE2C 56 (Arabidopsisthaliana) |
PF00481(PP2C) | 5 | GLY B 241GLY B 260ASP B 261ASP B 317ILE B 324 | None | 0.85A | 3prsA-3kdjB:undetectable | 3prsA-3kdjB:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llc | PUTATIVE HYDROLASE (Agrobacteriumvitis) |
PF12697(Abhydrolase_6) | 5 | ASP A 58ASP A 72GLY A 77ASP A 48THR A 50 | None | 0.96A | 3prsA-3llcA:undetectable | 3prsA-3llcA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n5l | BINDING PROTEINCOMPONENT OF ABCPHOSPHONATETRANSPORTER (Pseudomonasaeruginosa) |
PF12974(Phosphonate-bd) | 5 | ASP A 147GLY A 228ASP A 229THR A 151ILE A 281 | NoneNoneUNL A 401 ( 2.7A)UNL A 401 ( 3.7A)None | 0.94A | 3prsA-3n5lA:undetectable | 3prsA-3n5lA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o3p | MANNOSYL-3-PHOSPHOGLYCERATE SYNTHASE (Rubrobacterxylanophilus) |
PF00535(Glycos_transf_2) | 5 | ASP A 137ASP A 135GLY A 209GLY A 116PHE A 211 | MG A 339 ( 2.5A)GDD A 340 (-3.2A)GDD A 340 (-3.5A)NoneNone | 0.83A | 3prsA-3o3pA:undetectable | 3prsA-3o3pA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psg | PEPSINOGEN (Sus scrofa) |
PF00026(Asp)PF07966(A1_Propeptide) | 5 | ASP A 32GLY A 34ASP A 215THR A 218ILE A 300 | None | 0.71A | 3prsA-3psgA:34.7 | 3prsA-3psgA:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qs1 | PLASMEPSIN-1 (Plasmodiumfalciparum) |
PF00026(Asp) | 5 | ASP A 32GLY A 34ASP A 215THR A 218ILE A 300 | 006 A 330 (-2.8A)006 A 330 (-3.2A)006 A 330 (-2.8A)006 A 330 (-3.5A)None | 0.30A | 3prsA-3qs1A:36.0 | 3prsA-3qs1A:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tc8 | LEUCINEAMINOPEPTIDASE (Parabacteroidesdistasonis) |
PF04389(Peptidase_M28) | 5 | ASP A 147ASP A 146GLY A 223GLY A 153ASP A 124 | ZN A 350 ( 2.3A)NoneNoneNoneNone | 1.12A | 3prsA-3tc8A:undetectable | 3prsA-3tc8A:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umm | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE (Salmonellaenterica) |
PF02769(AIRS_C)PF13507(GATase_5) | 6 | ASP A 667GLY A 334GLY A 416ASP A 657THR A 386ILE A 697 | NoneADP A2005 ( 4.2A)NoneNoneADP A2005 (-3.8A)None | 1.36A | 3prsA-3ummA:undetectable | 3prsA-3ummA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3a | V-TYPE ATP SYNTHASEALPHA CHAIN (Thermusthermophilus) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 5 | ASP A 452GLY A 514ASP A 446ASP A 436PHE A 563 | None | 1.13A | 3prsA-3w3aA:undetectable | 3prsA-3w3aA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wev | L-LYSINE 6-OXIDASE (Marinomonasmediterranea) |
no annotation | 6 | ASP A 219ASP A 138GLY A 140GLY A 224ASP A 223ILE A 153 | None | 1.32A | 3prsA-3wevA:undetectable | 3prsA-3wevA:19.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aa9 | CHYMOSIN (Camelusdromedarius) |
PF00026(Asp) | 5 | ASP A 34GLY A 36ASP A 216THR A 219ILE A 297 | NoneNoneGOL A1334 (-3.5A)NoneGOL A1334 (-4.2A) | 0.37A | 3prsA-4aa9A:35.8 | 3prsA-4aa9A:30.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 5 | ASP A 215ASP A 305GLY A 306PHE A 308ILE A 272 | None | 1.13A | 3prsA-4aefA:undetectable | 3prsA-4aefA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ayg | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | ASP A1033ASP A1069GLY A1066ASP A1028THR A 966 | NoneGOL A2792 (-3.7A)GOL A2792 ( 3.8A)GOL A2792 (-3.4A)GOL A2792 (-3.5A) | 1.07A | 3prsA-4aygA:undetectable | 3prsA-4aygA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4egt | MAJOR CAPSID PROTEINVP60 (Rabbithemorrhagicdisease virus) |
PF00915(Calici_coat) | 5 | ASP A 531GLY A 488ASP A 338THR A 273ILE A 443 | None | 1.13A | 3prsA-4egtA:undetectable | 3prsA-4egtA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxp | BETA-GLUCOSIDASECHIMERIC PROTEIN (Thermotogamaritima;Trichodermareesei) |
