SIMILAR PATTERNS OF AMINO ACIDS FOR 3PGH_C_FLPC701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1au8 CATHEPSIN G

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  68
ALA A  85
SER A 109
LEU A 108
 None
 0.83A 3pghC-1au8A:
0.0		 3pghC-1au8A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.01A 3pghC-1dkpA:
0.0		 3pghC-1dkpA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 VAL A 116
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.42A 3pghC-1ebvA:
25.5		 3pghC-1ebvA:
64.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elt ELASTASE

(Salmo salar) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.94A 3pghC-1eltA:
0.0		 3pghC-1eltA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  52
LEU B  67
ALA B  85
SER B 109
LEU B 108
 None
 0.95A 3pghC-1eptA:
undetectable		 3pghC-1eptA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ff9 SACCHAROPINE
REDUCTASE

(Magnaporthe
grisea) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		6 VAL A 358
LEU A 436
LEU A 380
VAL A 401
GLY A 400
LEU A 125
 None
 1.46A 3pghC-1ff9A:
undetectable		 3pghC-1ff9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.98A 3pghC-1h4wA:
0.0		 3pghC-1h4wA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL E  52
LEU E  67
ALA E  85
SER E 109
LEU E 108
 None
 0.99A 3pghC-1h9hE:
0.0		 3pghC-1h9hE:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hrd GLUTAMATE
DEHYDROGENASE

([Clostridium]
symbiosum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A 233
VAL A 241
GLY A 244
ALA A 245
LEU A 249
 None
 0.99A 3pghC-1hrdA:
1.9		 3pghC-1hrdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 VAL A   7
TYR A 236
LEU A 214
ALA A 221
SER A 219
 FAD  A 450 (-4.7A)
None
FAD  A 450 ( 4.1A)
None
None
 1.00A 3pghC-1i8tA:
undetectable		 3pghC-1i8tA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 VAL T  52
LEU T  68
ALA T  85
SER T 109
LEU T 108
 None
 0.96A 3pghC-1j17T:
undetectable		 3pghC-1j17T:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 VAL A 332
LEU A  81
GLY A 179
ALA A 178
LEU A 125
 None
 0.93A 3pghC-1l8wA:
undetectable		 3pghC-1l8wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 186
VAL A 165
VAL A  63
GLY A  33
LEU A 129
 None
None
None
NAD  A5500 (-3.2A)
None
 0.93A 3pghC-1m2wA:
undetectable		 3pghC-1m2wA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 VAL E  97
LEU E 115
LEU E  78
GLY E 132
ALA E 133
 None
 0.95A 3pghC-1nfiE:
1.0		 3pghC-1nfiE:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlr ENDO-1,4-BETA-GLUCAN
ASE

(Streptomyces
lividans) 		PF01670
(Glyco_hydro_12) 		5 VAL A 180
VAL A 198
VAL A 220
ALA A  85
SER A  87
 None
 1.02A 3pghC-1nlrA:
undetectable		 3pghC-1nlrA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		6 VAL A  19
LEU A  54
TYR A   2
GLY A  97
ALA A  74
LEU A 189
 None
 1.28A 3pghC-1nr9A:
undetectable		 3pghC-1nr9A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		5 VAL A 500
VAL A 402
LEU A 430
ALA A 466
LEU A 504
 None
 0.85A 3pghC-1oa1A:
undetectable		 3pghC-1oa1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
 None
 0.84A 3pghC-1ps9A:
undetectable		 3pghC-1ps9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q77 HYPOTHETICAL PROTEIN
AQ_178

(Aquifex
aeolicus) 		PF00582
(Usp) 		5 VAL A 102
LEU A   4
VAL A 123
GLY A 126
LEU A 129
 None
 0.97A 3pghC-1q77A:
undetectable		 3pghC-1q77A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq6 PROTEIN
(L-2-HALOACID
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00702
(Hydrolase) 		6 VAL A 241
LEU A 234
LEU A 105
VAL A 231
ALA A 188
LEU A 168
 None
 1.36A 3pghC-1qq6A:
undetectable		 3pghC-1qq6A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr3 APO-CCME

