SIMILAR PATTERNS OF AMINO ACIDS FOR 3PHA_B_ACRB701_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 PRO A 135
TYR A 190
TRP A 209
TRP A 142
 None
 1.28A 3phaB-3a0fA:
0.0		 3phaB-3a0fA:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PRO A  75
TRP A 305
MET A 308
TRP A 417
 None
None
ACR  A 664 ( 3.8A)
ACR  A 664 (-4.6A)
 0.30A 3phaB-3pocA:
62.6		 3phaB-3pocA:
99.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PRO A1159
TYR A1251
MET A1421
TRP A1523
 ACR  A   1 (-3.9A)
ACR  A   1 ( 4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
 0.81A 3phaB-3topA:
37.7		 3phaB-3topA:
24.38