SIMILAR PATTERNS OF AMINO ACIDS FOR 3PMZ_E_TUBE220_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ax8 OBESITY PROTEIN

(Homo sapiens) 		PF02024
(Leptin) 		4 TYR A  61
MET A  68
ILE A  64
SER A 132
 None
 1.18A 3pmzD-1ax8A:
undetectable		 3pmzD-1ax8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5f PROTEIN (CARDOSIN A)

(Cynara
cardunculus) 		PF00026
(Asp) 		4 TYR A  75
ILE A  80
SER A  36
SER A  35
 None
 1.29A 3pmzD-1b5fA:
0.0		 3pmzD-1b5fA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 275
GLN A 307
ILE A 302
SER A 271
 None
 1.26A 3pmzD-1b8uA:
0.0		 3pmzD-1b8uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9o PROTEIN
(ALPHA-LACTALBUMIN)

(Homo sapiens) 		PF00062
(Lys) 		4 TYR A  50
ILE A  41
SER A  64
SER A  63
 None
 1.16A 3pmzD-1b9oA:
0.0		 3pmzD-1b9oA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		4 GLN L  90
MET L   4
ILE L  29
SER H 105
 None
 1.34A 3pmzD-1dqlL:
1.3		 3pmzD-1dqlL:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		4 TYR A 132
ILE A 216
SER A 125
SER A 126
 None
 0.95A 3pmzD-1gojA:
0.0		 3pmzD-1gojA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7c TUBULIN-SPECIFIC
CHAPERONE A

(Homo sapiens) 		PF02970
(TBCA) 		4 GLN A  53
MET A  40
ILE A  37
SER A  60
 None
 1.33A 3pmzD-1h7cA:
undetectable		 3pmzD-1h7cA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hml ALPHA-LACTALBUMIN

(Homo sapiens) 		PF00062
(Lys) 		4 TYR A  50
ILE A  41
SER A  64
SER A  63
 None
 1.30A 3pmzD-1hmlA:
undetectable		 3pmzD-1hmlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ou0 PRECORRIN-8X
METHYLMUTASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF02570
(CbiC) 		4 TYR A  98
MET A 107
ILE A 122
SER A 130
 None
 1.35A 3pmzD-1ou0A:
0.0		 3pmzD-1ou0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q44 STEROID
SULFOTRANSFERASE

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		4 TYR A  39
GLN A  52
ILE A  24
SER A  36
 None
 1.29A 3pmzD-1q44A:
undetectable		 3pmzD-1q44A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN B 333
ILE B 367
SER B 357
SER B 319
 None
 1.27A 3pmzD-1t3qB:
undetectable		 3pmzD-1t3qB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  50
ILE A  96
SER A  45
SER A  46
 None
 0.93A 3pmzD-1tkiA:
undetectable		 3pmzD-1tkiA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 GLN A 187
MET A   4
ILE A 240
SER A 180
 None
 0.90A 3pmzD-1vf8A:
undetectable		 3pmzD-1vf8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlt 176AA LONG
HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 TYR A 130
GLN A  46
ILE A 132
SER A  50
 None
 1.16A 3pmzD-1wltA:
undetectable		 3pmzD-1wltA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 TYR 3 106
MET 3  98
ILE 3 102
SER 1 174
 None
 1.08A 3pmzD-1z7z3:
undetectable		 3pmzD-1z7z3:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT

(Chlamydia
trachomatis) 		PF00268
(Ribonuc_red_sm) 		4 TYR A 220
GLN A 219
MET A  58
ILE A 216
 None
 1.31A 3pmzD-2aniA:
undetectable		 3pmzD-2aniA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9u HYPOTHETICAL
DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Sulfurisphaera
tokodaii) 		PF00908
(dTDP_sugar_isom) 		4 TYR A 130
GLN A  46
ILE A 132
SER A  50
 None
 1.16A 3pmzD-2b9uA:
undetectable		 3pmzD-2b9uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		4 TYR A  25
GLN A  26
ILE A  72
SER A 264
 None
 1.26A 3pmzD-2gsjA:
undetectable		 3pmzD-2gsjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igs HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF11508
(DUF3218) 		4 TYR A   7
GLN A   8
ILE A  56
SER A  13
 None
None
None
SO4  A2006 ( 3.8A)
 1.08A 3pmzD-2igsA:
undetectable		 3pmzD-2igsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 TYR 1 303
ILE 1 313
SER 1 362
SER 1 363
 None
 1.07A 3pmzD-2ijd1:
undetectable		 3pmzD-2ijd1:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLN A 300
ILE A 297
SER A 210
SER A 209
 None
None
CL  A1437 ( 4.6A)
FAD  A1433 (-2.8A)
 1.34A 3pmzD-2jifA:
undetectable		 3pmzD-2jifA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osy ENDOGLYCOCERAMIDASE
II

