SIMILAR PATTERNS OF AMINO ACIDS FOR 3PP1_A_ACTA590_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 LEU A 531
GLN A 195
HIS A 448
GLY A 486
 None
AMO  A 831 (-3.7A)
AMO  A 831 (-3.9A)
AMO  A 831 (-3.5A)
 1.19A 3pp1A-1c0aA:
0.0		 3pp1A-1c0aA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 GLU A 869
LEU A 872
GLN A 807
GLY A 811
 MCN  A 914 ( 3.7A)
None
MCN  A 914 (-2.9A)
None
 1.21A 3pp1A-1dgjA:
0.0		 3pp1A-1dgjA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 GLU A1211
LEU A1210
HIS A1314
GLY A1209
 None
 1.02A 3pp1A-1fnfA:
0.0		 3pp1A-1fnfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlm HEMOGLOBIN (CYANO
MET)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 GLU A  63
LEU A  59
GLN A  50
GLY A  58
 None
 1.09A 3pp1A-1hlmA:
undetectable		 3pp1A-1hlmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 GLU P  86
LEU P  88
GLN P 203
GLY P  89
 None
 1.25A 3pp1A-1hynP:
0.0		 3pp1A-1hynP:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsd HAEMAGGLUTININ (HA1
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLU A 275
LEU A 263
HIS A  37
GLY A  39
 None
 1.27A 3pp1A-1jsdA:
undetectable		 3pp1A-1jsdA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 LEU A 381
GLN A 102
HIS A  99
GLY A 382
 None
 1.21A 3pp1A-1kaeA:
0.0		 3pp1A-1kaeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 GLU A 108
LEU A 107
GLN A 196
GLY A 156
 None
 1.29A 3pp1A-1n21A:
0.0		 3pp1A-1n21A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 GLU A  31
LEU A  29
HIS A  82
GLY A  35
 None
 1.24A 3pp1A-1ps9A:
0.0		 3pp1A-1ps9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9w REPLICATION PROTEIN
E1

(Alphapapillomavirus
7) 		PF00519
(PPV_E1_C) 		4 GLU A 338
GLN A 272
HIS A 270
GLY A 332
 None
 1.32A 3pp1A-1r9wA:
undetectable		 3pp1A-1r9wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 GLU A  51
LEU A  10
HIS A 100
GLY A 260
 None
 1.28A 3pp1A-1rqgA:
undetectable		 3pp1A-1rqgA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 GLU A  96
LEU A  97
HIS A  75
GLY A  93
 None
 1.03A 3pp1A-1rqgA:
undetectable		 3pp1A-1rqgA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  67
GLN A 120
HIS A 123
GLY A 135
 None
 0.54A 3pp1A-1s9iA:
42.4		 3pp1A-1s9iA:
80.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V
COAGULATION FACTOR V

(Bos taurus;
Bos taurus) 		PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 LEU B1818
GLN A  87
HIS A 142
GLY B1819
 None
 1.18A 3pp1A-1sddB:
undetectable		 3pp1A-1sddB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 GLU A 684
LEU A 682
GLN A 722
GLY A 676
 None
 1.31A 3pp1A-1vbgA:
undetectable		 3pp1A-1vbgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 328
LEU A 332
GLN A 315
GLY A 314
 None
 1.31A 3pp1A-1vknA:
0.8		 3pp1A-1vknA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		4 GLU A 247
LEU A 248
GLN A 241
GLY A 226
 None
 1.29A 3pp1A-1w4tA:
undetectable		 3pp1A-1w4tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLU A  85
GLN A  86
HIS A 132
GLY A 121
 None
 1.18A 3pp1A-2akzA:
undetectable		 3pp1A-2akzA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 GLU A 383
LEU A 385
HIS A 363
GLY A 304
 ZN  A1006 (-2.1A)
None
None
None
 1.13A 3pp1A-2ek8A:
undetectable		 3pp1A-2ek8A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 GLU A 523
LEU A 521
HIS A 494
GLY A 520
 None
 1.17A 3pp1A-2hroA:
undetectable		 3pp1A-2hroA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A  71
LEU A  45
HIS A  81
GLY A  43
 None
 1.07A 3pp1A-2i3aA:
undetectable		 3pp1A-2i3aA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 386
GLN A 206
HIS A 208
GLY A 408
 None
 1.23A 3pp1A-2ip4A:
undetectable		 3pp1A-2ip4A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jss CHIMERA OF HISTONE
H2B.1 AND HISTONE
H2A.Z
UNCHARACTERIZED
PROTEIN YER030W

