SIMILAR PATTERNS OF AMINO ACIDS FOR 3PEO_F_CU9F301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		4 TYR A 250
TYR A 178
CYH A 142
TYR A 214
 None
 1.48A 3peoF-1z7dA:
0.0		 3peoF-1z7dA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		4 TRP A 415
TYR A 571
CYH A 622
TYR A 497
 None
 1.44A 3peoF-2gh8A:
0.0		 3peoF-2gh8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk7 BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00653
(BIR) 		4 TRP A 310
TYR A 329
CYH A 327
CYH A 303
 BI6  A1346 (-3.7A)
None
ZN  A1347 (-2.3A)
ZN  A1347 (-2.2A)
 1.14A 3peoF-2jk7A:
0.0		 3peoF-2jk7A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.27A 3peoF-2vfkA:
0.0		 3peoF-2vfkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4r A-KINASE ANCHOR
PROTEIN 18

(Homo sapiens) 		PF10469
(AKAP7_NLS)
PF10470
(AKAP7_RIRII_bdg) 		4 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.34A 3peoF-3j4rA:
0.0		 3peoF-3j4rA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TYR A4429
TRP A4286
TYR A4454
CYH A4444
 None
 1.36A 3peoF-4opeA:
0.0		 3peoF-4opeA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 TYR A  93
TRP A 147
TYR A 188
TYR A 195
 None
 1.26A 3peoF-4zjsA:
28.9		 3peoF-4zjsA:
82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj2 A-KINASE ANCHOR
PROTEIN 7 ISOFORM
GAMMA

(Homo sapiens) 		PF10469
(AKAP7_NLS) 		4 TYR A 275
CYH A 263
CYH A 277
TYR A 274
 MLI  A 303 ( 4.5A)
None
None
None
 1.24A 3peoF-5jj2A:
0.0		 3peoF-5jj2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6m E3 UBIQUITIN-PROTEIN
LIGASE XIAP

(Homo sapiens) 		PF00653
(BIR) 		4 TRP A 310
TYR A 329
CYH A 327
CYH A 303
 7H8  A 403 (-2.8A)
None
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 1.15A 3peoF-5m6mA:
0.0		 3peoF-5m6mA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7f PROTEIN (SXL-LETHAL
PROTEIN)

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		4 GLN A 282
GLN A 226
ILE A 222
SER A 281
 None
 1.03A 3peoG-1b7fA:
0.0		 3peoG-1b7fA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dql IGM MEZ
IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		4 GLN L  37
TYR L  86
GLN L   6
ILE L  21
 None
 1.27A 3peoG-1dqlL:
1.4		 3peoG-1dqlL:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo9
PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLN B 477
TYR B 479
ILE B 486
SER B 476
 SO4  B 999 (-3.6A)
None
None
None
 1.13A 3peoG-1eo9B:
0.0		 3peoG-1eo9B:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo9
PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLN B 477
TYR B 479
ILE B 505
SER B 476
 SO4  B 999 (-3.6A)
None
None
None
 1.20A 3peoG-1eo9B:
0.0		 3peoG-1eo9B:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex9 LACTONIZING LIPASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		4 THR A 103
TYR A 196
ILE A 243
SER A 101
 None
 1.18A 3peoG-1ex9A:
undetectable		 3peoG-1ex9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.88A 3peoG-1fskC:
1.2		 3peoG-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		4 GLN A 175
GLN A  25
ILE A  22
SER A 177
 None
 1.14A 3peoG-1h09A:
0.0		 3peoG-1h09A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h8s MUTANT AL2 6E7P9G

(Mus musculus) 		PF07686
(V-set) 		4 GLN A  40
TYR A  89
GLN A   9
ILE A  24
 None
 1.30A 3peoG-1h8sA:
0.0		 3peoG-1h8sA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htj KIAA0380

(Homo sapiens) 		PF09128
(RGS-like) 		4 GLN F 334
TYR F 431
GLN F 453
SER F 333
 None
 1.29A 3peoG-1htjF:
undetectable		 3peoG-1htjF:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 THR A 734
GLN A 731
TYR A 709
ILE A 707
 None
 1.11A 3peoG-1jx2A:
undetectable		 3peoG-1jx2A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kho ALPHA-TOXIN

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 THR A 306
GLN A 304
TYR A 261
ILE A 346
 None
 1.03A 3peoG-1khoA:
0.0		 3peoG-1khoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 THR B 199
GLN B 111
ILE B  16
SER B 197
 None
 0.86A 3peoG-1mqtB:
undetectable		 3peoG-1mqtB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n26 IL-6 RECEPTOR ALPHA
CHAIN

