SIMILAR PATTERNS OF AMINO ACIDS FOR 3P5N_A_RBFA190_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlv REGULATOR OF
G-PROTEIN SIGNALING
18

(Homo sapiens) 		PF00615
(RGS) 		4 TYR A 113
ASN A  84
ASN A  44
PHE A  32
 None
 1.32A 3p5nA-2dlvA:
undetectable		 3p5nA-2dlvA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 161
ASN A 225
ASN A 251
PHE A 565
 None
 1.48A 3p5nA-3iayA:
0.4		 3p5nA-3iayA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 TYR A 252
ASN A 275
ASN A 322
PHE A 225
 None
 1.22A 3p5nA-3vbeA:
1.8		 3p5nA-3vbeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 TYR A 855
ASN A 996
ASN A 898
PHE A 853
 None
 1.44A 3p5nA-4d72A:
0.0		 3p5nA-4d72A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR A1305
ASN A1068
ASN A1230
PHE A1197
 None
 1.41A 3p5nA-4lnvA:
0.0		 3p5nA-4lnvA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 TYR A 482
ASN A 534
ASN A 567
PHE A 490
 None
 1.16A 3p5nA-5jm7A:
0.0		 3p5nA-5jm7A:
16.00