SIMILAR PATTERNS OF AMINO ACIDS FOR 3P5N_A_RBFA190

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 THR A 321
ASP A 316
GLY A 352
ALA A 355
ALA A 359
 None
 0.90A 3p5nA-13pkA:
0.5		 3p5nA-13pkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 320
GLY A 276
ALA A 279
ALA A 282
ASN A 396
 None
 1.17A 3p5nA-1b3nA:
0.0		 3p5nA-1b3nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cid T CELL SURFACE
GLYCOPROTEIN CD4

(Rattus
norvegicus) 		PF05790
(C2-set)
PF09191
(CD4-extracel) 		5 LEU A  74
THR A  73
ALA A  13
ALA A   5
LEU A 104
 None
 1.07A 3p5nA-1cidA:
undetectable		 3p5nA-1cidA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 LEU A 100
GLY A 157
ALA A 160
ALA A 164
LEU A  58
 None
 1.12A 3p5nA-1eyyA:
0.0		 3p5nA-1eyyA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 THR A 334
GLY A 467
ALA A 471
ALA A 475
LEU A 417
 None
 1.09A 3p5nA-1gpeA:
0.0		 3p5nA-1gpeA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 133
THR A 132
GLY A 272
ALA A 141
LEU A 295
 None
 1.17A 3p5nA-1i41A:
0.5		 3p5nA-1i41A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		5 LEU A 163
ASP A 155
GLY A  38
ALA A  41
ALA A  45
 None
 1.00A 3p5nA-1krqA:
2.1		 3p5nA-1krqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 GLY A 732
ALA A 728
ALA A 726
LEU A 759
ASN A 582
 None
 1.12A 3p5nA-1p15A:
1.5		 3p5nA-1p15A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 THR A 299
ASP A 294
GLY A 330
ALA A 333
ALA A 337
 None
 0.81A 3p5nA-1phpA:
0.0		 3p5nA-1phpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 155
THR A 154
ALA A 161
ALA A 165
LEU A 127
 None
 1.17A 3p5nA-1qapA:
1.4		 3p5nA-1qapA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r66 TDP-GLUCOSE-4,6-DEHY
DRATASE

(Streptomyces
venezuelae) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  39
THR A  40
GLY A   7
LEU A  48
LEU A  36
 None
NAD  A 900 (-3.3A)
NAD  A 900 ( 3.7A)
None
None
 1.10A 3p5nA-1r66A:
undetectable		 3p5nA-1r66A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B  32
GLY B 359
ALA B 358
LEU B 216
ASN B  14
 None
 1.18A 3p5nA-1tqyB:
undetectable		 3p5nA-1tqyB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A  33
GLY A 327
ALA A 319
LEU A 314
LEU A 277
 None
 1.15A 3p5nA-1vcgA:
undetectable		 3p5nA-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		5 LEU A  33
GLY A 327
ALA A 325
LEU A 314
LEU A 277
 None
 1.11A 3p5nA-1vcgA:
undetectable		 3p5nA-1vcgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vel STARVATION-INDUCED
DNA PROTECTING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF00210
(Ferritin) 		5 GLY A  63
ALA A  65
ALA A  69
LEU A  25
ASN A  29
 None
 1.13A 3p5nA-1velA:
undetectable		 3p5nA-1velA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ws6 METHYLTRANSFERASE

(Thermus
thermophilus) 		PF03602
(Cons_hypoth95) 		5 LEU A  28
GLY A  25
ALA A  23
LEU A 102
LEU A  19
 None
 1.15A 3p5nA-1ws6A:
undetectable		 3p5nA-1ws6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 LEU A 430
THR A 431
GLY A 424
ALA A 425
LEU A 513
 None
 1.19A 3p5nA-2bxyA:
undetectable		 3p5nA-2bxyA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		5 THR A 191
ALA A 197
LEU A  11
LEU A 158
ASN A  31
 None
 0.99A 3p5nA-2czqA:
undetectable		 3p5nA-2czqA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		5 THR A 418
ASP A 405
GLY A 404
ALA A 415
LEU A 406
 None
NAD  A2001 (-3.7A)
None
None
None
 1.12A 3p5nA-2d4vA:
undetectable		 3p5nA-2d4vA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A   5
THR A   4
ALA A   9
ALA A  79
LEU A  58
 None
 1.17A 3p5nA-2g17A:
undetectable		 3p5nA-2g17A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 302
ALA A 305
ALA A 309
LEU A 186
LEU A 334
 None
 1.15A 3p5nA-2i7pA:
undetectable		 3p5nA-2i7pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 THR A 296
ASP A 291
GLY A 327
ALA A 330
ALA A 334
 None
 0.77A 3p5nA-2ie8A:
undetectable		 3p5nA-2ie8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 417
THR A 418
ALA A 412
ALA A 435
LEU A 436
 None
 1.04A 3p5nA-2ja2A:
undetectable		 3p5nA-2ja2A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jac GLUTAREDOXIN-1

