SIMILAR PATTERNS OF AMINO ACIDS FOR 3PMZ_E_TUBE220
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ax8 | OBESITY PROTEIN (Homo sapiens) |
PF02024(Leptin) | 4 | TYR A 61MET A 68ILE A 64SER A 132 | None | 1.18A | 3pmzD-1ax8A:undetectable | 3pmzD-1ax8A:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b5f | PROTEIN (CARDOSIN A) (Cynaracardunculus) |
PF00026(Asp) | 4 | TYR A 75ILE A 80SER A 36SER A 35 | None | 1.29A | 3pmzD-1b5fA:0.0 | 3pmzD-1b5fA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8u | PROTEIN (MALATEDEHYDROGENASE) (Aquaspirillumarcticum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | TYR A 275GLN A 307ILE A 302SER A 271 | None | 1.26A | 3pmzD-1b8uA:0.0 | 3pmzD-1b8uA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b9o | PROTEIN(ALPHA-LACTALBUMIN) (Homo sapiens) |
PF00062(Lys) | 4 | TYR A 50ILE A 41SER A 64SER A 63 | None | 1.16A | 3pmzD-1b9oA:0.0 | 3pmzD-1b9oA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dql | IGM MEZIMMUNOGLOBULIN (Homo sapiens) |
PF07686(V-set) | 4 | GLN L 90MET L 4ILE L 29SER H 105 | None | 1.34A | 3pmzD-1dqlL:1.3 | 3pmzD-1dqlL:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1goj | KINESIN HEAVY CHAIN (Neurosporacrassa) |
PF00225(Kinesin) | 4 | TYR A 132ILE A 216SER A 125SER A 126 | None | 0.95A | 3pmzD-1gojA:0.0 | 3pmzD-1gojA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h7c | TUBULIN-SPECIFICCHAPERONE A (Homo sapiens) |
PF02970(TBCA) | 4 | GLN A 53MET A 40ILE A 37SER A 60 | None | 1.33A | 3pmzD-1h7cA:undetectable | 3pmzD-1h7cA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hml | ALPHA-LACTALBUMIN (Homo sapiens) |
PF00062(Lys) | 4 | TYR A 50ILE A 41SER A 64SER A 63 | None | 1.30A | 3pmzD-1hmlA:undetectable | 3pmzD-1hmlA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ou0 | PRECORRIN-8XMETHYLMUTASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF02570(CbiC) | 4 | TYR A 98MET A 107ILE A 122SER A 130 | None | 1.35A | 3pmzD-1ou0A:0.0 | 3pmzD-1ou0A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q44 | STEROIDSULFOTRANSFERASE (Arabidopsisthaliana) |
PF00685(Sulfotransfer_1) | 4 | TYR A 39GLN A 52ILE A 24SER A 36 | None | 1.29A | 3pmzD-1q44A:undetectable | 3pmzD-1q44A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | GLN B 333ILE B 367SER B 357SER B 319 | None | 1.27A | 3pmzD-1t3qB:undetectable | 3pmzD-1t3qB:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tki | TITIN (Homo sapiens) |
PF00069(Pkinase) | 4 | TYR A 50ILE A 96SER A 45SER A 46 | None | 0.93A | 3pmzD-1tkiA:undetectable | 3pmzD-1tkiA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vf8 | SECRETORY PROTEIN (Mus musculus) |
PF00704(Glyco_hydro_18) | 4 | GLN A 187MET A 4ILE A 240SER A 180 | None | 0.90A | 3pmzD-1vf8A:undetectable | 3pmzD-1vf8A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wlt | 176AA LONGHYPOTHETICALDTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Sulfurisphaeratokodaii) |
PF00908(dTDP_sugar_isom) | 4 | TYR A 130GLN A 46ILE A 132SER A 50 | None | 1.16A | 3pmzD-1wltA:undetectable | 3pmzD-1wltA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7z | HUMAN COXSACKIEVIRUSA21 (Enterovirus C) |
