SIMILAR PATTERNS OF AMINO ACIDS FOR 3P6G_A_IZPA133_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		8 PHE A  17
MET A  21
VAL A  26
PRO A  39
ILE A 106
ARG A 108
ARG A 128
TYR A 130
 None
 0.87A 3p6gA-1ftpA:
19.9		 3p6gA-1ftpA:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PHE A 448
VAL A 475
ARG A 308
VAL A 410
ARG A 411
 None
 1.25A 3p6gA-1gpmA:
undetectable		 3p6gA-1gpmA:
15.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		6 MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
TYR A 128
 None
 1.22A 3p6gA-1jjxA:
22.0		 3p6gA-1jjxA:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
MET A  20
VAL A  25
ARG A  78
TYR A 128
 None
 1.05A 3p6gA-1jjxA:
22.0		 3p6gA-1jjxA:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mdc INSECT FATTY ACID
BINDING PROTEIN

(Manduca sexta) 		PF00061
(Lipocalin) 		5 PHE A  15
PRO A  37
VAL A 114
ARG A 127
TYR A 129
 None
None
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 0.69A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mdc INSECT FATTY ACID
BINDING PROTEIN

(Manduca sexta) 		PF00061
(Lipocalin) 		5 PRO A  37
ASP A  77
VAL A 114
ARG A 127
TYR A 129
 None
PLM  A 133 ( 4.4A)
PLM  A 133 (-4.8A)
PLM  A 133 (-3.8A)
PLM  A 133 (-4.7A)
 1.13A 3p6gA-1mdcA:
19.0		 3p6gA-1mdcA:
31.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mh6 BLEOMYCIN RESISTANCE
PROTEIN

(Klebsiella
pneumoniae) 		no annotation 5 PHE A 272
ILE A 281
ARG A 223
VAL A 279
CYH A 276
 None
 1.47A 3p6gA-1mh6A:
undetectable		 3p6gA-1mh6A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o8v FATTY ACID BINDING
PROTEIN HOMOLOG

(Echinococcus
granulosus) 		PF00061
(Lipocalin) 		10 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  77
ARG A  79
ILE A 105
ARG A 107
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
PLM  A1136 (-3.5A)
None
None
PLM  A1136 (-3.8A)
PLM  A1136 (-4.6A)
None
PLM  A1136 (-3.9A)
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 0.55A 3p6gA-1o8vA:
23.7		 3p6gA-1o8vA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o8v FATTY ACID BINDING
PROTEIN HOMOLOG

(Echinococcus
granulosus) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
VAL A  25
PRO A  38
CYH A 125
ARG A 127
TYR A 129
 PLM  A1136 (-4.7A)
PLM  A1136 (-3.5A)
None
None
None
PLM  A1136 (-4.4A)
PLM  A1136 (-4.6A)
 1.24A 3p6gA-1o8vA:
23.7		 3p6gA-1o8vA:
41.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
None
OLA  A 200 (-3.2A)
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.70A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		8 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 1.23A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp3 CYTOCHROME C,
PUTATIVE

(Shewanella
oneidensis) 		PF11783
(Cytochrome_cB)
PF13435
(Cytochrome_C554) 		5 VAL A 170
PRO A 328
ASP A 169
CYH A 209
TYR A 327
 HEM  A 806 ( 4.5A)
None
None
HEM  A 806 (-1.9A)
None
 1.41A 3p6gA-1sp3A:
undetectable		 3p6gA-1sp3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		5 MET A 278
VAL A 281
ASP A 103
ILE A 120
VAL A 144
 None
 1.25A 3p6gA-1szqA:
undetectable		 3p6gA-1szqA:
15.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 0.43A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 CRZ  A 501 (-4.5A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
 1.19A 3p6gA-1towA:
26.1		 3p6gA-1towA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 VAL A 248
ARG A 282
ILE A 201
VAL A 198
TYR A 217
 None
 1.47A 3p6gA-1uf2A:
undetectable		 3p6gA-1uf2A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmi HYPOTHETICAL PROTEIN
PHS013

