SIMILAR PATTERNS OF AMINO ACIDS FOR 3PO7_B_ZONB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		5 TYR A 179
LEU A 250
ILE A 227
PHE A 152
TYR A 197
 HBI  A 500 ( 4.0A)
None
None
None
None
 1.41A 3po7B-1ltzA:
0.0		 3po7B-1ltzA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		6 TYR A  69
ILE A 207
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
None
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.66A 3po7B-1o5wA:
61.6		 3po7B-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzq GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		5 TYR A  20
LEU A  55
ILE A  76
TYR A  34
PHE A  37
 None
 1.31A 3po7B-2dzqA:
undetectable		 3po7B-2dzqA:
11.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		6 TYR A  69
ILE A 207
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 600 (-4.2A)
None
HRM  A 700 (-3.4A)
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.23A 3po7B-2z5xA:
62.8		 3po7B-2z5xA:
72.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		8 TYR A  60
LEU A 171
CYH A 172
ILE A 198
GLN A 206
PHE A 343
TYR A 398
TYR A 435
 FAD  A 600 (-4.4A)
MBT  A 601 (-4.2A)
None
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
 0.14A 3po7B-3zyxA:
64.8		 3po7B-3zyxA:
99.61