PF00073(Rhv) | 4 | TYR 3 106MET 3 98ILE 3 102SER 1 174 | None | 1.08A | 3pmzD-1z7z3:undetectable | 3pmzD-1z7z3:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 4 | TYR A 220GLN A 219MET A 58ILE A 216 | None | 1.31A | 3pmzD-2aniA:undetectable | 3pmzD-2aniA:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b9u | HYPOTHETICALDTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (Sulfurisphaeratokodaii) |
PF00908(dTDP_sugar_isom) | 4 | TYR A 130GLN A 46ILE A 132SER A 50 | None | 1.16A | 3pmzD-2b9uA:undetectable | 3pmzD-2b9uA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsj | PROTEIN PPL-2 (Parkiaplatycephala) |
PF00704(Glyco_hydro_18) | 4 | TYR A 25GLN A 26ILE A 72SER A 264 | None | 1.26A | 3pmzD-2gsjA:undetectable | 3pmzD-2gsjA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igs | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF11508(DUF3218) | 4 | TYR A 7GLN A 8ILE A 56SER A 13 | NoneNoneNoneSO4 A2006 ( 3.8A) | 1.08A | 3pmzD-2igsA:undetectable | 3pmzD-2igsA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 4 | TYR 1 303ILE 1 313SER 1 362SER 1 363 | None | 1.07A | 3pmzD-2ijd1:undetectable | 3pmzD-2ijd1:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jif | SHORT/BRANCHED CHAINSPECIFIC ACYL-COADEHYDROGENASE (Homo sapiens) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | GLN A 300ILE A 297SER A 210SER A 209 | NoneNone CL A1437 ( 4.6A)FAD A1433 (-2.8A) | 1.34A | 3pmzD-2jifA:undetectable | 3pmzD-2jifA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osy | ENDOGLYCOCERAMIDASEII (Rhodococcus sp.) |
PF00150(Cellulase) | 4 | TYR A 301MET A 375ILE A 347SER A 284 | None | 1.16A | 3pmzD-2osyA:undetectable | 3pmzD-2osyA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rcb | GLUTAMATE [NMDA]RECEPTOR SUBUNIT 3B (Rattusnorvegicus) |
PF10613(Lig_chan-Glu_bd) | 4 | TYR A 182MET A 194ILE A 183SER A 142 | None | 0.97A | 3pmzD-2rcbA:undetectable | 3pmzD-2rcbA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yk6 | CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE (Neisseriameningitidis) |
PF07922(Glyco_transf_52) | 4 | TYR A 302MET A 328ILE A 303SER A 295 | None | 1.26A | 3pmzD-2yk6A:undetectable | 3pmzD-2yk6A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zah | COAT PROTEIN (Melon necroticspot virus) |
PF00729(Viral_coat) | 4 | TYR A 310ILE A 379SER A 330SER A 353 | None | 1.09A | 3pmzD-2zahA:undetectable | 3pmzD-2zahA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zah | COAT PROTEIN (Melon necroticspot virus) |
PF00729(Viral_coat) | 4 | TYR A 310MET A 377ILE A 379SER A 353 | None | 1.02A | 3pmzD-2zahA:undetectable | 3pmzD-2zahA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al8 | SEMAPHORIN-6A (Mus musculus) |
PF01403(Sema)PF01437(PSI) | 4 | TYR A 500GLN A 491ILE A 61SER A 496 | None | 1.22A | 3pmzD-3al8A:undetectable | 3pmzD-3al8A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b6u | KINESIN-LIKE PROTEINKIF3B (Homo sapiens) |
PF00225(Kinesin) | 4 | TYR A 138ILE A 223SER A 131SER A 133 | None | 1.27A | 3pmzD-3b6uA:undetectable | 3pmzD-3b6uA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c73 | THIOL-DISULFIDEOXIDOREDUCTASE RESA (Bacillussubtilis) |
PF00578(AhpC-TSA) | 4 | TYR A 83GLN A 87MET A 169ILE A 165 | None | 1.31A | 3pmzD-3c73A:undetectable | 3pmzD-3c73A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc1 | PUTATIVEALPHA-N-ACETYLGALACTOSAMINIDASE (Bacillushalodurans) |
