SIMILAR PATTERNS OF AMINO ACIDS FOR 3P50_A_PFLA319_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  78
TYR A 367
THR A 364
ILE A 251
 None
CAA  A 400 (-3.8A)
None
None
 0.91A 3p50A-1jqiA:
2.4		 3p50A-1jqiA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 PRO A 802
ILE A 765
LEU A 825
ILE A 807
 None
 0.95A 3p50A-1k32A:
2.2		 3p50A-1k32A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		4 ILE B   2
LEU B 164
THR B 195
ILE B 196
 None
 0.90A 3p50A-1kwcB:
undetectable		 3p50A-1kwcB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 ILE A 208
LEU A 195
TYR A 282
ASN A 233
 None
 0.92A 3p50A-1oltA:
0.0		 3p50A-1oltA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 183
ILE A 319
LEU A 314
ASN A 158
 None
 0.97A 3p50A-1smkA:
undetectable		 3p50A-1smkA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		4 PRO A 100
ILE A 138
LEU A 106
ILE A  77
 None
 0.80A 3p50A-1wlsA:
undetectable		 3p50A-1wlsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zs3 LACTOCOCCUS LACTIS
MG1363 DPSA

(Lactococcus
lactis) 		no annotation 4 ILE A  75
LEU A  38
ILE A 129
ASN A 155
 None
 0.78A 3p50A-1zs3A:
4.1		 3p50A-1zs3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.97A 3p50A-2b3xA:
0.0		 3p50A-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 PRO A 265
ILE A 336
LEU A 337
ILE A 182
 None
 0.93A 3p50A-2efjA:
0.0		 3p50A-2efjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9x PUTATIVE SEPTATION
PROTEIN SPOVG

(Staphylococcus
epidermidis) 		PF04026
(SpoVG) 		4 PRO A  48
ILE A  31
LEU A  25
ILE A  72
 None
 0.95A 3p50A-2i9xA:
undetectable		 3p50A-2i9xA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2im9 HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF07313
(DUF1460) 		4 ILE A 335
LEU A 250
THR A 178
ILE A 181
 None
 0.86A 3p50A-2im9A:
undetectable		 3p50A-2im9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwa GLUTAMINE
CYCLOTRANSFERASE

(Carica papaya) 		PF05096
(Glu_cyclase_2) 		4 ILE A 210
LEU A 212
ILE A 233
ASN A 189
 None
 0.94A 3p50A-2iwaA:
undetectable		 3p50A-2iwaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld6 CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01627
(Hpt) 		4 ILE A  69
LEU A  70
THR A  81
ILE A  80
 None
 0.89A 3p50A-2ld6A:
3.5		 3p50A-2ld6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 PRO A 219
LEU A 208
TYR A 221
ASN A 156
 None
None
None
HEM  A 401 (-4.2A)
 0.95A 3p50A-2nwbA:
2.7		 3p50A-2nwbA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 LEU A 244
TYR A 226
THR A 227
ILE A 230
 None
 0.97A 3p50A-2p35A:
undetectable		 3p50A-2p35A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6d DIPHTHINE SYNTHASE

(Pyrococcus
horikoshii) 		PF00590
(TP_methylase) 		4 ILE A   6
LEU A  83
THR A  17
ILE A  16
 None
 0.74A 3p50A-2p6dA:
undetectable		 3p50A-2p6dA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 PRO A 176
ILE A 149
LEU A 115
ILE A 166
 None
SAH  A 301 (-4.3A)
None
None
 0.89A 3p50A-2pbfA:
undetectable		 3p50A-2pbfA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PRO A 264
ILE A 292
LEU A 290
ILE A 352
 None
 0.96A 3p50A-2v6oA:
2.4		 3p50A-2v6oA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ILE A  55
THR A  74
ILE A  75
ASN A   8
 None
None
None
NAP  A2001 (-3.2A)
 0.93A 3p50A-2yyyA:
undetectable		 3p50A-2yyyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.99A 3p50A-2z7xA:
undetectable		 3p50A-2z7xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.97A 3p50A-2z80A:
undetectable		 3p50A-2z80A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 181
LEU A 203
TYR A 189
ILE A 216
 None
 0.95A 3p50A-2z81A:
undetectable		 3p50A-2z81A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans) 		PF00232
(Glyco_hydro_1) 		4 PRO A 392
ILE A 346
LEU A 255
ILE A 339
 None
 0.91A 3p50A-3ahxA:
undetectable		 3p50A-3ahxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 PRO A 104
ILE A  98
LEU A  94
ASN A 115
 None
 0.96A 3p50A-3b89A:
undetectable		 3p50A-3b89A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cec PUTATIVE ANTIDOTE
PROTEIN OF PLASMID
MAINTENANCE SYSTEM

