SIMILAR PATTERNS OF AMINO ACIDS FOR 3PEO_C_CU9C301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zjs ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR,ACETYLCHOLI
NE RECEPTOR SUBUNIT
ALPHA,SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica;
Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 THR A  36
GLN A  38
TYR A  55
GLN A  57
SER A 167
 None
 1.16A 3peoC-4zjsA:
28.1
3peoD-4zjsA:
29.2		 3peoC-4zjsA:
82.17
3peoD-4zjsA:
82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF01547
(SBP_bac_1) 		5 TRP A 316
TYR A 111
TYR A 106
GLN A 399
TYR A  75
 RB0  A 501 (-3.9A)
None
None
None
None
 1.45A 3peoC-5iaiA:
0.0
3peoD-5iaiA:
0.0		 3peoC-5iaiA:
20.48
3peoD-5iaiA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 5 THR A  34
GLN A  36
TYR A  53
GLN A  55
SER A 165
 None
 0.70A 3peoC-5xglA:
30.6
3peoD-5xglA:
30.6		 3peoC-5xglA:
98.75
3peoD-5xglA:
98.75