(Homo sapiens) 		PF00047
(ig)
PF09240
(IL6Ra-bind) 		4 GLN A 153
TYR A 148
GLN A 147
SER A 152
 None
None
NDG  A 636 (-3.9A)
None
 1.04A 3peoG-1n26A:
undetectable		 3peoG-1n26A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvg DNA TOPOISOMERASE II

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 GLN A 171
TYR A 169
GLN A 167
ILE A 106
 None
 0.96A 3peoG-1pvgA:
undetectable		 3peoG-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 GLN A 153
TYR A 187
GLN A 210
ILE A 211
 None
NAG  A 801 (-4.2A)
None
None
 1.17A 3peoG-1q5aA:
undetectable		 3peoG-1q5aA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		4 THR D 108
TYR D 207
ILE E 277
SER D 106
 None
 1.30A 3peoG-1qgeD:
undetectable		 3peoG-1qgeD:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoz ACETYL XYLAN
ESTERASE

(Trichoderma
reesei) 		PF01083
(Cutinase) 		4 GLN A  94
TYR A  57
GLN A  49
SER A  90
 None
 1.19A 3peoG-1qozA:
undetectable		 3peoG-1qozA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		4 THR A 243
GLN A 248
ILE A 214
SER A 246
 None
 1.22A 3peoG-1rmgA:
undetectable		 3peoG-1rmgA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		4 GLN A 357
GLN A 334
ILE A 351
SER A 211
 None
869  A1501 ( 3.8A)
None
None
 1.02A 3peoG-1sqiA:
undetectable		 3peoG-1sqiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 THR A 371
GLN A 372
TYR A 368
ILE A 256
 None
 1.26A 3peoG-1xzqA:
undetectable		 3peoG-1xzqA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd1 SULFOTRANSFERASE 4A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 GLN A  70
TYR A  66
GLN A  62
SER A  69
 None
 1.31A 3peoG-1zd1A:
undetectable		 3peoG-1zd1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		4 THR A 109
TYR A 135
ILE A  75
SER A 105
 None
 1.30A 3peoG-2btwA:
undetectable		 3peoG-2btwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dib FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		4 THR A  82
TYR A  83
GLN A  84
SER A  48
 None
 1.30A 3peoG-2dibA:
2.5		 3peoG-2dibA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 GLN A 298
GLN A 348
ILE A 266
SER A 299
 None
 1.25A 3peoG-2dw4A:
undetectable		 3peoG-2dw4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 GLN L  37
TYR L  86
GLN L   6
ILE L  21
 None
 1.31A 3peoG-2e27L:
undetectable		 3peoG-2e27L:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gkp HYPOTHETICAL PROTEIN
NMB0488

(Neisseria
meningitidis) 		PF07262
(CdiI) 		4 THR A  24
TYR A  37
GLN A  57
SER A  26
 None
 1.15A 3peoG-2gkpA:
undetectable		 3peoG-2gkpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 THR A 364
GLN A 367
TYR A 369
ILE A 491
 None
 1.19A 3peoG-2gy7A:
undetectable		 3peoG-2gy7A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 THR A 153
GLN A 132
ILE A 246
SER A 129
 None
 1.11A 3peoG-2gz3A:
undetectable		 3peoG-2gz3A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mx2 DEUBIQUITINATING
PROTEIN VCIP135

(Rattus
norvegicus) 		no annotation 4 THR A  14
GLN A  19
GLN A  48
ILE A  37
 None
 1.17A 3peoG-2mx2A:
undetectable		 3peoG-2mx2A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		4 THR A 336
GLN A 343
ILE A 300
SER A 338
 None
 1.17A 3peoG-2ntbA:
undetectable		 3peoG-2ntbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o79 LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.26A 3peoG-2o79A:
undetectable		 3peoG-2o79A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfy PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03480
(DctP) 		4 THR A 149
GLN A 123
TYR A 145
SER A  81
 None
PCA  A 302 (-3.0A)
PCA  A 302 (-3.9A)
None
 0.93A 3peoG-2pfyA:
undetectable		 3peoG-2pfyA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 THR A 151
GLN A  72
ILE A 176
SER A  69
 None
S4M  A 501 (-3.5A)
None
None
 1.30A 3peoG-2pt6A:
undetectable		 3peoG-2pt6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		4 GLN A 232
TYR A 347
GLN A 344
SER A 155
 None
 1.08A 3peoG-2pywA:
undetectable		 3peoG-2pywA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qho E3 UBIQUITIN-PROTEIN
LIGASE EDD1

