SIMILAR PATTERNS OF AMINO ACIDS FOR 3PO7_A_ZONA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU A 316
GLN A 280
TYR A 291
PHE A 290
 None
 1.35A 3po7A-1br2A:
undetectable		 3po7A-1br2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 TYR A 603
LEU A 595
CYH A 596
PHE A 691
 None
 1.28A 3po7A-1c4kA:
0.0		 3po7A-1c4kA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 126
GLN A 108
TYR A 124
TYR A  82
 None
 1.27A 3po7A-1deuA:
undetectable		 3po7A-1deuA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 LEU A  79
TYR A 140
TYR A 238
TYR A 243
 None
 1.23A 3po7A-1ef9A:
undetectable		 3po7A-1ef9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 307
GLN A 271
TYR A 282
PHE A 281
 None
 1.30A 3po7A-1g8xA:
undetectable		 3po7A-1g8xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 LEU A 318
GLN A 282
TYR A 293
PHE A 292
 None
 1.31A 3po7A-1jx2A:
undetectable		 3po7A-1jx2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltz PHENYLALANINE-4-HYDR
OXYLASE

(Chromobacterium
violaceum) 		PF00351
(Biopterin_H) 		4 TYR A 179
LEU A 250
TYR A 155
PHE A 152
 HBI  A 500 ( 4.0A)
None
None
None
 1.33A 3po7A-1ltzA:
undetectable		 3po7A-1ltzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 LEU A 364
TYR A 330
PHE A 363
TYR A 454
 None
 1.02A 3po7A-1mt5A:
undetectable		 3po7A-1mt5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 TYR A  78
LEU A  61
TYR A 137
TYR A 182
 None
 1.27A 3po7A-1ni6A:
undetectable		 3po7A-1ni6A:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		5 TYR A  69
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 652 (-4.3A)
MLG  A 709 (-3.8A)
None
MLG  A 709 ( 3.8A)
FAD  A 652 ( 4.5A)
 0.74A 3po7A-1o5wA:
61.3		 3po7A-1o5wA:
70.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 TYR A 223
CYH A 232
GLN A 368
TYR A 219
 None
FAD  A1656 ( 4.6A)
None
None
 1.03A 3po7A-1qlbA:
7.4		 3po7A-1qlbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 TYR A 244
GLN A 240
TYR A 128
TYR A 159
 None
CAC  A2004 (-2.8A)
CAC  A2004 ( 4.3A)
None
 0.79A 3po7A-1qqjA:
undetectable		 3po7A-1qqjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2d PURINE TRANS
DEOXYRIBOSYLASE

(Lactobacillus
helveticus) 		PF05014
(Nuc_deoxyrib_tr) 		4 TYR A 167
LEU A 114
TYR A  89
TYR A 164
 None
 1.07A 3po7A-1s2dA:
undetectable		 3po7A-1s2dA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z INTERCELLULAR
ADHESION MOLECULE-1

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU I 106
GLN I  98
TYR I 180
PHE I 157
 None
 1.30A 3po7A-1z7zI:
undetectable		 3po7A-1z7zI:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7k SCO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02630
(SCO1-SenC) 		4 LEU A 156
TYR A 142
PHE A 178
TYR A 194
 None
 1.21A 3po7A-2b7kA:
undetectable		 3po7A-2b7kA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 LEU A 470
CYH A 471
PHE A 341
TYR A 792
 None
 1.14A 3po7A-2bmbA:
undetectable		 3po7A-2bmbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 LEU A 183
CYH A 182
TYR A 164
PHE A 190
 None
 1.28A 3po7A-2c91A:
undetectable		 3po7A-2c91A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		4 LEU A 131
TYR A  63
PHE A 134
TYR A  49
 None
 1.20A 3po7A-2cdpA:
undetectable		 3po7A-2cdpA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 LEU A 216
CYH A 215
TYR A 197
PHE A 223
 None
 1.34A 3po7A-2clpA:
undetectable		 3po7A-2clpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlc TYROSYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 LEU X  76
GLN X 174
TYR X  43
TYR X 170
 YMP  X 601 (-4.8A)
YMP  X 601 (-3.2A)
YMP  X 601 (-4.7A)
YMP  X 601 (-4.6A)
 1.29A 3po7A-2dlcX:
undetectable		 3po7A-2dlcX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzq GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02946
(GTF2I) 		4 TYR A  20
LEU A  55
TYR A  34
PHE A  37
 None
 1.19A 3po7A-2dzqA:
undetectable		 3po7A-2dzqA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 360
GLN A 180
TYR A 356
PHE A 359
 None
 1.13A 3po7A-2exrA:
undetectable		 3po7A-2exrA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggt SCO1 PROTEIN
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF02630
(SCO1-SenC) 		4 LEU A 177
TYR A 163
PHE A 200
TYR A 216
 None
 1.16A 3po7A-2ggtA:
undetectable		 3po7A-2ggtA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i88 COLICIN-E1

