SIMILAR PATTERNS OF AMINO ACIDS FOR 3PEO_A_CU9A301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		5 TYR A 434
VAL A 356
MET A 363
ILE A 365
TYR A 322
 None
 1.38A 3peoA-1u2xA:
0.0
3peoE-1u2xA:
0.0		 3peoA-1u2xA:
17.30
3peoE-1u2xA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 TYR A 477
MET A 245
ILE A 481
SER A 946
TYR A 933
 None
A  B  -5 ( 3.5A)
None
None
None
 1.30A 3peoA-5wlhA:
0.0
3peoE-5wlhA:
0.0		 3peoA-5wlhA:
8.97
3peoE-5wlhA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhq CAPSID PROTEIN VP1

(Enterovirus A) 		no annotation 5 TYR A  80
VAL A  86
MET A 248
ILE A 250
SER A 121
 None
 1.48A 3peoA-5yhqA:
0.0
3peoE-5yhqA:
0.0		 3peoA-5yhqA:
20.58
3peoE-5yhqA:
20.58