(Rhodococcus sp.) 		PF00150
(Cellulase) 		4 TYR A 301
MET A 375
ILE A 347
SER A 284
 None
 1.16A 3pmzD-2osyA:
undetectable		 3pmzD-2osyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 TYR A 182
MET A 194
ILE A 183
SER A 142
 None
 0.97A 3pmzD-2rcbA:
undetectable		 3pmzD-2rcbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE

(Neisseria
meningitidis) 		PF07922
(Glyco_transf_52) 		4 TYR A 302
MET A 328
ILE A 303
SER A 295
 None
 1.26A 3pmzD-2yk6A:
undetectable		 3pmzD-2yk6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		4 TYR A 310
ILE A 379
SER A 330
SER A 353
 None
 1.09A 3pmzD-2zahA:
undetectable		 3pmzD-2zahA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zah COAT PROTEIN

(Melon necrotic
spot virus) 		PF00729
(Viral_coat) 		4 TYR A 310
MET A 377
ILE A 379
SER A 353
 None
 1.02A 3pmzD-2zahA:
undetectable		 3pmzD-2zahA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 TYR A 500
GLN A 491
ILE A  61
SER A 496
 None
 1.22A 3pmzD-3al8A:
undetectable		 3pmzD-3al8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		4 TYR A 138
ILE A 223
SER A 131
SER A 133
 None
 1.27A 3pmzD-3b6uA:
undetectable		 3pmzD-3b6uA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c73 THIOL-DISULFIDE
OXIDOREDUCTASE RESA

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		4 TYR A  83
GLN A  87
MET A 169
ILE A 165
 None
 1.31A 3pmzD-3c73A:
undetectable		 3pmzD-3c73A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 GLN A  54
MET A 114
ILE A  53
SER A 283
 GOL  A 441 ( 3.7A)
None
IMD  A 437 ( 4.4A)
None
 1.16A 3pmzD-3cc1A:
undetectable		 3pmzD-3cc1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cii NATURAL KILLER CELLS
ANTIGEN CD94

(Homo sapiens) 		PF00059
(Lectin_C) 		4 TYR G 115
ILE G 173
SER G 110
SER G 111
 None
 1.21A 3pmzD-3ciiG:
undetectable		 3pmzD-3ciiG:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		4 TYR A 180
GLN A 181
SER A 189
SER A 190
 None
 1.22A 3pmzD-3e15A:
undetectable		 3pmzD-3e15A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		4 TYR T 668
MET T 709
ILE T 715
SER T 605
 None
 1.30A 3pmzD-3icqT:
undetectable		 3pmzD-3icqT:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		4 TYR A 120
ILE A 130
SER A 179
SER A 180
 None
 1.11A 3pmzD-3n6nA:
undetectable		 3pmzD-3n6nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		4 TYR A 120
MET A 112
ILE A 117
SER A 169
 None
 1.22A 3pmzD-3nywA:
undetectable		 3pmzD-3nywA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB HEAVY CHAIN
HIV-1 GP41

(Homo sapiens;
Human
immunodeficiency
virus 1) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		4 TYR A 643
GLN A 650
ILE A 646
SER H 100
 None
 1.00A 3pmzD-3p30A:
undetectable		 3pmzD-3p30A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5u ACTINIDIN

(Actinidia
arguta) 		PF00112
(Peptidase_C1) 		4 TYR A 113
ILE A  78
SER A 134
SER A 213
 None
 1.11A 3pmzD-3p5uA:
undetectable		 3pmzD-3p5uA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		4 MET A 159
ILE A 216
SER A  40
SER A 137
 None
 1.18A 3pmzD-3p7nA:
undetectable		 3pmzD-3p7nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnv HELPER COMPONENT
PROTEINASE