(Escherichia
coli) 		PF01024
(Colicin) 		4 LEU A 513
CYH A 505
TYR A 396
PHE A 393
 None
 1.27A 3po7A-2i88A:
undetectable		 3po7A-2i88A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		4 LEU A 116
TYR A 124
PHE A 121
TYR A 193
 None
 1.16A 3po7A-2j7qA:
undetectable		 3po7A-2j7qA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 375
GLN A 187
TYR A 371
PHE A 374
 None
 1.11A 3po7A-2qpmA:
undetectable		 3po7A-2qpmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmr PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH) 		4 TYR A 129
LEU A 148
TYR A 144
PHE A 147
 None
 1.21A 3po7A-2rmrA:
undetectable		 3po7A-2rmrA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		4 TYR A 162
LEU A 233
TYR A 139
PHE A 136
 None
 1.29A 3po7A-2v28A:
undetectable		 3po7A-2v28A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woz KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 10

(Rattus
norvegicus) 		PF01344
(Kelch_1) 		4 TYR A 545
LEU A 308
CYH A 593
TYR A 317
 None
 1.29A 3po7A-2wozA:
undetectable		 3po7A-2wozA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 TYR A  69
GLN A 215
PHE A 352
TYR A 407
TYR A 444
 FAD  A 600 (-4.2A)
HRM  A 700 (-3.4A)
HRM  A 700 (-4.3A)
HRM  A 700 ( 3.9A)
FAD  A 600 ( 4.6A)
 0.24A 3po7A-2z5xA:
62.6		 3po7A-2z5xA:
72.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		4 LEU A 320
GLN A 115
TYR A 308
TYR A 416
 None
 1.34A 3po7A-3ayxA:
undetectable		 3po7A-3ayxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 LEU A 558
TYR A 554
PHE A 557
TYR A 461
 None
 1.30A 3po7A-3azqA:
undetectable		 3po7A-3azqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh4 SODIUM/GLUCOSE
COTRANSPORTER

(Vibrio
parahaemolyticus) 		PF00474
(SSF) 		4 TYR A 269
LEU A 137
TYR A 262
TYR A 263
 None
None
None
GAL  A 701 ( 4.1A)
 1.34A 3po7A-3dh4A:
undetectable		 3po7A-3dh4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 TYR A 141
LEU A 236
GLN A 195
PHE A 159
 None
 1.02A 3po7A-3e82A:
2.4		 3po7A-3e82A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 TYR A 231
LEU A 212
PHE A 181
TYR A 222
 None
 1.12A 3po7A-3ed3A:
undetectable		 3po7A-3ed3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 LEU B 188
GLN B   6
TYR B 275
PHE B 300
 None
 1.17A 3po7A-3egwB:
undetectable		 3po7A-3egwB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 LEU A 289
PHE A 447
TYR A 302
TYR A 223
 None
 1.27A 3po7A-3eu8A:
undetectable		 3po7A-3eu8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnd CHITINASE

(Bacteroides
thetaiotaomicron) 		PF00704
(Glyco_hydro_18) 		4 TYR A 159
LEU A 169
TYR A 156
TYR A 197
 None
 1.25A 3po7A-3fndA:
undetectable		 3po7A-3fndA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 165
TYR A 161
PHE A 164
TYR A 275
 None
 1.16A 3po7A-3fy4A:
undetectable		 3po7A-3fy4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 TYR A 105
LEU A 100
TYR A  21
TYR A  24
 None
 1.12A 3po7A-3g8gA:
undetectable		 3po7A-3g8gA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga4 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE-PROTEI
N
GLYCOSYLTRANSFERASE
SUBUNIT OST6

