SIMILAR PATTERNS OF AMINO ACIDS FOR 3POC_B_ACRB665

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3y ODORANT BINDING
PROTEIN

(Sus scrofa) 		PF00061
(Lipocalin) 		4 LYS A  72
ASP A  79
TYR A  78
LYS A  87
 None
 1.26A 3pocB-1a3yA:
undetectable		 3pocB-1a3yA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 GLU A 220
LYS A 221
ASP A 219
TYR A 217
 None
 1.48A 3pocB-1bf6A:
2.5		 3pocB-1bf6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLU A 482
ASP A 407
TYR A 382
LYS A 408
 None
CA  A3000 ( 2.2A)
None
CA  A3000 ( 4.0A)
 1.39A 3pocB-1cb8A:
undetectable		 3pocB-1cb8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		4 GLU A 418
ASP A 341
TYR A 355
ASP A 356
 None
 1.50A 3pocB-1h4pA:
8.2		 3pocB-1h4pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 GLU A  10
ASP A 304
TYR A 305
ASP A 302
 None
 1.09A 3pocB-1krmA:
2.2		 3pocB-1krmA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odf HYPOTHETICAL 33.3
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 159
ASP A  72
TYR A  74
LYS A 130
 None
None
SO4  A 502 (-4.6A)
None
 1.39A 3pocB-1odfA:
0.0		 3pocB-1odfA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 GLU A 166
ASP A 142
ASP A 136
LYS A 138
 None
 1.38A 3pocB-1ue8A:
undetectable		 3pocB-1ue8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 GLU A  13
ASP A 307
TYR A 308
ASP A 305
 None
 1.07A 3pocB-1uioA:
3.6		 3pocB-1uioA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		4 GLU A 271
ASP A 221
ASP A 217
LYS A 218
 None
 1.30A 3pocB-1vffA:
8.2		 3pocB-1vffA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqm KINDLING FLUORESCENT
PROTEIN

(Anemonia
sulcata) 		PF01353
(GFP) 		4 GLU A 195
ASP A  78
TYR A  79
LYS A  81
 None
 1.43A 3pocB-1xqmA:
undetectable		 3pocB-1xqmA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LYS A1243
ASP A1244
TYR A1245
ASP A1246
 None
 0.88A 3pocB-2b39A:
undetectable		 3pocB-2b39A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		4 GLU A  91
LYS A  90
TYR A 129
LYS A 104
 None
 1.07A 3pocB-2chgA:
2.5		 3pocB-2chgA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dba SMOOTH MUSCLE CELL
ASSOCIATED
PROTEIN-1, ISOFORM 2

(Homo sapiens) 		PF07719
(TPR_2)
PF13432
(TPR_16) 		4 ASP A  80
TYR A  81
ASP A  82
LYS A  83
 None
 1.03A 3pocB-2dbaA:
undetectable		 3pocB-2dbaA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 GLU A 260
ASP A 253
ASP A 254
LYS A 255
 None
 1.47A 3pocB-2dulA:
undetectable		 3pocB-2dulA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbn 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
falciparum) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		4 LYS A 102
ASP A 103
TYR A 104
LYS A 106
 None
 1.44A 3pocB-2fbnA:
undetectable		 3pocB-2fbnA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		4 GLU A  60
ASP A 302
TYR A 299
ASP A 301
 None
 1.34A 3pocB-2gwgA:
4.5		 3pocB-2gwgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7h NITROREDUCTASE-LIKE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 GLU A  99
ASP A 109
TYR A 110
ASP A 107
 None
 1.29A 3pocB-2i7hA:
undetectable		 3pocB-2i7hA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ASP A 244
TYR A 250
ASP A 253
LYS A 254
 None
 1.26A 3pocB-2iyoA:
undetectable		 3pocB-2iyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3d LIN0334 PROTEIN

