SIMILAR PATTERNS OF AMINO ACIDS FOR 3PQZ_M_CCSM11

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyc PUTATIVE GLYCOSIDE
HYDROLASE

(Parabacteroides
distasonis) 		PF12876
(Cellulase-like) 		4 LEU A 138
TRP A 163
PHE A 234
PRO A 233
 None
 1.45A 3pqzC-3gycA:
0.0
3pqzM-3gycA:
undetectable		 3pqzC-3gycA:
14.72
3pqzM-3gycA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		4 LEU A 205
TRP A 172
PHE A 181
PRO A 212
 None
 1.39A 3pqzC-3h7fA:
0.0
3pqzM-3h7fA:
undetectable		 3pqzC-3h7fA:
12.90
3pqzM-3h7fA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3
MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus;
Mus musculus) 		PF00069
(Pkinase)
PF07714
(Pkinase_Tyr) 		4 LEU B 375
TRP A 217
PHE B 373
PRO B 372
 None
 1.44A 3pqzC-4m69B:
0.0
3pqzM-4m69B:
undetectable		 3pqzC-4m69B:
16.96
3pqzM-4m69B:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3l MGS-M2

(unidentified) 		PF00561
(Abhydrolase_1) 		4 LEU A 223
TRP A 129
PHE A 227
PRO A 226
 None
 1.19A 3pqzC-4q3lA:
0.4
3pqzM-4q3lA:
undetectable		 3pqzC-4q3lA:
16.55
3pqzM-4q3lA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 264
TRP A 296
PHE A 283
PRO A 258
 None
 1.38A 3pqzC-5n9xA:
0.0
3pqzM-5n9xA:
undetectable		 3pqzC-5n9xA:
13.96
3pqzM-5n9xA:
2.16