SIMILAR PATTERNS OF AMINO ACIDS FOR 3PGH_B_FLPB701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 VAL A  32
LEU A 177
LEU A 170
GLY A 209
ALA A 210
 None
 1.01A 3pghB-1dkpA:
0.0		 3pghB-1dkpA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dml DNA POLYMERASE
DNA POLYMERASE
PROCESSIVITY FACTOR

(Human
alphaherpesvirus
1) 		PF02282
(Herpes_UL42)
PF11590
(DNAPolymera_Pol) 		5 VAL A 167
LEU A 168
LEU A  58
GLY B1217
ALA B1216
 None
 1.24A 3pghB-1dmlA:
0.0		 3pghB-1dmlA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
MET A 522
GLY A 526
ALA A 527
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 0.45A 3pghB-1ebvA:
21.7		 3pghB-1ebvA:
64.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A  43
LEU A  44
LEU A   3
TYR A 104
ALA A  56
 None
 1.24A 3pghB-1f59A:
0.0		 3pghB-1f59A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 VAL A 287
LEU A 288
LEU A   2
GLY A  51
ALA A  98
 None
 1.13A 3pghB-1fhfA:
undetectable		 3pghB-1fhfA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		5 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.21A 3pghB-1ga8A:
0.0		 3pghB-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hus RIBOSOMAL PROTEIN S7

(Geobacillus
stearothermophilus) 		PF00177
(Ribosomal_S7) 		5 LEU A 100
LEU A 119
MET A  69
VAL A  68
ALA A  64
 None
 1.20A 3pghB-1husA:
0.0		 3pghB-1husA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A  58
LEU A  65
VAL A 190
GLY A 189
ALA A 191
 None
 1.27A 3pghB-1ir6A:
0.0		 3pghB-1ir6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		5 VAL A  43
LEU A  42
VAL A 103
GLY A 107
ALA A 108
 None
KPL  A 265 (-4.9A)
None
None
None
 1.06A 3pghB-1m3uA:
0.0		 3pghB-1m3uA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9) 		5 VAL A  96
LEU A  99
LEU A 125
VAL A  81
GLY A  83
 COA  A 600 (-3.8A)
None
None
None
KAN  A 500 (-3.7A)
 1.25A 3pghB-1m4iA:
0.0		 3pghB-1m4iA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ope SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Sus scrofa) 		PF01144
(CoA_trans) 		5 VAL A  94
LEU A  92
MET A 375
VAL A 381
GLY A 383
 None
 1.26A 3pghB-1opeA:
undetectable		 3pghB-1opeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouu HEMOGLOBIN I

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		5 VAL A 133
LEU A  77
LEU A 137
GLY A  68
ALA A  66
 None
None
HEM  A 143 (-4.7A)
None
HEM  A 143 ( 3.9A)
 1.24A 3pghB-1ouuA:
undetectable		 3pghB-1ouuA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9n MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		PF03205
(MobB) 		5 LEU A  18
LEU A 101
VAL A 154
GLY A 156
ALA A 158
 None
 1.24A 3pghB-1p9nA:
undetectable		 3pghB-1p9nA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 VAL A 436
LEU A 571
LEU A 589
VAL A 439
ALA A 541
 None
 1.24A 3pghB-1qjmA:
undetectable		 3pghB-1qjmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		5 VAL A  29
LEU A  26
VAL A 106
GLY A  85
ALA A  86
 None
 1.20A 3pghB-1tzqA:
undetectable		 3pghB-1tzqA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 LEU A 220
LEU A 316
VAL A 236
GLY A 208
ALA A 213
 None
 1.07A 3pghB-1ukcA:
undetectable		 3pghB-1ukcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Deinococcus
radiodurans) 		PF02566
(OsmC) 		5 LEU B 113
LEU B 135
VAL B  65
GLY B  63
ALA B  61
 None
 1.12A 3pghB-1uspB:
undetectable		 3pghB-1uspB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6a L-LACTATE
DEHYDROGENASE A
CHAIN