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C)
PF09649
(CHZ) 		4 GLU B  56
LEU B  58
GLN A 166
GLY A 171
 None
 1.23A 3pp1A-2jssB:
undetectable		 3pp1A-2jssB:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kij COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00122
(E1-E2_ATPase) 		4 GLU A  59
LEU A  95
HIS A  61
GLY A  93
 None
 1.29A 3pp1A-2kijA:
undetectable		 3pp1A-2kijA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 162
LEU A 160
HIS A 344
GLY A 159
 None
 0.85A 3pp1A-2nqlA:
undetectable		 3pp1A-2nqlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLU A  64
LEU A  90
GLN A  95
GLY A  93
 None
 1.29A 3pp1A-2obyA:
undetectable		 3pp1A-2obyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 163
LEU A 161
HIS A 345
GLY A 160
 None
 1.06A 3pp1A-2ppgA:
undetectable		 3pp1A-2ppgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxj JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		4 GLU A   6
LEU A   8
HIS A  40
GLY A  38
 None
 1.00A 3pp1A-2pxjA:
undetectable		 3pp1A-2pxjA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 348
LEU A 352
GLN A 335
GLY A 334
 None
 1.31A 3pp1A-2q49A:
0.8		 3pp1A-2q49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU A 377
LEU A 379
GLN A 340
GLY A 330
 None
 1.24A 3pp1A-2v4jA:
1.6		 3pp1A-2v4jA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU A 377
LEU A 379
GLN A 340
GLY A 330
 None
 1.29A 3pp1A-2xsjA:
2.0		 3pp1A-2xsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 GLU A 139
LEU A 119
GLN A 113
GLY A  96
 None
D12  A1008 ( 4.6A)
None
D12  A1008 ( 4.2A)
 1.20A 3pp1A-2ynkA:
undetectable		 3pp1A-2ynkA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 327
GLN A 211
HIS A 213
GLY A 413
 None
 1.13A 3pp1A-2ys6A:
undetectable		 3pp1A-2ys6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 327
GLN A 211
HIS A 213
GLY A 415
 None
 1.16A 3pp1A-2yw2A:
undetectable		 3pp1A-2yw2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		4 GLU A  79
LEU A  33
GLN A 146
GLY A  32
 None
 1.12A 3pp1A-2zuaA:
undetectable		 3pp1A-2zuaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 GLU A 715
LEU A 711
GLN A 645
GLY A 709
 None
 1.32A 3pp1A-3ayfA:
undetectable		 3pp1A-3ayfA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLU A  85
GLN A  86
HIS A 132
GLY A 121
 None
 1.13A 3pp1A-3b97A:
undetectable		 3pp1A-3b97A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djd FRUCTOSYL AMINE:
OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		4 GLU A 247
LEU A 250
GLN A 323
GLY A 137
 None
 1.25A 3pp1A-3djdA:
undetectable		 3pp1A-3djdA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 GLU A  85
GLN A 180
HIS A 179
GLY A  87
 None
 1.19A 3pp1A-3fijA:
undetectable		 3pp1A-3fijA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		4 GLU A  71
LEU A  23
GLN A  30
HIS A  66
 None
 1.27A 3pp1A-3ggyA:
undetectable		 3pp1A-3ggyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggy INCREASED SODIUM
TOLERANCE PROTEIN 1

