SIMILAR PATTERNS OF AMINO ACIDS FOR 3P73_A_ACTA275_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		3 ILE A 225
VAL A 245
ARG A 249
 None
 0.76A 3p73A-1axnA:
0.0		 3p73A-1axnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6b SAR1

(Cricetulus
griseus) 		PF00025
(Arf) 		3 ILE A  96
VAL A 127
ARG A 171
 None
 0.73A 3p73A-1f6bA:
0.0		 3p73A-1f6bA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q TRPG

(Serratia
marcescens) 		PF00117
(GATase) 		3 ILE B  30
VAL B  18
ARG B  22
 None
 0.61A 3p73A-1i7qB:
undetectable		 3p73A-1i7qB:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyl MYRISTOYL-COA:PROTEI
N
N-MYRISTOYLTRANSFERA
SE

(Candida
albicans) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 ILE A 328
VAL A 320
ARG A 268
 None
 0.56A 3p73A-1iylA:
0.0		 3p73A-1iylA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		3 ILE A 298
VAL A 216
ARG A 196
 None
 0.74A 3p73A-1j71A:
0.0		 3p73A-1j71A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		3 ILE H 112
VAL H 118
ARG H 115
 None
 0.66A 3p73A-1kigH:
undetectable		 3p73A-1kigH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oki BETA CRYSTALLIN B1

(Homo sapiens) 		PF00030
(Crystall) 		3 ILE A 114
VAL A 193
ARG A 229
 None
 0.75A 3p73A-1okiA:
0.8		 3p73A-1okiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		3 ILE A 335
VAL A 282
ARG A 286
 None
 0.64A 3p73A-1t47A:
0.3		 3p73A-1t47A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		3 ILE A 117
VAL A 243
ARG A 244
 None
 0.49A 3p73A-1un1A:
0.0		 3p73A-1un1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		3 ILE A  56
VAL A  39
ARG A  37
 None
 0.64A 3p73A-1xs5A:
undetectable		 3p73A-1xs5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybx CONSERVED
HYPOTHETICAL PROTEIN

(Ruminiclostridium
thermocellum) 		PF02575
(YbaB_DNA_bd) 		3 ILE A 102
VAL A  30
ARG A  29
 None
 0.61A 3p73A-1ybxA:
undetectable		 3p73A-1ybxA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 ILE A 162
VAL A  29
ARG A  27
 None
 0.76A 3p73A-1yfjA:
undetectable		 3p73A-1yfjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens) 		no annotation 3 ILE A 172
VAL A 136
ARG A 140
 None
 0.64A 3p73A-1ynsA:
undetectable		 3p73A-1ynsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1v CONSERVED
HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF04237
(YjbR) 		3 ILE A  52
VAL A  10
ARG A  14
 None
 0.74A 3p73A-2a1vA:
undetectable		 3p73A-2a1vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		3 ILE A  37
VAL A 124
ARG A 128
 None
 0.74A 3p73A-2c5qA:
undetectable		 3p73A-2c5qA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		3 ILE A 626
VAL A 596
ARG A 577
 None
 0.76A 3p73A-2c79A:
undetectable		 3p73A-2c79A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		3 ILE A  96
VAL A 140
ARG A 138
 None
 0.76A 3p73A-2d6fA:
undetectable		 3p73A-2d6fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f17 THIAMIN
PYROPHOSPHOKINASE 1

(Mus musculus) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		3 ILE A  91
VAL A 107
ARG A 110
 None
 0.61A 3p73A-2f17A:
undetectable		 3p73A-2f17A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxf DIAMINE
ACETYLTRANSFERASE 1

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 ILE A  71
VAL A  56
ARG A   7
 None
 0.57A 3p73A-2fxfA:
undetectable		 3p73A-2fxfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ILE A 895
VAL A 884
ARG A 888
 None
 0.75A 3p73A-2i75A:
undetectable		 3p73A-2i75A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0m UNCHARACTERIZED
PROTEIN

