SIMILAR PATTERNS OF AMINO ACIDS FOR 3PHN_A_ACTA108_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 THR A 216
SER A 285
ARG A 287
 U  P   3 ( 3.9A)
None
G  P   4 ( 3.6A)
 0.80A 3phnA-1b7fA:
0.0		 3phnA-1b7fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 THR A  41
SER A  42
ARG A  43
 None
 0.78A 3phnA-1csjA:
0.0		 3phnA-1csjA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		3 THR A  87
SER A  53
ARG A  56
 None
 0.78A 3phnA-1ex9A:
undetectable		 3phnA-1ex9A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		3 THR A 169
SER A 228
ARG A 227
 None
 0.78A 3phnA-1gpjA:
0.0		 3phnA-1gpjA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
aquaticus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 THR A  54
SER A  55
ARG A 142
 None
 0.67A 3phnA-1hqmA:
0.0		 3phnA-1hqmA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij9 VASCULAR CELL
ADHESION PROTEIN 1

(Homo sapiens) 		PF05790
(C2-set)
PF07679
(I-set) 		3 THR A  72
SER A  34
ARG A  36
 None
 0.82A 3phnA-1ij9A:
0.0		 3phnA-1ij9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq6 (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Aeromonas
caviae) 		PF01575
(MaoC_dehydratas) 		3 THR A  94
SER A  14
ARG A  12
 None
 0.83A 3phnA-1iq6A:
0.0		 3phnA-1iq6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k82 FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE

(Escherichia
coli) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 THR A 105
SER A  76
ARG A  78
 None
 0.82A 3phnA-1k82A:
0.0		 3phnA-1k82A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lhu SEX HORMONE-BINDING
GLOBULIN

(Homo sapiens) 		PF00054
(Laminin_G_1) 		3 THR A 183
SER A 184
ARG A 186
 None
 0.76A 3phnA-1lhuA:
0.0		 3phnA-1lhuA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 THR A 106
SER A 107
ARG A 316
 None
 0.70A 3phnA-1q5nA:
undetectable		 3phnA-1q5nA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzz ACLACINOMYCIN-10-HYD
ROXYLASE

(Streptomyces
purpurascens) 		PF00891
(Methyltransf_2) 		3 THR A 338
SER A 349
ARG A 319
 None
 0.82A 3phnA-1qzzA:
undetectable		 3phnA-1qzzA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		3 THR A 232
SER A 233
ARG A 234
 UD2  A 343 (-4.1A)
None
UD2  A 343 (-3.7A)
 0.80A 3phnA-1sb8A:
undetectable		 3phnA-1sb8A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN

(Salmonella
enterica) 		PF13531
(SBP_bac_11) 		3 THR A  96
SER A  95
ARG A 261
 None
 0.82A 3phnA-1sbpA:
undetectable		 3phnA-1sbpA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 THR A  35
SER A  36
ARG A  37
 None
 0.50A 3phnA-1taqA:
undetectable		 3phnA-1taqA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Vibrio cholerae) 		PF12727
(PBP_like) 		3 THR A  82
SER A  83
ARG A  84
 None
PO4  A1500 (-2.7A)
None
 0.65A 3phnA-1twyA:
undetectable		 3phnA-1twyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		3 THR A  25
SER A  24
ARG A 164
 None
 0.71A 3phnA-1yiqA:
undetectable		 3phnA-1yiqA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 THR A 295
SER A 286
ARG A 269
 None
 0.75A 3phnA-1yr2A:
undetectable		 3phnA-1yr2A:
8.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yv7 P-30 PROTEIN

(Rana pipiens) 		PF00074
(RnaseA) 		3 THR A  71
SER A  72
ARG A  73
 None
 0.71A 3phnA-1yv7A:
21.2		 3phnA-1yv7A:
99.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5z HYPOTHETICAL PROTEIN
SO2946