PF00232(Glyco_hydro_1) | 5 | GLY A 209GLY A 225ASP A 295TYR A 263ILE A 262 | None | 1.00A | 3prsA-4gxpA:undetectable | 3prsA-4gxpA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hp4 | EAG-LIKE K[+]CHANNEL (Drosophilamelanogaster) |
PF13426(PAS_9) | 5 | GLY A 47GLY A 24ASP A 23ASP A 16ASP A 46 | NoneSO4 A 201 (-3.4A)GOL A 202 ( 2.6A)NoneNone | 1.13A | 3prsA-4hp4A:undetectable | 3prsA-4hp4A:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnd | CA(2+)/CALMODULIN-DEPENDENT PROTEINKINASE PHOSPHATASE (Caenorhabditiselegans) |
PF00481(PP2C) | 5 | GLY A 261GLY A 282ASP A 283ASP A 340ILE A 347 | None | 0.99A | 3prsA-4jndA:undetectable | 3prsA-4jndA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mo9 | PERIPLASMIC BINDINGPROTEIN (Veillonellaparvula) |
PF01497(Peripla_BP_2) | 5 | ASP A 231GLY A 217ASP A 255THR A 234ILE A 238 | None | 0.99A | 3prsA-4mo9A:undetectable | 3prsA-4mo9A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nsx | U3 SMALL NUCLEOLARRNA-ASSOCIATEDPROTEIN 21 (Saccharomycescerevisiae) |
PF00400(WD40)PF12894(ANAPC4_WD40) | 5 | GLY A 507GLY A 527ASP A 556TYR A 498ILE A 484 | None | 0.91A | 3prsA-4nsxA:undetectable | 3prsA-4nsxA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwz | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE (Caldalkalibacillusthermarum) |
PF07992(Pyr_redox_2) | 5 | GLY A 220GLY A 172ASP A 176PHE A 226ILE A 194 | None | 0.92A | 3prsA-4nwzA:undetectable | 3prsA-4nwzA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oic | PROBABLE PROTEINPHOSPHATASE 2C 6 (Oryza sativa) |
PF00481(PP2C) | 5 | GLY B 280GLY B 299ASP B 300ASP B 356ILE B 363 | None | 0.85A | 3prsA-4oicB:undetectable | 3prsA-4oicB:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qaf | LIPOCALIN-1 (Homo sapiens) |
PF00061(Lipocalin) | 5 | GLY A 112GLY A 27ASP A 25TYR A 77ILE A 80 | None | 1.06A | 3prsA-4qafA:undetectable | 3prsA-4qafA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r29 | UNCHARACTERIZEDPROTEIN (Escherichiacoli) |
no annotation | 5 | GLY A 105ASP A 121PHE A 84THR A 101ILE A 87 | None | 1.11A | 3prsA-4r29A:undetectable | 3prsA-4r29A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2g | SURFACE PROTEINGP160 (Humanimmunodeficiencyvirus 1) |
no annotation | 5 | ASP E 279GLY E 472ASP E 275PHE E 391THR E 455 | NAG E 512 (-4.3A)NoneNoneNoneNone | 1.14A | 3prsA-4r2gE:undetectable | 3prsA-4r2gE:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8u | GLOBIN B CHAINLINKER L1 (Glossoscolexpaulistus) |
PF00042(Globin)PF16915(Eryth_link_C) | 5 | ASP M 79GLY M 92GLY M 85ASP M 84ASP B 27 | NoneNoneNone CA M 301 (-3.1A)None | 1.07A | 3prsA-4u8uM:undetectable | 3prsA-4u8uM:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uy6 | HISTIDINE-SPECIFICMETHYLTRANSFERASEEGTD (Mycolicibacteriumsmegmatis) |
PF10017(Methyltransf_33) | 5 | ASP A 45ASP A 115ASP A 113GLY A 86PHE A 159 | NoneNoneSAH A 801 (-3.0A)SAH A 801 (-3.0A)None | 1.13A | 3prsA-4uy6A:undetectable | 3prsA-4uy6A:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x81 | MYCINAMICIN III3''-O-METHYLTRANSFERASE (Micromonosporagriseorubida) |
PF05711(TylF) | 5 | ASP A 48ASP A 191GLY A 190GLY A 247ASP A 189 | NoneMVI A 305 ( 2.7A)SAH A 301 ( 4.0A)None MG A 304 (-2.5A) | 1.14A | 3prsA-4x81A:undetectable | 3prsA-4x81A:20.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4y9w | ASPARTIC ACIDENDOPEPTIDASE SAPP2 (Candidaparapsilosis) |
PF00026(Asp) | 8 | ASP A 32GLY A 34GLY A 78ASP A 79ASP A 211THR A 214TYR A 218ILE A 298 | None | 0.45A | 3prsA-4y9wA:36.7 | 3prsA-4y9wA:32.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gw5 | T-COMPLEX PROTEIN 1SUBUNIT BETA (Saccharomycescerevisiae) |