(Escherichia
coli) 		PF03100
(CcmE) 		5 VAL A  80
LEU A 127
LEU A  99
GLY A 113
ALA A 123
 None
 0.88A 3pghC-1sr3A:
undetectable		 3pghC-1sr3A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		6 VAL C 165
LEU C  50
LEU C  21
GLY C  32
ALA C  31
LEU C  53
 FAD  C4931 ( 3.9A)
None
None
GOL  C3907 ( 3.4A)
FAD  C4931 (-3.5A)
None
 1.26A 3pghC-1t3qC:
undetectable		 3pghC-1t3qC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhb TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.98A 3pghC-1uhbA:
undetectable		 3pghC-1uhbA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 VAL A 493
VAL A 395
LEU A 423
ALA A 459
LEU A 497
 None
 0.85A 3pghC-1upxA:
undetectable		 3pghC-1upxA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 291
VAL A 160
GLY A 264
ALA A 262
LEU A 270
 None
 0.98A 3pghC-1vc2A:
undetectable		 3pghC-1vc2A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 VAL A 253
VAL A 217
VAL A 206
GLY A 208
LEU A 234
 None
 0.88A 3pghC-1wmrA:
undetectable		 3pghC-1wmrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 VAL A 122
LEU A 113
VAL A  35
ALA A  54
SER A  58
 None
 0.99A 3pghC-1ygpA:
undetectable		 3pghC-1ygpA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynq OXIDOREDUCTASE

(Bacillus
halodurans) 		PF00248
(Aldo_ket_red) 		5 VAL A 270
VAL A 195
TYR A  51
GLY A 256
ALA A 255
 None
None
SO4  A 300 ( 4.9A)
SO4  A 300 (-3.8A)
SO4  A 300 (-4.0A)
 1.02A 3pghC-1ynqA:
undetectable		 3pghC-1ynqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yoa PUTATIVE
FLAVOPROTEIN

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		5 VAL A  46
LEU A 106
LEU A 116
VAL A  60
GLY A  64
 None
 0.99A 3pghC-1yoaA:
undetectable		 3pghC-1yoaA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.03A 3pghC-2a0uA:
undetectable		 3pghC-2a0uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7m N-ACYL HOMOSERINE
LACTONE HYDROLASE

(Bacillus
thuringiensis) 		PF00753
(Lactamase_B) 		5 VAL A 123
LEU A 143
GLY A 111
ALA A 110
LEU A 105
 None
 1.00A 3pghC-2a7mA:
undetectable		 3pghC-2a7mA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aiz OUTER MEMBRANE
PROTEIN P6

(Haemophilus
influenzae) 		PF00691
(OmpA) 		5 VAL P  90
LEU P  49
GLY P  68
ALA P 130
LEU P 132
 None
 0.97A 3pghC-2aizP:
undetectable		 3pghC-2aizP:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A   6
LEU A  36
GLY A  25
ALA A  26
LEU A 158
 None
 1.00A 3pghC-2arkA:
undetectable		 3pghC-2arkA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		6 VAL A  75
VAL A  32
LEU A   7
LEU A  62
ALA A  50
LEU A  51
 None
 1.29A 3pghC-2bexA:
undetectable		 3pghC-2bexA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		6 VAL A 111
VAL A  34
LEU A 128
LEU A  36
GLY A 101
LEU A 103
 None
 1.44A 3pghC-2cu5A:
undetectable		 3pghC-2cu5A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A  42
GLY A  87
ALA A  88
SER A  91
LEU A  92
 None
 0.86A 3pghC-2dieA:
undetectable		 3pghC-2dieA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		5 VAL A 216
VAL A 241
GLY A 290
ALA A 289
LEU A 205
 None
None
FMN  A1904 ( 4.1A)
None
FMN  A1904 ( 4.8A)
 0.95A 3pghC-2gjnA:
undetectable		 3pghC-2gjnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 0.92A 3pghC-2gk9A:
undetectable		 3pghC-2gk9A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A  73
LEU A  23
VAL A 140
GLY A 144
ALA A  35
 None
 0.98A 3pghC-2hsmA:
undetectable		 3pghC-2hsmA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
 None
 1.01A 3pghC-2j6iA:
undetectable		 3pghC-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l0t SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00790
(VHS) 		6 VAL B  91
LEU B  76
VAL B  43
GLY B  49
ALA B  50
LEU B  54
 None
 1.41A 3pghC-2l0tB:
undetectable		 3pghC-2l0tB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  59
VAL A  52
VAL A 212
GLY A 197
LEU A  33
 None
 0.85A 3pghC-2v35A:
undetectable		 3pghC-2v35A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wba TRYPANOTHIONE
REDUCTASE

