SIMILAR PATTERNS OF AMINO ACIDS FOR 3P5N_B_RBFB190_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
5 THR A 321
ASP A 316
GLY A 352
ALA A 355
ALA A 359
None
0.91A 3p5nB-13pkA:
0.2
3p5nB-13pkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4


(Rattus
norvegicus)
PF05790
(C2-set)
PF09191
(CD4-extracel)
5 LEU A  74
THR A  73
ALA A  13
ALA A   5
LEU A 104
None
1.07A 3p5nB-1cidA:
undetectable
3p5nB-1cidA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE


(Rhodobacter
sphaeroides)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 ASN A 192
ASP A 200
GLY A 202
ALA A 205
ALA A 209
None
1.12A 3p5nB-1eu1A:
undetectable
3p5nB-1eu1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE


(Vibrio harveyi)
PF00171
(Aldedh)
5 LEU A 100
GLY A 157
ALA A 160
ALA A 164
LEU A  58
None
1.12A 3p5nB-1eyyA:
undetectable
3p5nB-1eyyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)


(Penicillium
amagasakiense)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 THR A 334
GLY A 467
ALA A 471
ALA A 475
LEU A 417
None
1.09A 3p5nB-1gpeA:
undetectable
3p5nB-1gpeA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE


(Nicotiana
tabacum)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 133
THR A 132
GLY A 272
ALA A 141
LEU A 295
None
1.17A 3p5nB-1i41A:
0.6
3p5nB-1i41A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni)
PF00210
(Ferritin)
5 LEU A 163
ASP A 155
GLY A  38
ALA A  41
ALA A  45
None
1.01A 3p5nB-1krqA:
2.2
3p5nB-1krqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA


(Mus musculus)
PF00102
(Y_phosphatase)
5 GLY A 732
ALA A 728
ALA A 726
LEU A 759
ASN A 582
None
1.11A 3p5nB-1p15A:
1.4
3p5nB-1p15A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE


(Geobacillus
stearothermophilus)
PF00162
(PGK)
5 THR A 299
ASP A 294
GLY A 330
ALA A 333
ALA A 337
None
0.82A 3p5nB-1phpA:
0.0
3p5nB-1phpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE


(Streptomyces
venezuelae)
PF16363
(GDP_Man_Dehyd)
5 LEU A  39
THR A  40
GLY A   7
LEU A  48
LEU A  36
None
NAD  A 900 (-3.3A)
NAD  A 900 ( 3.7A)
None
None
1.10A 3p5nB-1r66A:
undetectable
3p5nB-1r66A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 LEU A  33
GLY A 327
ALA A 319
LEU A 314
LEU A 277
None
1.15A 3p5nB-1vcgA:
undetectable
3p5nB-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 LEU A  33
GLY A 327
ALA A 325
LEU A 314
LEU A 277
None
1.11A 3p5nB-1vcgA:
undetectable
3p5nB-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vel STARVATION-INDUCED
DNA PROTECTING
PROTEIN


(Mycolicibacterium
smegmatis)
PF00210
(Ferritin)
5 GLY A  63
ALA A  65
ALA A  69
LEU A  25
ASN A  29
None
1.13A 3p5nB-1velA:
undetectable
3p5nB-1velA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN


(Caulobacter
vibrioides)
PF00072
(Response_reg)
PF00990
(GGDEF)
5 LEU A  52
GLY A  35
ALA A  38
ALA A  42
LEU A   6
None
1.13A 3p5nB-1w25A:
undetectable
3p5nB-1w25A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws6 METHYLTRANSFERASE

(Thermus
thermophilus)
PF03602
(Cons_hypoth95)
5 LEU A  28
GLY A  25
ALA A  23
LEU A 102
LEU A  19
None
1.15A 3p5nB-1ws6A:
undetectable
3p5nB-1ws6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN


(Cryptococcus
sp. S-2)
PF01083
(Cutinase)
5 THR A 191
ALA A 197
LEU A  11
LEU A 158
ASN A  31
None
0.99A 3p5nB-2czqA:
undetectable
3p5nB-2czqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE


(Pseudomonas
aeruginosa)
PF00682
(HMGL-like)
5 LEU A  91
GLY A  86
ALA A  81
ALA A  79
LEU A  84
None
1.15A 3p5nB-2ftpA:
undetectable
3p5nB-2ftpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Salmonella
enterica)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 LEU A   5
THR A   4
ALA A   9
ALA A  79
LEU A  58
None
1.17A 3p5nB-2g17A:
undetectable
3p5nB-2g17A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A 245
ASN A 400
GLY A 173
ALA A 176
ALA A 180
None
0.75A 3p5nB-2gp6A:
undetectable
3p5nB-2gp6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3


(Homo sapiens)
PF03630
(Fumble)
5 GLY A 302
ALA A 305
ALA A 309
LEU A 186
LEU A 334
None
1.14A 3p5nB-2i7pA:
undetectable
3p5nB-2i7pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE


(Thermus
caldophilus)
PF00162
(PGK)
5 THR A 296
ASP A 291
GLY A 327
ALA A 330
ALA A 334
None
0.77A 3p5nB-2ie8A:
undetectable
3p5nB-2ie8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE


(Mycobacterium
tuberculosis)
PF00749
(tRNA-synt_1c)
5 LEU A 417
THR A 418
ALA A 412
ALA A 435
LEU A 436
None
1.04A 3p5nB-2ja2A:
undetectable
3p5nB-2ja2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jac GLUTAREDOXIN-1

(Saccharomyces
cerevisiae)
PF00462
(Glutaredoxin)
5 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
1.04A 3p5nB-2jacA:
undetectable
3p5nB-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus)
PF05059
(Orbi_VP4)
5 LEU A 475
ASP A 469
GLY A 470
ALA A 120
LEU A 489
None
1.15A 3p5nB-2jh9A:
undetectable
3p5nB-2jh9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM


(Methylobacillus
flagellatus)
PF05050
(Methyltransf_21)
5 LEU A 189
THR A 188
ASP A 182
GLY A 392
ALA A 368
None
1.13A 3p5nB-2py6A:
undetectable
3p5nB-2py6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 LEU A1142
ALA A1095
ALA A1099
LEU A 798
LEU A1073
None
1.12A 3p5nB-2vdcA:
undetectable
3p5nB-2vdcA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC


(Mycobacterium
tuberculosis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 ASP A 210
GLY A 213
ALA A 215
ALA A 219
LEU A 247
None
1.15A 3p5nB-2vosA:
undetectable
3p5nB-2vosA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A 245
ASN A 399
GLY A 174
ALA A 177
ALA A 181
None
NA  A1426 (-3.2A)
None
None
None
0.72A 3p5nB-2wgeA:
undetectable
3p5nB-2wgeA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus)
PF00079
(Serpin)
5 GLY C 389
ALA C 376
LEU C 378
LEU C 244
ASN C 385
None
1.16A 3p5nB-2wy0C:
undetectable
3p5nB-2wy0C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY


(Desulfomicrobium
norvegicum)
PF04358
(DsrC)
5 LEU C  69
GLY C  87
ALA C  92
ALA C  96
LEU C  50
None
1.16A 3p5nB-2xsjC:
undetectable
3p5nB-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY


(Desulfomicrobium
norvegicum)
PF04358
(DsrC)
5 LEU C  69
GLY C  89
ALA C  92
ALA C  96
LEU C  50
None
1.14A 3p5nB-2xsjC:
undetectable
3p5nB-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium)
PF04744
(Monooxygenase_B)
6 LEU A 311
ASN A  55
GLY A 400
ALA A  47
LEU A 391
LEU A 299
None
1.38A 3p5nB-3chxA:
undetectable
3p5nB-3chxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN


(Escherichia
coli)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C)
5 LEU B  74
GLY B  65
ALA B 191
ALA B 194
ASN B 189
None
None
SF4  B 804 (-4.3A)
None
None
1.14A 3p5nB-3egwB:
undetectable
3p5nB-3egwB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 LEU A 330
GLY A 499
ALA A 502
ALA A 505
LEU A 511
None
XCC  A 800 ( 4.1A)
None
None
None
1.09A 3p5nB-3i04A:
undetectable
3p5nB-3i04A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)


(Legionella
pneumophila)
PF00378
(ECH_1)
5 LEU A 162
GLY A 112
ALA A 115
ALA A 119
LEU A 179
None
0.98A 3p5nB-3i47A:
undetectable
3p5nB-3i47A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
6 LEU A 417
GLY A 218
ALA A 220
ALA A 144
LEU A 192
LEU A 252
None
1.35A 3p5nB-3ihvA:
1.7
3p5nB-3ihvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imk PUTATIVE MOLYBDENUM
CARRIER PROTEIN


(Syntrophus
aciditrophicus)
PF12694
(MoCo_carrier)
5 LEU A  77
THR A  76
GLY A 135
ALA A  18
ALA A  22
None
None
GOL  A 158 (-4.1A)
None
None
0.89A 3p5nB-3imkA:
undetectable
3p5nB-3imkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A


(Archaeoglobus
fulgidus)
PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase)
5 GLY A 385
ALA A 387
ALA A 391
LEU A 723
ASN A 675
None
1.01A 3p5nB-3j09A:
undetectable
3p5nB-3j09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT


(Acidianus
tengchongensis)
PF00118
(Cpn60_TCP1)
6 LEU A 524
THR A 521
GLY A 134
ALA A 443
ALA A 446
LEU A 121
None
1.38A 3p5nB-3j1eA:
undetectable
3p5nB-3j1eA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN


(Vibrio
vulnificus)
PF00106
(adh_short)
5 LEU A  32
THR A   8
ASN A 129
GLY A 111
ALA A  74
None
1.08A 3p5nB-3p19A:
undetectable
3p5nB-3p19A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 393
ASP A 384
GLY A 425
ALA A 428
ALA A 432
None
0.59A 3p5nB-3qdkA:
undetectable
3p5nB-3qdkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora)
PF05711
(TylF)
5 LEU A 190
ASP A 119
GLY A 225
ALA A 229
LEU A 200
SAH  A 258 (-4.2A)
None
None
None
None
1.16A 3p5nB-3tosA:
1.6
3p5nB-3tosA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE


(Coxiella
burnetii)
PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2)
5 THR A 179
GLY A 163
ALA A 166
ALA A 170
LEU A 142
None
0.92A 3p5nB-3tqhA:
undetectable
3p5nB-3tqhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE


(Pyrococcus
horikoshii)
no annotation 5 LEU A  12
THR A 142
GLY A 139
ALA A  66
LEU A  44
None
1.11A 3p5nB-3u4gA:
undetectable
3p5nB-3u4gA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN


(Roseiflexus sp.
RS-1)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A  12
THR A  13
GLY A  50
ALA A 111
ALA A 107
None
1.14A 3p5nB-3u9iA:
undetectable
3p5nB-3u9iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE


(Bacillus
anthracis)
PF00162
(PGK)
5 THR A 299
ASP A 294
GLY A 330
ALA A 333
ALA A 337
None
0.83A 3p5nB-3uwdA:
undetectable
3p5nB-3uwdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
5 LEU A 110
GLY A 167
ALA A 170
ALA A 174
LEU A  68
None
1.13A 3p5nB-3v4cA:
undetectable
3p5nB-3v4cA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis)
PF00303
(Thymidylat_synt)
5 GLY A 229
ALA A 227
ALA A  44
LEU A  50
LEU A  59
None
1.11A 3p5nB-3v8hA:
undetectable
3p5nB-3v8hA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum)
PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11)
5 LEU A  84
THR A  87
ASP A  52
GLY A  51
ALA A  66
None
1.12A 3p5nB-3vtxA:
undetectable
3p5nB-3vtxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila)
PF00091
(Tubulin)
5 LEU A 173
GLY A 327
ALA A 325
LEU A 229
LEU A 331
None
1.01A 3p5nB-3zidA:
undetectable
3p5nB-3zidA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Actinomadura
sp. R39)
PF02113
(Peptidase_S13)
5 ASP A 345
GLY A 348
ALA A  48
ALA A 419
ASN A 438
None
B07  A 500 (-4.7A)
B07  A 500 (-3.8A)
None
None
1.10A 3p5nB-3zvtA:
undetectable
3p5nB-3zvtA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN


(Deinococcus
radiodurans)
PF02463
(SMC_N)
5 GLY A  98
ALA A 111
ALA A 123
LEU A 135
LEU A  34
None
1.16A 3p5nB-4abyA:
undetectable
3p5nB-4abyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 305
THR A 304
ALA A 332
LEU A 426
LEU A 290
None
1.12A 3p5nB-4bc5A:
undetectable
3p5nB-4bc5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
5 LEU A 656
THR A 655
GLY A 623
ALA A 622
ALA A 620
None
1.09A 3p5nB-4bevA:
undetectable
3p5nB-4bevA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens)
PF01979
(Amidohydro_1)
5 LEU A1474
GLY A1526
ALA A1523
ALA A1519
LEU A1533
None
0.91A 3p5nB-4c6oA:
undetectable
3p5nB-4c6oA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE


(Methylococcus
capsulatus)
PF00815
(Histidinol_dh)
5 LEU A  56
THR A  57
GLY A 194
ALA A 195
ALA A 199
None
1.15A 3p5nB-4gicA:
undetectable
3p5nB-4gicA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE


(Escherichia
coli)
PF04227
(Indigoidine_A)
6 LEU A 185
ASN A 296
ALA A 165
ALA A 195
LEU A 171
LEU A 153
None
1.48A 3p5nB-4gijA:
undetectable
3p5nB-4gijA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmb CYSTEINE SYNTHASE

(Microcystis
aeruginosa)
PF00291
(PALP)
5 LEU A 307
ASN A  77
ALA A 270
ALA A 272
LEU A 265
None
PLP  A 403 ( 3.7A)
None
None
None
1.16A 3p5nB-4lmbA:
1.6
3p5nB-4lmbA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01368
(DHH)
PF02272
(DHHA1)
5 THR A 108
ASN A 139
GLY A 143
ALA A 145
ALA A  30
None
1.03A 3p5nB-4ls9A:
undetectable
3p5nB-4ls9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01368
(DHH)
PF02272
(DHHA1)
5 THR A 108
ASN A 139
GLY A 143
ALA A 145
LEU A  33
None
1.07A 3p5nB-4ls9A:
undetectable
3p5nB-4ls9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae)
PF00072
(Response_reg)
5 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
None
1.02A 3p5nB-4lzlA:
undetectable
3p5nB-4lzlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me2 UNCHARACTERIZED
PROTEIN


(Brachypodium
distachyon)
no annotation 5 LEU A  80
ALA A 104
ALA A  73
LEU A  56
LEU A  86
None
1.12A 3p5nB-4me2A:
undetectable
3p5nB-4me2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
5 THR A 301
GLY A 365
ALA A 363
LEU A 361
LEU A 383
SAM  A 601 (-4.1A)
SAM  A 601 ( 4.0A)
None
None
SAM  A 601 (-4.6A)
1.17A 3p5nB-4n49A:
undetectable
3p5nB-4n49A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE


(Coxiella
burnetii)
PF00162
(PGK)
5 THR A 298
ASP A 293
GLY A 329
ALA A 332
ALA A 336
None
MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
0.88A 3p5nB-4ng4A:
undetectable
3p5nB-4ng4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 LEU A6198
GLY A6340
ALA A6451
ALA A6277
LEU A6303
None
1.07A 3p5nB-4opfA:
undetectable
3p5nB-4opfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN


(Streptococcus
pyogenes)
PF16569
(GramPos_pilinBB)
5 THR A 157
GLY A  60
ALA A 124
ALA A 147
LEU A 167
None
1.16A 3p5nB-4p0dA:
undetectable
3p5nB-4p0dA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Chromobacterium
violaceum)
PF04348
(LppC)
5 LEU A 275
THR A 276
GLY A 254
ALA A 256
ALA A 258
None
1.12A 3p5nB-4pyrA:
undetectable
3p5nB-4pyrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
6 LEU B 526
THR B 523
GLY B 136
ALA B 445
ALA B 448
LEU B 123
None
1.36A 3p5nB-4xcgB:
2.7
3p5nB-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
5 THR B 519
GLY B 136
ALA B 445
ALA B 448
LEU B 123
None
1.11A 3p5nB-4xcgB:
2.7
3p5nB-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
6 LEU A 522
THR A 519
GLY A 123
ALA A 441
ALA A 444
LEU A 110
None
1.29A 3p5nB-4xciA:
undetectable
3p5nB-4xciA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxl CYTOCHROME C CLASS I

(Sideroxydans
lithotrophicus)
PF00034
(Cytochrom_C)
5 GLY A 100
ALA A 102
ALA A 106
LEU A  37
ASN A  41
None
1.09A 3p5nB-4xxlA:
undetectable
3p5nB-4xxlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD


(Shewanella
oneidensis)
PF03060
(NMO)
5 GLY A  85
ALA A 519
ALA A 522
LEU A 322
ASN A 326
None
1.08A 3p5nB-4z9rA:
undetectable
3p5nB-4z9rA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE


(Helicobacter
pylori)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 LEU A  70
GLY A  61
ALA A  60
ALA A  77
LEU A  20
None
1.13A 3p5nB-4zi6A:
undetectable
3p5nB-4zi6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA


(Methanothermobacter
marburgensis)
PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
5 THR C 117
ASN B 317
GLY B 326
ALA B 328
ALA B 356
None
1.14A 3p5nB-5a8rC:
undetectable
3p5nB-5a8rC:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE


(Acinetobacter
baumannii)
PF00162
(PGK)
5 THR A 300
ASP A 295
GLY A 331
ALA A 334
ALA A 338
None
0.95A 3p5nB-5bt8A:
undetectable
3p5nB-5bt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
5 THR A 215
GLY A 286
ALA A 282
ALA A 278
LEU A 508
None
1.08A 3p5nB-5ck0A:
1.4
3p5nB-5ck0A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 LEU A  70
GLY A  53
ALA A  56
ALA A  60
LEU A  24
None
EDO  A 303 (-3.7A)
None
None
None
1.13A 3p5nB-5ed4A:
undetectable
3p5nB-5ed4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana)
PF00230
(MIP)
5 LEU A  45
THR A  46
ASP A  52
GLY A  55
ALA A  58
None
1.14A 3p5nB-5i32A:
2.5
3p5nB-5i32A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C


(Mycobacterium
tuberculosis)
PF01368
(DHH)
PF02272
(DHHA1)
5 THR A 104
ASN A 135
GLY A 139
ALA A 141
ALA A  26
None
1.01A 3p5nB-5jjuA:
undetectable
3p5nB-5jjuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C


(Mycobacterium
tuberculosis)
PF01368
(DHH)
PF02272
(DHHA1)
5 THR A 104
ASN A 135
GLY A 139
ALA A 141
LEU A  29
None
1.00A 3p5nB-5jjuA:
undetectable
3p5nB-5jjuA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA


(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
5 LEU A 148
THR A 147
ALA A 110
LEU A 181
LEU A 151
None
0.94A 3p5nB-5k6zA:
undetectable
3p5nB-5k6zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
5 LEU A 148
THR A 147
ALA A 110
LEU A 181
LEU A 151
None
0.91A 3p5nB-5k70A:
undetectable
3p5nB-5k70A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU


(Thermotoga
maritima)
PF12822
(ECF_trnsprt)
6 LEU A  34
ASP A  73
GLY A  76
ASN A 123
ASN A 149
LYS A 152
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
0.88A 3p5nB-5kbwA:
24.2
3p5nB-5kbwA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU


(Thermotoga
maritima)
PF12822
(ECF_trnsprt)
6 LEU A  34
ASP A  73
GLY A  76
LEU A  83
ASN A 149
LYS A 152
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-4.5A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
1.39A 3p5nB-5kbwA:
24.2
3p5nB-5kbwA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lal DIRIGENT PROTEIN 6

(Arabidopsis
thaliana)
PF03018
(Dirigent)
5 LEU A 120
THR A 119
GLY A 129
ALA A 158
LEU A 183
None
None
None
EDO  A 211 (-3.9A)
None
1.15A 3p5nB-5lalA:
undetectable
3p5nB-5lalA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae)
no annotation 5 LEU B 540
ASN B 214
GLY B 511
ALA B 512
ALA B 514
None
1.16A 3p5nB-5oarB:
undetectable
3p5nB-5oarB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE


(Cupriavidus
necator)
PF07167
(PhaC_N)
5 LEU A 329
THR A 327
GLY A 322
LEU A 241
LEU A 345
None
1.13A 3p5nB-5t6oA:
undetectable
3p5nB-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE


(Paraburkholderia
xenovorans)
PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N)
5 LEU A 115
THR A 114
GLY A  67
ALA A  66
LEU A  69
None
1.06A 3p5nB-5ti1A:
undetectable
3p5nB-5ti1A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN


(Bos taurus)
PF00654
(Voltage_CLC)
5 THR A 492
GLY A 465
ALA A 467
ALA A 434
LEU A 361
None
1.08A 3p5nB-5tr1A:
2.8
3p5nB-5tr1A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE


(Staphylococcus
aureus)
PF07992
(Pyr_redox_2)
5 THR A  66
GLY A  13
ALA A  16
ALA A 304
LEU A  29
None
1.16A 3p5nB-5twbA:
undetectable
3p5nB-5twbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
5 LEU A 144
ASN A 151
GLY A 192
ALA A 195
LEU A 229
None
NA  A 501 ( 3.2A)
None
None
None
1.07A 3p5nB-5uldA:
undetectable
3p5nB-5uldA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
5 THR A 271
GLY A 102
ALA A 105
ALA A 109
LEU A 297
None
1.10A 3p5nB-5uldA:
undetectable
3p5nB-5uldA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae)
no annotation 5 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
None
1.03A 3p5nB-5vfaA:
undetectable
3p5nB-5vfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM


(Homo sapiens)
no annotation 5 THR A 908
ALA A 902
ALA A 987
LEU A 831
LEU A 929
None
1.16A 3p5nB-5xgjA:
undetectable
3p5nB-5xgjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU B1081
ASN A 743
ALA B 828
ALA B 826
LEU A 658
None
1.15A 3p5nB-5xogB:
undetectable
3p5nB-5xogB:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei)
no annotation 5 LEU A 383
GLY A 266
ALA A 162
ALA A 165
LEU A 413
None
0.94A 3p5nB-5ysmA:
2.7
3p5nB-5ysmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE


(Acinetobacter
baumannii)
no annotation 5 LEU A  32
GLY A  25
ALA A  93
LEU A  91
LEU A  64
None
0.99A 3p5nB-6a31A:
undetectable
3p5nB-6a31A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE


(Elizabethkingia
anophelis)
no annotation 5 THR A 212
ASN A 218
GLY A 154
ALA A 206
ALA A 241
G6P  A 601 (-3.1A)
None
None
None
None
1.15A 3p5nB-6bzcA:
undetectable
3p5nB-6bzcA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium)
no annotation 5 GLY A 214
ALA A 193
ALA A 191
LEU A 187
LEU A 230
None
1.15A 3p5nB-6eioA:
undetectable
3p5nB-6eioA:
19.35