(Rhodospirillum
rubrum) 		PF11523
(DUF3223) 		3 ILE A   7
VAL A  96
ARG A  51
 None
 0.76A 3p73A-2k0mA:
undetectable		 3p73A-2k0mA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9v PONSIN

(Homo sapiens) 		PF00018
(SH3_1) 		3 ILE A 871
VAL A 854
ARG A 852
 None
 0.69A 3p73A-2o9vA:
undetectable		 3p73A-2o9vA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		3 ILE A 150
VAL A 122
ARG A 126
 None
 0.73A 3p73A-2vj5A:
undetectable		 3p73A-2vj5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxk GLUCOSAMINE
6-PHOSPHATE
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		PF00583
(Acetyltransf_1) 		3 ILE A 106
VAL A  98
ARG A  51
 None
 0.71A 3p73A-2vxkA:
undetectable		 3p73A-2vxkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ILE B 585
VAL B 555
ARG B 558
 None
 0.57A 3p73A-2w55B:
undetectable		 3p73A-2w55B:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR

(Homo sapiens) 		no annotation 3 ILE A 559
VAL A 629
ARG A 632
 None
 0.57A 3p73A-2xocA:
undetectable		 3p73A-2xocA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoy RBAM17540

(Bacillus
amyloliquefaciens) 		PF03067
(LPMO_10) 		3 ILE A 182
VAL A 199
ARG A  37
 None
 0.72A 3p73A-2yoyA:
1.9		 3p73A-2yoyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 ILE A 261
VAL A 325
ARG A 329
 None
 0.65A 3p73A-2yr5A:
undetectable		 3p73A-2yr5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 ILE A 327
VAL A 413
ARG A 338
 None
 0.72A 3p73A-3agrA:
undetectable		 3p73A-3agrA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ILE A 435
VAL A 441
ARG A 405
 None
 0.71A 3p73A-3aw5A:
2.3		 3p73A-3aw5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bch 40S RIBOSOMAL
PROTEIN SA

(Homo sapiens) 		PF00318
(Ribosomal_S2)
PF16122
(40S_SA_C) 		3 ILE A  65
VAL A 182
ARG A 186
 None
 0.53A 3p73A-3bchA:
undetectable		 3p73A-3bchA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 ILE A  70
VAL A 195
ARG A 197
 None
None
NRQ  A  63 ( 3.9A)
 0.49A 3p73A-3bxaA:
1.4		 3p73A-3bxaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 ILE A 198
VAL A 140
ARG A 138
 None
 0.75A 3p73A-3c9rA:
0.9		 3p73A-3c9rA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ILE A 187
VAL A 293
ARG A  38
 None
 0.73A 3p73A-3cmgA:
1.8		 3p73A-3cmgA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ILE A 233
VAL A 182
ARG A 186
 None
 0.75A 3p73A-3ctzA:
undetectable		 3p73A-3ctzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxp GLUCOSAMINE
6-PHOSPHATE
N-ACETYLTRANSFERASE

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 ILE A  97
VAL A  88
ARG A  42
 None
 0.73A 3p73A-3cxpA:
undetectable		 3p73A-3cxpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3s L-2,4-DIAMINOBUTYRIC
ACID
ACETYLTRANSFERASE