PF16499(Melibiase_2) | 4 | GLN A 54MET A 114ILE A 53SER A 283 | GOL A 441 ( 3.7A)NoneIMD A 437 ( 4.4A)None | 1.16A | 3pmzD-3cc1A:undetectable | 3pmzD-3cc1A:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cii | NATURAL KILLER CELLSANTIGEN CD94 (Homo sapiens) |
PF00059(Lectin_C) | 4 | TYR G 115ILE G 173SER G 110SER G 111 | None | 1.21A | 3pmzD-3ciiG:undetectable | 3pmzD-3ciiG:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e15 | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Plasmodiumvivax) |
PF01182(Glucosamine_iso) | 4 | TYR A 180GLN A 181SER A 189SER A 190 | None | 1.22A | 3pmzD-3e15A:undetectable | 3pmzD-3e15A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icq | EXPORTIN-T (Schizosaccharomycespombe) |
PF08389(Xpo1) | 4 | TYR T 668MET T 709ILE T 715SER T 605 | None | 1.30A | 3pmzD-3icqT:undetectable | 3pmzD-3icqT:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6n | RNA-DEPENDENT RNAPOLYMERASE (Enterovirus A) |
PF00680(RdRP_1) | 4 | TYR A 120ILE A 130SER A 179SER A 180 | None | 1.11A | 3pmzD-3n6nA:undetectable | 3pmzD-3n6nA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyw | PUTATIVEOXIDOREDUCTASE (Bacteroidesthetaiotaomicron) |
PF00106(adh_short) | 4 | TYR A 120MET A 112ILE A 117SER A 169 | None | 1.22A | 3pmzD-3nywA:undetectable | 3pmzD-3nywA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p30 | 1281 FAB HEAVY CHAINHIV-1 GP41 (Homo sapiens;Humanimmunodeficiencyvirus 1) |
PF07654(C1-set)PF07686(V-set)no annotation | 4 | TYR A 643GLN A 650ILE A 646SER H 100 | None | 1.00A | 3pmzD-3p30A:undetectable | 3pmzD-3p30A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5u | ACTINIDIN (Actinidiaarguta) |
PF00112(Peptidase_C1) | 4 | TYR A 113ILE A 78SER A 134SER A 213 | None | 1.11A | 3pmzD-3p5uA:undetectable | 3pmzD-3p5uA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p7n | SENSOR HISTIDINEKINASE (Erythrobacterlitoralis) |
PF00196(GerE)PF13426(PAS_9) | 4 | MET A 159ILE A 216SER A 40SER A 137 | None | 1.18A | 3pmzD-3p7nA:undetectable | 3pmzD-3p7nA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rnv | HELPER COMPONENTPROTEINASE (Turnip mosaicvirus) |
PF00851(Peptidase_C6) | 4 | TYR A 455ILE A 416SER A 450SER A 451 | None | 0.96A | 3pmzD-3rnvA:undetectable | 3pmzD-3rnvA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 4 | TYR A 307GLN A 304ILE A 308SER A 481 | NoneFRU A 902 (-4.0A)NoneNone | 1.12A | 3pmzD-3s29A:undetectable | 3pmzD-3s29A:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 4 | TYR A 256ILE A 265SER A 298SER A 362 | None | 1.25A | 3pmzD-3to3A:undetectable | 3pmzD-3to3A:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtz | GLUCOSE1-DEHYDROGENASE (Thermoplasmavolcanium) |
PF13561(adh_short_C2) | 4 | TYR A 145ILE A 100SER A 135SER A 132 | None | 1.34A | 3pmzD-3vtzA:undetectable | 3pmzD-3vtzA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvr | PGM1 (Streptomycescirratus) |
no annotation | 4 | TYR A 343GLN A 280ILE A 342SER A 316 | None | 1.14A | 3pmzD-3wvrA:undetectable | 3pmzD-3wvrA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b6s | 3-DEHYDROQUINATEDEHYDRATASE (Helicobacterpylori) |