(Pyrococcus
horikoshii) 		PF05016
(ParE_toxin) 		5 PHE A  43
ASP A  31
ILE A  79
VAL A  66
TYR A  64
 None
 1.38A 3p6gA-1wmiA:
undetectable		 3p6gA-1wmiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 PHE A  44
VAL A  73
PRO A  57
ASP A  72
ARG A  76
 None
 1.38A 3p6gA-2canA:
undetectable		 3p6gA-2canA:
17.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
PRO A  39
ARG A 111
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.9A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.66A 3p6gA-2cbrA:
18.8		 3p6gA-2cbrA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cbr PROTEIN (CRABP-I)

(Bos taurus) 		PF00061
(Lipocalin) 		5 PHE A  15
PRO A  39
CYH A 129
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.9A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 1.40A 3p6gA-2cbrA:
18.8		 3p6gA-2cbrA:
36.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpl GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT B

(Pyrococcus
horikoshii) 		PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PHE A 231
VAL A 258
ARG A 101
VAL A 195
ARG A 196
 None
 1.20A 3p6gA-2dplA:
undetectable		 3p6gA-2dplA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		5 VAL A  45
ILE A  11
VAL A  90
CYH A  64
TYR A 135
 None
NAP  A1350 (-4.1A)
NAP  A1350 (-4.7A)
None
None
 1.46A 3p6gA-2f1kA:
undetectable		 3p6gA-2f1kA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 None
EIC  A 601 ( 4.1A)
None
EIC  A 601 (-4.6A)
EIC  A 601 (-3.6A)
EIC  A 601 ( 4.9A)
EIC  A 601 ( 4.5A)
None
EIC  A 601 (-4.3A)
EIC  A 601 (-3.3A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 0.55A 3p6gA-2q9sA:
25.7		 3p6gA-2q9sA:
81.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 None
None
EIC  A 601 (-4.6A)
EIC  A 601 (-4.5A)
EIC  A 601 (-4.7A)
 1.29A 3p6gA-2q9sA:
25.7		 3p6gA-2q9sA:
81.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A 627
VAL A 660
ILE A 588
VAL A 603
CYH A 591
 None
 1.47A 3p6gA-2qo3A:
undetectable		 3p6gA-2qo3A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 PHE A 186
VAL A 332
VAL A 310
ARG A 315
TYR A 306
 None
None
None
None
PO4  A 501 (-4.5A)
 1.44A 3p6gA-2r87A:
undetectable		 3p6gA-2r87A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 PRO A 372
ARG A 139
ILE A 144
VAL A 246
TYR A 286
 None
 1.37A 3p6gA-3cqfA:
undetectable		 3p6gA-3cqfA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A  52
ASP A 442
ILE A 455
VAL A 457
CYH A 431
 None
 1.42A 3p6gA-3eyaA:
undetectable		 3p6gA-3eyaA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 PHE A 162
ILE A  65
VAL A 174
CYH A 178
TYR A 170
 None
 1.34A 3p6gA-3ll8A:
undetectable		 3p6gA-3ll8A:
15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 107
CYH A 118
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 (-3.7A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 0.58A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
CYH A 125
ARG A 127
TYR A 129
 None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
 1.17A 3p6gA-3nr3A:
25.2		 3p6gA-3nr3A:
58.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 VAL A  93
PRO A  53
ILE A 139
VAL A  39
ARG A  36
 None
 1.30A 3p6gA-3p4eA:
undetectable		 3p6gA-3p4eA:
16.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		8 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 106
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
PAM  A 133 (-4.3A)
None
None
PAM  A 133 (-3.9A)
 0.44A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		6 PHE A  17
MET A  21
VAL A  26
PRO A  39
CYH A 124
ARG A 126
 None
PAM  A 133 ( 3.9A)
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.08A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp6 SODIUM-CALCIUM
EXCHANGER

