SIMILAR PATTERNS OF AMINO ACIDS FOR 3PFG_A_SAMA264

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 115
HIS A  43
LEU A 138
SER A 139
SER A  81
 None
ZN  A 600 (-3.3A)
None
None
None
 1.23A 3pfgA-1hp1A:
undetectable		 3pfgA-1hp1A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 TYR A  16
GLY A  74
LEU A  95
SER A  96
HIS A 141
 SAH  A1900 ( 4.2A)
SAH  A1900 (-3.2A)
SAH  A1900 (-4.4A)
None
SAH  A1900 (-4.4A)
 0.69A 3pfgA-1kphA:
15.0		 3pfgA-1kphA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 TYR A  24
GLY A  82
LEU A 103
SER A 104
HIS A 149
 SAH  A 900 ( 4.1A)
SAH  A 900 (-3.1A)
SAH  A 900 (-4.4A)
None
SAH  A 900 (-4.3A)
 0.64A 3pfgA-1kpiA:
14.1		 3pfgA-1kpiA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 TYR A 208
GLY A 179
LEU A 210
SER A 207
HIS A 261
 None
 0.92A 3pfgA-1rtrA:
undetectable		 3pfgA-1rtrA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s6r BETA-LACTAMASE

(Enterobacter
cloacae) 		PF00144
(Beta-lactamase) 		5 TYR A 170
ALA A 220
GLY A 222
LEU A 216
PHE A  69
 None
 1.26A 3pfgA-1s6rA:
undetectable		 3pfgA-1s6rA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 TYR A  16
GLY A  74
LEU A  95
SER A  96
HIS A 141
 SAH  A1900 ( 4.1A)
SAH  A1900 (-3.3A)
SAH  A1900 (-4.3A)
None
16A  A1901 ( 4.2A)
 0.70A 3pfgA-1tpyA:
14.9		 3pfgA-1tpyA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		5 ALA A 182
GLY A 184
SER A 205
ASP A   8
SER A 153
 HPD  A 801 (-3.2A)
HPD  A 801 (-3.9A)
HPD  A 801 (-2.6A)
None
None
 1.19A 3pfgA-1ub3A:
3.1		 3pfgA-1ub3A:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcv PROBABLE
DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Pyrobaculum
aerophilum) 		PF01791
(DeoC) 		5 ALA A 190
GLY A 192
SER A 220
ASP A   6
SER A 148
 None
 1.06A 3pfgA-1vcvA:
2.8		 3pfgA-1vcvA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  48
SER A  69
MET A  72
ASP A  93
SER A 112
HIS A 115
 SAM  A 302 (-3.4A)
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.61A 3pfgA-1ve3A:
8.0		 3pfgA-1ve3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 TYR A   7
GLY A  48
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-4.6A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 1.12A 3pfgA-1ve3A:
8.0		 3pfgA-1ve3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		5 ALA A  50
GLY A  52
LEU A  72
ASP A  98
HIS A 120
 None
 0.83A 3pfgA-1vl5A:
19.5		 3pfgA-1vl5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		7 TYR A   5
ALA A  49
GLY A  51
LEU A  71
MET A  75
ASP A  96
PHE A 113
 SAH  A1001 (-3.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
None
 0.28A 3pfgA-1wznA:
26.5		 3pfgA-1wznA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  48
LEU A  68
SER A  69
MET A  72
ASP A  93
SER A 112
 None
 0.58A 3pfgA-1y8cA:
26.2		 3pfgA-1y8cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		5 ALA A  97
GLY A 100
MET A 102
ASP A 284
PHE A 161
 None
 1.34A 3pfgA-2au1A:
undetectable		 3pfgA-2au1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 151
GLY A 149
LEU A 167
SER A 169
SER A  35
 None
 1.34A 3pfgA-2hk3A:
undetectable		 3pfgA-2hk3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		5 ALA A 331
GLY A 336
MET A 353
SER A 342
HIS A 347
 None
 1.33A 3pfgA-2hp3A:
undetectable		 3pfgA-2hp3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgw OUTER MEMBRANE
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00691
(OmpA) 		5 ALA A 224
GLY A 226
LEU A 232
SER A 231
ASP A 236
 None
 1.41A 3pfgA-2kgwA:
undetectable		 3pfgA-2kgwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kie INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF16726
(OCRL_clath_bd) 		6 ALA A  34
GLY A  22
HIS A 108
LEU A  50
ASP A  59
HIS A  56
 None
 1.29A 3pfgA-2kieA:
undetectable		 3pfgA-2kieA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		5 TYR X  86
ALA X 125
GLY X 127
LEU X 123
SER X 122
 None
 1.12A 3pfgA-2uydX:
2.1		 3pfgA-2uydX:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 GLY A 492
HIS A 490
LEU A 445
PHE A 498
SER A 452
 None
None
NAD  A3001 (-4.1A)
None
None
 1.16A 3pfgA-2v7gA:
7.1		 3pfgA-2v7gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 GLY A 493
HIS A 490
LEU A 445
PHE A 498
SER A 452
 NAD  A3001 (-3.1A)
None
NAD  A3001 (-4.1A)
None
None
 1.38A 3pfgA-2v7gA:
7.1		 3pfgA-2v7gA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkk TOPOISOMERASE IV

