SIMILAR PATTERNS OF AMINO ACIDS FOR 3PFG_A_SAMA264_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
3 TYR A 171
TYR A   7
GLU A 166
None
0.73A 3pfgA-1biiA:
undetectable
3pfgA-1biiA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddh MHC CLASS I H-2DD
HEAVY CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
3 TYR A 171
TYR A   7
GLU A 166
None
0.23A 3pfgA-1ddhA:
undetectable
3pfgA-1ddhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I


(Proteus
vulgaris)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt)
3 TYR A 664
TYR A 741
GLU A 782
None
0.88A 3pfgA-1hn0A:
undetectable
3pfgA-1hn0A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
3 TYR A  75
TYR A 167
GLU A 277
None
0.88A 3pfgA-1kcxA:
undetectable
3pfgA-1kcxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ld9 MHC CLASS I H-2LD
HEAVY CHAIN


(Mus musculus)
PF00129
(MHC_I)
PF07654
(C1-set)
3 TYR A 171
TYR A   7
GLU A 166
None
0.74A 3pfgA-1ld9A:
undetectable
3pfgA-1ld9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli)
no annotation 3 TYR B 307
TYR B 288
GLU B 347
None
0.92A 3pfgA-1p3wB:
undetectable
3pfgA-1p3wB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN


(Enterococcus
faecalis)
PF05899
(Cupin_3)
PF07883
(Cupin_2)
3 TYR A 162
TYR A 254
GLU A 160
None
0.93A 3pfgA-1sefA:
undetectable
3pfgA-1sefA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus)
PF06283
(ThuA)
3 TYR A 155
TYR A 194
GLU A 152
None
0.69A 3pfgA-1t0bA:
undetectable
3pfgA-1t0bA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN


(Thermus
thermophilus)
PF06778
(Chlor_dismutase)
3 TYR A  62
TYR A 237
GLU A  56
None
0.90A 3pfgA-1vdhA:
undetectable
3pfgA-1vdhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqy HYPOTHETICAL PROTEIN
AGR_PAT_315


(Agrobacterium
fabrum)
PF07978
(NIPSNAP)
3 TYR A   8
TYR A  40
GLU A   4
None
0.95A 3pfgA-1vqyA:
undetectable
3pfgA-1vqyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A 128
TYR A 109
GLU A 101
None
0.72A 3pfgA-1w93A:
3.4
3pfgA-1w93A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
3 TYR A 273
TYR A 266
GLU A 277
None
0.75A 3pfgA-1x9nA:
undetectable
3pfgA-1x9nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwe COMPLEMENT C5

(Homo sapiens)
PF01759
(NTR)
3 TYR A1619
TYR A1543
GLU A1579
None
0.91A 3pfgA-1xweA:
undetectable
3pfgA-1xweA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN


(Homo sapiens)
PF00102
(Y_phosphatase)
3 TYR A 697
TYR A 859
GLU A 693
None
0.85A 3pfgA-1yguA:
undetectable
3pfgA-1yguA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuj HYPOTHETICAL PROTEIN
LLACC01001955


(Lactococcus
lactis)
no annotation 3 TYR A  57
TYR A 161
GLU A 112
None
0.75A 3pfgA-1zujA:
undetectable
3pfgA-1zujA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4


(Vibrio cholerae)
PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4)
3 TYR A  33
TYR A  79
GLU A  52
None
0.87A 3pfgA-2a3vA:
undetectable
3pfgA-2a3vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind)
3 TYR A 476
TYR A 483
GLU A 432
None
0.91A 3pfgA-2exrA:
undetectable
3pfgA-2exrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25


(Archaeoglobus
fulgidus)
PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C)
3 TYR A 286
TYR A 279
GLU A 324
None
0.98A 3pfgA-2fwrA:
3.5
3pfgA-2fwrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea)
PF07143
(CrtC)
PF17186
(Lipocalin_9)
3 TYR A 186
TYR A 143
GLU A  48
None
0.93A 3pfgA-2ichA:
2.9
3pfgA-2ichA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)