(Saccharomyces
cerevisiae) 		PF03398
(Ist1) 		4 GLU A  71
LEU A  73
GLN A  30
HIS A  66
 None
 1.21A 3pp1A-3ggyA:
undetectable		 3pp1A-3ggyA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 GLU B 289
LEU B 292
GLN B 223
GLY B 227
 MOS  B 920 (-2.7A)
None
MCN  B 921 (-3.0A)
None
 1.22A 3pp1A-3hrdB:
undetectable		 3pp1A-3hrdB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 GLU A 324
LEU A 328
GLN A 285
HIS A 281
 None
 1.27A 3pp1A-3jbhA:
undetectable		 3pp1A-3jbhA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 GLU A 125
LEU A 100
GLN A 131
GLY A 145
 None
IMD  A 313 ( 4.1A)
None
None
 1.27A 3pp1A-3k1nA:
undetectable		 3pp1A-3k1nA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		4 GLU A 126
LEU A 125
HIS A 231
GLY A 129
 None
 0.81A 3pp1A-3m3pA:
undetectable		 3pp1A-3m3pA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 332
GLN A 213
HIS A 215
GLY A 420
 None
GOL  A 501 (-3.8A)
GOL  A 501 (-3.9A)
None
 1.11A 3pp1A-3mjfA:
undetectable		 3pp1A-3mjfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 GLU A 377
LEU A 379
GLN A 340
GLY A 330
 None
 1.26A 3pp1A-3or2A:
2.4		 3pp1A-3or2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 GLU A 407
LEU A 406
GLN A 456
GLY A 423
 None
 1.24A 3pp1A-3p27A:
undetectable		 3pp1A-3p27A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp4 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		4 GLU A 146
LEU A  63
HIS A 179
GLY A 151
 None
 1.21A 3pp1A-3qp4A:
undetectable		 3pp1A-3qp4A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp5 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 GLU A 146
LEU A  63
HIS A 179
GLY A 151
 None
 1.12A 3pp1A-3qp5A:
undetectable		 3pp1A-3qp5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 GLU A  65
LEU A  80
GLN A 268
GLY A 216
 None
 1.19A 3pp1A-3ri6A:
undetectable		 3pp1A-3ri6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLU A 428
LEU A 427
GLN A 277
GLY A 478
 None
 0.95A 3pp1A-3s6pA:
undetectable		 3pp1A-3s6pA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		4 GLU A 114
LEU A 113
HIS A 110
GLY A 111
 None
 1.18A 3pp1A-3tr7A:
undetectable		 3pp1A-3tr7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		4 GLU A   3
LEU A   4
GLN A 178
GLY A  59
 None
 1.00A 3pp1A-3twkA:
undetectable		 3pp1A-3twkA:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLU A  63
LEU A  64
GLN A 117
HIS A 120
GLY A 132
 None
 0.57A 3pp1A-3wigA:
41.6		 3pp1A-3wigA:
87.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae7 THIOESTERASE
SUPERFAMILY MEMBER 5

(Homo sapiens) 		PF03061
(4HBT) 		4 GLU A 151
LEU A 150
GLN A 125
GLY A 126
 None
 1.16A 3pp1A-4ae7A:
undetectable		 3pp1A-4ae7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 GLU A 721
LEU A 720
GLN A 462
GLY A 743
 None
 1.12A 3pp1A-4bs9A:
undetectable		 3pp1A-4bs9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2f CARBOXY-TERMINAL
PROCESSING PROTEASE
CTPB

(Bacillus
subtilis) 		PF01471
(PG_binding_1)
PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		4 GLU A 320
GLN A 272
HIS A 323
GLY A 322
 None
 1.31A 3pp1A-4c2fA:
undetectable		 3pp1A-4c2fA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 GLU D 563
GLN D 525
HIS D 534
GLY D 561
 None
 1.05A 3pp1A-4cymD:
undetectable		 3pp1A-4cymD:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
COP9 SIGNALOSOME
COMPLEX SUBUNIT 8