(Listeria
innocua) 		PF07252
(DUF1433) 		4 GLU A  16
ASP A  66
TYR A  87
ASP A  88
 None
 1.48A 3pocB-2k3dA:
undetectable		 3pocB-2k3dA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mn2 YMOB

(Yersinia
enterocolitica) 		PF10757
(YbaJ) 		4 GLU A  74
ASP A  69
TYR A 115
ASP A  68
 None
 1.00A 3pocB-2mn2A:
undetectable		 3pocB-2mn2A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mnw PROTEIN SHQ1 HOMOLOG

(Homo sapiens) 		no annotation 4 GLU A  34
LYS A  39
TYR A  41
ASP A  30
 None
 1.45A 3pocB-2mnwA:
2.6		 3pocB-2mnwA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p68 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		4 GLU A 111
ASP A 108
ASP A  98
LYS A  99
 None
 1.23A 3pocB-2p68A:
undetectable		 3pocB-2p68A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  37
LYS A  35
TYR A  45
ASP A 109
 None
 1.40A 3pocB-2p88A:
5.8		 3pocB-2p88A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 ASP A 138
TYR A 274
ASP A 275
LYS A 272
 None
 1.44A 3pocB-2qfvA:
undetectable		 3pocB-2qfvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azc CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Thermosynechococcus
elongatus) 		PF00355
(Rieske) 		4 LYS A  65
ASP A  63
ASP A  58
LYS A  57
 None
 1.44A 3pocB-3azcA:
undetectable		 3pocB-3azcA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 GLU A 141
ASP A 142
TYR A 143
LYS A 154
 None
 1.27A 3pocB-3fsnA:
undetectable		 3pocB-3fsnA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5w MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A  83
ASP A  85
ASP A  86
LYS A  44
 None
 1.28A 3pocB-3g5wA:
undetectable		 3pocB-3g5wA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gae PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL) 		4 LYS A 463
ASP A 712
ASP A 709
LYS A 708
 None
 1.17A 3pocB-3gaeA:
undetectable		 3pocB-3gaeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		4 LYS A  41
ASP A  40
TYR A  36
ASP A  28
 None
None
None
SO4  A 278 ( 4.2A)
 1.32A 3pocB-3go4A:
undetectable		 3pocB-3go4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		4 LYS A 231
ASP A 233
TYR A 234
ASP A 235
 None
 1.03A 3pocB-3gwfA:
undetectable		 3pocB-3gwfA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		4 GLU A 149
ASP A 156
ASP A 168
LYS A 166
 None
 1.50A 3pocB-3ka7A:
undetectable		 3pocB-3ka7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kae POSSIBLE PROTEIN OF
NUCLEAR SCAFFOLD

(Encephalitozoon
cuniculi) 		no annotation 4 LYS A  76
ASP A  77
TYR A  78
LYS A  80
 None
 1.45A 3pocB-3kaeA:
undetectable		 3pocB-3kaeA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 54

(Mus musculus) 		PF07928
(Vps54) 		4 GLU A 856
ASP A 852
ASP A 849
LYS A 848
 None
 1.40A 3pocB-3n1bA:
undetectable		 3pocB-3n1bA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 4 GLU A 185
ASP A 233
ASP A 235
LYS A 236
 None
 1.41A 3pocB-3qkwA:
undetectable		 3pocB-3qkwA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3reb TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF00018
(SH3_1) 		4 GLU B 125
LYS B 116
TYR B 127
ASP B  96
 None
 1.33A 3pocB-3rebB:
undetectable		 3pocB-3rebB:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsn SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2