(Cyprinus carpio) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  25
LEU A  50
VAL A  31
GLY A 253
ALA A  34
 None
 1.26A 3pghB-1v6aA:
undetectable		 3pghB-1v6aA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		5 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.10A 3pghB-1xm9A:
undetectable		 3pghB-1xm9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		6 ARG A 367
VAL A 320
LEU A 321
LEU A 310
GLY A 362
ALA A 364
 None
 1.50A 3pghB-1yniA:
undetectable		 3pghB-1yniA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 353
LEU A 356
LEU A  20
GLY A 454
ALA A 453
 None
 1.26A 3pghB-1zfjA:
undetectable		 3pghB-1zfjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		5 VAL A 182
LEU A 138
VAL A  83
GLY A 153
ALA A 152
 None
 1.27A 3pghB-2aj4A:
undetectable		 3pghB-2aj4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 122
LEU A 134
VAL A  47
GLY A   5
ALA A 117
 None
 1.18A 3pghB-2hk3A:
undetectable		 3pghB-2hk3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 238
TYR A 194
VAL A 227
GLY A 171
ALA A 229
 None
 1.02A 3pghB-2j6iA:
undetectable		 3pghB-2j6iA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		5 LEU A 176
MET A 255
VAL A 256
GLY A 258
ALA A 260
 None
 0.95A 3pghB-2jg5A:
undetectable		 3pghB-2jg5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		5 VAL A  96
LEU A  97
LEU A  88
GLY A  33
ALA A  34
 None
 1.25A 3pghB-2p10A:
undetectable		 3pghB-2p10A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR
PROBABLE
TRANSCRIPTIONAL
REPRESSOR TRAM

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind)
PF09228
(Prok-TraM) 		5 LEU C  92
TYR C  20
LEU C  28
TRP A 186
ALA C  35
 None
 1.26A 3pghB-2q0oC:
undetectable		 3pghB-2q0oC:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxa DODECIN

(Halorhodospira
halophila) 		PF07311
(Dodecin) 		5 VAL A  63
LEU A  37
VAL A  23
GLY A  13
ALA A  26
 None
 1.19A 3pghB-2vxaA:
undetectable		 3pghB-2vxaA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 VAL A 583
LEU A 620
MET A 636
VAL A 635
GLY A 580
 None
 1.16A 3pghB-2wdaA:
undetectable		 3pghB-2wdaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 0.97A 3pghB-2xn8A:
undetectable		 3pghB-2xn8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		5 VAL A 161
LEU A 160
LEU A 144
GLY A  79
ALA A  84
 None
 1.08A 3pghB-2ywdA:
undetectable		 3pghB-2ywdA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgz THIOREDOXIN
REDUCTASE 2

(Mus musculus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 261
LEU A 189
VAL A 165
GLY A 167
ALA A 168
 None
 1.13A 3pghB-3dgzA:
undetectable		 3pghB-3dgzA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 361
TYR A 305
LEU A 367
VAL A 378
GLY A 380
 None
None
None
FAB  A 701 ( 4.7A)
None
 1.21A 3pghB-3e9yA:
undetectable		 3pghB-3e9yA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		5 VAL A 349
LEU A 351
VAL A 128
GLY A 126
ALA A 124
 None
 1.22A 3pghB-3fnrA:
undetectable		 3pghB-3fnrA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg7 UNCHARACTERIZED
METALLOPROTEIN

(Deinococcus
radiodurans) 		PF01026
(TatD_DNase) 		5 LEU A 217
MET A 171
VAL A 172
GLY A 177
ALA A 178
 None
 1.22A 3pghB-3gg7A:
undetectable		 3pghB-3gg7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqx NOP5P PROTEIN

(Pyrococcus
horikoshii) 		no annotation 5 ARG B 343
LEU B 270
LEU B 277
GLY B 336
ALA B 339
 None
None
IOD  B   3 ( 4.8A)
None
None
 1.03A 3pghB-3gqxB:
undetectable		 3pghB-3gqxB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 VAL A  30
LEU A  39
LEU A  32
GLY A 116
ALA A 115
 None
 1.12A 3pghB-3h1qA:
undetectable		 3pghB-3h1qA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 155
LEU A 163
TYR A 194
GLY A 214
ALA A 215
 None
 0.92A 3pghB-3mi9A:
undetectable		 3pghB-3mi9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbm PTS SYSTEM,
LACTOSE-SPECIFIC
IIBC COMPONENTS