(Acinetobacter
baumannii) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 ALA A1163
HIS A1037
LEU A1135
SER A1133
ASP A1472
 None
 1.19A 3pfgA-2xkkA:
undetectable		 3pfgA-2xkkA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		5 TYR A 280
GLY A 318
LEU A 335
ASP A 346
MET A 347
 None
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
 0.98A 3pfgA-2zfuA:
11.6		 3pfgA-2zfuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		5 GLY A  52
LEU A  73
SER A  74
MET A  77
ASP A  96
 None
 0.70A 3pfgA-3bkwA:
15.7		 3pfgA-3bkwA:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		10 ALA A  46
GLY A  48
HIS A  52
LEU A  68
SER A  69
MET A  72
ASP A  89
MET A  90
PHE A 106
SER A 108
 SAM  A 238 (-3.2A)
SAM  A 238 ( 3.7A)
SAM  A 238 (-4.1A)
SAM  A 238 (-3.9A)
SAM  A 238 (-4.6A)
SAM  A 238 (-4.2A)
SAM  A 238 (-3.0A)
SAM  A 238 (-4.4A)
UPP  A 239 ( 3.6A)
SAM  A 238 (-3.2A)
 0.38A 3pfgA-3bxoA:
36.7		 3pfgA-3bxoA:
59.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		7 GLY A  42
LEU A  61
SER A  62
MET A  65
ASP A  86
MET A  87
SER A 105
 None
 0.69A 3pfgA-3d2lA:
26.2		 3pfgA-3d2lA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		5 GLY A  52
SER A  75
MET A  78
ASP A  98
HIS A 119
 None
 0.68A 3pfgA-3dtnA:
17.5		 3pfgA-3dtnA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		5 GLY A  52
SER A  75
MET A  78
SER A 116
HIS A 119
 None
 1.00A 3pfgA-3dtnA:
17.5		 3pfgA-3dtnA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		5 ALA A  80
GLY A 313
HIS A 315
LEU A  78
SER A  75
 None
None
None
None
AHZ  A1100 (-3.6A)
 1.38A 3pfgA-3fpzA:
undetectable		 3pfgA-3fpzA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		7 ALA A  71
GLY A  73
LEU A  93
SER A  94
ASP A 122
MET A 123
SER A 141
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.0A)
 0.59A 3pfgA-3g2pA:
18.0		 3pfgA-3g2pA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		5 GLY A  52
HIS A  56
LEU A  73
SER A  74
MET A  77
 None
 0.69A 3pfgA-3g5lA:
15.3		 3pfgA-3g5lA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnr PROBABLE
METHYLTRANSFERASE
BT9727_4108

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		5 GLY A  55
SER A  76
MET A  79
ASP A  97
HIS A 118
 None
 0.75A 3pfgA-3hnrA:
16.8		 3pfgA-3hnrA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htv D-ALLOSE KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 ALA A 293
GLY A  10
HIS A  31
LEU A 295
PHE A 286
 None
 1.38A 3pfgA-3htvA:
undetectable		 3pfgA-3htvA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 ALA A  45
GLY A  41
LEU A  46
MET A  49
PHE A  99
 None
 1.29A 3pfgA-3khzA:
undetectable		 3pfgA-3khzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxi GTP-BINDING PROTEIN
(HFLX)

(Sulfolobus
solfataricus) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		5 ALA A 335
GLY A 191
LEU A 336
PHE A 196
SER A 198
 GDP  A 500 (-3.8A)
GDP  A 500 (-3.2A)
GDP  A 500 (-3.9A)
None
SCN  A 366 ( 4.0A)
 1.21A 3pfgA-3kxiA:
2.5		 3pfgA-3kxiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 TYR A 141
ALA A   1
GLY A  34
ASP A 186
HIS A 148
 None
 1.22A 3pfgA-3lq0A:
undetectable		 3pfgA-3lq0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mve UPF0255 PROTEIN
VV1_0328