(Bordetella
parapertussis) 		PF00583
(Acetyltransf_1) 		3 ILE A  54
VAL A  46
ARG A   5
 None
 0.63A 3p73A-3d3sA:
undetectable		 3p73A-3d3sA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		3 ILE A  50
VAL A  30
ARG A  23
 None
 0.74A 3p73A-3e9mA:
undetectable		 3p73A-3e9mA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ILE A 166
VAL A 239
ARG A 262
 None
 0.75A 3p73A-3gfbA:
undetectable		 3p73A-3gfbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4q PUTATIVE
ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00583
(Acetyltransf_1) 		3 ILE A  60
VAL A  53
ARG A   3
 None
 0.61A 3p73A-3h4qA:
undetectable		 3p73A-3h4qA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6t GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		3 ILE A 200
VAL A 178
ARG A 182
 None
 0.59A 3p73A-3h6tA:
undetectable		 3p73A-3h6tA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		3 ILE A 148
VAL A 112
ARG A 116
 None
 0.35A 3p73A-3hjzA:
undetectable		 3p73A-3hjzA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlm ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Mus musculus) 		PF00155
(Aminotran_1_2) 		3 ILE A 265
VAL A 120
ARG A 125
 None
 0.72A 3p73A-3hlmA:
undetectable		 3p73A-3hlmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i24 HIT FAMILY HYDROLASE

(Aliivibrio
fischeri) 		PF01230
(HIT) 		3 ILE A  14
VAL A 126
ARG A 130
 None
 0.35A 3p73A-3i24A:
undetectable		 3p73A-3i24A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idv PROTEIN
DISULFIDE-ISOMERASE
A4

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 ILE A 107
VAL A 161
ARG A 165
 None
 0.45A 3p73A-3idvA:
undetectable		 3p73A-3idvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 3 ILE A 196
VAL A 163
ARG A 167
 None
ACT  A 383 (-4.5A)
ACT  A 384 ( 2.7A)
 0.66A 3p73A-3iupA:
undetectable		 3p73A-3iupA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvn ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF00583
(Acetyltransf_1) 		3 ILE A  67
VAL A  60
ARG A   6
 None
 0.61A 3p73A-3jvnA:
undetectable		 3p73A-3jvnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		3 ILE A  43
VAL A 349
ARG A 353
 None
 0.74A 3p73A-3khjA:
undetectable		 3p73A-3khjA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica) 		PF00923
(TAL_FSA) 		3 ILE A 152
VAL A 116
ARG A 120
 None
 0.60A 3p73A-3m16A:
undetectable		 3p73A-3m16A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		3 ILE A 299
VAL A 303
ARG A 306
 None
 0.77A 3p73A-3nxsA:
undetectable		 3p73A-3nxsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		3 ILE A 247
VAL A 221
ARG A 225
 None
 0.51A 3p73A-3o0yA:
undetectable		 3p73A-3o0yA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ILE A 106
VAL A 162
ARG A 166
 ACT  A 276 ( 4.7A)
None
ACT  A 276 (-2.8A)
 0.07A 3p73A-3p77A:
37.1		 3p73A-3p77A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t90 GLUCOSE-6-PHOSPHATE
ACETYLTRANSFERASE 1

(Arabidopsis
thaliana) 		PF00583
(Acetyltransf_1) 		3 ILE A  64
VAL A  55
ARG A   8
 None
 0.72A 3p73A-3t90A:
undetectable		 3p73A-3t90A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		3 ILE A 114
VAL A 109
ARG A  85
 None
 0.58A 3p73A-3ty1A:
undetectable		 3p73A-3ty1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		3 ILE A  76
VAL A  46
ARG A  49
 None
 0.75A 3p73A-3us8A:
undetectable		 3p73A-3us8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		3 ILE A  74
VAL A  87
ARG A 101
 None
 0.74A 3p73A-4akrA:
undetectable		 3p73A-4akrA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		3 ILE A 336
VAL A 144
ARG A 148
 None
 0.77A 3p73A-4b45A:
undetectable		 3p73A-4b45A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blq P4