(Homo sapiens;
Homo sapiens) 		PF01399
(PCI)
PF10075
(CSN8_PSD8_EIF3K) 		4 GLU H  26
LEU H  25
GLN C 126
GLY C 122
 None
 1.13A 3pp1A-4d10H:
undetectable		 3pp1A-4d10H:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		4 GLU A 394
LEU A 391
GLN A 484
GLY A 485
 None
 1.25A 3pp1A-4f3eA:
undetectable		 3pp1A-4f3eA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 GLU A 576
LEU A 574
HIS A 774
GLY A 571
 None
None
GOL  A1006 (-4.7A)
None
 0.90A 3pp1A-4f7zA:
undetectable		 3pp1A-4f7zA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 GLU A  51
LEU A  50
GLN A  86
GLY A  79
 None
 1.20A 3pp1A-4fdwA:
undetectable		 3pp1A-4fdwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk6 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Mycobacteroides
abscessus) 		PF00692
(dUTPase) 		4 GLU A 116
LEU A 117
GLN A 114
GLY A  52
 None
 1.18A 3pp1A-4gk6A:
undetectable		 3pp1A-4gk6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		4 GLU A  93
GLN A  84
HIS A  81
GLY A  59
 GOL  A 505 (-4.0A)
None
None
None
 1.05A 3pp1A-4k7cA:
0.5		 3pp1A-4k7cA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		4 GLU A 174
LEU A 243
HIS A  70
GLY A 240
 None
 1.15A 3pp1A-4kqkA:
undetectable		 3pp1A-4kqkA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 GLU A  48
LEU A 437
HIS A  80
GLY A  37
 None
 1.20A 3pp1A-4ld7A:
undetectable		 3pp1A-4ld7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 GLU A   8
LEU A  10
GLN A   6
GLY A  11
 None
 1.29A 3pp1A-4lz6A:
undetectable		 3pp1A-4lz6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 GLU A 356
LEU A 355
HIS A 466
GLY A 359
 None
 1.18A 3pp1A-4m9xA:
undetectable		 3pp1A-4m9xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 GLU E 576
LEU E 574
HIS E 774
GLY E 571
 None
 0.93A 3pp1A-4mh0E:
undetectable		 3pp1A-4mh0E:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mld RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		4 GLU A  58
LEU A   6
HIS A  62
GLY A  37
 None
 1.06A 3pp1A-4mldA:
undetectable		 3pp1A-4mldA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0f IGG RECEPTOR FCRN
LARGE SUBUNIT P51

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLU A 151
LEU A 152
GLN A 142
GLY A 125
 None
 1.25A 3pp1A-4n0fA:
undetectable		 3pp1A-4n0fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcz FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Lactococcus
lactis) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 GLU A   2
LEU A   3
GLN A 163
GLY A  56
 None
 1.19A 3pp1A-4pczA:
undetectable		 3pp1A-4pczA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		4 GLU A 762
LEU A 759
GLN A 566
GLY A 567
 None
 1.28A 3pp1A-4pmwA:
undetectable		 3pp1A-4pmwA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		4 GLU A 119
LEU A 121
HIS A  92
GLY A 117
 None
 1.15A 3pp1A-4qniA:
undetectable		 3pp1A-4qniA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3f SPLICEOSOMAL PROTEIN
CWC27

(Chaetomium
thermophilum) 		PF00160
(Pro_isomerase) 		4 GLU A 181
GLN A  64
HIS A  55
GLY A  72
 None
EDO  A 303 (-2.4A)
None
None
 1.20A 3pp1A-4r3fA:
undetectable		 3pp1A-4r3fA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgz XAA-PRO
AMINOPEPTIDASE