(Vibrio
vulnificus) 		PF06500
(DUF1100) 		5 ALA A 277
LEU A 281
SER A 282
PHE A 271
SER A 199
 None
 1.12A 3pfgA-3mveA:
undetectable		 3pfgA-3mveA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		5 ALA A 185
GLY A 187
HIS A 162
SER A 208
ASP A  11
 None
 1.21A 3pfgA-3ngjA:
4.7		 3pfgA-3ngjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		5 TYR A  15
ALA A  54
GLY A  56
MET A  80
HIS A 119
 SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.0A)
SO4  A 301 (-4.0A)
 0.98A 3pfgA-3ou6A:
14.4		 3pfgA-3ou6A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		6 TYR A  15
ALA A  54
GLY A  56
SER A  77
MET A  80
ASP A  98
 SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
 0.96A 3pfgA-3ou6A:
14.4		 3pfgA-3ou6A:
28.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		11 TYR A  14
ALA A  58
GLY A  60
HIS A  64
LEU A  80
SER A  81
MET A  84
ASP A 101
MET A 102
PHE A 118
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.3A)
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
SAH  A 263 (-3.3A)
 0.15A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		6 TYR A  14
GLY A  60
SER A  81
MET A  84
PHE A 118
HIS A 210
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
T3Q  A 301 ( 3.2A)
T3Q  A 301 ( 4.5A)
 1.46A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 ALA L 385
GLY L 395
LEU L 389
PHE L 340
SER L 464
 None
None
None
LFA  L 616 (-4.4A)
None
 1.34A 3pfgA-3rkoL:
undetectable		 3pfgA-3rkoL:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  92
GLY A  31
LEU A  94
PHE A  20
SER A  33
 None
 1.32A 3pfgA-3sn0A:
undetectable		 3pfgA-3sn0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 ALA A 907
GLY A 879
MET A 913
PHE A 902
HIS A 909
 None
None
None
None
SO4  A   6 (-4.1A)
 1.35A 3pfgA-3tzwA:
undetectable		 3pfgA-3tzwA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 TYR A 315
LEU A 263
SER A 260
ASP A 279
SER A 275
 None
 1.27A 3pfgA-3upyA:
4.5		 3pfgA-3upyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  35
GLY A  33
MET A  92
PHE A  18
HIS A 289
 None
 1.37A 3pfgA-3vcnA:
undetectable		 3pfgA-3vcnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		5 ALA A 443
GLY A 369
LEU A 445
SER A 449
PHE A 364
 None
 1.33A 3pfgA-4av6A:
undetectable		 3pfgA-4av6A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		5 TYR A 217
ALA A 224
GLY A 152
HIS A 146
LEU A 222
 None
 1.26A 3pfgA-4bxjA:
undetectable		 3pfgA-4bxjA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk1 PUTATIVE MACA,
MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa;
Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		5 ALA A 186
GLY A 160
HIS A 256
ASP A  59
SER A  54
 None
 1.31A 3pfgA-4dk1A:
undetectable		 3pfgA-4dk1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		5 GLY A 115
HIS A  58
LEU A 136
SER A 137
MET A 164
 None
 1.35A 3pfgA-4f85A:
15.9		 3pfgA-4f85A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		5 GLY A 115
LEU A 136
SER A 137
MET A 164
SER A 182
 None
 1.03A 3pfgA-4f85A:
15.9		 3pfgA-4f85A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Caulobacter sp.
K31) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  35
GLY A  33
MET A  92
PHE A  18
HIS A 289
 None
 1.38A 3pfgA-4fi4A:
2.2		 3pfgA-4fi4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 ALA A 386
HIS A 403
ASP A 384
MET A 383
HIS A 363
 None
 1.41A 3pfgA-4fwtA:
undetectable		 3pfgA-4fwtA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		5 ALA A 326
GLY A 324
LEU A 291
ASP A   7
MET A   8
 None
 1.26A 3pfgA-4ifrA:
undetectable		 3pfgA-4ifrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  45
GLY A  43
MET A 102
PHE A  28
HIS A 301
 None
 1.40A 3pfgA-4il2A:
undetectable		 3pfgA-4il2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		7 TYR A 187
GLY A 234
LEU A 255
SER A 256
MET A 259
ASP A 281
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.67A 3pfgA-4ineA:
13.0		 3pfgA-4ineA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 TYR A 187
GLY A 234
SER A 256
MET A 259
PHE A 199
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
None
 1.33A 3pfgA-4ineA:
13.0		 3pfgA-4ineA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 GLY A 337
LEU A 358
SER A 357
PHE A 267
HIS A 524
 None
None
None
1LF  A 601 (-4.8A)
1LF  A 601 (-3.3A)
 1.38A 3pfgA-4jncA:
undetectable		 3pfgA-4jncA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		7 TYR A 183
GLY A 230
LEU A 251
SER A 252
MET A 255
ASP A 277
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.4A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-3.4A)
SAH  A 701 (-4.2A)
 0.62A 3pfgA-4kriA:
16.1		 3pfgA-4kriA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TYR A 183
GLY A 230
SER A 252
MET A 255
PHE A 195
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
None
 1.29A 3pfgA-4kriA:
16.1		 3pfgA-4kriA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kws D-MANNONATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A  36
GLY A  34
MET A  93
PHE A  19
HIS A 291
 None
 1.36A 3pfgA-4kwsA:
undetectable		 3pfgA-4kwsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		6 TYR A  16
GLY A  62
MET A  87
ASP A 107
SER A 126
HIS A 129
 SAM  A 301 ( 4.3A)
SAM  A 301 ( 3.8A)
SAM  A 301 (-3.0A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.2A)
SAM  A 301 (-3.9A)
 0.82A 3pfgA-4mwzA:
15.6		 3pfgA-4mwzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		5 ALA A 202
GLY A 200
MET A 170
PHE A 194
SER A 247
 None
 1.20A 3pfgA-4n03A:
4.5		 3pfgA-4n03A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		5 TYR A  23
GLY A  82
HIS A  41
SER A 104
ASP A 130
 SAH  A 301 (-3.0A)
SAH  A 301 (-2.9A)
SAH  A 301 ( 3.6A)
None
SAH  A 301 (-2.7A)
 1.34A 3pfgA-4pneA:
15.3		 3pfgA-4pneA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris) 		PF12697
(Abhydrolase_6) 		5 GLY A 117
HIS A  77
LEU A 138
SER A 137
HIS A 271
 None
 1.31A 3pfgA-4psuA:
2.2		 3pfgA-4psuA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		5 GLY A  72
SER A  93
MET A  96
ASP A 120
HIS A 139
 SAH  A 301 (-3.6A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.8A)
None
 0.75A 3pfgA-4qdkA:
16.8		 3pfgA-4qdkA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		5 GLY A 226
HIS A 152
LEU A 398
MET A 251
ASP A 443
 None
 1.39A 3pfgA-4qlaA:
undetectable		 3pfgA-4qlaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 GLY B  57
SER B  79
MET B  82
ASP B  99
MET B 100
 SAM  B 301 (-3.3A)
EDO  B 310 ( 3.0A)
SAM  B 301 (-4.4A)
SAM  B 301 (-3.7A)
SAM  B 301 (-4.2A)
 0.31A 3pfgA-4qtuB:
17.9		 3pfgA-4qtuB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		5 TYR B  14
GLY B  57
SER B  79
ASP B  99
MET B 100
 None
SAM  B 301 (-3.3A)
EDO  B 310 ( 3.0A)
SAM  B 301 (-3.7A)
SAM  B 301 (-4.2A)
 0.95A 3pfgA-4qtuB:
17.9		 3pfgA-4qtuB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 TYR B  74
ALA B 323
GLY B 321
HIS B 311
SER B  14
 None
 1.25A 3pfgA-4yjfB:
3.6		 3pfgA-4yjfB:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER

(Escherichia
coli) 		PF01554
(MatE) 		5 ALA A 446
GLY A 442
HIS A 413
LEU A 448
SER A 389
 None
None
OLC  A 501 (-4.2A)
OLC  A 505 ( 4.7A)
None
 1.05A 3pfgA-4z3nA:
undetectable		 3pfgA-4z3nA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 144
GLY A  63
HIS A  61
MET A  32
ASP A 139
 None
None
ZN  A 401 (-3.3A)
None
None
 1.31A 3pfgA-4z6kA:
8.3		 3pfgA-4z6kA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLY A 845
SER A 849
ASP A 464
PHE A 479
SER A 480
 None
 1.35A 3pfgA-5a0zA:
undetectable		 3pfgA-5a0zA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 GLY A 337
LEU A 358
SER A 357
PHE A 267
HIS A 524
 None
None
None
None
II6  A1552 (-3.6A)
 1.39A 3pfgA-5allA:
undetectable		 3pfgA-5allA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		9 ALA A  53
GLY A  55
HIS A  59
LEU A  75
SER A  76
MET A  79
ASP A  96
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-4.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 ( 4.4A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.72A 3pfgA-5bszA:
32.3		 3pfgA-5bszA:
42.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 TYR B  92
ALA B 261
HIS B 288
PHE B 259
SER B 418
 None
 1.39A 3pfgA-5cyrB:
undetectable		 3pfgA-5cyrB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR C 307
ALA C 178
GLY C 176
SER C 304
MET C 300
 None
 1.28A 3pfgA-5dwzC:
undetectable		 3pfgA-5dwzC:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		5 GLY A  87
SER A 109
ASP A 135
SER A 154
HIS A 157
 SAH  A 301 (-3.1A)
None
SAH  A 301 (-3.6A)
SAH  A 301 (-4.4A)
SAH  A 301 ( 4.3A)
 0.86A 3pfgA-5gm2A:
16.2		 3pfgA-5gm2A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		5 ALA A  67
GLY A  69
SER A  90
MET A  93
SER A 135
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.1A)
 0.46A 3pfgA-5h02A:
20.6		 3pfgA-5h02A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		5 GLY A  69
SER A  90
MET A  93
ASP A 114
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.1A)
 0.74A 3pfgA-5h02A:
20.6		 3pfgA-5h02A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		5 GLY A 338
HIS A 342
LEU A 336
SER A 335
ASP A 289
 None
 1.22A 3pfgA-5inwA:
undetectable		 3pfgA-5inwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		5 ALA A 145
GLY A 147
LEU A 434
PHE A  22
SER A  23
 None
FAD  A 601 (-3.4A)
None
FAD  A 601 (-4.9A)
FAD  A 601 (-2.7A)
 1.38A 3pfgA-5j7xA:
undetectable		 3pfgA-5j7xA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae) 		PF13847
(Methyltransf_31) 		5 ALA A  47
GLY A  49
SER A  71
MET A  74
ASP A  95
 SAH  A 301 (-3.2A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 4.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.7A)
 0.43A 3pfgA-5je3A:
18.7		 3pfgA-5je3A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kut MITOCHONDRIAL RHO
GTPASE 2

(Homo sapiens) 		no annotation 5 GLY A 531
LEU A 528
ASP A 527
PHE A 501
SER A 523
 None
GDP  A 601 (-4.1A)
GDP  A 601 (-3.0A)
None
None
 1.32A 3pfgA-5kutA:
undetectable		 3pfgA-5kutA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		5 ALA A 183
GLY A 185
LEU A 192
SER A 193
SER A 235
 None
 1.34A 3pfgA-5lgxA:
undetectable		 3pfgA-5lgxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		5 GLY A  49
LEU A  71
SER A  72
MET A  75
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.5A)
 0.48A 3pfgA-5m58A:
7.8		 3pfgA-5m58A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		5 HIS A 117
LEU A  71
SER A  72
MET A  75
ASP A  96
 None
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.1A)
SAH  A 301 (-3.5A)
 1.27A 3pfgA-5m58A:
7.8		 3pfgA-5m58A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		5 GLY A  49
LEU A  71
SER A  72
MET A  75
ASP A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.0A)
SAH  A 301 (-3.5A)
 0.45A 3pfgA-5mgzA:
7.5		 3pfgA-5mgzA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tja MUCOLIPIN-1