(Trypanosoma
brucei) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 VAL A  33
LEU A  26
LEU A 120
VAL A 346
GLY A 342
ALA A  19
 None
 1.40A 3pghC-2wbaA:
0.8		 3pghC-2wbaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xj9 MIPZ

(Caulobacter
vibrioides) 		PF09140
(MipZ) 		5 VAL A 183
TYR A 159
LEU A 143
GLY A  15
ALA A  16
 None
None
None
AGS  A1272 (-3.3A)
AGS  A1272 (-4.2A)
 0.99A 3pghC-2xj9A:
undetectable		 3pghC-2xj9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 0.98A 3pghC-2xn8A:
0.8		 3pghC-2xn8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		6 VAL A  31
VAL A  66
LEU A  37
GLY A  54
ALA A  57
LEU A   8
 None
 1.47A 3pghC-2ywdA:
undetectable		 3pghC-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		6 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
LEU A 103
 None
 1.13A 3pghC-2ywdA:
undetectable		 3pghC-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
 None
 0.92A 3pghC-2zecA:
undetectable		 3pghC-2zecA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 VAL A 396
VAL A 367
LEU A 371
VAL A 253
LEU A 398
 None
 1.02A 3pghC-3dqqA:
undetectable		 3pghC-3dqqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13578
(Methyltransf_24) 		6 VAL A 160
LEU A  75
LEU A  45
GLY A  59
ALA A  60
LEU A 132
 None
 1.43A 3pghC-3dr5A:
undetectable		 3pghC-3dr5A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 VAL A 254
LEU A 253
LEU A  52
GLY A 161
LEU A  74
 None
 0.95A 3pghC-3efbA:
undetectable		 3pghC-3efbA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 LEU A 566
VAL A 507
GLY A 561
SER A 598
LEU A 558
 None
 0.97A 3pghC-3eqnA:
undetectable		 3pghC-3eqnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		6 VAL A 373
VAL A 349
LEU A 351
VAL A 128
GLY A 126
ALA A 124
 None
 1.32A 3pghC-3fnrA:
undetectable		 3pghC-3fnrA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 VAL A 482
LEU A 527
LEU A 499
VAL A 525
ALA A 508
 None
 0.93A 3pghC-3fw6A:
undetectable		 3pghC-3fw6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		6 VAL A 380
LEU A 164
VAL A 340
ALA A 285
SER A 287
LEU A 288
 None
 1.49A 3pghC-3gtdA:
undetectable		 3pghC-3gtdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 VAL A 200
VAL A 251
LEU A 253
GLY A 182
LEU A 207
 None
 1.02A 3pghC-3gxoA:
undetectable		 3pghC-3gxoA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 VAL A 339
VAL A 228
LEU A 232
GLY A 343
LEU A 341
 None
 0.94A 3pghC-3i32A:
undetectable		 3pghC-3i32A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		6 VAL A 113
LEU A  11
LEU A 180
GLY A 159
ALA A 160
LEU A 164
 None
 1.48A 3pghC-3i7aA:
0.3		 3pghC-3i7aA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		5 VAL A 252
LEU A  16
ALA A 202
SER A 222
LEU A 204
 None
 1.02A 3pghC-3ib7A:
undetectable		 3pghC-3ib7A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq PLAKOGLOBIN