(Turnip mosaic
virus) 		PF00851
(Peptidase_C6) 		4 TYR A 455
ILE A 416
SER A 450
SER A 451
 None
 0.96A 3pmzD-3rnvA:
undetectable		 3pmzD-3rnvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 TYR A 307
GLN A 304
ILE A 308
SER A 481
 None
FRU  A 902 (-4.0A)
None
None
 1.12A 3pmzD-3s29A:
undetectable		 3pmzD-3s29A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 TYR A 256
ILE A 265
SER A 298
SER A 362
 None
 1.25A 3pmzD-3to3A:
undetectable		 3pmzD-3to3A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 TYR A 145
ILE A 100
SER A 135
SER A 132
 None
 1.34A 3pmzD-3vtzA:
undetectable		 3pmzD-3vtzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 TYR A 343
GLN A 280
ILE A 342
SER A 316
 None
 1.14A 3pmzD-3wvrA:
undetectable		 3pmzD-3wvrA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6s 3-DEHYDROQUINATE
DEHYDRATASE

(Helicobacter
pylori) 		PF01220
(DHquinase_II) 		4 TYR A  70
MET A 141
ILE A   3
SER A  68
 None
 1.26A 3pmzD-4b6sA:
undetectable		 3pmzD-4b6sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 MET A 424
ILE A 437
SER A 480
SER A 479
 None
 1.24A 3pmzD-4c1sA:
undetectable		 3pmzD-4c1sA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 TYR A 433
MET A 404
ILE A 432
SER A 445
 None
 1.17A 3pmzD-4cvuA:
undetectable		 3pmzD-4cvuA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7q RALF,
PROLINE/BETAINE
TRANSPORTER

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 GLN A 296
ILE A 294
SER A  64
SER A  63
 GOL  A1349 (-3.4A)
None
GOL  A1350 (-2.7A)
None
 1.33A 3pmzD-4d7qA:
undetectable		 3pmzD-4d7qA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae) 		PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr) 		4 TYR A 303
GLN A 475
MET A 478
ILE A 474
 None
 1.20A 3pmzD-4de8A:
undetectable		 3pmzD-4de8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqk BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 TYR A 695
ILE A 882
SER A 833
SER A 834
 None
 1.11A 3pmzD-4dqkA:
undetectable		 3pmzD-4dqkA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2l FERRIC ENTEROBACTIN
(ENTEROCHELIN)
TRANSPORT

(Escherichia
coli) 		no annotation 4 TYR A 194
ILE A 195
SER A 124
SER A 123
 None
 1.15A 3pmzD-4e2lA:
undetectable		 3pmzD-4e2lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		4 TYR A  54
ILE A 305
SER A  78
SER A  49
 ACT  A 411 ( 4.3A)
SO4  A 406 (-4.8A)
None
None
 1.02A 3pmzD-4i1dA:
undetectable		 3pmzD-4i1dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLN A 583
MET A 630
SER A 384
SER A 383
 None
 1.34A 3pmzD-4j0mA:
undetectable		 3pmzD-4j0mA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2h SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 TYR A 159
ILE A 114
SER A 149
SER A 146
 1PE  A 307 (-3.6A)
None
None
EDO  A 303 (-2.7A)
 1.23A 3pmzD-4j2hA:
undetectable		 3pmzD-4j2hA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE

(Campylobacter
jejuni) 		PF00551
(Formyl_trans_N) 		4 GLN A 139
ILE A 136
SER A 188
SER A 187
 None
 1.34A 3pmzD-4lxyA:
undetectable		 3pmzD-4lxyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLN A 269
MET A 299
SER A  45
SER A  46
 XYL  A 401 (-3.1A)
None
XYL  A 401 ( 4.8A)
CL  A 418 ( 4.3A)
 1.06A 3pmzD-4rs3A:
undetectable		 3pmzD-4rs3A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		4 GLN A 269
MET A 299
SER A  45
SER A  46
 3VB  A 401 (-3.1A)
None
3VB  A 401 ( 4.7A)
None
 1.04A 3pmzD-4rsmA:
undetectable		 3pmzD-4rsmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u65 TWO COMPONENT
HISTIDINE KINASE,
GGDEF DOMAIN
PROTEIN/EAL DOMAIN
PROTEIN