(Homo sapiens) 		no annotation 5 TYR A 170
GLY A 173
LEU A 228
PHE A 182
HIS A 267
 None
 1.32A 3pfgA-5tjaA:
2.9		 3pfgA-5tjaA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		5 TYR A 141
ALA A 401
GLY A 399
HIS A  21
LEU A 406
 None
 1.35A 3pfgA-5u7wA:
undetectable		 3pfgA-5u7wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 7 TYR A 246
GLY A 292
LEU A 313
SER A 314
MET A 317
ASP A 338
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.1A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-3.3A)
SAH  A 703 (-4.0A)
 0.57A 3pfgA-5wp4A:
16.1		 3pfgA-5wp4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 TYR A 246
GLY A 292
SER A 314
MET A 317
PHE A 258
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
None
 1.33A 3pfgA-5wp4A:
16.1		 3pfgA-5wp4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 6 GLY A 292
LEU A 313
SER A 314
MET A 317
ASP A 338
HIS A 360
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.9A)
None
SAH  A 501 (-4.0A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
 0.43A 3pfgA-5wp5A:
16.4		 3pfgA-5wp5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 ALA A 138
GLY A 152
LEU A 144
MET A 148
HIS A 180
 None
 1.16A 3pfgA-5wqnA:
7.9		 3pfgA-5wqnA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 GLY A 236
LEU A 242
ASP A 206
PHE A  74
SER A 209
 None
 1.32A 3pfgA-6cjbA:
2.2		 3pfgA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 TYR A  58
GLY A 236
LEU A 242
ASP A 206
PHE A  74
 None
 1.23A 3pfgA-6cjbA:
2.2		 3pfgA-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 ALA A  99
GLY A  65
MET A 135
MET A  97
PHE A 263
 None
 1.39A 3pfgA-6d0pA:
undetectable		 3pfgA-6d0pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 ALA B  76
GLY B 139
HIS B 207
LEU B  72
HIS B  93
 None
 1.08A 3pfgA-6dbrB:
undetectable		 3pfgA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gkv COCLAURINE
N-METHYLTRANSFERASE

(Coptis japonica) 		no annotation 5 TYR A  81
GLY A 139
SER A 162
ASP A 187
HIS A 208
 SAH  A 501 (-3.6A)
SAH  A 501 (-3.1A)
None
SAH  A 501 (-4.2A)
SAH  A 501 ( 4.6A)
 0.97A 3pfgA-6gkvA:
13.3		 3pfgA-6gkvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bii MHC CLASS I H-2DD

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 171
TYR A   7
GLU A 166
 None
 0.73A 3pfgA-1biiA:
undetectable		 3pfgA-1biiA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddh MHC CLASS I H-2DD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 171
TYR A   7
GLU A 166
 None
 0.23A 3pfgA-1ddhA:
undetectable		 3pfgA-1ddhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TYR A 664
TYR A 741
GLU A 782
 None
 0.88A 3pfgA-1hn0A:
undetectable		 3pfgA-1hn0A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		3 TYR A  75
TYR A 167
GLU A 277
 None
 0.88A 3pfgA-1kcxA:
undetectable		 3pfgA-1kcxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ld9 MHC CLASS I H-2LD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 171
TYR A   7
GLU A 166
 None
 0.74A 3pfgA-1ld9A:
undetectable		 3pfgA-1ld9A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 3 TYR B 307
TYR B 288
GLU B 347
 None
 0.92A 3pfgA-1p3wB:
undetectable		 3pfgA-1p3wB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sef CONSERVED
HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF05899
(Cupin_3)
PF07883
(Cupin_2) 		3 TYR A 162
TYR A 254
GLU A 160
 None
 0.93A 3pfgA-1sefA:
undetectable		 3pfgA-1sefA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 TYR A 155
TYR A 194
GLU A 152
 None
 0.69A 3pfgA-1t0bA:
undetectable		 3pfgA-1t0bA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdh MUCONOLACTONE
ISOMERASE-LIKE
PROTEIN

(Thermus
thermophilus) 		PF06778
(Chlor_dismutase) 		3 TYR A  62
TYR A 237
GLU A  56
 None
 0.90A 3pfgA-1vdhA:
undetectable		 3pfgA-1vdhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqy HYPOTHETICAL PROTEIN
AGR_PAT_315

(Agrobacterium
fabrum) 		PF07978
(NIPSNAP) 		3 TYR A   8
TYR A  40
GLU A   4
 None
 0.95A 3pfgA-1vqyA:
undetectable		 3pfgA-1vqyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 128
TYR A 109
GLU A 101
 None
 0.72A 3pfgA-1w93A:
3.4		 3pfgA-1w93A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 TYR A 273
TYR A 266
GLU A 277
 None
 0.75A 3pfgA-1x9nA:
undetectable		 3pfgA-1x9nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwe COMPLEMENT C5

(Homo sapiens) 		PF01759
(NTR) 		3 TYR A1619
TYR A1543
GLU A1579
 None
 0.91A 3pfgA-1xweA:
undetectable		 3pfgA-1xweA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TYR A 697
TYR A 859
GLU A 693
 None
 0.85A 3pfgA-1yguA:
undetectable		 3pfgA-1yguA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zuj HYPOTHETICAL PROTEIN
LLACC01001955

(Lactococcus
lactis) 		no annotation 3 TYR A  57
TYR A 161
GLU A 112
 None
 0.75A 3pfgA-1zujA:
undetectable		 3pfgA-1zujA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4

(Vibrio cholerae) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		3 TYR A  33
TYR A  79
GLU A  52
 None
 0.87A 3pfgA-2a3vA:
undetectable		 3pfgA-2a3vA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 TYR A 476
TYR A 483
GLU A 432
 None
 0.91A 3pfgA-2exrA:
undetectable		 3pfgA-2exrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 TYR A 286
TYR A 279
GLU A 324
 None
 0.98A 3pfgA-2fwrA:
3.5		 3pfgA-2fwrA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		3 TYR A 186
TYR A 143
GLU A  48
 None
 0.93A 3pfgA-2ichA:
2.9		 3pfgA-2ichA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 TYR A 378
TYR A 450
GLU A 374
 AKY  A 601 (-4.5A)
AKY  A 601 (-4.4A)
AKY  A 601 ( 4.6A)
 0.92A 3pfgA-2ipiA:
undetectable		 3pfgA-2ipiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 TYR A 210
TYR A 555
GLU A 191
 None
 0.83A 3pfgA-2iukA:
undetectable		 3pfgA-2iukA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A  81
TYR A  91
GLU A 158
 None
 0.94A 3pfgA-2iwzA:
undetectable		 3pfgA-2iwzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8a ENDOGLUCANASE