(Streptomyces
galilaeus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 TYR A 378
TYR A 450
GLU A 374
AKY  A 601 (-4.5A)
AKY  A 601 (-4.4A)
AKY  A 601 ( 4.6A)
0.92A 3pfgA-2ipiA:
undetectable
3pfgA-2ipiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
3 TYR A 210
TYR A 555
GLU A 191
None
0.83A 3pfgA-2iukA:
undetectable
3pfgA-2iukA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 TYR A  81
TYR A  91
GLU A 158
None
0.94A 3pfgA-2iwzA:
undetectable
3pfgA-2iwzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8a ENDOGLUCANASE

(Bacillus
subtilis)
PF00942
(CBM_3)
3 TYR A 358
TYR A 470
GLU A 435
None
0.81A 3pfgA-2l8aA:
undetectable
3pfgA-2l8aA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3


(Saccharomyces
cerevisiae)
no annotation 3 TYR A  74
TYR A  29
GLU A 223
None
0.92A 3pfgA-2lgzA:
undetectable
3pfgA-2lgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E)
PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C)
3 TYR A  77
TYR A 319
GLU A  73
None
0.99A 3pfgA-2obeA:
undetectable
3pfgA-2obeA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE


(Bacillus
thuringiensis)
PF00388
(PI-PLC-X)
3 TYR A  57
TYR A 285
GLU A  52
None
0.94A 3pfgA-2or2A:
undetectable
3pfgA-2or2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otx SRC
KINASE-ASSOCIATED
PHOSPHOPROTEIN 2


(Mus musculus)
PF00169
(PH)
3 TYR A 197
TYR A 169
GLU A  15
None
0.89A 3pfgA-2otxA:
undetectable
3pfgA-2otxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris)
PF00190
(Cupin_1)
3 TYR A  96
TYR A 119
GLU A 202
None
0.95A 3pfgA-2phlA:
undetectable
3pfgA-2phlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA


(Homo sapiens)
PF01504
(PIP5K)
3 TYR A 192
TYR A  93
GLU A 150
None
0.83A 3pfgA-2ybxA:
2.5
3pfgA-2ybxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1


(Homo sapiens)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A 224
TYR A 205
GLU A 197
None
0.83A 3pfgA-2yl2A:
undetectable
3pfgA-2yl2A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywy NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN


(Orectolobus
maculatus)
PF07686
(V-set)
3 TYR A  86
TYR A  37
GLU A 101
TYR  A  86 ( 1.3A)
TYR  A  37 ( 1.3A)
GLU  A 101 ( 0.6A)
0.85A 3pfgA-2ywyA:
undetectable
3pfgA-2ywyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER


(Escherichia
coli)
PF03797
(Autotransporter)
3 TYR A1137
TYR A1363
GLU A1098
None
0.98A 3pfgA-3aehA:
undetectable
3pfgA-3aehA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E


(Homo sapiens)
PF00129
(MHC_I)
PF07654
(C1-set)
3 TYR A 171
TYR A   7
GLU A 166
None
0.71A 3pfgA-3bzeA:
undetectable
3pfgA-3bzeA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE


(Escherichia
coli)
PF00425
(Chorismate_bind)
3 TYR A  50
TYR A 225
GLU A 231
None
0.98A 3pfgA-3bzmA:
undetectable
3pfgA-3bzmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894


(Bacteroides
uniformis)
no annotation 3 TYR A 312
TYR A 283
GLU A 321
None
0.97A 3pfgA-3dsmA:
2.3
3pfgA-3dsmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Streptococcus
agalactiae)
PF01408
(GFO_IDH_MocA)
3 TYR A 182
TYR A 157
GLU A  97
None
0.74A 3pfgA-3evnA:
4.6
3pfgA-3evnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE


(Aspergillus
niger)
PF13714
(PEP_mutase)
3 TYR A  92
TYR A 105
GLU A 116
None
0.52A 3pfgA-3fa3A:
undetectable
3pfgA-3fa3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN


(Thermoplasma
acidophilum)
PF01012
(ETF)
3 TYR A  45
TYR A  67
GLU A 146
None
0.80A 3pfgA-3fetA:
undetectable
3pfgA-3fetA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC


(Escherichia
coli)
PF00577
(Usher)
3 TYR A 448
TYR A 382
GLU A 467
None
0.74A 3pfgA-3fipA:
1.7
3pfgA-3fipA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
3 TYR A 422
TYR A 375
GLU A 275
None
0.92A 3pfgA-3gwjA:
undetectable
3pfgA-3gwjA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5