(Legionella
pneumophila) 		PF16448
(LapD_MoxY_N) 		4 TYR A 142
MET A  27
ILE A 111
SER A 101
 None
 1.16A 3pmzD-4u65A:
undetectable		 3pmzD-4u65A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		4 GLN A 444
ILE A 445
SER A 370
SER A 236
 GOL  A 507 ( 3.9A)
None
HIS  A 502 ( 4.1A)
None
 1.13A 3pmzD-4xkqA:
undetectable		 3pmzD-4xkqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 TYR A 374
GLN A 375
SER A 367
SER A 309
 None
 1.14A 3pmzD-4xwlA:
undetectable		 3pmzD-4xwlA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 GLN A 401
MET A 279
ILE A 398
SER A 350
 None
 1.14A 3pmzD-4y7iA:
undetectable		 3pmzD-4y7iA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9d PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		4 MET A 113
ILE A  91
SER A  40
SER A  48
 None
 1.29A 3pmzD-4z9dA:
undetectable		 3pmzD-4z9dA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 TYR A  55
GLN A  57
MET A 116
ILE A 118
SER A 167
 None
 1.02A 3pmzD-4zjsA:
29.3		 3pmzD-4zjsA:
81.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		4 TYR A 120
ILE A 130
SER A 179
SER A 180
 None
 1.36A 3pmzD-4zpdA:
undetectable		 3pmzD-4zpdA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		4 TYR A 211
GLN A 210
MET A 255
ILE A 212
 None
 1.35A 3pmzD-5b2dA:
undetectable		 3pmzD-5b2dA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLN A 503
MET A 380
ILE A 500
SER A 450
 None
 1.20A 3pmzD-5c16A:
undetectable		 3pmzD-5c16A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 GLN A 485
MET A 520
ILE A 488
SER A 880
 None
 1.33A 3pmzD-5chcA:
undetectable		 3pmzD-5chcA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLN A 191
MET A 195
ILE A 317
SER A 376
 None
 1.13A 3pmzD-5cniA:
undetectable		 3pmzD-5cniA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyl FIMBRIAL SUBUNIT
CUPB6

(Pseudomonas
aeruginosa) 		PF00419
(Fimbrial) 		4 TYR A 122
GLN A 124
ILE A  86
SER A 120
 None
 1.26A 3pmzD-5cylA:
undetectable		 3pmzD-5cylA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 GLN A 365
ILE A 362
SER A 153
SER A 152
 None
 1.17A 3pmzD-5d01A:
undetectable		 3pmzD-5d01A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 TYR A 291
ILE A 290
SER A 299
SER A 300
 None
 0.94A 3pmzD-5f4zA:
undetectable		 3pmzD-5f4zA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 TYR A 189
ILE A 566
SER A 204
SER A 198
 None
 1.36A 3pmzD-5favA:
undetectable		 3pmzD-5favA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 TYR A  73
MET A  85
ILE A  81
SER A  71
 None
 1.03A 3pmzD-5fyaA:
undetectable		 3pmzD-5fyaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-MBP
REPEBODY

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 GLN H 222
MET H 136
ILE H 134
SER B 123
 None
 1.27A 3pmzD-5gs2H:
undetectable		 3pmzD-5gs2H:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-MBP
REPEBODY

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 GLN H 222
MET H 136
ILE H 134
SER B 123
 None
 1.27A 3pmzD-5gs2H:
undetectable		 3pmzD-5gs2H:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 TYR A  37
GLN A  58
SER A  44
SER A  41
 None
 1.23A 3pmzD-5i84A:
undetectable		 3pmzD-5i84A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8

(Clostridioides
difficile) 		PF04122
(CW_binding_2) 		4 TYR A 522
ILE A 580
SER A 547
SER A 548
 SO4  A 707 (-3.9A)
None
None
SO4  A 707 ( 4.6A)
 0.97A 3pmzD-5j6qA:
undetectable		 3pmzD-5j6qA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		4 GLN A   2
ILE A   4
SER A 126
SER A 124
 None
 1.13A 3pmzD-5k1zA:
undetectable		 3pmzD-5k1zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 TYR A 831
GLN A 720
ILE A 764
SER A 778
 None
 1.19A 3pmzD-5ksdA:
undetectable		 3pmzD-5ksdA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF06444
(NADH_dehy_S2_C) 		4 GLN N 134
ILE N  40
SER N  67
SER N  64
 None
 1.16A 3pmzD-5lc5N:
undetectable		 3pmzD-5lc5N:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcn UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF12146
(Hydrolase_4) 		4 TYR A  84
GLN A 269
ILE A 268
SER A  77
 None
 1.28A 3pmzD-5lcnA:
undetectable		 3pmzD-5lcnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzk PROTEIN FAM83B