(Streptococcus
pneumoniae) 		PF02302
(PTS_IIB) 		5 VAL A 512
LEU A 508
TYR A 538
VAL A 460
GLY A 491
 None
 0.96A 3pghB-3nbmA:
undetectable		 3pghB-3nbmA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 0.99A 3pghB-3tfyA:
undetectable		 3pghB-3tfyA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 ARG A 833
LEU A 799
LEU A 826
GLY A 805
ALA A 804
 None
 1.18A 3pghB-3un9A:
undetectable		 3pghB-3un9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 LEU A 266
TYR A 285
VAL A 287
GLY A 192
ALA A 193
 None
 1.20A 3pghB-3zpcA:
undetectable		 3pghB-3zpcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		5 ARG A 115
MET A  45
VAL A  75
GLY A  71
ALA A  72
 EDO  A1394 (-4.0A)
None
None
None
None
 1.24A 3pghB-4akkA:
undetectable		 3pghB-4akkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A1645
MET A1631
VAL A1632
GLY A1597
ALA A1598
 None
 1.25A 3pghB-4bpcA:
undetectable		 3pghB-4bpcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 VAL A 517
LEU A 521
LEU A 514
GLY A 548
ALA A 476
 None
 1.20A 3pghB-4c51A:
undetectable		 3pghB-4c51A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		5 VAL A 287
LEU A 288
LEU A   2
GLY A  51
ALA A  98
 None
 1.22A 3pghB-4cuoA:
0.0		 3pghB-4cuoA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 1.21A 3pghB-4db1A:
undetectable		 3pghB-4db1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		5 LEU A 122
LEU A 134
VAL A  47
GLY A   5
ALA A 117
 None
 1.21A 3pghB-4dpyA:
undetectable		 3pghB-4dpyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 VAL A  86
TYR A 238
LEU A 229
GLY A 210
ALA A 213
 None
 1.24A 3pghB-4eipA:
undetectable		 3pghB-4eipA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex6 ALNB

(Streptomyces
sp. CM020) 		PF13419
(HAD_2) 		5 VAL A  99
LEU A 100
TYR A 195
GLY A  18
ALA A  21
 None
None
None
MG  A 301 ( 4.3A)
None
 1.20A 3pghB-4ex6A:
undetectable		 3pghB-4ex6A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 144
LEU A 143
VAL A 179
GLY A 183
ALA A 184
 None
 1.13A 3pghB-4eyeA:
undetectable		 3pghB-4eyeA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		5 VAL B 148
LEU B 151
VAL B  44
GLY B  47
ALA B  48
 None
 1.21A 3pghB-4f0aB:
1.3		 3pghB-4f0aB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f32 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Burkholderia
vietnamiensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ARG A 419
LEU A 403
LEU A 366
VAL A 302
GLY A 300
 None
 1.03A 3pghB-4f32A:
undetectable		 3pghB-4f32A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		5 ARG A 464
LEU A 383
TYR B 526
LEU A 419
ALA A 425
 None
 1.27A 3pghB-4fddA:
1.3		 3pghB-4fddA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		5 ARG A 464
LEU A 383
TYR B 526
LEU A 419
GLY A 427
 None
 1.16A 3pghB-4fddA:
1.3		 3pghB-4fddA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 441
LEU A 444
VAL A 400
GLY A 402
ALA A 401
 None
 1.18A 3pghB-4im7A:
undetectable		 3pghB-4im7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU E 568
TYR E 633
VAL E 605
GLY E 632
ALA E 631
 None
 1.19A 3pghB-4iw4E:
undetectable		 3pghB-4iw4E:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 297
LEU A 226
VAL A 202
GLY A 204
ALA A 205
 None
 1.05A 3pghB-4j57A:
undetectable		 3pghB-4j57A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 VAL A 196
LEU A 197
LEU A 207
GLY A 237
ALA A 238
 None
 1.14A 3pghB-4lmpA:
undetectable		 3pghB-4lmpA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 1.09A 3pghB-4p7hA:
undetectable		 3pghB-4p7hA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 360
TYR A 386
TRP A 388
MET A 523
VAL A 524
GLY A 527
ALA A 528
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.8A)
None
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
 0.42A 3pghB-4ph9A:
25.4		 3pghB-4ph9A:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA

(Pseudomonas
aeruginosa) 		PF03162
(Y_phosphatase2) 		5 LEU A 141
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.20A 3pghB-4r0sA:
undetectable		 3pghB-4r0sA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA

(Pseudomonas
aeruginosa) 		PF03162
(Y_phosphatase2) 		5 VAL A 112
LEU A 116
VAL A 180
GLY A 182
ALA A 183
 None
 1.22A 3pghB-4r0sA:
undetectable		 3pghB-4r0sA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 384
LEU A 341
LEU A 386
VAL A 367
GLY A 369
ALA A 368
 None
 1.33A 3pghB-4rnwA:
undetectable		 3pghB-4rnwA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 134
LEU A  91
LEU A 136
VAL A 117
GLY A 119
ALA A 118
 None
 1.33A 3pghB-4rnxA:
undetectable		 3pghB-4rnxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		5 LEU A 227
LEU A 230
VAL A  13
GLY A  14
ALA A 219
 FAD  A 502 (-4.2A)
None
FAD  A 502 (-4.5A)
FAD  A 502 (-3.6A)
None
 1.20A 3pghB-4rslA:
undetectable		 3pghB-4rslA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usc PEROXIDASE

(Trachycarpus
fortunei) 		PF00141
(peroxidase) 		5 VAL A 287
LEU A 288
LEU A   2
GLY A  51
ALA A  98
 None
 1.16A 3pghB-4uscA:
undetectable		 3pghB-4uscA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		6 VAL A 285
LEU A 242
LEU A 287
VAL A 268
GLY A 270
ALA A 269
 None
 1.35A 3pghB-4yncA:
0.0		 3pghB-4yncA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A 797
LEU A 560
LEU A 799
TYR A 564
GLY A 911
 None
 0.95A 3pghB-4zdnA:
undetectable		 3pghB-4zdnA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3f PHOSPHORIBULOKINASE/
URIDINE KINASE

(Methanospirillum
hungatei) 		PF00485
(PRK) 		5 VAL A  51
LEU A  80
VAL A  22
GLY A  24
ALA A  23
 None
 1.17A 3pghB-5b3fA:
undetectable		 3pghB-5b3fA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqn CYTOCHROME P450
CYP125

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 VAL A 296
LEU A 398
VAL A 250
GLY A 252
ALA A 251
 None
None
1PE  A 505 (-4.4A)
HEM  A 501 (-3.4A)
1PE  A 505 ( 3.4A)
 1.14A 3pghB-5dqnA:
undetectable		 3pghB-5dqnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 TYR A  67
LEU A 336
TYR A 146
GLY A 164
ALA A 163
 None
 1.25A 3pghB-5e4yA:
undetectable		 3pghB-5e4yA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		5 VAL B 537
TYR B 562
LEU B 541
VAL B 473
ALA B 476
 None
 1.18A 3pghB-5flzB:
undetectable		 3pghB-5flzB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyq SPIKE GLYCOPROTEIN

(Rousettus bat
coronavirus
HKU9) 		PF09408
(Spike_rec_bind) 		5 LEU A  29
TRP A  24
MET A  71
VAL A  70
ALA A 154
 None
 1.18A 3pghB-5gyqA:
undetectable		 3pghB-5gyqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ARG A 743
LEU A 773
LEU A 745
GLY A 755
ALA A 754
 None
 0.89A 3pghB-5h42A:
0.4		 3pghB-5h42A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		5 LEU A  54
LEU B 371
TRP A 111
GLY A 106
ALA A 105
 None
 1.13A 3pghB-5hftA:
undetectable		 3pghB-5hftA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 359
TYR A 385
TRP A 387
MET A 522
VAL A 523
GLY A 526
ALA A 527
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-4.2A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
 0.49A 3pghB-5ikrA:
24.0		 3pghB-5ikrA:
87.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo8 CEP104