(Bacillus
subtilis) 		PF00942
(CBM_3) 		3 TYR A 358
TYR A 470
GLU A 435
 None
 0.81A 3pfgA-2l8aA:
undetectable		 3pfgA-2l8aA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A  74
TYR A  29
GLU A 223
 None
 0.92A 3pfgA-2lgzA:
undetectable		 3pfgA-2lgzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A  77
TYR A 319
GLU A  73
 None
 0.99A 3pfgA-2obeA:
undetectable		 3pfgA-2obeA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Bacillus
thuringiensis) 		PF00388
(PI-PLC-X) 		3 TYR A  57
TYR A 285
GLU A  52
 None
 0.94A 3pfgA-2or2A:
undetectable		 3pfgA-2or2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otx SRC
KINASE-ASSOCIATED
PHOSPHOPROTEIN 2

(Mus musculus) 		PF00169
(PH) 		3 TYR A 197
TYR A 169
GLU A  15
 None
 0.89A 3pfgA-2otxA:
undetectable		 3pfgA-2otxA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phl PHASEOLIN

(Phaseolus
vulgaris) 		PF00190
(Cupin_1) 		3 TYR A  96
TYR A 119
GLU A 202
 None
 0.95A 3pfgA-2phlA:
undetectable		 3pfgA-2phlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA

(Homo sapiens) 		PF01504
(PIP5K) 		3 TYR A 192
TYR A  93
GLU A 150
 None
 0.83A 3pfgA-2ybxA:
2.5		 3pfgA-2ybxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 224
TYR A 205
GLU A 197
 None
 0.83A 3pfgA-2yl2A:
undetectable		 3pfgA-2yl2A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywy NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Orectolobus
maculatus) 		PF07686
(V-set) 		3 TYR A  86
TYR A  37
GLU A 101
 TYR  A  86 ( 1.3A)
TYR  A  37 ( 1.3A)
GLU  A 101 ( 0.6A)
 0.85A 3pfgA-2ywyA:
undetectable		 3pfgA-2ywyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 TYR A1137
TYR A1363
GLU A1098
 None
 0.98A 3pfgA-3aehA:
undetectable		 3pfgA-3aehA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bze HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHA CHAIN
E

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 171
TYR A   7
GLU A 166
 None
 0.71A 3pfgA-3bzeA:
undetectable		 3pfgA-3bzeA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		3 TYR A  50
TYR A 225
GLU A 231
 None
 0.98A 3pfgA-3bzmA:
undetectable		 3pfgA-3bzmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 TYR A 312
TYR A 283
GLU A 321
 None
 0.97A 3pfgA-3dsmA:
2.3		 3pfgA-3dsmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evn OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
agalactiae) 		PF01408
(GFO_IDH_MocA) 		3 TYR A 182
TYR A 157
GLU A  97
 None
 0.74A 3pfgA-3evnA:
4.6		 3pfgA-3evnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		3 TYR A  92
TYR A 105
GLU A 116
 None
 0.52A 3pfgA-3fa3A:
undetectable		 3pfgA-3fa3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fet ELECTRON TRANSFER
FLAVOPROTEIN SUBUNIT
ALPHA RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01012
(ETF) 		3 TYR A  45
TYR A  67
GLU A 146
 None
 0.80A 3pfgA-3fetA:
undetectable		 3pfgA-3fetA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		3 TYR A 448
TYR A 382
GLU A 467
 None
 0.74A 3pfgA-3fipA:
1.7		 3pfgA-3fipA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 422
TYR A 375
GLU A 275
 None
 0.92A 3pfgA-3gwjA:
undetectable		 3pfgA-3gwjA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 5

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
PF00329
(Complex1_30kDa) 		3 TYR 5 184
TYR 3 137
GLU 3 129
 None
 0.77A 3pfgA-3i9v5:
undetectable		 3pfgA-3i9v5:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A 171
TYR A   7
GLU A 166
 None
 0.75A 3pfgA-3kyoA:
undetectable		 3pfgA-3kyoA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6

(Homo sapiens) 		PF02373
(JmjC) 		3 TYR A 137
TYR A 150
GLU A 166
 None
None
SO4  A 344 (-4.1A)
 0.95A 3pfgA-3ld8A:
undetectable		 3pfgA-3ld8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE

(Cryphonectria
parasitica) 		PF13714
(PEP_mutase) 		3 TYR A 160
TYR A 173
GLU A 184
 None
None
CA  A 501 ( 4.4A)
 0.44A 3pfgA-3lyeA:
2.4		 3pfgA-3lyeA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		3 TYR A  85
TYR A  26
GLU A  30
 None
 0.82A 3pfgA-3mipA:
undetectable		 3pfgA-3mipA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A  14
TYR A  49
GLU A 387
 None
 0.98A 3pfgA-3mwcA:
undetectable		 3pfgA-3mwcA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Ectromelia
virus) 		PF00047
(ig)
PF13895
(Ig_2) 		3 TYR B 303
TYR B 308
GLU B 297
 None
 0.94A 3pfgA-3oq3B:
undetectable		 3pfgA-3oq3B:
20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		3 TYR A  22
TYR A  33
GLU A  79
 SAH  A 263 (-4.6A)
SAH  A 263 (-4.6A)
SAH  A 263 (-2.7A)
 0.07A 3pfgA-3px2A:
42.3		 3pfgA-3px2A:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		3 TYR A 143
TYR A 100
GLU A 148
 ANP  A 201 (-4.7A)
None
ANP  A 201 (-4.9A)
 0.90A 3pfgA-3se5A:
undetectable		 3pfgA-3se5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		3 TYR A  76
TYR A 188
GLU A 256
 GOL  A 292 (-3.9A)
None
MG  A 291 ( 2.8A)
 0.93A 3pfgA-3tvaA:
undetectable		 3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tva XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

(Planctopirus
limnophila) 		PF01261
(AP_endonuc_2) 		3 TYR A  76
TYR A 188
GLU A 258
 GOL  A 292 (-3.9A)
None
GOL  A 292 (-3.1A)
 0.99A 3pfgA-3tvaA:
undetectable		 3pfgA-3tvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tvi ASPARTOKINASE

(Clostridium
acetobutylicum) 		PF00696
(AA_kinase)
PF01842
(ACT) 		3 TYR A 117
TYR A 110
GLU A 136
 None
 0.88A 3pfgA-3tviA:
undetectable		 3pfgA-3tviA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vax PUTATIVE
UNCHARACTERIZED
PROTEIN DNDA

(Streptomyces
lividans) 		PF00266
(Aminotran_5) 		3 TYR A  51
TYR A 180
GLU A 253
 None
 0.78A 3pfgA-3vaxA:
undetectable		 3pfgA-3vaxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		3 TYR A 287
TYR A 314
GLU A 326
 None
 0.91A 3pfgA-4a1fA:
3.1		 3pfgA-4a1fA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		3 TYR A 394
TYR A  46
GLU A  75
 None
 0.90A 3pfgA-4aoaA:
3.1		 3pfgA-4aoaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		3 TYR A  26
TYR A  55
GLU A 114
 None
 0.95A 3pfgA-4arpA:
undetectable		 3pfgA-4arpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 NOP5/NOP56 RELATED
PROTEIN

(Pyrococcus
furiosus) 		PF01798
(Nop) 		3 TYR C  23
TYR C  10
GLU C 104
 None
 0.94A 3pfgA-4by9C:
undetectable		 3pfgA-4by9C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		3 TYR A 559
TYR A 506
GLU A 556
 NAG  A1955 (-4.6A)
None
None
 0.76A 3pfgA-4cvuA:
2.6		 3pfgA-4cvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE

(Drosophila
melanogaster) 		PF07859
(Abhydrolase_3) 		3 TYR A 225
TYR A 255
GLU A 216
 None
 0.87A 3pfgA-4e14A:
undetectable		 3pfgA-4e14A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eg9 UNCHARACTERIZED
PROTEIN
SAOUHSC_02783

(Staphylococcus
aureus) 		PF04507
(DUF576) 		3 TYR A 205
TYR A 162
GLU A 152
 None
 0.91A 3pfgA-4eg9A:
2.3		 3pfgA-4eg9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4en8 HEMAGGLUTININ
COMPONENTS
HA-22/23/53

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		3 TYR B 429
TYR B 214
GLU B 377
 None
 0.95A 3pfgA-4en8B:
undetectable		 3pfgA-4en8B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuv PORIN PROTEIN
ASSOCIATED WITH
IMIPENEM RESISTANCE

(Acinetobacter
baumannii) 		no annotation 3 TYR A  76
TYR A 171
GLU A  80
 None
 0.98A 3pfgA-4fuvA:
3.2		 3pfgA-4fuvA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TYR A 329
TYR A 310
GLU A 302
 None
 0.85A 3pfgA-4hq6A:
2.6		 3pfgA-4hq6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 TYR A  84
TYR A 144
GLU A 407
 CL  A 807 (-4.9A)
None
None
 0.70A 3pfgA-4hvtA:
undetectable		 3pfgA-4hvtA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		3 TYR A  56
TYR A  34
GLU A  60
 None
 0.94A 3pfgA-4ihqA:
undetectable		 3pfgA-4ihqA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjh POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set) 		3 TYR A  94
TYR A 125
GLU A  78
 None
 0.78A 3pfgA-4jjhA:
undetectable		 3pfgA-4jjhA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 283
TYR A  68
GLU A  15
 None
 0.90A 3pfgA-4koaA:
4.2		 3pfgA-4koaA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 TYR A 635
TYR A 230
GLU A 184
 None
 0.95A 3pfgA-4q1vA:
undetectable		 3pfgA-4q1vA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		3 TYR A 323
TYR A 219
GLU A 139
 None
 0.55A 3pfgA-4q3oA:
2.8		 3pfgA-4q3oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qex ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  96
TYR H 101
GLU H  31
 None
 0.94A 3pfgA-4qexH:
undetectable		 3pfgA-4qexH:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlb CARBAPENEM-ASSOCIATE
D RESISTANCE PROTEIN

(Acinetobacter
baumannii) 		no annotation 3 TYR A  76
TYR A 171
GLU A  80
 None
 0.98A 3pfgA-4rlbA:
undetectable		 3pfgA-4rlbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8b EXO-XYLOGLUCANASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 TYR A 452
TYR A 460
GLU A 405
 None
 0.83A 3pfgA-4w8bA:
undetectable		 3pfgA-4w8bA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjb PUTATIVE
AMIDOHYDROLASE/PEPTI
DASE