(Saccharomyces
cerevisiae) 		PF04756
(OST3_OST6) 		4 TYR A 130
LEU A  57
PHE A  61
TYR A  42
 EDO  A 182 (-4.2A)
None
None
None
 1.13A 3po7A-3ga4A:
undetectable		 3po7A-3ga4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		4 LEU A 256
PHE A 476
TYR A 461
TYR A 266
 None
 1.00A 3po7A-3h68A:
undetectable		 3po7A-3h68A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A  52
LEU A 227
PHE A 278
TYR A  60
 None
 1.31A 3po7A-3mcxA:
undetectable		 3po7A-3mcxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 TYR A 611
LEU A 556
TYR A 562
TYR A 608
 None
 1.21A 3po7A-3nvqA:
undetectable		 3po7A-3nvqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		4 TYR A 165
LEU A 174
CYH A 176
TYR A 168
 None
 1.33A 3po7A-3opxA:
undetectable		 3po7A-3opxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		4 LEU A  19
TYR A 420
PHE A  36
TYR A  80
 None
 1.18A 3po7A-3qt3A:
undetectable		 3po7A-3qt3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		4 LEU L 321
GLN L 114
TYR L 309
TYR L 417
 None
 1.31A 3po7A-3rgwL:
undetectable		 3po7A-3rgwL:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 LEU N 184
GLN K  55
TYR N 178
TYR J 137
 None
 1.18A 3po7A-3rkoN:
undetectable		 3po7A-3rkoN:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN

([Eubacterium]
rectale) 		PF16472
(DUF5050) 		4 TYR A 216
PHE A 178
TYR A  44
TYR A 258
 None
EDO  A 335 (-4.3A)
EDO  A 334 (-4.4A)
EDO  A 334 (-3.5A)
 1.32A 3po7A-3s25A:
undetectable		 3po7A-3s25A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 4 LEU A 185
TYR A 181
PHE A 184
TYR A 141
 None
 1.18A 3po7A-3sksA:
undetectable		 3po7A-3sksA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		4 TYR A  25
LEU A  40
TYR A 237
TYR A  52
 None
 1.25A 3po7A-3ufgA:
undetectable		 3po7A-3ufgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 TYR A 412
LEU A 423
TYR A 443
TYR A 349
 None
 1.20A 3po7A-3vtrA:
undetectable		 3po7A-3vtrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		4 TYR A 189
CYH A 149
TYR A 108
PHE A 132
 None
 1.27A 3po7A-3w2xA:
undetectable		 3po7A-3w2xA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 187
LEU A 156
TYR A 106
TYR A 172
 None
 1.27A 3po7A-3wdjA:
undetectable		 3po7A-3wdjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcj CAGL