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 523
LEU A 510
GLY A 565
ALA A 566
LEU A 570
 None
 0.99A 3pghC-3ifqA:
undetectable		 3pghC-3ifqA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khn MOTB PROTEIN,
PUTATIVE

(Desulfovibrio
vulgaris) 		PF00691
(OmpA) 		5 VAL A 116
VAL A  49
GLY A  65
ALA A  66
LEU A  70
 None
 0.89A 3pghC-3khnA:
undetectable		 3pghC-3khnA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		6 LEU A  37
LEU A  40
VAL A  81
GLY A 103
ALA A  76
LEU A  72
 None
 1.46A 3pghC-3ki8A:
undetectable		 3pghC-3ki8A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		5 LEU A 260
LEU A 187
VAL A 280
GLY A 282
LEU A 235
 None
 0.97A 3pghC-3l4dA:
undetectable		 3pghC-3l4dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 VAL A 108
LEU A 112
GLY A  76
SER A  79
LEU A  80
 None
None
AKG  A 224 (-3.1A)
None
None
 0.96A 3pghC-3la2A:
undetectable		 3pghC-3la2A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 155
LEU A 163
TYR A 194
GLY A 214
ALA A 215
 None
 0.93A 3pghC-3mi9A:
undetectable		 3pghC-3mi9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS

(Streptococcus
pneumoniae) 		PF02302
(PTS_IIB) 		5 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.95A 3pghC-3nbmA:
undetectable		 3pghC-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzt GLUTAMATE--CYSTEINE
LIGASE

(Francisella
tularensis) 		PF04262
(Glu_cys_ligase) 		5 VAL A 308
VAL A 331
TYR A 169
LEU A 335
VAL A 312
 None
 0.72A 3pghC-3nztA:
undetectable		 3pghC-3nztA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		6 VAL A 329
VAL A 301
LEU A  50
ALA A 320
SER A 319
LEU A 323
 None
 1.50A 3pghC-3obeA:
undetectable		 3pghC-3obeA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		5 VAL A  23
LEU A  71
LEU A  64
VAL A 124
LEU A 132
 None
 0.99A 3pghC-3oheA:
undetectable		 3pghC-3oheA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A 283
VAL A 189
GLY A 192
ALA A 193
LEU A  58
 None
 0.98A 3pghC-3p41A:
undetectable		 3pghC-3p41A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 VAL A 186
VAL A  43
LEU A  31
VAL A  21
LEU A 188
 None
 0.88A 3pghC-3p54A:
undetectable		 3pghC-3p54A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 0.97A 3pghC-3redA:
0.7		 3pghC-3redA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.98A 3pghC-3tfyA:
undetectable		 3pghC-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp9 BETA-LACTAMASE AND
RHODANESE DOMAIN
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00581
(Rhodanese)
PF00753
(Lactamase_B) 		6 VAL A 338
LEU A 304
LEU A 328
GLY A 317
ALA A 316
LEU A 342
 None
 1.28A 3pghC-3tp9A:
undetectable		 3pghC-3tp9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		5 VAL A  10
TYR A  71
GLY A  21
ALA A  22
LEU A  26
 None
 0.97A 3pghC-3ukfA:
undetectable		 3pghC-3ukfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 VAL A 199
TYR A  96
GLY A 164
ALA A 165
LEU A 171
 None
FMN  A 500 (-3.4A)
None
None
None
 1.02A 3pghC-3x0yA:
undetectable		 3pghC-3x0yA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay7 METHYLCOBALAMIN:
COENZYME M
METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF01208
(URO-D) 		5 VAL A 262
LEU A 249
GLY A 310
ALA A 269
LEU A 282
 None
 1.03A 3pghC-4ay7A:
undetectable		 3pghC-4ay7A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE

(Roseobacter
denitrificans) 		PF00557
(Peptidase_M24) 		5 VAL A 178
LEU A 186
GLY A 136
ALA A 137
LEU A 139
 None
 0.94A 3pghC-4b28A:
undetectable		 3pghC-4b28A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 1.01A 3pghC-4c13A:
undetectable		 3pghC-4c13A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL38

(Sus scrofa) 		no annotation 6 VAL b 204
LEU b 271
LEU b 216
TYR b 154
ALA b 317
LEU b 173
 None
 1.32A 3pghC-4ce4b:
undetectable		 3pghC-4ce4b:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e51 HISTIDINE--TRNA
LIGASE

(Burkholderia
thailandensis) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 VAL A 392
LEU A 433
VAL A 334
GLY A 387
ALA A 388
 None
 1.02A 3pghC-4e51A:
undetectable		 3pghC-4e51A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 VAL A 270
LEU A  83
VAL A 276
GLY A 256
LEU A 251
 None
 1.02A 3pghC-4emiA:
undetectable		 3pghC-4emiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 310
VAL A 335
GLY A 333
ALA A 329
LEU A 330
 None
 1.01A 3pghC-4fwgA:
undetectable		 3pghC-4fwgA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 LEU A 261
LEU A 188
VAL A 281
GLY A 283
LEU A 236
 None
 0.83A 3pghC-4g3jA:
undetectable		 3pghC-4g3jA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 VAL A 237
LEU A 239
VAL A 211
GLY A 233
LEU A 228
 None
 1.01A 3pghC-4hq1A:
undetectable		 3pghC-4hq1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huj UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored) 		5 VAL A  63
VAL A  79
LEU A  58
GLY A 119
ALA A 120
 None
 0.95A 3pghC-4hujA:
undetectable		 3pghC-4hujA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		5 VAL A 155
VAL A 243
VAL A 233
GLY A 231
ALA A 230
 None
 0.99A 3pghC-4iwsA:
undetectable		 3pghC-4iwsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  45
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.95A 3pghC-4j9uA:
2.1		 3pghC-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.83A 3pghC-4j9uA:
2.1		 3pghC-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 VAL A 278
GLY A 262
ALA A 263
SER A 266
LEU A 267
 None
 0.89A 3pghC-4kmrA:
undetectable		 3pghC-4kmrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		5 VAL A  81
LEU A  56
GLY A  34
ALA A  35
LEU A  45
 None
 0.96A 3pghC-4m73A:
undetectable		 3pghC-4m73A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		5 LEU A 286
VAL A 266
GLY A 268
ALA A 270
LEU A 274
 None
 0.88A 3pghC-4o1mA:
undetectable		 3pghC-4o1mA:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 VAL A 117
VAL A 350
LEU A 353
TYR A 356
LEU A 360
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 (-3.9A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.52A 3pghC-4ph9A:
63.3		 3pghC-4ph9A:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 384
LEU A 341
LEU A 386
VAL A 367
GLY A 369
ALA A 368
 None
 1.33A 3pghC-4rnwA:
undetectable		 3pghC-4rnwA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 134
LEU A  91
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.32A 3pghC-4rnxA:
undetectable		 3pghC-4rnxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru5 TAILSPIKE GP27

(Pseudomonas
phage phi297) 		no annotation 5 VAL A 389
VAL A 400
VAL A 437
GLY A 414
LEU A 387
 None
 1.00A 3pghC-4ru5A:
undetectable		 3pghC-4ru5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 1.01A 3pghC-4tx2B:
undetectable		 3pghC-4tx2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 1.00A 3pghC-4wwyA:
undetectable		 3pghC-4wwyA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		5 VAL A 642
VAL A 609
GLY A 611
ALA A 612
LEU A 616
 None
 1.01A 3pghC-4yk6A:
undetectable		 3pghC-4yk6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 285
LEU A 242
LEU A 287
VAL A 268
GLY A 270
ALA A 269
 None
 1.35A 3pghC-4yncA:
undetectable		 3pghC-4yncA:
21.18