(Doryteuthis
pealeii) 		PF00061
(Lipocalin) 		5 PHE A  17
VAL A  24
PRO A  39
CYH A 124
ARG A 126
 None
None
PAM  A 133 (-4.4A)
None
PAM  A 133 (-3.9A)
 1.37A 3p6gA-3pp6A:
23.1		 3p6gA-3pp6A:
42.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ARG A 106
ARG A 126
TYR A 128
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
None
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.9A)
2AN  A 201 ( 4.8A)
None
2AN  A 201 ( 4.9A)
None
 0.72A 3p6gA-3wbgA:
24.8		 3p6gA-3wbgA:
59.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		8 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
None
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.9A)
None
2AN  A 201 ( 4.9A)
None
 1.16A 3p6gA-3wbgA:
24.8		 3p6gA-3wbgA:
59.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		10 MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 107
VAL A 116
CYH A 118
ARG A 127
TYR A 129
 EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
None
None
 0.78A 3p6gA-4a60A:
24.2		 3p6gA-4a60A:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		10 MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
VAL A 116
CYH A 118
ARG A 127
TYR A 129
 EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
None
None
 0.71A 3p6gA-4a60A:
24.2		 3p6gA-4a60A:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 107
ARG A 127
TYR A 129
 None
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
 0.86A 3p6gA-4a60A:
24.2		 3p6gA-4a60A:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		9 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 127
TYR A 129
 None
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
 0.83A 3p6gA-4a60A:
24.2		 3p6gA-4a60A:
56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		8 MET A  23
VAL A  28
ARG A  81
ARG A 109
VAL A 118
CYH A 120
ARG A 129
TYR A 131
 None
 0.79A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		7 MET A  23
VAL A  28
PRO A  41
ARG A  81
ARG A 109
CYH A 120
ARG A 129
 None
 0.95A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  19
MET A  23
VAL A  28
ARG A  81
ARG A 129
TYR A 131
 None
 1.06A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
MET A  23
VAL A  28
CYH A 127
TYR A 131
 None
 1.28A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		6 PHE A  19
MET A  23
VAL A  28
PRO A  41
ARG A  81
ARG A 129
 None
 1.11A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
MET A  23
VAL A  28
PRO A  41
CYH A 127
 None
 1.30A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		7 PHE A  19
VAL A  28
ASP A  79
ARG A  81
ILE A 107
ARG A 129
TYR A 131
 None
 0.89A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
VAL A  28
ASP A  79
CYH A 127
TYR A 131
 None
 0.92A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		7 PHE A  19
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 129
 None
 0.96A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		5 PHE A  19
VAL A  28
PRO A  41
ASP A  79
CYH A 127
 None
 0.88A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		9 VAL A  28
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
CYH A 120
ARG A 129
TYR A 131
 None
 0.65A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		8 VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
CYH A 120
ARG A 129
 None
 0.84A 3p6gA-4aznA:
22.5		 3p6gA-4aznA:
47.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
CYH A 120
ARG A 129
TYR A 131
 None
A9M  A1136 (-3.7A)
None
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
A9M  A1136 (-4.4A)
None
None
A9M  A1136 ( 3.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
 0.65A 3p6gA-4azpA:
24.1		 3p6gA-4azpA:
50.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Mus musculus) 		PF00061
(Lipocalin) 		8 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
CYH A 127
ARG A 129
TYR A 131
 None
A9M  A1136 (-3.7A)
None
A9M  A1136 ( 4.7A)
A9M  A1136 (-4.0A)
None
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
 1.22A 3p6gA-4azpA:
24.1		 3p6gA-4azpA:
50.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 PHE A 179
MET A 183
PRO A 283
ILE A 160
VAL A 163
 None
 1.13A 3p6gA-4conA:
undetectable		 3p6gA-4conA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 PRO X 430
ARG X 197
ILE X 202
VAL X 304
TYR X 344
 None
 1.36A 3p6gA-4hscX:
undetectable		 3p6gA-4hscX:
13.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i3c BILIRUBIN-INDUCIBLE
FLUORESCENT PROTEIN
UNAG