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		5 ASP A  89
GLY A  87
ALA A  22
LEU A  66
ASN A  70
 GSH  A1000 (-3.2A)
GSH  A1000 (-3.5A)
None
None
None
 1.05A 3p5nA-2jacA:
undetectable		 3p5nA-2jacA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		5 LEU A 475
ASP A 469
GLY A 470
ALA A 120
LEU A 489
 None
 1.16A 3p5nA-2jh9A:
undetectable		 3p5nA-2jh9A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 LEU A 189
THR A 188
ASP A 182
GLY A 392
ALA A 368
 None
 1.13A 3p5nA-2py6A:
undetectable		 3p5nA-2py6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1142
ALA A1095
ALA A1099
LEU A 798
LEU A1073
 None
 1.14A 3p5nA-2vdcA:
undetectable		 3p5nA-2vdcA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 ASP A 210
GLY A 213
ALA A 215
ALA A 219
LEU A 247
 None
 1.15A 3p5nA-2vosA:
undetectable		 3p5nA-2vosA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 THR A1697
GLY A1681
ALA A1684
ALA A1688
LEU A1659
 None
 1.08A 3p5nA-2vz9A:
undetectable		 3p5nA-2vz9A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		5 GLY C 389
ALA C 376
LEU C 378
LEU C 244
ASN C 385
 None
 1.16A 3p5nA-2wy0C:
undetectable		 3p5nA-2wy0C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY

(Desulfomicrobium
norvegicum) 		PF04358
(DsrC) 		5 LEU C  69
GLY C  87
ALA C  92
ALA C  96
LEU C  50
 None
 1.15A 3p5nA-2xsjC:
undetectable		 3p5nA-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFUR RELAY
PROTEIN,
TUSE/DSRC/DSVC
FAMILY

(Desulfomicrobium
norvegicum) 		PF04358
(DsrC) 		5 LEU C  69
GLY C  89
ALA C  92
ALA C  96
LEU C  50
 None
 1.14A 3p5nA-2xsjC:
undetectable		 3p5nA-2xsjC:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		5 ASP A 161
GLY A  82
ALA A  76
LEU A  84
ASN A  13
 None
None
TLA  A 401 ( 4.8A)
None
None
 1.17A 3p5nA-3a3uA:
undetectable		 3p5nA-3a3uA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		5 LEU B  74
GLY B  65
ALA B 191
ALA B 194
ASN B 189
 None
None
SF4  B 804 (-4.3A)
None
None
 1.14A 3p5nA-3egwB:
undetectable		 3p5nA-3egwB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA

(Moorella
thermoacetica) 		PF03063
(Prismane) 		5 LEU A 330
GLY A 499
ALA A 502
ALA A 505
LEU A 511
 None
XCC  A 800 ( 4.1A)
None
None
None
 1.09A 3p5nA-3i04A:
undetectable		 3p5nA-3i04A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)

(Legionella
pneumophila) 		PF00378
(ECH_1) 		5 LEU A 162
GLY A 112
ALA A 115
ALA A 119
LEU A 179
 None
 0.98A 3p5nA-3i47A:
undetectable		 3p5nA-3i47A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		6 LEU A 417
GLY A 218
ALA A 220
ALA A 144
LEU A 192
LEU A 252
 None
 1.35A 3p5nA-3ihvA:
undetectable		 3p5nA-3ihvA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imk PUTATIVE MOLYBDENUM
CARRIER PROTEIN

(Syntrophus
aciditrophicus) 		PF12694
(MoCo_carrier) 		5 LEU A  77
THR A  76
GLY A 135
ALA A  18
ALA A  22
 None
None
GOL  A 158 (-4.1A)
None
None
 0.90A 3p5nA-3imkA:
undetectable		 3p5nA-3imkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 GLY A 385
ALA A 387
ALA A 391
LEU A 723
ASN A 675
 None
 1.01A 3p5nA-3j09A:
undetectable		 3p5nA-3j09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1e CHAPERONIN BETA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		6 LEU A 524
THR A 521
GLY A 134
ALA A 443
ALA A 446
LEU A 121
 None
 1.38A 3p5nA-3j1eA:
undetectable		 3p5nA-3j1eA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2q PYROPHOSPHATE-DEPEND
ENT
PHOSPHOFRUCTOKINASE