(Homo sapiens) 		PF11547
(E3_UbLigase_EDD) 		4 GLN B 194
GLN B 210
ILE B 185
SER B 201
 None
 1.25A 3peoG-2qhoB:
undetectable		 3peoG-2qhoB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00041
(fn3)
PF00047
(ig)
PF00629
(MAM) 		4 GLN A 515
TYR A 539
GLN A 558
SER A 513
 None
 0.77A 3peoG-2v5yA:
undetectable		 3peoG-2v5yA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 THR A 302
GLN A 262
ILE A 260
SER A 397
 None
 1.00A 3peoG-3bitA:
undetectable		 3peoG-3bitA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch0 GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Cytophaga
hutchinsonii) 		PF03009
(GDPD) 		4 THR A 171
GLN A 173
GLN A 131
SER A 193
 None
CIT  A 272 ( 4.5A)
EDO  A 285 (-3.0A)
None
 0.88A 3peoG-3ch0A:
undetectable		 3peoG-3ch0A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dml PUTATIVE
UNCHARACTERIZED
PROTEIN

(Paracoccus
denitrificans) 		no annotation 4 THR A  30
TYR A  27
GLN A  26
ILE A  23
 None
 1.23A 3peoG-3dmlA:
undetectable		 3peoG-3dmlA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e99 BENZOATE
1,2-DIOXYGENASE BETA
SUBUNIT

(Burkholderia
mallei) 		PF00866
(Ring_hydroxyl_B) 		4 THR A 114
TYR A 125
ILE A 163
SER A 116
 None
 1.11A 3peoG-3e99A:
undetectable		 3peoG-3e99A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 GLN A 377
TYR A 289
ILE A 274
SER A 373
 None
 1.21A 3peoG-3ehmA:
undetectable		 3peoG-3ehmA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		4 THR A 267
GLN A 266
TYR A 232
ILE A 233
 None
 1.20A 3peoG-3eqxA:
undetectable		 3peoG-3eqxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		4 GLN A 299
TYR A  42
ILE A  76
SER A  38
 None
 1.22A 3peoG-3gffA:
undetectable		 3peoG-3gffA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijp DIHYDRODIPICOLINATE
REDUCTASE

(Bartonella
henselae) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 THR A  98
GLN A  76
ILE A 109
SER A  75
 NAP  A 300 ( 4.4A)
NAP  A 300 (-4.9A)
None
NAP  A 300 (-4.7A)
 1.00A 3peoG-3ijpA:
undetectable		 3peoG-3ijpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljy PUTATIVE ADHESIN

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 THR A 103
TYR A  54
ILE A  44
SER A  61
 None
 1.29A 3peoG-3ljyA:
undetectable		 3peoG-3ljyA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml3 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin) 		4 GLN A 637
TYR A 635
GLN A 633
ILE A 596
 None
 1.03A 3peoG-3ml3A:
undetectable		 3peoG-3ml3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw6 UNCHARACTERIZED
PROTEIN NMB1681

(Neisseria
meningitidis) 		PF04352
(ProQ) 		4 THR A  17
GLN A  16
ILE A  27
SER A  13
 None
 1.23A 3peoG-3mw6A:
undetectable		 3peoG-3mw6A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 TYR A 204
GLN A 419
ILE A 206
SER A 251
 None
 1.18A 3peoG-3pdiA:
undetectable		 3peoG-3pdiA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 THR A 116
TYR A 117
ILE A 129
SER A  77
 None
 1.23A 3peoG-3q3hA:
undetectable		 3peoG-3q3hA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.27A 3peoG-3qakA:
undetectable		 3peoG-3qakA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpi LIGHT CHAIN FROM
HIGHLY POTENT
ANTI-HIV
NEUTRALIZING
ANTIBODY

(Homo sapiens) 		no annotation 4 GLN L  36
TYR L  84
GLN L   6
ILE L  21
 None
 1.26A 3peoG-3rpiL:
2.9		 3peoG-3rpiL:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 TYR A 673
GLN A 691
ILE A 693
SER A 564
 None
 1.08A 3peoG-3szeA:
undetectable		 3peoG-3szeA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		4 GLN A 448
TYR A 444
GLN A 440
ILE A 421
 None
 1.15A 3peoG-3t66A:
undetectable		 3peoG-3t66A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 THR A  71
GLN A 119
TYR A  73
ILE A  75
 None
None
None
P6G  A 401 ( 4.1A)
 1.14A 3peoG-3tdgA:
undetectable		 3peoG-3tdgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up6 HYPOTHETICAL PROTEIN
BACOVA_04078