PF01220(DHquinase_II) | 4 | TYR A 70MET A 141ILE A 3SER A 68 | None | 1.26A | 3pmzD-4b6sA:undetectable | 3pmzD-4b6sA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1s | GLYCOSIDE HYDROLASEFAMILY 76MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF03663(Glyco_hydro_76) | 4 | MET A 424ILE A 437SER A 480SER A 479 | None | 1.24A | 3pmzD-4c1sA:undetectable | 3pmzD-4c1sA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvu | BETA-MANNOSIDASE (Trichodermaharzianum) |
PF00703(Glyco_hydro_2) | 4 | TYR A 433MET A 404ILE A 432SER A 445 | None | 1.17A | 3pmzD-4cvuA:undetectable | 3pmzD-4cvuA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7q | RALF,PROLINE/BETAINETRANSPORTER (Legionellapneumophila;Rickettsiaprowazekii) |
PF01369(Sec7) | 4 | GLN A 296ILE A 294SER A 64SER A 63 | GOL A1349 (-3.4A)NoneGOL A1350 (-2.7A)None | 1.33A | 3pmzD-4d7qA:undetectable | 3pmzD-4d7qA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de8 | CPS2A (Streptococcuspneumoniae) |
PF02916(DNA_PPF)PF03816(LytR_cpsA_psr) | 4 | TYR A 303GLN A 475MET A 478ILE A 474 | None | 1.20A | 3pmzD-4de8A:undetectable | 3pmzD-4de8A:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqk | BIFUNCTIONALP-450/NADPH-P450REDUCTASE (Bacillusmegaterium) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | TYR A 695ILE A 882SER A 833SER A 834 | None | 1.11A | 3pmzD-4dqkA:undetectable | 3pmzD-4dqkA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e2l | FERRIC ENTEROBACTIN(ENTEROCHELIN)TRANSPORT (Escherichiacoli) |
no annotation | 4 | TYR A 194ILE A 195SER A 124SER A 123 | None | 1.15A | 3pmzD-4e2lA:undetectable | 3pmzD-4e2lA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1d | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Bradyrhizobiumdiazoefficiens) |
PF13416(SBP_bac_8) | 4 | TYR A 54ILE A 305SER A 78SER A 49 | ACT A 411 ( 4.3A)SO4 A 406 (-4.8A)NoneNone | 1.02A | 3pmzD-4i1dA:undetectable | 3pmzD-4i1dA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0m | SERINE/THREONINE-PROTEIN KINASEBRI1-LIKE 1 (Arabidopsisthaliana) |
PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 4 | GLN A 583MET A 630SER A 384SER A 383 | None | 1.34A | 3pmzD-4j0mA:undetectable | 3pmzD-4j0mA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j2h | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 4 | TYR A 159ILE A 114SER A 149SER A 146 | 1PE A 307 (-3.6A)NoneNoneEDO A 303 (-2.7A) | 1.23A | 3pmzD-4j2hA:undetectable | 3pmzD-4j2hA:17.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lxy | WLARD, A SUGAR3N-FORMYLTRANSFERASE (Campylobacterjejuni) |
PF00551(Formyl_trans_N) | 4 | GLN A 139ILE A 136SER A 188SER A 187 | None | 1.34A | 3pmzD-4lxyA:undetectable | 3pmzD-4lxyA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rs3 | ABC TRANSPORTER,CARBOHYDRATE UPTAKETRANSPORTER-2 (CUT2)FAMILY, PERIPLASMICSUGAR-BINDINGPROTEIN (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 4 | GLN A 269MET A 299SER A 45SER A 46 | XYL A 401 (-3.1A)NoneXYL A 401 ( 4.8A) CL A 418 ( 4.3A) | 1.06A | 3pmzD-4rs3A:undetectable | 3pmzD-4rs3A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsm | PERIPLASMIC BINDINGPROTEIN/LACITRANSCRIPTIONALREGULATOR (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 4 | GLN A 269MET A 299SER A 45SER A 46 | 3VB A 401 (-3.1A)None3VB A 401 ( 4.7A)None | 1.04A | 3pmzD-4rsmA:undetectable | 3pmzD-4rsmA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u65 | TWO COMPONENTHISTIDINE KINASE,GGDEF DOMAINPROTEIN/EAL DOMAINPROTEIN (Legionellapneumophila) |