(Marinobacter
hydrocarbonoclasticus) 		PF00365
(PFK) 		5 GLY A  74
ALA A  75
ALA A 403
LEU A 405
ASN A 407
 None
 1.18A 3p5nA-3k2qA:
undetectable		 3p5nA-3k2qA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 320
GLY A 276
ALA A 279
ALA A 282
ASN A 395
 None
 1.17A 3p5nA-3o04A:
undetectable		 3p5nA-3o04A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		5 LEU B 210
GLY B 225
ALA B 229
ALA B 232
LEU B 168
 None
 1.16A 3p5nA-3o1hB:
undetectable		 3p5nA-3o1hB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 393
ASP A 384
GLY A 425
ALA A 428
ALA A 432
 None
 0.59A 3p5nA-3qdkA:
undetectable		 3p5nA-3qdkA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		5 LEU A 190
ASP A 119
GLY A 225
ALA A 229
LEU A 200
 SAH  A 258 (-4.2A)
None
None
None
None
 1.18A 3p5nA-3tosA:
undetectable		 3p5nA-3tosA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 THR A 179
GLY A 163
ALA A 166
ALA A 170
LEU A 142
 None
 0.91A 3p5nA-3tqhA:
undetectable		 3p5nA-3tqhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A  12
THR A 142
GLY A 139
ALA A  66
LEU A  44
 None
 1.11A 3p5nA-3u4gA:
undetectable		 3p5nA-3u4gA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  12
THR A  13
GLY A  50
ALA A 111
ALA A 107
 None
 1.13A 3p5nA-3u9iA:
undetectable		 3p5nA-3u9iA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 LEU A 234
ALA A 241
LEU A 187
ASN A 261
LEU A 264
 None
 1.18A 3p5nA-3uhjA:
undetectable		 3p5nA-3uhjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 THR A 299
ASP A 294
GLY A 330
ALA A 333
ALA A 337
 None
 0.82A 3p5nA-3uwdA:
undetectable		 3p5nA-3uwdA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 110
GLY A 167
ALA A 170
ALA A 174
LEU A  68
 None
 1.14A 3p5nA-3v4cA:
undetectable		 3p5nA-3v4cA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		5 GLY A 229
ALA A 227
ALA A  44
LEU A  50
LEU A  59
 None
 1.10A 3p5nA-3v8hA:
undetectable		 3p5nA-3v8hA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtx MAMA

(Candidatus
Magnetobacterium
bavaricum) 		PF00515
(TPR_1)
PF13174
(TPR_6)
PF13181
(TPR_8)
PF13414
(TPR_11) 		5 LEU A  84
THR A  87
ASP A  52
GLY A  51
ALA A  66
 None
 1.12A 3p5nA-3vtxA:
undetectable		 3p5nA-3vtxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 LEU A 173
GLY A 327
ALA A 325
LEU A 229
LEU A 331
 None
 1.01A 3p5nA-3zidA:
undetectable		 3p5nA-3zidA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 ASP A 345
GLY A 348
ALA A  48
ALA A 419
ASN A 438
 None
B07  A 500 (-4.7A)
B07  A 500 (-3.8A)
None
None
 1.10A 3p5nA-3zvtA:
undetectable		 3p5nA-3zvtA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		5 GLY A  98
ALA A 111
ALA A 123
LEU A 135
LEU A  34
 None
 1.17A 3p5nA-4abyA:
undetectable		 3p5nA-4abyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 305
THR A 304
ALA A 332
LEU A 426
LEU A 290
 None
 1.13A 3p5nA-4bc5A:
undetectable		 3p5nA-4bc5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU A 656
THR A 655
GLY A 623
ALA A 622
ALA A 620
 None
 1.10A 3p5nA-4bevA:
undetectable		 3p5nA-4bevA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 LEU A1474
GLY A1526
ALA A1523
ALA A1519
LEU A1533
 None
 0.91A 3p5nA-4c6oA:
undetectable		 3p5nA-4c6oA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gic HISTIDINOL
DEHYDROGENASE

(Methylococcus
capsulatus) 		PF00815
(Histidinol_dh) 		5 LEU A  56
THR A  57
GLY A 194
ALA A 195
ALA A 199
 None
 1.15A 3p5nA-4gicA:
undetectable		 3p5nA-4gicA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzl RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
 None
 1.01A 3p5nA-4lzlA:
undetectable		 3p5nA-4lzlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me2 UNCHARACTERIZED
PROTEIN