(Anguilla
japonica) 		PF00061
(Lipocalin) 		8 PHE A  17
PRO A  39
ASP A  81
ARG A  83
ARG A 112
VAL A 121
ARG A 132
TYR A 134
 BLR  A 200 (-3.6A)
None
None
None
BLR  A 200 (-3.6A)
BLR  A 200 (-4.7A)
BLR  A 200 (-3.5A)
None
 0.85A 3p6gA-4i3cA:
22.1		 3p6gA-4i3cA:
45.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 VAL A 219
PRO A  60
ILE A 205
VAL A  21
CYH A  66
 None
 1.30A 3p6gA-4i7iA:
undetectable		 3p6gA-4i7iA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 PHE A 495
ILE A 398
VAL A 507
CYH A 511
TYR A 503
 None
 1.34A 3p6gA-4il1A:
undetectable		 3p6gA-4il1A:
12.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 None
75D  A 201 (-3.6A)
None
75D  A 201 (-4.4A)
75D  A 201 (-4.1A)
75D  A 201 (-4.7A)
75D  A 201 ( 4.4A)
75D  A 201 ( 4.6A)
None
75D  A 201 (-3.5A)
75D  A 201 (-3.9A)
None
 0.39A 3p6gA-4nnsA:
27.7		 3p6gA-4nnsA:
90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
 None
None
75D  A 201 (-4.4A)
75D  A 201 (-3.9A)
None
 1.25A 3p6gA-4nnsA:
27.7		 3p6gA-4nnsA:
90.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		5 PHE A 171
ILE A  74
VAL A 183
CYH A 187
TYR A 179
 None
 1.28A 3p6gA-4oraA:
undetectable		 3p6gA-4oraA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		5 PHE A 162
ILE A  65
VAL A 174
CYH A 178
TYR A 170
 None
 1.33A 3p6gA-4orbA:
undetectable		 3p6gA-4orbA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 VAL A 147
ILE A  52
VAL A 230
ARG A 134
TYR A 234
 None
None
None
CA  A 601 ( 4.6A)
None
 1.35A 3p6gA-4r1dA:
undetectable		 3p6gA-4r1dA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 VAL A 144
PRO A 513
ILE A 399
CYH A 421
TYR A 293
 None
 1.44A 3p6gA-4rbnA:
undetectable		 3p6gA-4rbnA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		5 VAL A 219
PRO A  60
ILE A 205
VAL A  21
CYH A  66
 None
 1.34A 3p6gA-4uwaA:
undetectable		 3p6gA-4uwaA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		5 VAL A 232
PRO A 208
ILE A 272
VAL A 270
CYH A 273
 None
 1.32A 3p6gA-4wfqA:
undetectable		 3p6gA-4wfqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 VAL A 816
PRO A 683
ILE A 772
VAL A 733
TYR A 634
 None
None
GOL  A 915 ( 4.6A)
None
None
 1.37A 3p6gA-4zg7A:
undetectable		 3p6gA-4zg7A:
9.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		8 MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ARG A 106
ARG A 126
TYR A 128
 PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 0.60A 3p6gA-5b29A:
24.5		 3p6gA-5b29A:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		7 MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
 1.14A 3p6gA-5b29A:
24.5		 3p6gA-5b29A:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		5 PHE A 180
ILE A  83
VAL A 192
CYH A 196
TYR A 188
 None
None
None
None
EDO  A 408 (-4.3A)
 1.30A 3p6gA-5b8iA:
undetectable		 3p6gA-5b8iA:
16.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		6 PHE A  17
MET A  21
VAL A  26
ASP A  77
ARG A 127
TYR A 129
 None
 1.32A 3p6gA-5bvqA:
23.4		 3p6gA-5bvqA:
75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvq FATTY ACID-BINDING
PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		11 PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 107
VAL A 116
CYH A 118
TYR A 129
 None
 0.71A 3p6gA-5bvqA:
23.4		 3p6gA-5bvqA:
75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		12 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 108
ARG A 110
VAL A 119
CYH A 121
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 3.8A)
None
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.7A)
PAM  A 201 ( 4.6A)
None
PAM  A 201 ( 4.0A)
PAM  A 201 ( 4.6A)
None
 0.65A 3p6gA-5bvtA:
24.5		 3p6gA-5bvtA:
52.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		8 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
CYH A 128
ARG A 130
TYR A 132
 PAM  A 201 ( 4.9A)
PAM  A 201 ( 3.8A)
None
PAM  A 201 ( 4.8A)
PAM  A 201 (-4.0A)
None
PAM  A 201 ( 4.6A)
None
 1.08A 3p6gA-5bvtA:
24.5		 3p6gA-5bvtA:
52.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbq THIOREDOXIN