(Thermococcus
sibiricus) 		no annotation 4 LEU A  60
GLN A  16
HIS A  13
GLY A  59
 None
 1.02A 3pp1A-4rgzA:
undetectable		 3pp1A-4rgzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4h TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 GLU A 147
LEU A 137
GLN A  -5
GLY A 136
 None
 1.13A 3pp1A-4u4hA:
undetectable		 3pp1A-4u4hA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		4 GLU A 236
LEU A  90
GLN A 171
GLY A  91
 BDP  A 401 (-3.0A)
None
BDP  A 401 (-3.7A)
None
 1.14A 3pp1A-4xfeA:
undetectable		 3pp1A-4xfeA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		4 GLU A 310
LEU A 307
HIS A 365
GLY A 304
 None
 1.16A 3pp1A-5a4jA:
undetectable		 3pp1A-5a4jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5u EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 GLU I 313
LEU I  13
HIS I 292
GLY I 311
 None
 0.99A 3pp1A-5a5uI:
undetectable		 3pp1A-5a5uI:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		4 GLU A1026
LEU A1103
HIS A1023
GLY A1104
 None
 1.28A 3pp1A-5dczA:
undetectable		 3pp1A-5dczA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 GLU A 318
LEU A 319
HIS A 351
GLY A 326
 None
 1.16A 3pp1A-5dx5A:
undetectable		 3pp1A-5dx5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLU A 218
LEU A 217
HIS A  51
GLY A  53
 None
 1.27A 3pp1A-5eqdA:
undetectable		 3pp1A-5eqdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 4 GLU A 540
LEU A 539
GLN A 602
GLY A 538
 None
 1.25A 3pp1A-5fodA:
undetectable		 3pp1A-5fodA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 GLU A 299
LEU A 296
GLN A 259
GLY A 257
 None
 1.30A 3pp1A-5g56A:
undetectable		 3pp1A-5g56A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU C 358
GLN C 287
HIS C 304
GLY C 357
 None
 1.11A 3pp1A-5g5gC:
undetectable		 3pp1A-5g5gC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr3 CARMINOMYCIN
4-O-METHYLTRANSFERAS
E DNRK

(Streptomyces
peucetius) 		PF00891
(Methyltransf_2) 		4 GLU A 225
LEU A 222
GLN A 164
GLY A 191
 None
 1.07A 3pp1A-5jr3A:
undetectable		 3pp1A-5jr3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		4 GLU A  22
LEU A  23
HIS B 274
GLY B 234
 None
 1.18A 3pp1A-5l3xA:
undetectable		 3pp1A-5l3xA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		4 GLU A 183
GLN A 139
HIS A 141
GLY A 185
 None
 1.31A 3pp1A-5loaA:
undetectable		 3pp1A-5loaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 4 GLU A 710
LEU A 711
GLN A 636
GLY A 705
 None
CL  A 803 ( 4.3A)
None
None
 1.22A 3pp1A-5n8dA:
undetectable		 3pp1A-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 2

(Homo sapiens) 		PF04056
(Ssl1) 		4 GLU E 119
LEU E 120
HIS E 127
GLY E 105
 None
 1.07A 3pp1A-5of4E:
undetectable		 3pp1A-5of4E:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob FAB 8I21 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLU H   3
LEU H   4
GLN H 114
GLY H 113
 None
 1.17A 3pp1A-5vobH:
undetectable		 3pp1A-5vobH:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 GLU A 244
LEU A 242
GLN A 216
GLY A 219
 None
 1.15A 3pp1A-5wyrA:
undetectable		 3pp1A-5wyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 GLU A 294
LEU A 297
GLN A 361
GLY A 359
 None
 1.31A 3pp1A-5xn8A:
undetectable		 3pp1A-5xn8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 LEU L  52
GLN L 105
HIS L 107
GLY H 114
 None
 1.25A 3pp1A-5xs7L:
undetectable		 3pp1A-5xs7L:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 GLU A 100
LEU A 103
HIS A  67
GLY A 248
 None
 1.15A 3pp1A-5yxeA:
undetectable		 3pp1A-5yxeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 4 GLU A 173
LEU A 242
HIS A  69
GLY A 239
 None
 1.19A 3pp1A-6b5fA:
undetectable		 3pp1A-6b5fA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv9 SHORT TRANSIENT
RECEPTOR POTENTIAL
CHANNEL 6

(Mus musculus) 		no annotation 4 GLU A 106
GLN A 888
HIS A 144
GLY A 108
 None
 0.98A 3pp1A-6cv9A:
undetectable		 3pp1A-6cv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 4 GLU A  62
LEU A 107
HIS A  29
GLY A  51
 None
 1.28A 3pp1A-6gneA:
undetectable		 3pp1A-6gneA:
undetectable