PF16448(LapD_MoxY_N) | 4 | TYR A 142MET A 27ILE A 111SER A 101 | None | 1.16A | 3pmzD-4u65A:undetectable | 3pmzD-4u65A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkq | NICKEL ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Staphylococcusaureus) |
PF00496(SBP_bac_5) | 4 | GLN A 444ILE A 445SER A 370SER A 236 | GOL A 507 ( 3.9A)NoneHIS A 502 ( 4.1A)None | 1.13A | 3pmzD-4xkqA:undetectable | 3pmzD-4xkqA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwl | EXOGLUCANASE S (Clostridiumcellulovorans) |
PF02011(Glyco_hydro_48) | 4 | TYR A 374GLN A 375SER A 367SER A 309 | None | 1.14A | 3pmzD-4xwlA:undetectable | 3pmzD-4xwlA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y7i | MYOTUBULARIN-RELATEDPROTEIN 8 (Homo sapiens) |
PF06602(Myotub-related) | 4 | GLN A 401MET A 279ILE A 398SER A 350 | None | 1.14A | 3pmzD-4y7iA:undetectable | 3pmzD-4y7iA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9d | PERTUSSIS TOXIN-LIKESUBUNIT ARTA (Escherichiacoli) |
PF02917(Pertussis_S1) | 4 | MET A 113ILE A 91SER A 40SER A 48 | None | 1.29A | 3pmzD-4z9dA:undetectable | 3pmzD-4z9dA:20.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zjs | ACETYLCHOLINERECEPTOR SUBUNITALPHA,SOLUBLEACETYLCHOLINERECEPTOR,ACETYLCHOLINE RECEPTOR SUBUNITALPHA,SOLUBLEACETYLCHOLINERECEPTOR (Aplysiacalifornica;Homo sapiens) |
PF02931(Neur_chan_LBD) | 5 | TYR A 55GLN A 57MET A 116ILE A 118SER A 167 | None | 1.02A | 3pmzD-4zjsA:29.3 | 3pmzD-4zjsA:81.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpd | RNA-DIRECTED RNAPOLYMERASE (Enterovirus B) |
PF00680(RdRP_1) | 4 | TYR A 120ILE A 130SER A 179SER A 180 | None | 1.36A | 3pmzD-4zpdA:undetectable | 3pmzD-4zpdA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2d | HN PROTEIN (Mumpsrubulavirus) |
PF00423(HN) | 4 | TYR A 211GLN A 210MET A 255ILE A 212 | None | 1.35A | 3pmzD-5b2dA:undetectable | 3pmzD-5b2dA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c16 | MYOTUBULARIN-RELATEDPROTEIN 1 (Homo sapiens) |
PF02893(GRAM)PF06602(Myotub-related) | 4 | GLN A 503MET A 380ILE A 500SER A 450 | None | 1.20A | 3pmzD-5c16A:undetectable | 3pmzD-5c16A:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | GLN A 485MET A 520ILE A 488SER A 880 | None | 1.33A | 3pmzD-5chcA:undetectable | 3pmzD-5chcA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cni | METABOTROPICGLUTAMATE RECEPTOR 2 (Homo sapiens) |
PF01094(ANF_receptor) | 4 | GLN A 191MET A 195ILE A 317SER A 376 | None | 1.13A | 3pmzD-5cniA:undetectable | 3pmzD-5cniA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyl | FIMBRIAL SUBUNITCUPB6 (Pseudomonasaeruginosa) |
PF00419(Fimbrial) | 4 | TYR A 122GLN A 124ILE A 86SER A 120 | None | 1.26A | 3pmzD-5cylA:undetectable | 3pmzD-5cylA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d01 | N-ACETYL-ALPHA-D-GLUCOSAMINYL L-MALATESYNTHASE (Bacillussubtilis) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 4 | GLN A 365ILE A 362SER A 153SER A 152 | None | 1.17A | 3pmzD-5d01A:undetectable | 3pmzD-5d01A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f4z | EPOXIDE HYDROLASE (Streptomycescarzinostaticus) |