(Burkholderia
cenocepacia) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 TYR A 367
TYR A 152
GLU A 133
 None
None
ZN  A 501 ( 4.1A)
 0.96A 3pfgA-4wjbA:
undetectable		 3pfgA-4wjbA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 TYR A 682
TYR A 669
GLU A 706
 None
 0.83A 3pfgA-4xhjA:
undetectable		 3pfgA-4xhjA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxi NUCLEOSIDE
DIPHOSPHATE KINASE

(Toxoplasma
gondii) 		PF00334
(NDK) 		3 TYR A  35
TYR A 153
GLU A   7
 None
 0.98A 3pfgA-5bxiA:
undetectable		 3pfgA-5bxiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		3 TYR A  69
TYR A  89
GLU A  50
 None
 0.91A 3pfgA-5cagA:
undetectable		 3pfgA-5cagA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chh ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF12625
(Arabinose_bd)
PF12833
(HTH_18) 		3 TYR A  19
TYR A 134
GLU A  64
 None
 0.55A 3pfgA-5chhA:
undetectable		 3pfgA-5chhA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		3 TYR A 128
TYR A 109
GLU A 101
 None
 0.86A 3pfgA-5cslA:
2.1		 3pfgA-5cslA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		3 TYR A 294
TYR A 372
GLU A 403
 None
 0.95A 3pfgA-5dt5A:
undetectable		 3pfgA-5dt5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h12 DEEP VENT DNA
POLYMERASE

(Pyrococcus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 356
TYR A 494
GLU A 460
 None
 0.96A 3pfgA-5h12A:
undetectable		 3pfgA-5h12A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005

(uncultured
bacterium) 		PF02522
(Antibiotic_NAT) 		3 TYR A 138
TYR A  62
GLU A 171
 None
COA  A 301 (-4.7A)
None
 0.83A 3pfgA-5ht0A:
undetectable		 3pfgA-5ht0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilq ASPARTATE
CARBAMOYLTRANSFERASE

(Plasmodium
falciparum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 TYR A 137
TYR A 158
GLU A 143
 None
 0.91A 3pfgA-5ilqA:
5.8		 3pfgA-5ilqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		3 TYR A 339
TYR A 379
GLU A 383
 None
 0.99A 3pfgA-5j7tA:
undetectable		 3pfgA-5j7tA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 TYR A 542
TYR A  73
GLU A 170
 None
 0.87A 3pfgA-5n0cA:
undetectable		 3pfgA-5n0cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oe7 UBIQUITIN
THIOESTERASE OTULIN

(Homo sapiens) 		PF16218
(Peptidase_C101) 		3 TYR A 319
TYR A 340
GLU A 314
 None
 0.78A 3pfgA-5oe7A:
undetectable		 3pfgA-5oe7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 3 TYR A 188
TYR A 637
GLU A 232
 None
 0.96A 3pfgA-5opqA:
2.3		 3pfgA-5opqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 TYR A 525
TYR A 468
GLU A 528
 None
 0.79A 3pfgA-5u03A:
undetectable		 3pfgA-5u03A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 3 TYR A 152
TYR A 178
GLU A  23
 None
 0.91A 3pfgA-5ujdA:
undetectable		 3pfgA-5ujdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		3 TYR A 103
TYR A 116
GLU A 127
 None
None
TLA  A 401 ( 4.6A)
 0.92A 3pfgA-5uncA:
2.6		 3pfgA-5uncA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 3 TYR A1223
TYR A1177
GLU A1231
 None
 0.69A 3pfgA-5wlhA:
undetectable		 3pfgA-5wlhA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 3 TYR A 287
TYR A 225
GLU A 229
 None
 0.66A 3pfgA-5xi0A:
1.2		 3pfgA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B 295
TYR B 562
GLU B 616
 None
 0.91A 3pfgA-5xogB:
undetectable		 3pfgA-5xogB:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzq HYDROXYNITRILE LYASE

(Passiflora
edulis) 		no annotation 3 TYR A  14
TYR A  64
GLU A  89
 None
 0.93A 3pfgA-5xzqA:
undetectable		 3pfgA-5xzqA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y79 PUTATIVE HEXOSE
PHOSPHATE
TRANSLOCATOR

(Galdieria
sulphuraria) 		PF03151
(TPT) 		3 TYR A 336
TYR A 289
GLU A 300
 3PG  A 516 ( 4.8A)
None
None
 0.90A 3pfgA-5y79A:
undetectable		 3pfgA-5y79A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 3 TYR B 400
TYR B  39
GLU B 366
 None
 0.94A 3pfgA-6bywB:
undetectable		 3pfgA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 3 TYR A  84
TYR A  74
GLU A 106
 None
 0.86A 3pfgA-6c4rA:
4.5		 3pfgA-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D

(Saccharomyces
cerevisiae) 		no annotation 3 TYR B  97
TYR B 161
GLU B 198
 None
 0.91A 3pfgA-6c6lB:
undetectable		 3pfgA-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 TYR A 228
TYR A 201
GLU A 180
 None
 0.78A 3pfgA-6cc2A:
2.9		 3pfgA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 3 TYR R 268
TYR R 191
GLU R 122
 None
 0.88A 3pfgA-6cmoR:
undetectable		 3pfgA-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 3 TYR A 211
TYR A 305
GLU A 203
 None
 0.92A 3pfgA-6fdfA:
9.3		 3pfgA-6fdfA:
undetectable