(Brachypodium
distachyon) 		no annotation 5 LEU A  80
ALA A 104
ALA A  73
LEU A  56
LEU A  86
 None
 1.13A 3p5nA-4me2A:
undetectable		 3p5nA-4me2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 THR A 301
GLY A 365
ALA A 363
LEU A 361
LEU A 383
 SAM  A 601 (-4.1A)
SAM  A 601 ( 4.0A)
None
None
SAM  A 601 (-4.6A)
 1.17A 3p5nA-4n49A:
undetectable		 3p5nA-4n49A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		5 THR A 298
ASP A 293
GLY A 329
ALA A 332
ALA A 336
 None
MG  A 401 (-2.9A)
MG  A 401 ( 4.0A)
None
None
 0.88A 3p5nA-4ng4A:
undetectable		 3p5nA-4ng4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A6198
GLY A6340
ALA A6451
ALA A6277
LEU A6303
 None
 1.07A 3p5nA-4opfA:
undetectable		 3p5nA-4opfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		5 THR A 157
GLY A  60
ALA A 124
ALA A 147
LEU A 167
 None
 1.15A 3p5nA-4p0dA:
undetectable		 3p5nA-4p0dA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF00118
(Cpn60_TCP1) 		5 LEU A 262
THR A 261
ALA A 236
ALA A 240
LEU A 247
 None
 1.18A 3p5nA-4pj1A:
undetectable		 3p5nA-4pj1A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		5 LEU A 275
THR A 276
GLY A 254
ALA A 256
ALA A 258
 None
 1.12A 3p5nA-4pyrA:
undetectable		 3p5nA-4pyrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		6 LEU B 526
THR B 523
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.36A 3p5nA-4xcgB:
2.7		 3p5nA-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		5 THR B 519
GLY B 136
ALA B 445
ALA B 448
LEU B 123
 None
 1.12A 3p5nA-4xcgB:
2.7		 3p5nA-4xcgB:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		6 LEU A 522
THR A 519
GLY A 123
ALA A 441
ALA A 444
LEU A 110
 None
 1.30A 3p5nA-4xciA:
undetectable		 3p5nA-4xciA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxl CYTOCHROME C CLASS I

(Sideroxydans
lithotrophicus) 		PF00034
(Cytochrom_C) 		5 GLY A 100
ALA A 102
ALA A 106
LEU A  37
ASN A  41
 None
 1.10A 3p5nA-4xxlA:
undetectable		 3p5nA-4xxlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 GLY A  85
ALA A 519
ALA A 522
LEU A 322
ASN A 326
 None
 1.09A 3p5nA-4z9rA:
undetectable		 3p5nA-4z9rA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A  70
GLY A  61
ALA A  60
ALA A  77
LEU A  20
 None
 1.12A 3p5nA-4zi6A:
undetectable		 3p5nA-4zi6A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 THR A 300
ASP A 295
GLY A 331
ALA A 334
ALA A 338
 None
 0.94A 3p5nA-5bt8A:
undetectable		 3p5nA-5bt8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 THR A 215
GLY A 286
ALA A 282
ALA A 278
LEU A 508
 None
 1.07A 3p5nA-5ck0A:
1.4		 3p5nA-5ck0A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LYS A   8
GLY A 209
ALA A 213
ALA A 217
LEU A 191
 None
 1.05A 3p5nA-5co8A:
undetectable		 3p5nA-5co8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed4 RESPONSE REGULATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A  70
GLY A  53
ALA A  56
ALA A  60
LEU A  24
 None
EDO  A 303 (-3.7A)
None
None
None
 1.13A 3p5nA-5ed4A:
undetectable		 3p5nA-5ed4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 LEU A  45
THR A  46
ASP A  52
GLY A  55
ALA A  58
 None
 1.14A 3p5nA-5i32A:
2.5		 3p5nA-5i32A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 LEU A 148
THR A 147
ALA A 110
LEU A 181
LEU A 151
 None
 0.94A 3p5nA-5k6zA:
undetectable		 3p5nA-5k6zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		5 LEU A 148
THR A 147
ALA A 110
LEU A 181
LEU A 151
 None
 0.91A 3p5nA-5k70A:
undetectable		 3p5nA-5k70A:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		6 LEU A  34
ASP A  73
GLY A  76
ASN A 123
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 0.87A 3p5nA-5kbwA:
24.2		 3p5nA-5kbwA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		6 LEU A  34
ASP A  73
GLY A  76
LEU A  83
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-4.5A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 1.38A 3p5nA-5kbwA:
24.2		 3p5nA-5kbwA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lal DIRIGENT PROTEIN 6