PF06441(EHN) | 4 | TYR A 291ILE A 290SER A 299SER A 300 | None | 0.94A | 3pmzD-5f4zA:undetectable | 3pmzD-5f4zA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fav | CHOLINETRIMETHYLAMINE-LYASE (Desulfovibrioalaskensis) |
PF01228(Gly_radical)PF02901(PFL-like) | 4 | TYR A 189ILE A 566SER A 204SER A 198 | None | 1.36A | 3pmzD-5favA:undetectable | 3pmzD-5favA:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 4 | TYR A 73MET A 85ILE A 81SER A 71 | None | 1.03A | 3pmzD-5fyaA:undetectable | 3pmzD-5fyaA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs2 | ANTI-MBPREPEBODY (Escherichiacoli;Homo sapiens) |
PF07686(V-set)PF11921(DUF3439)PF12354(Internalin_N)PF13855(LRR_8) | 4 | GLN H 222MET H 136ILE H 134SER B 123 | None | 1.27A | 3pmzD-5gs2H:undetectable | 3pmzD-5gs2H:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gs2 | ANTI-MBPREPEBODY (Escherichiacoli;Homo sapiens) |
PF07686(V-set)PF11921(DUF3439)PF12354(Internalin_N)PF13855(LRR_8) | 4 | GLN H 222MET H 136ILE H 134SER B 123 | None | 1.27A | 3pmzD-5gs2H:undetectable | 3pmzD-5gs2H:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i84 | PHOSPHATE-BINDINGPROTEIN PSTS (Xanthomonascitri) |
PF12849(PBP_like_2) | 4 | TYR A 37GLN A 58SER A 44SER A 41 | None | 1.23A | 3pmzD-5i84A:undetectable | 3pmzD-5i84A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6q | CELL WALL BINDINGPROTEIN CWP8 (Clostridioidesdifficile) |
PF04122(CW_binding_2) | 4 | TYR A 522ILE A 580SER A 547SER A 548 | SO4 A 707 (-3.9A)NoneNoneSO4 A 707 ( 4.6A) | 0.97A | 3pmzD-5j6qA:undetectable | 3pmzD-5j6qA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1z | AMINODEOXYFUTALOSINENUCLEOSIDASE (Helicobacterpylori) |
PF01048(PNP_UDP_1) | 4 | GLN A 2ILE A 4SER A 126SER A 124 | None | 1.13A | 3pmzD-5k1zA:undetectable | 3pmzD-5k1zA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ksd | ATPASE 2, PLASMAMEMBRANE-TYPE (Arabidopsisthaliana) |
PF00122(E1-E2_ATPase)PF00690(Cation_ATPase_N)PF00702(Hydrolase) | 4 | TYR A 831GLN A 720ILE A 764SER A 778 | None | 1.19A | 3pmzD-5ksdA:undetectable | 3pmzD-5ksdA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN2 (Bos taurus) |
PF00361(Proton_antipo_M)PF06444(NADH_dehy_S2_C) | 4 | GLN N 134ILE N 40SER N 67SER N 64 | None | 1.16A | 3pmzD-5lc5N:undetectable | 3pmzD-5lc5N:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcn | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF12146(Hydrolase_4) | 4 | TYR A 84GLN A 269ILE A 268SER A 77 | None | 1.28A | 3pmzD-5lcnA:undetectable | 3pmzD-5lcnA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lzk | PROTEIN FAM83B (Homo sapiens) |
PF07894(DUF1669) | 4 | TYR A 244MET A 142ILE A 139SER A 256 | NoneNoneEDO A 307 ( 4.9A)None | 1.27A | 3pmzD-5lzkA:undetectable | 3pmzD-5lzkA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mev | FAB HEAVY CHAININDUCED MYELOIDLEUKEMIA CELLDIFFERENTIATIONPROTEIN MCL-1HOMOLOG,INDUCEDMYELOID LEUKEMIACELL DIFFERENTIATIONPROTEIN MCL-1 (Homo sapiens;Mus musculus) |
PF00452(Bcl-2)PF07654(C1-set)PF07686(V-set) | 4 | GLN A 177ILE A 181SER H 52SER H 53 | None | 1.09A | 3pmzD-5mevA:undetectable | 3pmzD-5mevA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg3 | PROTEIN TRANSLOCASESUBUNIT SECDPROTEIN TRANSLOCASESUBUNIT SECF (Escherichiacoli) |