(Helicobacter
pylori) 		no annotation 4 LEU A  82
TYR A 163
PHE A  86
TYR A  34
 MLY  A  83 ( 4.2A)
None
None
None
 1.34A 3po7A-3zcjA:
undetectable		 3po7A-3zcjA:
16.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		7 TYR A  60
LEU A 171
CYH A 172
GLN A 206
PHE A 343
TYR A 398
TYR A 435
 FAD  A 600 (-4.4A)
MBT  A 601 (-4.2A)
None
MBT  A 601 (-3.4A)
MBT  A 601 (-4.7A)
MBT  A 601 ( 3.6A)
MBT  A 601 ( 4.6A)
 0.19A 3po7A-3zyxA:
65.2		 3po7A-3zyxA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 TYR B 539
LEU B 526
TYR B 491
PHE B 488
 None
 1.32A 3po7A-4d0kB:
undetectable		 3po7A-4d0kB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		4 LEU B 216
TYR B 188
PHE B 191
TYR B 246
 None
 1.29A 3po7A-4dhiB:
undetectable		 3po7A-4dhiB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		4 TYR A  75
LEU A 275
TYR A 144
PHE A 278
 None
 1.30A 3po7A-4eogA:
undetectable		 3po7A-4eogA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		4 LEU A 193
CYH A 196
GLN A 121
TYR A 282
 None
 1.30A 3po7A-4eswA:
undetectable		 3po7A-4eswA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 TYR A  13
LEU A 149
GLN A  88
TYR A   9
 None
 1.28A 3po7A-4fznA:
undetectable		 3po7A-4fznA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		4 TYR A 292
LEU A 338
PHE A 354
TYR A 260
 None
None
None
CTT  A 401 (-4.3A)
 1.33A 3po7A-4hu0A:
undetectable		 3po7A-4hu0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		4 LEU A 788
CYH A 789
PHE A 828
TYR A 793
 None
 0.99A 3po7A-4ifqA:
undetectable		 3po7A-4ifqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 TYR A 381
LEU A 310
TYR A 332
PHE A 329
 None
 1.35A 3po7A-4ipeA:
undetectable		 3po7A-4ipeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6r HEAVY CHAIN OF
ANTIBODY VRC23
LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN H  39
TYR L  87
PHE L  98
TYR H  91
 None
 1.19A 3po7A-4j6rH:
undetectable		 3po7A-4j6rH:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 162
TYR A 158
PHE A 161
TYR A 281
 None
 1.15A 3po7A-4jzyA:
undetectable		 3po7A-4jzyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 LEU A 181
TYR A 175
TYR A 110
TYR A 138
 None
 1.22A 3po7A-4kc8A:
undetectable		 3po7A-4kc8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmg IRON-REGULATED
TRANSCRIPTIONAL
ACTIVATOR AFT2

(Saccharomyces
cerevisiae) 		PF08731
(AFT) 		4 LEU A 155
GLN A  62
PHE A 167
TYR A 148
 None
 1.30A 3po7A-4lmgA:
undetectable		 3po7A-4lmgA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mla CYTOKININ OXIDASE 2

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 351
GLN A 176
TYR A 347
PHE A 350
 None
 1.11A 3po7A-4mlaA:
undetectable		 3po7A-4mlaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 LEU A 367
GLN A 188
TYR A 363
PHE A 366
 None
 1.12A 3po7A-4oalA:
undetectable		 3po7A-4oalA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		4 TYR A  64
LEU A  74
PHE A  52
TYR A 117
 None
 1.27A 3po7A-4obsA:
undetectable		 3po7A-4obsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 HEAVY CHAIN
AB53 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L  36
TYR L  87
PHE L  98
TYR H  97
 None
 1.35A 3po7A-4pb0L:
undetectable		 3po7A-4pb0L:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		4 LEU A 299
PHE A 457
TYR A 312
TYR A 233
 None
 1.30A 3po7A-4qt9A:
undetectable		 3po7A-4qt9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 TYR A 507
LEU A 523
TYR A 457
TYR A 373
 None
 1.17A 3po7A-4sliA:
undetectable		 3po7A-4sliA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  60
LEU H  79
PHE H  81
TYR H  47
 None
 1.35A 3po7A-4utaH:
undetectable		 3po7A-4utaH:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 TYR A  78
LEU A  61
TYR A 137
TYR A 182
 None
 1.31A 3po7A-4wd4A:
undetectable		 3po7A-4wd4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmh HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 TYR A  98
LEU A  81
TYR A 157
TYR A 202
 None
 1.28A 3po7A-4wmhA:
undetectable		 3po7A-4wmhA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z48 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
piger) 		PF17131
(LolA_like) 		4 LEU A 150
GLN A 191
TYR A 156
TYR A 158
 None
 1.14A 3po7A-4z48A:
undetectable		 3po7A-4z48A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 LEU A 639
CYH A 684
GLN A 646
PHE A 631
 None
 1.28A 3po7A-5d9aA:
undetectable		 3po7A-5d9aA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		4 TYR A  25
LEU A  40
TYR A 233
TYR A  52
 None
 1.16A 3po7A-5f5wA:
undetectable		 3po7A-5f5wA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG
PAXT-1