(Pseudomonas
phage phi8) 		PF11602
(NTPase_P4) 		3 ILE A  48
VAL A 207
ARG A  93
 None
 0.75A 3p73A-4blqA:
undetectable		 3p73A-4blqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		3 ILE A 175
VAL A 170
ARG A 169
 CL  A1327 (-4.0A)
None
CL  A1327 (-3.0A)
 0.58A 3p73A-4ce5A:
undetectable		 3p73A-4ce5A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		3 ILE A 174
VAL A 169
ARG A 168
 None
 0.58A 3p73A-4cmfA:
undetectable		 3p73A-4cmfA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		3 ILE A 137
VAL A 167
ARG A 171
 ILE  A 137 ( 0.6A)
VAL  A 167 ( 0.6A)
ARG  A 171 ( 0.6A)
 0.76A 3p73A-4dlkA:
1.6		 3p73A-4dlkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egv ACETYL-COA
ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 3 ILE A   9
VAL A 379
ARG A 383
 None
 0.67A 3p73A-4egvA:
undetectable		 3p73A-4egvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6a BH1408 PROTEIN

(Bacillus
halodurans) 		PF00583
(Acetyltransf_1) 		3 ILE A  66
VAL A  58
ARG A   4
 None
 0.65A 3p73A-4f6aA:
undetectable		 3p73A-4f6aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ILE A 276
VAL A 236
ARG A 237
 None
 0.71A 3p73A-4fquA:
undetectable		 3p73A-4fquA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g43 MHC CLASS I ALPHA
CHAIN 2

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 ILE A 107
VAL A 162
ARG A 166
 None
 0.71A 3p73A-4g43A:
30.4		 3p73A-4g43A:
62.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 ILE A 223
VAL A 236
ARG A 238
 None
 0.75A 3p73A-4h1xA:
undetectable		 3p73A-4h1xA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Mycobacterium
tuberculosis) 		PF02126
(PTE) 		3 ILE A 237
VAL A 234
ARG A 243
 None
 0.76A 3p73A-4if2A:
undetectable		 3p73A-4if2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inq OXYSTEROL-BINDING
PROTEIN HOMOLOG 3

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		3 ILE A 910
VAL A 627
ARG A 629
 None
 0.68A 3p73A-4inqA:
undetectable		 3p73A-4inqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln2 SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		3 ILE A 917
VAL A 900
ARG A 898
 None
 0.75A 3p73A-4ln2A:
undetectable		 3p73A-4ln2A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1b POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		3 ILE A 206
VAL A 176
ARG A 154
 None
 0.73A 3p73A-4m1bA:
undetectable		 3p73A-4m1bA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phq HEMOLYSIN E,
CHROMOSOMAL

(Escherichia
coli) 		PF06109
(HlyE) 		3 ILE A 208
VAL A 170
ARG A 174
 None
 0.59A 3p73A-4phqA:
undetectable		 3p73A-4phqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Aspergillus
fumigatus) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 ILE A 367
VAL A 358
ARG A 306
 None
 0.57A 3p73A-4qbjA:
undetectable		 3p73A-4qbjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		3 ILE A  55
VAL A 277
ARG A 281
 None
 0.62A 3p73A-4rxmA:
undetectable		 3p73A-4rxmA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 ILE P 235
VAL P 184
ARG P 188
 None
 0.73A 3p73A-4s2tP:
undetectable		 3p73A-4s2tP:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ILE A 280
VAL A 187
ARG A 186
 None
 0.74A 3p73A-4w7sA:
undetectable		 3p73A-4w7sA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR

(Trypanosoma
brucei) 		no annotation 3 ILE E  65
VAL E 244
ARG E 248
 None
 0.69A 3p73A-4wjgE:
undetectable		 3p73A-4wjgE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		3 ILE A 115
VAL A 261
ARG A 265
 None
 0.46A 3p73A-4x9tA:
undetectable		 3p73A-4x9tA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 ILE A 513
VAL A 579
ARG A 583
 None
 0.76A 3p73A-4xhpA:
undetectable		 3p73A-4xhpA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 ILE A 367
VAL A 355
ARG A 359
 None
 0.67A 3p73A-4xr9A:
undetectable		 3p73A-4xr9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		3 ILE A  66
VAL A 301
ARG A 309
 None
 0.71A 3p73A-4zpxA:
undetectable		 3p73A-4zpxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx7 ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE

(Salmonella
enterica) 		PF03928
(Haem_degrading) 		3 ILE A 141
VAL A 143
ARG A 112
 None
 0.64A 3p73A-5cx7A:
undetectable		 3p73A-5cx7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl6 PUTATIVE PORIN FOR
VANILLATE
TRAFFICKING (VANP)

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ILE A 381
VAL A 169
ARG A 172
 None
 0.70A 3p73A-5dl6A:
undetectable		 3p73A-5dl6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		3 ILE A 432
VAL A 416
ARG A 420
 None
 0.75A 3p73A-5gxvA:
0.9		 3p73A-5gxvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ILE A 374
VAL A   8
ARG A   6
 None
 0.67A 3p73A-5irpA:
undetectable		 3p73A-5irpA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021

(Burkholderia
pseudomallei) 		PF00282
(Pyridoxal_deC) 		3 ILE A 355
VAL A 425
ARG A 429
 None
 0.74A 3p73A-5k1rA:
undetectable		 3p73A-5k1rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5keu TAURINE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF02668
(TauD) 		3 ILE A 301
VAL A 168
ARG A 170
 None
 0.74A 3p73A-5keuA:
undetectable		 3p73A-5keuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ILE A 712
VAL A 690
ARG A 694
 None
 0.76A 3p73A-5l1bA:
undetectable		 3p73A-5l1bA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		3 ILE A  16
VAL A 161
ARG A 192
 None
 0.77A 3p73A-5mzyA:
undetectable		 3p73A-5mzyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 3 ILE D   7
VAL D 228
ARG D 232
 None
 0.59A 3p73A-5n03D:
undetectable		 3p73A-5n03D:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0o PEPTIDE
N-METHYLTRANSFERASE

(Omphalotus
olearius) 		no annotation 3 ILE A 114
VAL A  84
ARG A  88
 None
None
EDO  A 503 (-4.0A)
 0.56A 3p73A-5n0oA:
undetectable		 3p73A-5n0oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		3 ILE A 350
VAL A 302
ARG A 306
 None
 0.73A 3p73A-5nvrA:
undetectable		 3p73A-5nvrA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN SA

(Trypanosoma
cruzi) 		no annotation 3 ILE f  68
VAL f 185
ARG f 189
 None
 0.72A 3p73A-5optf:
undetectable		 3p73A-5optf:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ILE D  75
VAL B 118
ARG B 124
 None
 0.72A 3p73A-5uz5D:
undetectable		 3p73A-5uz5D:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 3 ILE A 117
VAL A  98
ARG A 161
 None
 0.73A 3p73A-5vfaA:
undetectable		 3p73A-5vfaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		3 ILE A 712
VAL A 690
ARG A 694
 None
 0.39A 3p73A-5welA:
undetectable		 3p73A-5welA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ILE A 712
VAL A 690
ARG A 694
 None
 0.57A 3p73A-5weoA:
undetectable		 3p73A-5weoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2

(Toxoplasma
gondii) 		PF00318
(Ribosomal_S2) 		3 ILE A  66
VAL A 183
ARG A 187
 None
 0.73A 3p73A-5xxuA:
undetectable		 3p73A-5xxuA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN S2

(Leishmania
donovani) 		no annotation 3 ILE B  68
VAL B 185
ARG B 189
 None
 0.61A 3p73A-6az1B:
undetectable		 3p73A-6az1B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmz DIHYDROLIPOYL
DEHYDROGENASE

(Burkholderia
cenocepacia) 		no annotation 3 ILE A 137
VAL A  32
ARG A 112
 None
 0.76A 3p73A-6cmzA:
undetectable		 3p73A-6cmzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 3 ILE K 513
VAL K 785
ARG K 789
 None
 0.76A 3p73A-6d6qK:
undetectable		 3p73A-6d6qK:
undetectable