(Anticarsia
gemmatalis) 		PF00085
(Thioredoxin) 		5 PHE A  90
PRO A  76
ASP A  96
ILE A 102
VAL A  24
 None
 1.45A 3p6gA-5dbqA:
undetectable		 3p6gA-5dbqA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 5 MET A  72
VAL A 115
ILE A 132
VAL A 258
TYR A  55
 None
 1.48A 3p6gA-5dmuA:
undetectable		 3p6gA-5dmuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 PHE A  71
VAL A 171
ILE A  78
VAL A 100
ARG A  96
 None
 1.47A 3p6gA-5evjA:
undetectable		 3p6gA-5evjA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		5 MET A 218
ARG A 234
ILE A  90
VAL A  96
TYR A  98
 None
 1.44A 3p6gA-5f8vA:
undetectable		 3p6gA-5f8vA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		7 PHE A  16
MET A  20
VAL A  25
PRO A  38
CYH A 123
ARG A 125
TYR A 127
 None
 1.21A 3p6gA-5gkbA:
20.4		 3p6gA-5gkbA:
47.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		8 PHE A  16
MET A  20
VAL A  25
PRO A  38
ILE A 103
ARG A 105
ARG A 125
TYR A 127
 None
 0.66A 3p6gA-5gkbA:
20.4		 3p6gA-5gkbA:
47.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL

(Homo sapiens) 		PF00061
(Lipocalin) 		11 PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
ARG A 129
TYR A 131
 65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
None
65X  A 203 (-4.4A)
65X  A 203 ( 4.2A)
None
65X  A 203 (-3.9A)
65X  A 203 (-4.0A)
None
65X  A 203 (-3.9A)
None
 0.58A 3p6gA-5hz5A:
23.7		 3p6gA-5hz5A:
51.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 MET A 355
PRO A 372
VAL A 338
CYH A 333
TYR A 380
 None
 1.49A 3p6gA-5i6vA:
undetectable		 3p6gA-5i6vA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 VAL A  91
PRO A 181
ILE A  84
ARG A 185
CYH A  86
 None
 1.30A 3p6gA-5kjuA:
undetectable		 3p6gA-5kjuA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3

(Bos taurus) 		PF00146
(NADHdh)
PF00507
(Oxidored_q4) 		5 VAL H 144
PRO A  74
ILE A  95
VAL H 305
CYH H 301
 None
 1.44A 3p6gA-5lc5H:
undetectable		 3p6gA-5lc5H:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		5 PHE A 509
MET A 521
VAL A 493
PRO A 471
ILE A 453
 None
 1.48A 3p6gA-5m60A:
undetectable		 3p6gA-5m60A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 5 MET A 270
VAL A 273
ASP A  95
ILE A 112
VAL A 136
 None
 1.25A 3p6gA-5muxA:
undetectable		 3p6gA-5muxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1

(Porphyromonas
gingivalis) 		no annotation 5 MET A  80
VAL A 131
PRO A 117
VAL A  76
TYR A 101
 None
 1.41A 3p6gA-5nf2A:
undetectable		 3p6gA-5nf2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL 6 232
PRO 6 208
ILE 6 272
VAL 6 270
CYH 6 273
 None
 1.26A 3p6gA-5oqj6:
undetectable		 3p6gA-5oqj6:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2

(Homo sapiens) 		no annotation 5 PRO g  21
ASP g  86
ARG g  85
ARG g  29
VAL g  75
 None
 1.44A 3p6gA-5xtcg:
undetectable		 3p6gA-5xtcg:
16.30