(Caenorhabditis
elegans) 		PF03159
(XRN_N)
PF11952
(XTBD) 		4 TYR A 655
LEU A 676
PHE A 119
TYR B  56
 None
 1.35A 3po7A-5firA:
undetectable		 3po7A-5firA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 TYR A 366
LEU A 295
TYR A 317
PHE A 314
 None
 1.26A 3po7A-5hphA:
undetectable		 3po7A-5hphA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 TYR A  48
TYR A  75
TYR A  41
TYR A  14
 None
 1.20A 3po7A-5hrzA:
undetectable		 3po7A-5hrzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 LEU A 174
GLN A 130
TYR A 178
TYR A 123
 None
 1.35A 3po7A-5koiA:
3.3		 3po7A-5koiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8

(Homo sapiens) 		PF07686
(V-set) 		4 TYR H  59
LEU H  78
PHE H  80
TYR H  47
 None
 1.31A 3po7A-5lbsH:
undetectable		 3po7A-5lbsH:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr8 E3 UBIQUITIN-PROTEIN
LIGASE TRIM33

(Homo sapiens) 		no annotation 4 LEU A1010
TYR A1018
PHE A1024
TYR A 974
 None
 1.34A 3po7A-5mr8A:
undetectable		 3po7A-5mr8A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmw FLAVIN-CONTAINING
MONOOXYGENASE

(Zonocerus
variegatus) 		no annotation 4 LEU A 355
GLN A 314
TYR A 362
PHE A 363
 None
 1.07A 3po7A-5nmwA:
12.1		 3po7A-5nmwA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLN A 200
TYR A 212
PHE A 211
TYR A 236
 None
 1.33A 3po7A-5nz7A:
undetectable		 3po7A-5nz7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pwy NUCLEAR AUTOANTIGEN
SP-100

(Homo sapiens) 		PF00439
(Bromodomain) 		4 LEU A 822
TYR A 827
PHE A 833
TYR A 787
 None
 1.36A 3po7A-5pwyA:
undetectable		 3po7A-5pwyA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 TYR A 263
GLN A 259
TYR A 147
TYR A 178
 None
 0.90A 3po7A-5ti1A:
undetectable		 3po7A-5ti1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 348
GLN A 377
TYR A 344
TYR A 396
 None
 1.19A 3po7A-5vocA:
undetectable		 3po7A-5vocA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1g NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E FAMILY

(uncultured
archaeon
MedDCM-OCT-S05-C57) 		no annotation 4 LEU A  15
TYR A  67
PHE A 107
TYR A 163
 None
None
None
NAD  A 402 (-4.9A)
 1.36A 3po7A-5y1gA:
2.3		 3po7A-5y1gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk7 MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 171
CYH B 170
TYR B  67
PHE B  66
 None
 1.19A 3po7A-5yk7B:
undetectable		 3po7A-5yk7B:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 4 TYR A  76
LEU A 279
CYH A 280
TYR A  22
 None
9ER  A1201 (-4.8A)
None
9ER  A1201 (-4.6A)
 1.28A 3po7A-5zkpA:
2.4		 3po7A-5zkpA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 LEU P 235
GLN P 198
TYR P 209
PHE P 208
 None
 1.35A 3po7A-6c1dP:
undetectable		 3po7A-6c1dP:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, C
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 4 LEU B  34
TYR C 118
PHE B  31
TYR A 196
 None
 1.14A 3po7A-6cxhB:
undetectable		 3po7A-6cxhB:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 4 TYR A 381
LEU A 310
TYR A 332
PHE A 329
 None
 1.24A 3po7A-6d14A:
undetectable		 3po7A-6d14A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 4 TYR B1047
CYH B 707
GLN B1049
PHE B 769
 None
 1.31A 3po7A-6exvB:
undetectable		 3po7A-6exvB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 TYR A1844
LEU A1837
TYR A1901
PHE A1898
 None
 1.32A 3po7A-6ez8A:
undetectable		 3po7A-6ez8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 TYR D 131
LEU D  94
PHE D  28
TYR D 142
 None
 1.18A 3po7A-6gsaD:
undetectable		 3po7A-6gsaD:
undetectable