(Homo sapiens) 		PF07894
(DUF1669) 		4 TYR A 244
MET A 142
ILE A 139
SER A 256
 None
None
EDO  A 307 ( 4.9A)
None
 1.27A 3pmzD-5lzkA:
undetectable		 3pmzD-5lzkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mev FAB HEAVY CHAIN
INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens;
Mus musculus) 		PF00452
(Bcl-2)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLN A 177
ILE A 181
SER H  52
SER H  53
 None
 1.09A 3pmzD-5mevA:
undetectable		 3pmzD-5mevA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECD
PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG)
PF13721
(SecD-TM1) 		4 GLN D 452
ILE D 441
SER F  90
SER F  91
 None
 1.30A 3pmzD-5mg3D:
undetectable		 3pmzD-5mg3D:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Bos taurus;
Mus musculus) 		PF00654
(Voltage_CLC)
PF07686
(V-set) 		4 GLN L  90
MET L   4
ILE L   2
SER A 366
 None
 1.33A 3pmzD-5tr1L:
undetectable		 3pmzD-5tr1L:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucy TUBULIN ALPHA CHAIN

(Tetrahymena
thermophila) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 TYR A 272
ILE A 275
SER A 236
SER A 237
 None
 1.00A 3pmzD-5ucyA:
undetectable		 3pmzD-5ucyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 TYR A 158
ILE A 109
SER A 148
SER A 145
 ACT  A 302 ( 4.2A)
None
None
ACT  A 302 ( 2.6A)
 1.27A 3pmzD-5vn2A:
undetectable		 3pmzD-5vn2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn2 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 TYR A 158
ILE A 109
SER A 148
SER A 147
 ACT  A 302 ( 4.2A)
None
None
ACT  A 302 (-3.3A)
 1.28A 3pmzD-5vn2A:
undetectable		 3pmzD-5vn2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 4 TYR A 477
MET A 245
ILE A 481
SER A 946
 None
A  B  -5 ( 3.5A)
None
None
 1.34A 3pmzD-5wlhA:
undetectable		 3pmzD-5wlhA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		no annotation 4 GLN A 110
ILE A 115
SER A  72
SER A  75
 None
 1.23A 3pmzD-5xf7A:
undetectable		 3pmzD-5xf7A:
15.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 GLN A  55
MET A 114
ILE A 116
SER A 164
 None
 1.04A 3pmzD-5xglA:
30.9		 3pmzD-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 6 TYR A  53
GLN A  55
MET A 114
ILE A 116
SER A 164
SER A 165
 None
 0.83A 3pmzD-5xglA:
30.9		 3pmzD-5xglA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE
SUBUNIT ABC10-ALPHA
SPT4/5 COMPLEX
COMPONENT

(Komagataella
phaffii) 		PF00467
(KOW)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF03604
(DNA_RNApol_7kD) 		4 GLN L  68
MET L  66
ILE W 767
SER C  82
 None
 0.93A 3pmzD-5xogL:
undetectable		 3pmzD-5xogL:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE

(Pseudomonas sp.
MC1) 		PF13561
(adh_short_C2) 		4 TYR B 153
ILE B 109
SER B 143
SER B 140
 NAD  B 301 (-4.7A)
None
None
NAD  B 301 (-2.1A)
 1.26A 3pmzD-5xtgB:
undetectable		 3pmzD-5xtgB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1
ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 GLN B 226
MET A 535
ILE B 222
SER B 233
 None
 1.28A 3pmzD-5y58B:
undetectable		 3pmzD-5y58B:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 4 GLN A 187
MET A 181
ILE A 177
SER A 167
 None
 1.12A 3pmzD-5yhiA:
undetectable		 3pmzD-5yhiA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 TYR A1187
GLN A 335
ILE A 178
SER A1190
 None
 1.19A 3pmzD-6apxA:
undetectable		 3pmzD-6apxA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 4 TYR L  90
GLN L   6
ILE L  21
SER L  88
 None
 1.30A 3pmzD-6aq7L:
undetectable		 3pmzD-6aq7L:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 4 TYR C 180
ILE C 513
SER C 188
SER C 189
 None
 1.18A 3pmzD-6c08C:
undetectable		 3pmzD-6c08C:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 TYR A 362
GLN A 366
ILE A 390
SER A 492
 None
 1.32A 3pmzD-6ei1A:
undetectable		 3pmzD-6ei1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flx ABC TRANSPORTER
SYSTEM, ATP-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		no annotation 4 MET A  98
ILE A  95
SER A  30
SER A  31
 None
 1.36A 3pmzD-6flxA:
undetectable		 3pmzD-6flxA:
18.42