(Thermus
thermophilus;
Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00329
(Complex1_30kDa)
3 TYR 5 184
TYR 3 137
GLU 3 129
None
0.77A 3pfgA-3i9v5:
undetectable
3pfgA-3i9v5:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens)
PF00129
(MHC_I)
PF07654
(C1-set)
3 TYR A 171
TYR A   7
GLU A 166
None
0.75A 3pfgA-3kyoA:
undetectable
3pfgA-3kyoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6


(Homo sapiens)
PF02373
(JmjC)
3 TYR A 137
TYR A 150
GLU A 166
None
None
SO4  A 344 (-4.1A)
0.95A 3pfgA-3ld8A:
undetectable
3pfgA-3ld8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE


(Cryphonectria
parasitica)
PF13714
(PEP_mutase)
3 TYR A 160
TYR A 173
GLU A 184
None
None
CA  A 501 ( 4.4A)
0.44A 3pfgA-3lyeA:
2.4
3pfgA-3lyeA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct)
PF00961
(LAGLIDADG_1)
3 TYR A  85
TYR A  26
GLU A  30
None
0.82A 3pfgA-3mipA:
undetectable
3pfgA-3mipA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Kosmotoga
olearia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
3 TYR A  14
TYR A  49
GLU A 387
None
0.98A 3pfgA-3mwcA:
undetectable
3pfgA-3mwcA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R


(Ectromelia
virus)
PF00047
(ig)
PF13895
(Ig_2)
3 TYR B 303
TYR B 308
GLU B 297
None
0.94A 3pfgA-3oq3B:
undetectable
3pfgA-3oq3B:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
3 TYR A  22
TYR A  33
GLU A  79
SAH  A 263 (-4.6A)
SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
0.07A 3pfgA-3px2A:
42.3
3pfgA-3px2A:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN


(Neisseria
meningitidis)
PF02661
(Fic)
3 TYR A 143
TYR A 100
GLU A 148
ANP  A 201 (-4.7A)
None
ANP  A 201 (-4.9A)
0.90A 3pfgA-3se5A:
undetectable
3pfgA-3se5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL


(Planctopirus
limnophila)
PF01261
(AP_endonuc_2)
3 TYR A  76
TYR A 188
GLU A 256
GOL  A 292 (-3.9A)
None
MG  A 291 ( 2.8A)
0.93A 3pfgA-3tvaA:
undetectable
3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL


(Planctopirus
limnophila)
PF01261
(AP_endonuc_2)
3 TYR A  76
TYR A 188
GLU A 258
GOL  A 292 (-3.9A)
None
GOL  A 292 (-3.1A)
0.99A 3pfgA-3tvaA:
undetectable
3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum)
PF00696
(AA_kinase)
PF01842
(ACT)
3 TYR A 117
TYR A 110
GLU A 136
None
0.88A 3pfgA-3tviA:
undetectable
3pfgA-3tviA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA


(Streptomyces
lividans)
PF00266
(Aminotran_5)
3 TYR A  51
TYR A 180
GLU A 253
None
0.78A 3pfgA-3vaxA:
undetectable
3pfgA-3vaxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE


(Helicobacter
pylori)
PF03796
(DnaB_C)
3 TYR A 287
TYR A 314
GLU A 326
None
0.91A 3pfgA-4a1fA:
3.1
3pfgA-4a1fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE


(Variovorax
paradoxus)
PF00202
(Aminotran_3)
3 TYR A 394
TYR A  46
GLU A  75
None
0.90A 3pfgA-4aoaA:
3.1
3pfgA-4aoaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis)
PF16754
(Pesticin)
3 TYR A  26
TYR A  55
GLU A 114
None
0.95A 3pfgA-4arpA:
undetectable
3pfgA-4arpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN


(Pyrococcus
furiosus)
PF01798
(Nop)
3 TYR C  23
TYR C  10
GLU C 104
None
0.94A 3pfgA-4by9C:
undetectable
3pfgA-4by9C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
3 TYR A 559
TYR A 506
GLU A 556
NAG  A1955 (-4.6A)
None
None
0.76A 3pfgA-4cvuA:
2.6
3pfgA-4cvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE


(Drosophila
melanogaster)
PF07859
(Abhydrolase_3)
3 TYR A 225
TYR A 255
GLU A 216
None
0.87A 3pfgA-4e14A:
undetectable
3pfgA-4e14A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783


