SIMILAR PATTERNS OF AMINO ACIDS FOR 3PEO_F_CU9F301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		4 TYR A 250
TYR A 178
CYH A 142
TYR A 214
 None
 1.48A 3peoF-1z7dA:
0.0		 3peoF-1z7dA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		4 TRP A 415
TYR A 571
CYH A 622
TYR A 497
 None
 1.44A 3peoF-2gh8A:
0.0		 3peoF-2gh8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk7 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00653
(BIR) 		4 TRP A 310
TYR A 329
CYH A 327
CYH A 303
 BI6  A1346 (-3.7A)
None
ZN  A1347 (-2.3A)
ZN  A1347 (-2.2A)
 1.14A 3peoF-2jk7A:
0.0		 3peoF-2jk7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.27A 3peoF-2vfkA:
0.0		 3peoF-2vfkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.34A 3peoF-3j4rA:
0.0		 3peoF-3j4rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A4429
TRP A4286
TYR A4454
CYH A4444
 None
 1.36A 3peoF-4opeA:
0.0		 3peoF-4opeA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A  93
TRP A 147
TYR A 188
TYR A 195
 None
 1.26A 3peoF-4zjsA:
28.9		 3peoF-4zjsA:
82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 275
CYH A 263
CYH A 277
TYR A 274
 MLI  A 303 ( 4.5A)
None
None
None
 1.24A 3peoF-5jj2A:
0.0		 3peoF-5jj2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6m E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		4 TRP A 310
TYR A 329
CYH A 327
CYH A 303
 7H8  A 403 (-2.8A)
None
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 1.15A 3peoF-5m6mA:
0.0		 3peoF-5m6mA:
20.09