(Bacteroides
ovatus) 		no annotation 4 THR A 340
GLN A 349
GLN A 338
ILE A 353
 None
 1.09A 3peoG-3up6A:
undetectable		 3peoG-3up6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw7 PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.24A 3peoG-3vw7A:
undetectable		 3peoG-3vw7A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		4 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 1.19A 3peoG-3w9uA:
undetectable		 3peoG-3w9uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsq CATHEPSIN S

(Mus musculus) 		PF00112
(Peptidase_C1) 		4 GLN A 238
TYR A 236
ILE A 202
SER A 336
 None
None
SO4  A1345 (-4.3A)
None
 1.13A 3peoG-4bsqA:
undetectable		 3peoG-4bsqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1)
no annotation 		4 THR C  35
GLN C  37
ILE B 193
SER C 187
 None
 1.29A 3peoG-4ejsC:
undetectable		 3peoG-4ejsC:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 GLN A 171
TYR A 169
GLN A 167
ILE A 106
 None
 0.92A 3peoG-4gfhA:
undetectable		 3peoG-4gfhA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		4 GLN A 244
TYR A 326
GLN A 327
ILE A 325
 None
 1.21A 3peoG-4haqA:
undetectable		 3peoG-4haqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hj3 LOV PROTEIN

(Rhodobacter
sphaeroides) 		PF13426
(PAS_9) 		4 THR A  43
GLN A 118
GLN A  49
ILE A  50
 None
FMN  A 201 (-3.8A)
None
None
 1.18A 3peoG-4hj3A:
undetectable		 3peoG-4hj3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7l LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.27A 3peoG-4i7lA:
undetectable		 3peoG-4i7lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqr HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF14717
(DUF4465) 		4 GLN A  56
TYR A  73
GLN A  43
ILE A  45
 None
None
EDO  A 313 (-3.0A)
None
 1.04A 3peoG-4jqrA:
undetectable		 3peoG-4jqrA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr9 IMMUNOGLOBULIN
KAPPA, LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN L  37
TYR L  86
GLN L   6
ILE L  21
 None
 1.30A 3peoG-4jr9L:
undetectable		 3peoG-4jr9L:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		4 THR A 290
GLN A 302
ILE A 292
SER A 324
 None
 1.27A 3peoG-4lg9A:
undetectable		 3peoG-4lg9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		4 GLN A 302
TYR A 218
GLN A 216
ILE A 219
 None
 1.18A 3peoG-4okoA:
undetectable		 3peoG-4okoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 THR A 594
GLN A 760
TYR A 598
ILE A 675
 None
 1.31A 3peoG-4p6wA:
undetectable		 3peoG-4p6wA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 THR A3212
GLN A2871
TYR A3213
ILE A2858
 None
 1.27A 3peoG-4rh7A:
undetectable		 3peoG-4rh7A:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 GLN A  18
TYR A   4
GLN A  42
SER A  14
 None
SO4  A 502 ( 4.9A)
None
None
 0.87A 3peoG-4s3kA:
undetectable		 3peoG-4s3kA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN

(Homo sapiens) 		PF07686
(V-set) 		4 GLN B  37
TYR B  86
GLN B   6
ILE B  21
 None
 1.30A 3peoG-4x4yB:
undetectable		 3peoG-4x4yB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 THR A 141
GLN A 137
GLN A 422
ILE A 423
 3GC  A 501 ( 4.6A)
AVI  A 502 (-3.1A)
None
None
 0.90A 3peoG-4x8dA:
undetectable		 3peoG-4x8dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.23A 3peoG-4xeeA:
undetectable		 3peoG-4xeeA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 THR A 141
GLN A 322
ILE A 254
SER A 139
 None
 1.26A 3peoG-4zhtA:
undetectable		 3peoG-4zhtA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		4 GLN A  38
TYR A  55
ILE A 118
SER A 167
 None
 1.21A 3peoG-4zjsA:
29.3		 3peoG-4zjsA:
82.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 THR A  36
GLN A  38
GLN A  57
ILE A 118
SER A 167
 None
 0.77A 3peoG-4zjsA:
29.3		 3peoG-4zjsA:
82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.24A 3peoG-4zwjA:
2.0		 3peoG-4zwjA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzp CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
purpureum) 		PF00840
(Glyco_hydro_7) 		4 THR A  96
GLN A  97
ILE A 103
SER A  98
 None
 1.29A 3peoG-4zzpA:
undetectable		 3peoG-4zzpA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 GLN A 318
TYR A 309
GLN A 311
ILE A 285
 None
 0.76A 3peoG-4zzqA:
undetectable		 3peoG-4zzqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		4 GLN D 235
TYR D 284
GLN D 206
ILE D 221
 None
 1.27A 3peoG-5d9qD:
undetectable		 3peoG-5d9qD:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLN A  74
GLN A  38
ILE A  40
SER A  63
 None
 1.20A 3peoG-5dmhA:
undetectable		 3peoG-5dmhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 GLN A 380
TYR A 419
ILE A 416
SER A 383
 None
 1.13A 3peoG-5ejyA:
undetectable		 3peoG-5ejyA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 GLN A 206
TYR A 158
GLN A  23
ILE A 159
 None
 1.17A 3peoG-5jmdA:
undetectable		 3peoG-5jmdA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kan 16.G.07 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN I  89
TYR I  36
GLN I  38
SER I  98
 None
 1.23A 3peoG-5kanI:
undetectable		 3peoG-5kanI:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 GLN A 418
TYR A 483
GLN A 545
ILE A 532
 None
 0.94A 3peoG-5kd5A:
undetectable		 3peoG-5kd5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 THR B 102
GLN B 101
ILE B 182
SER B  98
 None
 1.25A 3peoG-5ltmB:
undetectable		 3peoG-5ltmB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1

(Rhodococcus
jostii) 		PF00296
(Bac_luciferase) 		4 THR A  35
GLN A  68
ILE A 192
SER A  33
 None
 0.82A 3peoG-5lxeA:
undetectable		 3peoG-5lxeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 GLN A 312
TYR A 303
GLN A 305
ILE A 288
 None
 0.65A 3peoG-5o5dA:
undetectable		 3peoG-5o5dA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5o RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		4 TYR A 264
GLN A 260
ILE A 219
SER A 267
 None
 1.27A 3peoG-5o5oA:
undetectable		 3peoG-5o5oA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		4 THR A  34
TYR A  25
ILE A  17
SER A  36
 None
 1.24A 3peoG-5v88A:
undetectable		 3peoG-5v88A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Escherichia
virus T4;
Mycobacterium
kansasii) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.30A 3peoG-5vbaA:
undetectable		 3peoG-5vbaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpr CYSTEINE DESULFURASE

(Elizabethkingia
anophelis) 		PF00266
(Aminotran_5) 		4 TYR A 385
GLN A  10
ILE A   7
SER A  32
 None
None
None
LLP  A 225 ( 3.3A)
 1.10A 3peoG-5vprA:
undetectable		 3peoG-5vprA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 6 THR A  34
GLN A  36
TYR A  53
GLN A  55
ILE A 116
SER A 165
 None
 0.62A 3peoG-5xglA:
30.8		 3peoG-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 THR A  34
GLN A  55
ILE A 116
SER A 164
 None
 0.82A 3peoG-5xglA:
30.8		 3peoG-5xglA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2z LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 THR B 545
GLN B 230
ILE B 547
SER B 236
 None
 1.28A 3peoG-5y2zB:
undetectable		 3peoG-5y2zB:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 THR A 681
GLN A 645
ILE A 652
SER A 379
 None
 1.15A 3peoG-6cgmA:
undetectable		 3peoG-6cgmA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 4 GLN A  11
TYR A   9
ILE A   6
SER A 214
 None
 1.14A 3peoG-6et9A:
undetectable		 3peoG-6et9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC
CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 4 THR A 327
GLN A 326
TYR C 346
ILE C 343
 FAD  A 401 (-4.0A)
None
FAD  A 401 ( 4.7A)
FAD  A 401 ( 4.3A)
 1.11A 3peoG-6fahA:
undetectable		 3peoG-6fahA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.26A 3peoG-6ffhA:
undetectable		 3peoG-6ffhA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Cyanidioschyzon
merolae) 		no annotation 4 THR A 158
TYR A  88
GLN A 154
ILE A 149
 CLA  A1112 (-3.7A)
None
CLA  A1114 (-4.4A)
None
 1.17A 3peoG-6fosA:
undetectable		 3peoG-6fosA:
18.54