(Arabidopsis
thaliana) 		PF03018
(Dirigent) 		5 LEU A 120
THR A 119
GLY A 129
ALA A 158
LEU A 183
 None
None
None
EDO  A 211 (-3.9A)
None
 1.16A 3p5nA-5lalA:
undetectable		 3p5nA-5lalA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n57 SUPEROXIDE DISMUTASE

(Staphylococcus
aureus) 		no annotation 5 LEU A 150
THR A 151
GLY A  76
LEU A 159
LEU A  53
 None
 1.18A 3p5nA-5n57A:
undetectable		 3p5nA-5n57A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		5 LEU A   4
ASP A  64
GLY A  69
ALA A 205
ALA A 207
 None
 1.18A 3p5nA-5swnA:
undetectable		 3p5nA-5swnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 GLY A 427
ALA A 429
ALA A 589
LEU A 390
ASN A 400
 None
 1.18A 3p5nA-5t6oA:
undetectable		 3p5nA-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 LEU A 329
THR A 327
GLY A 322
LEU A 241
LEU A 345
 None
 1.12A 3p5nA-5t6oA:
undetectable		 3p5nA-5t6oA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 LEU A 115
THR A 114
GLY A  67
ALA A  66
LEU A  69
 None
 1.06A 3p5nA-5ti1A:
undetectable		 3p5nA-5ti1A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		5 THR A 492
GLY A 465
ALA A 467
ALA A 434
LEU A 361
 None
 1.09A 3p5nA-5tr1A:
undetectable		 3p5nA-5tr1A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 THR A  66
GLY A  13
ALA A  16
ALA A 304
LEU A  29
 None
 1.15A 3p5nA-5twbA:
undetectable		 3p5nA-5twbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 THR A 271
GLY A 102
ALA A 105
ALA A 109
LEU A 297
 None
 1.10A 3p5nA-5uldA:
undetectable		 3p5nA-5uldA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 5 ASP A  58
GLY A  35
ALA A  38
ALA A  42
LEU A   6
 None
 1.02A 3p5nA-5vfaA:
undetectable		 3p5nA-5vfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 THR A 908
ALA A 902
ALA A 987
LEU A 831
LEU A 929
 None
 1.16A 3p5nA-5xgjA:
undetectable		 3p5nA-5xgjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU B 431
THR B 432
ALA B 394
ALA B 396
LEU B 344
 None
 1.18A 3p5nA-5y58B:
undetectable		 3p5nA-5y58B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 LEU A 383
GLY A 266
ALA A 162
ALA A 165
LEU A 413
 None
 0.94A 3p5nA-5ysmA:
2.7		 3p5nA-5ysmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 5 LEU A  32
GLY A  25
ALA A  93
LEU A  91
LEU A  64
 None
 0.99A 3p5nA-6a31A:
undetectable		 3p5nA-6a31A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 THR A1059
ASP A1356
GLY A1354
ALA A1353
LEU A 374
 None
9SL  A1610 (-2.8A)
9SL  A1610 (-3.3A)
9SL  A1610 ( 3.9A)
None
 1.07A 3p5nA-6a91A:
1.6		 3p5nA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eio ANTIFREEZE PROTEIN

(uncultured
bacterium) 		no annotation 5 GLY A 214
ALA A 193
ALA A 191
LEU A 187
LEU A 230
 None
 1.16A 3p5nA-6eioA:
undetectable		 3p5nA-6eioA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlv REGULATOR OF
G-PROTEIN SIGNALING
18

(Homo sapiens) 		PF00615
(RGS) 		4 TYR A 113
ASN A  84
ASN A  44
PHE A  32
 None
 1.32A 3p5nA-2dlvA:
undetectable		 3p5nA-2dlvA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 161
ASN A 225
ASN A 251
PHE A 565
 None
 1.48A 3p5nA-3iayA:
0.4		 3p5nA-3iayA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vbe BETA-CYANOALNINE
SYNTHASE

(Glycine max) 		PF00291
(PALP) 		4 TYR A 252
ASN A 275
ASN A 322
PHE A 225
 None
 1.22A 3p5nA-3vbeA:
1.8		 3p5nA-3vbeA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 TYR A 855
ASN A 996
ASN A 898
PHE A 853
 None
 1.44A 3p5nA-4d72A:
0.0		 3p5nA-4d72A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnv THIOESTER-CONTAINING
PROTEIN I

(Anopheles
gambiae) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 TYR A1305
ASN A1068
ASN A1230
PHE A1197
 None
 1.41A 3p5nA-4lnvA:
0.0		 3p5nA-4lnvA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 TYR A 482
ASN A 534
ASN A 567
PHE A 490
 None
 1.16A 3p5nA-5jm7A:
0.0		 3p5nA-5jm7A:
16.00