(Staphylococcus
aureus)
PF04507
(DUF576)
3 TYR A 205
TYR A 162
GLU A 152
None
0.91A 3pfgA-4eg9A:
2.3
3pfgA-4eg9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53


(Clostridium
botulinum)
PF03505
(Clenterotox)
3 TYR B 429
TYR B 214
GLU B 377
None
0.95A 3pfgA-4en8B:
undetectable
3pfgA-4en8B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuv PORIN PROTEIN
ASSOCIATED WITH
IMIPENEM RESISTANCE


(Acinetobacter
baumannii)
no annotation 3 TYR A  76
TYR A 171
GLU A  80
None
0.98A 3pfgA-4fuvA:
3.2
3pfgA-4fuvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2


(Homo sapiens)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 TYR A 329
TYR A 310
GLU A 302
None
0.85A 3pfgA-4hq6A:
2.6
3pfgA-4hq6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME


(Rickettsia
typhi)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
3 TYR A  84
TYR A 144
GLU A 407
CL  A 807 (-4.9A)
None
None
0.70A 3pfgA-4hvtA:
undetectable
3pfgA-4hvtA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius)
PF00437
(T2SSE)
3 TYR A  56
TYR A  34
GLU A  60
None
0.94A 3pfgA-4ihqA:
undetectable
3pfgA-4ihqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjh POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4


(Homo sapiens)
PF07686
(V-set)
3 TYR A  94
TYR A 125
GLU A  78
None
0.78A 3pfgA-4jjhA:
undetectable
3pfgA-4jjhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE


(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
3 TYR A 283
TYR A  68
GLU A  15
None
0.90A 3pfgA-4koaA:
4.2
3pfgA-4koaA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV


(Bacteroides
ovatus)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
3 TYR A 635
TYR A 230
GLU A 184
None
0.95A 3pfgA-4q1vA:
undetectable
3pfgA-4q1vA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified)
PF07859
(Abhydrolase_3)
3 TYR A 323
TYR A 219
GLU A 139
None
0.55A 3pfgA-4q3oA:
2.8
3pfgA-4q3oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 TYR H  96
TYR H 101
GLU H  31
None
0.94A 3pfgA-4qexH:
undetectable
3pfgA-4qexH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN


(Acinetobacter
baumannii)
no annotation 3 TYR A  76
TYR A 171
GLU A  80
None
0.98A 3pfgA-4rlbA:
undetectable
3pfgA-4rlbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
3 TYR A 452
TYR A 460
GLU A 405
None
0.83A 3pfgA-4w8bA:
undetectable
3pfgA-4w8bA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE


(Burkholderia
cenocepacia)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 TYR A 367
TYR A 152
GLU A 133
None
None
ZN  A 501 ( 4.1A)
0.96A 3pfgA-4wjbA:
undetectable
3pfgA-4wjbA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H


(Human
alphaherpesvirus
3)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
3 TYR A 682
TYR A 669
GLU A 706
None
0.83A 3pfgA-4xhjA:
undetectable
3pfgA-4xhjA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxi NUCLEOSIDE
DIPHOSPHATE KINASE


(Toxoplasma
gondii)
PF00334
(NDK)
3 TYR A  35
TYR A 153
GLU A   7
None
0.98A 3pfgA-5bxiA:
undetectable
3pfgA-5bxiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF17145
(DUF5119)
3 TYR A  69
TYR A  89
GLU A  50
None
0.91A 3pfgA-5cagA:
undetectable
3pfgA-5cagA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF12625
(Arabinose_bd)
PF12833
(HTH_18)
3 TYR A  19
TYR A 134
GLU A  64
None
0.55A 3pfgA-5chhA:
undetectable
3pfgA-5chhA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE


(Saccharomyces
cerevisiae)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central)
3 TYR A 128
TYR A 109
GLU A 101
None
0.86A 3pfgA-5cslA:
2.1
3pfgA-5cslA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum)
PF00232
(Glyco_hydro_1)
3 TYR A 294
TYR A 372
GLU A 403
None
0.95A 3pfgA-5dt5A:
undetectable
3pfgA-5dt5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE


(Pyrococcus)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
3 TYR A 356
TYR A 494
GLU A 460
None
0.96A 3pfgA-5h12A:
undetectable
3pfgA-5h12A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005