PF02355(SecD_SecF)PF07549(Sec_GG)PF13721(SecD-TM1) | 4 | GLN D 452ILE D 441SER F 90SER F 91 | None | 1.30A | 3pmzD-5mg3D:undetectable | 3pmzD-5mg3D:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEINMONOCLONAL ANTIBODY,FAB FRAGMENT, LIGHTCHAIN (Bos taurus;Mus musculus) |
PF00654(Voltage_CLC)PF07686(V-set) | 4 | GLN L 90MET L 4ILE L 2SER A 366 | None | 1.33A | 3pmzD-5tr1L:undetectable | 3pmzD-5tr1L:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 4 | TYR A 272ILE A 275SER A 236SER A 237 | None | 1.00A | 3pmzD-5ucyA:undetectable | 3pmzD-5ucyA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vn2 | 3-OXOACYL-(ACYL-CARRIER PROTEIN)REDUCTASE (Brucellamelitensis) |
PF13561(adh_short_C2) | 4 | TYR A 158ILE A 109SER A 148SER A 145 | ACT A 302 ( 4.2A)NoneNoneACT A 302 ( 2.6A) | 1.27A | 3pmzD-5vn2A:undetectable | 3pmzD-5vn2A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vn2 | 3-OXOACYL-(ACYL-CARRIER PROTEIN)REDUCTASE (Brucellamelitensis) |
PF13561(adh_short_C2) | 4 | TYR A 158ILE A 109SER A 148SER A 147 | ACT A 302 ( 4.2A)NoneNoneACT A 302 (-3.3A) | 1.28A | 3pmzD-5vn2A:undetectable | 3pmzD-5vn2A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wlh | LBACAS13A H328A(C2C2) (LachnospiraceaebacteriumNK4A179) |
no annotation | 4 | TYR A 477MET A 245ILE A 481SER A 946 | None A B -5 ( 3.5A)NoneNone | 1.34A | 3pmzD-5wlhA:undetectable | 3pmzD-5wlhA:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xf7 | PROTEINDISULFIDE-ISOMERASE-LIKE PROTEIN OF THETESTIS (Homo sapiens) |
no annotation | 4 | GLN A 110ILE A 115SER A 72SER A 75 | None | 1.23A | 3pmzD-5xf7A:undetectable | 3pmzD-5xf7A:15.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xgl | SOLUBLEACETYLCHOLINERECEPTOR (Aplysiacalifornica) |
no annotation | 4 | GLN A 55MET A 114ILE A 116SER A 164 | None | 1.04A | 3pmzD-5xglA:30.9 | 3pmzD-5xglA:98.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xgl | SOLUBLEACETYLCHOLINERECEPTOR (Aplysiacalifornica) |
no annotation | 6 | TYR A 53GLN A 55MET A 114ILE A 116SER A 164SER A 165 | None | 0.83A | 3pmzD-5xglA:30.9 | 3pmzD-5xglA:98.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | RNA POLYMERASE IITHIRD LARGESTSUBUNIT B44, PART OFCENTRAL CORERNA POLYMERASESUBUNIT ABC10-ALPHASPT4/5 COMPLEXCOMPONENT (Komagataellaphaffii) |
PF00467(KOW)PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L)PF03604(DNA_RNApol_7kD) | 4 | GLN L 68MET L 66ILE W 767SER C 82 | None | 0.93A | 3pmzD-5xogL:undetectable | 3pmzD-5xogL:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtg | 2,3-DIHYDROXY-2,3-DIHYDROPHENYLPROPIONATE DEHYDROGENASE (Pseudomonas sp.MC1) |
PF13561(adh_short_C2) | 4 | TYR B 153ILE B 109SER B 143SER B 140 | NAD B 301 (-4.7A)NoneNoneNAD B 301 (-2.1A) | 1.26A | 3pmzD-5xtgB:undetectable | 3pmzD-5xtgB:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y58 | ATP-DEPENDENT DNAHELICASE II SUBUNIT1ATP-DEPENDENT DNAHELICASE II SUBUNIT2 (Saccharomycescerevisiae) |
no annotation | 4 | GLN B 226MET A 535ILE B 222SER B 233 | None | 1.28A | 3pmzD-5y58B:undetectable | 3pmzD-5y58B:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yhi | PROTEIN YIIM (Escherichiacoli) |