(Shewanella
oneidensis) 		no annotation 3 THR A 213
SER A 214
ARG A 196
 None
 0.65A 3phnA-2a5zA:
undetectable		 3phnA-2a5zA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		3 THR A 116
SER A  68
ARG A  41
 NAP  A 800 (-3.0A)
NAP  A 800 ( 4.1A)
NAP  A 800 (-3.4A)
 0.67A 3phnA-2bd0A:
undetectable		 3phnA-2bd0A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 THR A 207
SER A 208
ARG A 209
 None
 0.60A 3phnA-2dc5A:
undetectable		 3phnA-2dc5A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm3 KIAA0992 PROTEIN

(Homo sapiens) 		PF07679
(I-set) 		3 THR A  74
SER A  75
ARG A  76
 None
 0.80A 3phnA-2dm3A:
undetectable		 3phnA-2dm3A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxq ACETYLTRANSFERASE

(Agrobacterium
fabrum) 		PF00583
(Acetyltransf_1) 		3 THR A  57
SER A   7
ARG A   9
 None
 0.77A 3phnA-2dxqA:
undetectable		 3phnA-2dxqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Gallus gallus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 THR A 403
SER A 404
ARG A  97
 None
 0.76A 3phnA-2fafA:
undetectable		 3phnA-2fafA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Bacillus cereus) 		PF02457
(DisA_N)
PF10372
(YojJ) 		3 THR A 202
SER A 193
ARG A 191
 None
 0.78A 3phnA-2fb5A:
undetectable		 3phnA-2fb5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		3 THR A 107
SER A 108
ARG A 312
 None
CL  A1507 ( 4.5A)
None
 0.73A 3phnA-2felA:
undetectable		 3phnA-2felA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl1 PDF1

(Vigna radiata) 		PF00304
(Gamma-thionin) 		3 THR A  44
SER A  32
ARG A  34
 None
 0.82A 3phnA-2gl1A:
undetectable		 3phnA-2gl1A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A 271
SER A 272
ARG A 286
 None
 0.66A 3phnA-2gp6A:
undetectable		 3phnA-2gp6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdi COLICIN I RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 576
SER A 592
ARG A  61
 None
 0.75A 3phnA-2hdiA:
undetectable		 3phnA-2hdiA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kua BCL-2-LIKE PROTEIN
10

(Mus musculus) 		PF00452
(Bcl-2) 		3 THR A  35
SER A  36
ARG A  14
 None
 0.82A 3phnA-2kuaA:
undetectable		 3phnA-2kuaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr4 CONSERVED
HYPOTHETICAL PROTEIN

(Methanosarcina
mazei) 		PF04289
(DUF447) 		3 THR A 129
SER A 132
ARG A  58
 None
 0.71A 3phnA-2nr4A:
undetectable		 3phnA-2nr4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		3 THR A 576
SER A 578
ARG A 134
 None
 0.82A 3phnA-2okjA:
undetectable		 3phnA-2okjA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		3 THR A 236
SER A 237
ARG A 238
 None
 0.81A 3phnA-2owzA:
undetectable		 3phnA-2owzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus) 		PF02275
(CBAH) 		3 THR A  63
SER A  64
ARG A  39
 None
 0.69A 3phnA-2quyA:
undetectable		 3phnA-2quyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 THR A  59
SER A  61
ARG A  62
 None
None
EDO  A 323 (-3.9A)
 0.70A 3phnA-2qytA:
undetectable		 3phnA-2qytA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2d ZN-DEPENDENT
HYDROLASES

(Agrobacterium
fabrum) 		PF00753
(Lactamase_B) 		3 THR A 271
SER A 270
ARG A  93
 None
 0.82A 3phnA-2r2dA:
undetectable		 3phnA-2r2dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		3 THR A 393
SER A 427
ARG A 425
 None
 0.77A 3phnA-2r98A:
undetectable		 3phnA-2r98A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdf OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF07239
(OpcA) 		3 THR A 186
SER A 167
ARG A 134
 None
 0.72A 3phnA-2vdfA:
undetectable		 3phnA-2vdfA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		3 THR A  88
SER A  87
ARG A 510
 None
 0.74A 3phnA-2vgiA:
undetectable		 3phnA-2vgiA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsd CHIR AB1