(uncultured
bacterium)
PF02522
(Antibiotic_NAT)
3 TYR A 138
TYR A  62
GLU A 171
None
COA  A 301 (-4.7A)
None
0.83A 3pfgA-5ht0A:
undetectable
3pfgA-5ht0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE


(Plasmodium
falciparum)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 TYR A 137
TYR A 158
GLU A 143
None
0.91A 3pfgA-5ilqA:
5.8
3pfgA-5ilqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7


(Homo sapiens)
PF00443
(UCH)
PF12436
(USP7_ICP0_bdg)
3 TYR A 339
TYR A 379
GLU A 383
None
0.99A 3pfgA-5j7tA:
undetectable
3pfgA-5j7tA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
3 TYR A 542
TYR A  73
GLU A 170
None
0.87A 3pfgA-5n0cA:
undetectable
3pfgA-5n0cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe7 UBIQUITIN
THIOESTERASE OTULIN


(Homo sapiens)
PF16218
(Peptidase_C101)
3 TYR A 319
TYR A 340
GLU A 314
None
0.78A 3pfgA-5oe7A:
undetectable
3pfgA-5oe7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE


(Zobellia
galactanivorans)
no annotation 3 TYR A 188
TYR A 637
GLU A 232
None
0.96A 3pfgA-5opqA:
2.3
3pfgA-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens)
PF00117
(GATase)
PF06418
(CTP_synth_N)
3 TYR A 525
TYR A 468
GLU A 528
None
0.79A 3pfgA-5u03A:
undetectable
3pfgA-5u03A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI


(Staphylococcus
pseudintermedius)
no annotation 3 TYR A 152
TYR A 178
GLU A  23
None
0.91A 3pfgA-5ujdA:
undetectable
3pfgA-5ujdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE


(Streptomyces
platensis)
PF13714
(PEP_mutase)
3 TYR A 103
TYR A 116
GLU A 127
None
None
TLA  A 401 ( 4.6A)
0.92A 3pfgA-5uncA:
2.6
3pfgA-5uncA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)


(Lachnospiraceae
bacterium
NK4A179)
no annotation 3 TYR A1223
TYR A1177
GLU A1231
None
0.69A 3pfgA-5wlhA:
undetectable
3pfgA-5wlhA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aliivibrio
fischeri)
no annotation 3 TYR A 287
TYR A 225
GLU A 229
None
0.66A 3pfgA-5xi0A:
1.2
3pfgA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
3 TYR B 295
TYR B 562
GLU B 616
None
0.91A 3pfgA-5xogB:
undetectable
3pfgA-5xogB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzq HYDROXYNITRILE LYASE

(Passiflora
edulis)
no annotation 3 TYR A  14
TYR A  64
GLU A  89
None
0.93A 3pfgA-5xzqA:
undetectable
3pfgA-5xzqA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR


(Galdieria
sulphuraria)
PF03151
(TPT)
3 TYR A 336
TYR A 289
GLU A 300
3PG  A 516 ( 4.8A)
None
None
0.90A 3pfgA-5y79A:
undetectable
3pfgA-5y79A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea)
no annotation 3 TYR B 400
TYR B  39
GLU B 366
None
0.94A 3pfgA-6bywB:
undetectable
3pfgA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE


(Staphylococcus
aureus)
no annotation 3 TYR A  84
TYR A  74
GLU A 106
None
0.86A 3pfgA-6c4rA:
4.5
3pfgA-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D


(Saccharomyces
cerevisiae)
no annotation 3 TYR B  97
TYR B 161
GLU B 198
None
0.91A 3pfgA-6c6lB:
undetectable
3pfgA-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE


(Entamoeba
histolytica)
no annotation 3 TYR A 228
TYR A 201
GLU A 180
None
0.78A 3pfgA-6cc2A:
2.9
3pfgA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN


(Escherichia
coli;
Homo sapiens)
no annotation 3 TYR R 268
TYR R 191
GLU R 122
None
0.88A 3pfgA-6cmoR:
undetectable
3pfgA-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE


(Schizosaccharomyces
pombe)
no annotation 3 TYR A 211
TYR A 305
GLU A 203
None
0.92A 3pfgA-6fdfA:
9.3
3pfgA-6fdfA:
undetectable