(Gallus gallus) 		no annotation 5 VAL A  64
LEU A 109
VAL A  46
GLY A  48
ALA A  49
 None
 1.25A 3pghB-5jo8A:
undetectable		 3pghB-5jo8A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 5 VAL A 163
LEU A 177
TYR A 125
GLY A 106
ALA A 174
 None
 1.15A 3pghB-5jvbA:
undetectable		 3pghB-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 5 VAL A 163
LEU A 177
VAL A 104
GLY A 106
ALA A 174
 None
 1.16A 3pghB-5jvbA:
undetectable		 3pghB-5jvbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		5 VAL A  97
LEU A 102
VAL A  37
GLY A  20
ALA A  16
 None
 1.21A 3pghB-5m10A:
undetectable		 3pghB-5m10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 0.96A 3pghB-5nugA:
undetectable		 3pghB-5nugA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 ARG A 170
VAL A 311
LEU A 314
MET A 161
ALA A 166
 None
 1.27A 3pghB-5o1mA:
undetectable		 3pghB-5o1mA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 0.98A 3pghB-5tp4A:
undetectable		 3pghB-5tp4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 5 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.13A 3pghB-5v2mA:
undetectable		 3pghB-5v2mA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veg FLAVODOXIN

(Lactobacillus
reuteri) 		no annotation 5 VAL A  22
LEU A  26
VAL A 122
GLY A  89
ALA A  88
 None
 1.21A 3pghB-5vegA:
undetectable		 3pghB-5vegA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		5 VAL A 309
LEU A 314
LEU A 244
GLY A 265
ALA A 262
 None
None
CIT  A 509 (-4.2A)
None
None
 1.25A 3pghB-5viuA:
undetectable		 3pghB-5viuA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 5 VAL A 524
LEU A 528
LEU A 521
GLY A 554
ALA A 484
 None
 1.17A 3pghB-5whsA:
undetectable		 3pghB-5whsA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		5 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
 None
 1.13A 3pghB-5wu3A:
undetectable		 3pghB-5wu3A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		5 LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
 None
 1.14A 3pghB-5wu6A:
undetectable		 3pghB-5wu6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwo ESSENTIAL NUCLEAR
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF05291
(Bystin) 		5 LEU A 311
LEU A 283
VAL A 341
GLY A 339
ALA A 338
 None
 1.25A 3pghB-5wwoA:
undetectable		 3pghB-5wwoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S5,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 VAL e 286
LEU e 238
VAL e 187
GLY e 185
ALA e 260
 None
 1.20A 3pghB-5x8re:
undetectable		 3pghB-5x8re:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 5 VAL A 434
LEU A 303
VAL A 463
GLY A 476
ALA A 477
 None
 1.09A 3pghB-5xilA:
undetectable		 3pghB-5xilA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		5 LEU A 199
LEU A 203
VAL A  54
GLY A  56
ALA A  55
 None
 1.13A 3pghB-5xjjA:
undetectable		 3pghB-5xjjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 VAL A1194
TYR A1196
TRP A1507
VAL A1209
GLY A1214
 None
 1.26A 3pghB-5xsyA:
undetectable		 3pghB-5xsyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 VAL A  89
LEU A  88
LEU A  93
GLY A 110
ALA A 113
 None
None
None
CL  A 401 (-3.5A)
CL  A 401 (-3.8A)
 1.09A 3pghB-6bq6A:
undetectable		 3pghB-6bq6A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 5 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.05A 3pghB-6byqA:
undetectable		 3pghB-6byqA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ

(Pseudomonas
fragi) 		no annotation 5 VAL A  28
LEU A 103
LEU A  32
GLY A  15
ALA A 228
 None
 1.26A 3pghB-6d79A:
undetectable		 3pghB-6d79A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A1088
LEU A1070
TRP A1041
GLY A1061
ALA A1063
 None
 1.16A 3pghB-6ez8A:
undetectable		 3pghB-6ez8A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 1.21A 3pghB-6fsaA:
undetectable		 3pghB-6fsaA:
undetectable