(Gallus gallus) 		PF13895
(Ig_2) 		3 THR A  86
SER A  87
ARG A  77
 None
 0.62A 3phnA-2vsdA:
undetectable		 3phnA-2vsdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 THR A 271
SER A 272
ARG A 286
 None
 0.73A 3phnA-2wgeA:
undetectable		 3phnA-2wgeA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv3 NEUROPLASTIN

(Rattus
norvegicus) 		PF13927
(Ig_3) 		3 THR A  28
SER A  29
ARG A   5
 None
 0.53A 3phnA-2wv3A:
undetectable		 3phnA-2wv3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2e GINKBILOBIN-2

(Ginkgo biloba) 		PF01657
(Stress-antifung) 		3 THR A  45
SER A  46
ARG A  47
 None
 0.75A 3phnA-3a2eA:
undetectable		 3phnA-3a2eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1

(Mycobacterium
tuberculosis) 		PF00296
(Bac_luciferase) 		3 THR A 195
SER A 196
ARG A 283
 FLC  A 337 ( 3.4A)
None
FLC  A 337 (-2.8A)
 0.75A 3phnA-3b4yA:
undetectable		 3phnA-3b4yA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqx GLYOXALASE-RELATED
ENZYME

(Fulvimarina
pelagi) 		PF00903
(Glyoxalase) 		3 THR A  65
SER A  66
ARG A  67
 None
 0.72A 3phnA-3bqxA:
undetectable		 3phnA-3bqxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		3 THR A 137
SER A 136
ARG A 171
 None
 0.73A 3phnA-3c0bA:
undetectable		 3phnA-3c0bA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb7 ISOCHORISMATASE
HYDROLASE

(Alkaliphilus
metalliredigens) 		PF00857
(Isochorismatase) 		3 THR A 135
SER A 132
ARG A 131
 NA  A 202 (-3.2A)
NA  A 202 (-3.6A)
NA  A 202 ( 4.9A)
 0.83A 3phnA-3hb7A:
undetectable		 3phnA-3hb7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		3 THR A  88
SER A  89
ARG A  93
 None
 0.53A 3phnA-3hvuA:
undetectable		 3phnA-3hvuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		3 THR A  49
SER A  74
ARG A  81
 None
 0.78A 3phnA-3iomA:
undetectable		 3phnA-3iomA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE

(Chelativorans
sp. BNC1) 		PF07171
(MlrC_C)
PF07364
(DUF1485) 		3 THR A 155
SER A 156
ARG A 158
 None
 0.61A 3phnA-3iuuA:
undetectable		 3phnA-3iuuA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 THR A 379
SER A 380
ARG A 381
 None
 0.76A 3phnA-3jb9A:
undetectable		 3phnA-3jb9A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF01789
(PsbP) 		3 THR P  56
SER P  57
ARG P 167
 None
 0.55A 3phnA-3jcuP:
undetectable		 3phnA-3jcuP:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 THR A  39
SER A  40
ARG A  43
 None
 0.75A 3phnA-3l22A:
undetectable		 3phnA-3l22A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		3 THR A 232
SER A 233
ARG A 234
 UD2  A 344 (-3.6A)
None
UD2  A 344 (-3.6A)
 0.77A 3phnA-3rucA:
undetectable		 3phnA-3rucA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 3 THR B 147
SER B 144
ARG B 143
 None
 0.64A 3phnA-3w0lB:
undetectable		 3phnA-3w0lB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wva UPF0254 PROTEIN
MJ1251

(Methanocaldococcus
jannaschii) 		PF06787
(UPF0254) 		3 THR A 130
SER A 131
ARG A 115
 None
 0.81A 3phnA-3wvaA:
undetectable		 3phnA-3wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA

(Homo sapiens) 		PF01504
(PIP5K) 		3 THR A 221
SER A 220
ARG A 406
 None
 0.52A 3phnA-3x05A:
undetectable		 3phnA-3x05A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ads PDX2 PROTEIN