no annotation | 4 | GLN A 187MET A 181ILE A 177SER A 167 | None | 1.12A | 3pmzD-5yhiA:undetectable | 3pmzD-5yhiA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apx | MALTOSE-BINDINGPERIPLASMICPROTEIN,DUALSPECIFICITY PROTEINPHOSPHATASE 1 (Escherichiacoli;Homo sapiens) |
no annotation | 4 | TYR A1187GLN A 335ILE A 178SER A1190 | None | 1.19A | 3pmzD-6apxA:undetectable | 3pmzD-6apxA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6aq7 | POM6 FAB LIGHT CHAIN (Mus musculus) |
no annotation | 4 | TYR L 90GLN L 6ILE L 21SER L 88 | None | 1.30A | 3pmzD-6aq7L:undetectable | 3pmzD-6aq7L:13.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c08 | SODIUM-COUPLEDNEUTRAL AMINO ACIDTRANSPORTER 9 (Danio rerio) |
no annotation | 4 | TYR C 180ILE C 513SER C 188SER C 189 | None | 1.18A | 3pmzD-6c08C:undetectable | 3pmzD-6c08C:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ei1 | ZINC FINGER WITHUFM1-SPECIFICPEPTIDASE DOMAINPROTEIN (Homo sapiens) |
no annotation | 4 | TYR A 362GLN A 366ILE A 390SER A 492 | None | 1.32A | 3pmzD-6ei1A:undetectable | 3pmzD-6ei1A:15.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6flx | ABC TRANSPORTERSYSTEM, ATP-BINDINGPROTEIN (Burkholderiapseudomallei) |
no annotation | 4 | MET A 98ILE A 95SER A 30SER A 31 | None | 1.36A | 3pmzD-6flxA:undetectable | 3pmzD-6flxA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e73 | LANC-LIKE PROTEIN 1 (Homo sapiens) |
PF05147(LANC_like) | 4 | TYR A 153CYH A 276CYH A 322TYR A 62 | None ZN A 501 (-2.1A) ZN A 501 ( 2.1A)None | 1.45A | 3pmzE-3e73A:undetectable | 3pmzE-3e73A:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t33 | G PROTEIN COUPLEDRECEPTOR (Arabidopsisthaliana) |
PF05147(LANC_like) | 4 | TYR A 167CYH A 283CYH A 328TYR A 76 | None ZN A 411 ( 2.2A) ZN A 411 ( 2.3A)None | 1.48A | 3pmzE-3t33A:undetectable | 3pmzE-3t33A:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wso | F-BOX ONLY PROTEIN44 (Homo sapiens) |
PF04300(FBA)PF12937(F-box-like) | 4 | TYR A 125TRP A 206CYH A 170TYR A 239 | None | 1.29A | 3pmzE-3wsoA:0.0 | 3pmzE-3wsoA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2a | HYPOTHETICAL PROTEIN (Legionellapneumophila) |
PF13308(YARHG)PF14415(DUF4424) | 4 | TRP A 245TYR A 73CYH A 75TYR A 186 | None | 1.37A | 3pmzE-4g2aA:0.0 | 3pmzE-4g2aA:23.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hqp | ALPHA7 NICOTINICRECEPTOR CHIMERA (Homo sapiens;Lymnaeastagnalis) |
PF02931(Neur_chan_LBD) | 4 | TYR A 91LYS A 141TRP A 145TYR A 191 | None | 0.82A | 3pmzE-4hqpA:25.6 | 3pmzE-4hqpA:34.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hqp | ALPHA7 NICOTINICRECEPTOR CHIMERA (Homo sapiens;Lymnaeastagnalis) |
PF02931(Neur_chan_LBD) | 4 | TYR A 91TRP A 145TYR A 184TYR A 191 | None | 0.72A | 3pmzE-4hqpA:25.6 | 3pmzE-4hqpA:34.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzy | PROBABLE THYMIDYLATEKINASE (Sulfurisphaeratokodaii) |
PF02223(Thymidylate_kin) | 4 | TYR A 94LYS A 121TYR A 99TYR A 116 | None | 1.42A | 3pmzE-4nzyA:0.0 | 3pmzE-4nzyA:25.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4zjs | ACETYLCHOLINERECEPTOR SUBUNITALPHA,SOLUBLEACETYLCHOLINERECEPTOR,ACETYLCHOLINE RECEPTOR SUBUNITALPHA,SOLUBLEACETYLCHOLINERECEPTOR (Aplysiacalifornica;Homo sapiens) |
PF02931(Neur_chan_LBD) | 5 | TYR A 93LYS A 143TRP A 147TYR A 188TYR A 195 | None | 0.68A | 3pmzE-4zjsA:29.2 | 3pmzE-4zjsA:81.22 |