SIMILAR PATTERNS OF AMINO ACIDS FOR 3PMZ_E_TUBE220_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		4 TYR A 153
CYH A 276
CYH A 322
TYR A  62
 None
ZN  A 501 (-2.1A)
ZN  A 501 ( 2.1A)
None
 1.45A 3pmzE-3e73A:
undetectable		 3pmzE-3e73A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 TYR A 167
CYH A 283
CYH A 328
TYR A  76
 None
ZN  A 411 ( 2.2A)
ZN  A 411 ( 2.3A)
None
 1.48A 3pmzE-3t33A:
undetectable		 3pmzE-3t33A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wso F-BOX ONLY PROTEIN
44

(Homo sapiens) 		PF04300
(FBA)
PF12937
(F-box-like) 		4 TYR A 125
TRP A 206
CYH A 170
TYR A 239
 None
 1.29A 3pmzE-3wsoA:
0.0		 3pmzE-3wsoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2a HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF13308
(YARHG)
PF14415
(DUF4424) 		4 TRP A 245
TYR A  73
CYH A  75
TYR A 186
 None
 1.37A 3pmzE-4g2aA:
0.0		 3pmzE-4g2aA:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Homo sapiens;
Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 TYR A  91
LYS A 141
TRP A 145
TYR A 191
 None
 0.82A 3pmzE-4hqpA:
25.6		 3pmzE-4hqpA:
34.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA

(Homo sapiens;
Lymnaea
stagnalis) 		PF02931
(Neur_chan_LBD) 		4 TYR A  91
TRP A 145
TYR A 184
TYR A 191
 None
 0.72A 3pmzE-4hqpA:
25.6		 3pmzE-4hqpA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE

(Sulfurisphaera
tokodaii) 		PF02223
(Thymidylate_kin) 		4 TYR A  94
LYS A 121
TYR A  99
TYR A 116
 None
 1.42A 3pmzE-4nzyA:
0.0		 3pmzE-4nzyA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 TYR A  93
LYS A 143
TRP A 147
TYR A 188
TYR A 195
 None
 0.68A 3pmzE-4zjsA:
29.2		 3pmzE-4zjsA:
81.22