(Plasmodium
falciparum) 		PF01174
(SNO) 		3 THR G  55
SER G  54
ARG G 121
 None
 0.82A 3phnA-4adsG:
undetectable		 3phnA-4adsG:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		3 THR A 348
SER A 370
ARG A 368
 None
None
CL  A 803 (-4.1A)
 0.51A 3phnA-4c00A:
undetectable		 3phnA-4c00A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 THR A 396
SER A 395
ARG A 370
 None
 0.82A 3phnA-4c2kA:
undetectable		 3phnA-4c2kA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 THR A1132
SER A1133
ARG A 227
 None
 0.76A 3phnA-4f1nA:
undetectable		 3phnA-4f1nA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		3 THR A 158
SER A 162
ARG A 123
 None
 0.69A 3phnA-4fqdA:
undetectable		 3phnA-4fqdA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 THR A 324
SER A 347
ARG A 345
 None
 0.82A 3phnA-4fspA:
undetectable		 3phnA-4fspA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 THR A 232
SER A 258
ARG A 257
 None
 0.73A 3phnA-4i7iA:
undetectable		 3phnA-4i7iA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i96 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR) 		3 THR A 232
SER A 258
ARG A 257
 None
 0.72A 3phnA-4i96A:
undetectable		 3phnA-4i96A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		3 THR A 257
SER A 258
ARG A 261
 None
 0.78A 3phnA-4j34A:
undetectable		 3phnA-4j34A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt0 PHOTOSYSTEM I
SUBUNIT III

(Synechocystis
sp. PCC 6803) 		PF02507
(PSI_PsaF) 		3 THR F 140
SER F 141
ARG F 143
 None
 0.72A 3phnA-4kt0F:
undetectable		 3phnA-4kt0F:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf0 ALIPHATIC AMIDASE

(Bacillus sp.
(in: Bacteria)) 		PF00795
(CN_hydrolase) 		3 THR A  12
SER A 259
ARG A   2
 None
 0.82A 3phnA-4lf0A:
undetectable		 3phnA-4lf0A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 THR A 401
SER A 391
ARG A 403
 None
 0.82A 3phnA-4mmhA:
undetectable		 3phnA-4mmhA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		3 THR A 348
SER A 370
ARG A 368
 None
 0.56A 3phnA-4n74A:
undetectable		 3phnA-4n74A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 THR A 218
SER A 210
ARG A 208
 None
 0.80A 3phnA-4o9xA:
undetectable		 3phnA-4o9xA:
3.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H  80
SER H  21
ARG H  19
 None
 0.82A 3phnA-4r90H:
undetectable		 3phnA-4r90H:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s37 PHAGE BASEPLATE
PROTEIN

(Pseudomonas
aeruginosa) 		PF04717
(Phage_base_V) 		3 THR A 125
SER A 138
ARG A 136
 None
 0.54A 3phnA-4s37A:
undetectable		 3phnA-4s37A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 THR A 561
SER A 562
ARG A 527
 None
POL  A 707 (-3.1A)
None
 0.83A 3phnA-4uzsA:
undetectable		 3phnA-4uzsA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 THR A 513
SER A 514
ARG A 515
 None
None
EDO  A 705 (-4.1A)
 0.21A 3phnA-4wd1A:
undetectable		 3phnA-4wd1A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 THR A 771
SER A 772
ARG A 747
 None
 0.82A 3phnA-4wgkA:
undetectable		 3phnA-4wgkA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		3 THR A 569
SER A 567
ARG A 495
 None
 0.81A 3phnA-4wrnA:
undetectable		 3phnA-4wrnA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7l TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		3 THR A1031
SER A1030
ARG A1076
 None
 0.70A 3phnA-4y7lA:
undetectable		 3phnA-4y7lA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfk PROLIFERATING CELL
NUCLEAR
ANTIGEN,PROLIFERATIN
G CELL NUCLEAR
ANTIGEN

(Leishmania
donovani) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		3 THR A 102
SER A  89
ARG A  91
 None
 0.82A 3phnA-5cfkA:
undetectable		 3phnA-5cfkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl HISTONE H2A.Z