(Homo sapiens) 		no annotation 4 GLU A 154
ASP A 156
ASP A 100
LYS A 101
 None
 1.26A 3pocB-3rsnA:
undetectable		 3pocB-3rsnA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 GLU A 297
ASP A 510
ASP A 507
LYS A 506
 None
 1.47A 3pocB-3zgbA:
4.9		 3pocB-3zgbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A1041
ASP A1043
ASP A1044
LYS A1002
 None
 1.32A 3pocB-4e9xA:
undetectable		 3pocB-4e9xA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		4 GLU A 370
ASP A 447
ASP A 442
LYS A 441
 None
 1.17A 3pocB-4ftdA:
undetectable		 3pocB-4ftdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASP A  17
TYR A  16
ASP A  15
LYS A 275
 None
 1.24A 3pocB-4h7uA:
undetectable		 3pocB-4h7uA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o3s DNA POLYMERASE ETA

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 GLU A 101
ASP A 358
ASP A 355
LYS A 354
 None
 1.49A 3pocB-4o3sA:
undetectable		 3pocB-4o3sA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozx ALGINATE LYASE

(Klebsiella
pneumoniae) 		PF08787
(Alginate_lyase2) 		4 ASP A 289
TYR A 291
ASP A 290
LYS A 287
 None
 1.50A 3pocB-4ozxA:
undetectable		 3pocB-4ozxA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 GLU B 283
ASP B 226
ASP B 228
LYS B 200
 None
 1.38A 3pocB-4peqB:
0.5		 3pocB-4peqB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xba APRATAXIN-LIKE
PROTEIN

(Schizosaccharomyces
pombe) 		PF01230
(HIT)
PF16278
(zf-C2HE) 		4 GLU A 220
ASP A 224
ASP A 227
LYS A 228
 None
 1.28A 3pocB-4xbaA:
undetectable		 3pocB-4xbaA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo7 SUGAR ABC
TRANSPORTER
(SUGAR-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF13407
(Peripla_BP_4) 		4 GLU A 299
TYR A  70
ASP A  72
LYS A  43
 None
 1.27A 3pocB-4yo7A:
undetectable		 3pocB-4yo7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LYS A 212
ASP A 213
TYR A 214
LYS A 245
 None
 1.26A 3pocB-4zhtA:
2.9		 3pocB-4zhtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2

(Rattus
norvegicus) 		no annotation 4 GLU A 564
LYS A 525
ASP A 526
ASP A 542
 None
 1.43A 3pocB-5a9iA:
undetectable		 3pocB-5a9iA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 GLU B  77
ASP B  48
TYR B  49
LYS B  44
 None
 1.42A 3pocB-5d9aB:
undetectable		 3pocB-5d9aB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 GLU A  86
LYS A  84
ASP A 262
TYR A 264
 None
 1.23A 3pocB-5i84A:
undetectable		 3pocB-5i84A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1a BETA-2-MICROGLOBULIN

(Homo sapiens) 		PF07654
(C1-set) 		4 GLU B  44
LYS B  41
TYR B  78
LYS B  94
 None
 1.28A 3pocB-5j1aB:
undetectable		 3pocB-5j1aB:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 GLU A  56
LYS A 489
ASP A 177
LYS A 173
 None
 1.45A 3pocB-5l25A:
2.1		 3pocB-5l25A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 4 GLU A 239
ASP A 240
ASP A 259
LYS A 262
 None
 1.27A 3pocB-5oklA:
undetectable		 3pocB-5oklA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM6

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 6 721
LYS 6 722
ASP 6 724
ASP 6 718
 None
 1.44A 3pocB-5udb6:
undetectable		 3pocB-5udb6:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vky TOPOISOMERASE I
DAMAGE AFFECTED
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03645
(Tctex-1) 		4 GLU A  81
LYS A 111
ASP A 110
LYS A  34
 None
 1.43A 3pocB-5vkyA:
undetectable		 3pocB-5vkyA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 4 LYS A 383
ASP A 382
TYR A 377
LYS A 380
 None
 1.32A 3pocB-5xbjA:
undetectable		 3pocB-5xbjA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ASP A 234
TYR A  55
ASP A  54
LYS A 236
 None
 0.87A 3pocB-6eksA:
undetectable		 3pocB-6eksA:
21.68