PF00118(Cpn60_TCP1) | 5 | ASP b 386GLY b 89GLY b 60ASP b 378ASP b 85 | None | 1.10A | 3prsA-5gw5b:undetectable | 3prsA-5gw5b:22.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 10 | ASP A 15ASP A 33ASP A 35GLY A 37ASP A 119PHE A 194ASP A 219THR A 222TYR A 226ILE A 304 | PG4 A 408 (-3.7A)61P A 406 (-4.0A)61P A 406 (-2.7A)61P A 406 ( 4.0A)61P A 406 ( 4.9A)None61P A 406 (-2.9A)61P A 406 ( 3.5A)61P A 406 (-4.0A)None | 0.64A | 3prsA-5hctA:58.2 | 3prsA-5hctA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 11 | ASP A 15ASP A 33ASP A 35GLY A 37GLY A 80ASP A 81PHE A 194ASP A 219THR A 222TYR A 226ILE A 304 | PG4 A 408 (-3.7A)61P A 406 (-4.0A)61P A 406 (-2.7A)61P A 406 ( 4.0A)61P A 406 (-4.1A)61P A 406 ( 2.8A)None61P A 406 (-2.9A)61P A 406 ( 3.5A)61P A 406 (-4.0A)None | 0.34A | 3prsA-5hctA:58.2 | 3prsA-5hctA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i70 | PLASMEPSIN IV (Plasmodiumfalciparum) |
no annotation | 6 | ASP B 34GLY B 36GLY B 78ASP B 214THR B 217ILE B 300 | None | 0.53A | 3prsA-5i70B:36.4 | 3prsA-5i70B:27.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbk | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 5 | GLY A 202GLY A 221ASP A 291TYR A 259ILE A 258 | None | 1.08A | 3prsA-5jbkA:undetectable | 3prsA-5jbkA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7q | PUTATIVE CATHEPSIN D (Ixodes ricinus) |
no annotation | 6 | ASP A 36GLY A 38GLY A 80ASP A 227THR A 230ILE A 313 | None | 0.47A | 3prsA-5n7qA:39.9 | 3prsA-5n7qA:13.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nfg | PROCARDOSIN-B,PROCARDOSIN-B (Cynaracardunculus) |
no annotation | 5 | ASP A 80GLY A 82ASP A 267THR A 270ILE A 357 | None | 0.57A | 3prsA-5nfgA:38.3 | 3prsA-5nfgA:26.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 12 | ASP A 15ASP A 33ASP A 35GLY A 37GLY A 80ASP A 81ASP A 119PHE A 194ASP A 219THR A 222TYR A 226ILE A 304 | None | 0.46A | 3prsA-5p60A:58.1 | 3prsA-5p60A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5pep | PEPSIN (Sus scrofa) |
PF00026(Asp) | 6 | ASP A 32GLY A 34GLY A 76ASP A 215THR A 218ILE A 301 | None | 0.53A | 3prsA-5pepA:38.5 | 3prsA-5pepA:31.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux4 | CATHEPSIN D (Rattusnorvegicus) |
no annotation | 5 | ASP A 33GLY A 35ASP A 226THR A 229ILE A 315 | 3UT A 404 (-2.9A)3UT A 404 (-3.5A)3UT A 404 (-2.4A)3UT A 404 ( 4.8A)None | 0.24A | 3prsA-5ux4A:37.5 | 3prsA-5ux4A:11.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1w | GLYCOSIDE HYDROLASE (Bacillushalodurans) |
PF03639(Glyco_hydro_81) | 5 | ASP A 678GLY A 722GLY A 362ASP A 363PHE A 738 | None | 1.14A | 3prsA-5v1wA:undetectable | 3prsA-5v1wA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjy | ATP-BINDING CASSETTESUB-FAMILY A MEMBER1 (Homo sapiens) |
PF00005(ABC_tran)PF12698(ABC2_membrane_3) | 5 | ASP A 571GLY A1533ASP A 585PHE A1390TYR A1513 | None | 1.15A | 3prsA-5xjyA:undetectable | 3prsA-5xjyA:9.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yid | PLASMEPSIN II (Plasmodiumfalciparum) |
no annotation | 5 | ASP A 36GLY A 38ASP A 216THR A 219ILE A 302 | K95 A 401 ( 2.6A)K95 A 401 ( 3.5A) NA A 403 ( 1.9A)K95 A 401 (-3.8A)None | 0.38A | 3prsA-5yidA:36.1 | 3prsA-5yidA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bs7 | ADENYLOSUCCINATESYNTHETASE (Legionellapneumophila) |
no annotation | 5 | ASP A 27GLY A 223GLY A 18ASP A 22ILE A 266 | None | 1.16A | 3prsA-6bs7A:undetectable | 3prsA-6bs7A:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6exv | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Sus scrofa) |
no annotation | 5 | ASP B1004ASP B 715GLY B 997ASP B 998ILE B1011 | None | 1.12A | 3prsA-6exvB:undetectable | 3prsA-6exvB:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fn1 | HUMAN-MOUSE CHIMERICABCB1 (ABCBHM) (Homo sapiens) |
no annotation | 5 | GLY A 603GLY A 429THR A 434TYR A 400ILE A 408 | None | 1.15A | 3prsA-6fn1A:undetectable | 3prsA-6fn1A:11.18 |