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 THR B  59
SER B  60
ARG B  61
 None
 0.52A 3phnA-5chlB:
undetectable		 3phnA-5chlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H) 		3 THR A 556
SER A 557
ARG A 560
 None
 0.83A 3phnA-5dmrA:
undetectable		 3phnA-5dmrA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		3 THR A 362
SER A 290
ARG A 311
 None
None
UM2  A 503 (-3.7A)
 0.81A 3phnA-5du9A:
undetectable		 3phnA-5du9A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		3 THR A 448
SER A 449
ARG A 455
 None
 0.64A 3phnA-5ed1A:
undetectable		 3phnA-5ed1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		3 THR X  54
SER X  55
ARG X  56
 ALY  X  75 ( 3.8A)
None
ALY  X  75 ( 4.0A)
 0.81A 3phnA-5eztX:
undetectable		 3phnA-5eztX:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6h DH427 ANTIBODY LIGHT
CHAIN

(Macaca mulatta) 		no annotation 3 THR L  25
SER L  27
ARG L  94
 None
 0.72A 3phnA-5f6hL:
undetectable		 3phnA-5f6hL:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 658
SER A 657
ARG A 248
 None
 0.80A 3phnA-5fokA:
undetectable		 3phnA-5fokA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 THR A 390
SER A 391
ARG A 340
 None
 0.71A 3phnA-5hy7A:
undetectable		 3phnA-5hy7A:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2
RNP (RRM RNA BINDING
DOMAIN) CONTAINING

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF03828
(PAP_assoc)
no annotation 		3 THR E 218
SER E 217
ARG A 694
 None
 0.66A 3phnA-5jnbE:
undetectable		 3phnA-5jnbE:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn ANTIBODY

(Mus musculus) 		no annotation 3 THR H  80
SER H  18
ARG H  16
 None
 0.76A 3phnA-5ldnH:
undetectable		 3phnA-5ldnH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 3 THR A  65
SER A  66
ARG A 138
 None
 0.56A 3phnA-5m22A:
undetectable		 3phnA-5m22A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		3 THR A2571
SER A2572
ARG A2574
 None
 0.52A 3phnA-5mc9A:
undetectable		 3phnA-5mc9A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 THR A 173
SER A 197
ARG A 199
 None
 0.80A 3phnA-5t9xA:
undetectable		 3phnA-5t9xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukn DH522UCA FAB
FRAGMENT LIGHT CHAIN

(Macaca mulatta) 		no annotation 3 THR L  26
SER L  27
ARG L  92
 None
 0.67A 3phnA-5uknL:
undetectable		 3phnA-5uknL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		3 THR A 148
SER A 147
ARG A 313
 None
 0.79A 3phnA-5um2A:
undetectable		 3phnA-5um2A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 3 THR B 366
SER B 367
ARG B 303
 None
 0.76A 3phnA-5wwpB:
undetectable		 3phnA-5wwpB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 3 THR A 106
SER A 107
ARG A 325
 None
 0.72A 3phnA-5xnzA:
undetectable		 3phnA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb LHCR3

(Cyanidioschyzon
merolae) 		no annotation 3 THR 3 118
SER 3 122
ARG 3 124
 None
 0.80A 3phnA-5zgb3:
undetectable		 3phnA-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3n NLEG5-1

(Escherichia
coli) 		no annotation 3 THR A  90
SER A  91
ARG A  92
 None
 0.81A 3phnA-6b3nA:
undetectable		 3phnA-6b3nA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwm TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Oryctolagus
cuniculus) 		no annotation 3 THR A 329
SER A 339
ARG A 337
 None
 0.74A 3phnA-6bwmA:
undetectable		 3phnA-6bwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gc6 50S RIBOSOMAL
PROTEIN L2

(Escherichia
coli) 		no annotation 3 THR C   8
SER C   9
ARG C  12
 G  A1695 ( 3.6A)
G  A 729 ( 3.1A)
A  A 727 ( 3.4A)
 0.78A 3phnA-6gc6C:
undetectable		 3phnA-6gc6C:
undetectable