(Nostoc
punctiforme) 		PF01381
(HTH_3) 		4 ILE A  61
LEU A  65
THR A  46
ILE A  47
 None
 0.82A 3p50A-3cecA:
undetectable		 3p50A-3cecA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ILE A 181
LEU A 179
TYR A 142
ILE A  93
 None
 0.96A 3p50A-3cmgA:
3.4		 3p50A-3cmgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzv 4-METHYL-5-(BETA-HYD
ROXYETHYL)THIAZOLE
KINASE

(Enterococcus
faecalis) 		PF02110
(HK) 		4 ILE A  38
LEU A  13
ILE A  10
ASN A 216
 None
 0.94A 3p50A-3dzvA:
undetectable		 3p50A-3dzvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PRO A 370
LEU A  11
THR A 341
ILE A 345
 None
 0.94A 3p50A-3e60A:
undetectable		 3p50A-3e60A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		4 ILE A 141
LEU A  22
THR A 138
ILE A 139
 None
 0.97A 3p50A-3fj1A:
undetectable		 3p50A-3fj1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		5 PRO A 238
ILE A 280
LEU A 257
TYR A 242
ILE A 246
 None
 1.49A 3p50A-3gjuA:
undetectable		 3p50A-3gjuA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h33 CYTOCHROME C7

(Geobacter
sulfurreducens) 		PF02085
(Cytochrom_CIII) 		4 PRO A   7
TYR A   6
THR A   5
ILE A   4
 None
HEM  A  77 ( 4.3A)
None
None
 0.88A 3p50A-3h33A:
undetectable		 3p50A-3h33A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN

(Pseudomonas
protegens) 		PF13407
(Peripla_BP_4) 		4 PRO A 324
ILE A 151
LEU A 127
ASN A 118
 None
 0.94A 3p50A-3h75A:
undetectable		 3p50A-3h75A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		4 ILE A 281
LEU A 258
TYR A 243
ILE A 247
 None
 0.98A 3p50A-3hmuA:
undetectable		 3p50A-3hmuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4t DIPHTHINE SYNTHASE

(Entamoeba
histolytica) 		PF00590
(TP_methylase) 		4 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.76A 3p50A-3i4tA:
undetectable		 3p50A-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128

(Homo sapiens) 		PF02225
(PA) 		4 PRO A  76
LEU A 117
TYR A  71
ILE A 169
 None
 0.71A 3p50A-3icuA:
undetectable		 3p50A-3icuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 PRO P 351
THR P 380
ILE P 418
ASN P 403
 None
 0.95A 3p50A-3izyP:
undetectable		 3p50A-3izyP:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 ILE A 119
LEU A 116
TYR A 317
ILE A 101
 None
 0.89A 3p50A-3k2gA:
undetectable		 3p50A-3k2gA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 LEU A 194
THR A  83
ILE A  86
ASN A  28
 None
 0.93A 3p50A-3m1tA:
undetectable		 3p50A-3m1tA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd1 PRECORRIN-6A
SYNTHASE/COBF
PROTEIN

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 ILE A   7
LEU A 110
THR A  18
ILE A  17
 None
 0.75A 3p50A-3nd1A:
undetectable		 3p50A-3nd1A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 ILE A   6
LEU A  79
THR A  17
ILE A  16
 None
 0.77A 3p50A-3ndcA:
undetectable		 3p50A-3ndcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PRO A 401
TYR A 400
THR A 399
ILE A 398
 None
 0.87A 3p50A-3ps9A:
undetectable		 3p50A-3ps9A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 ILE A  87
LEU A  86
THR A 111
ILE A 112
 None
 0.97A 3p50A-3qmjA:
undetectable		 3p50A-3qmjA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF16782
(SIL1) 		4 ILE C 225
LEU C 254
THR C 197
ILE C 200
 None
 0.89A 3p50A-3qmlC:
2.6		 3p50A-3qmlC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		4 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.95A 3p50A-3rucA:
undetectable		 3p50A-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 PRO A 138
LEU A  43
THR A 120
ILE A 121
 None
 0.86A 3p50A-3szbA:
undetectable		 3p50A-3szbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		4 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.85A 3p50A-3upuA:
undetectable		 3p50A-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0h MRNA CLEAVAGE AND
POLYADENYLATION
FACTOR CLP1

(Saccharomyces
cerevisiae) 		PF06807
(Clp1)
PF16573
(CLP1_N)
PF16575
(CLP1_P) 		4 ILE A  36
LEU A  44
THR A  96
ILE A  95
 None
 0.87A 3p50A-4c0hA:
undetectable		 3p50A-4c0hA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8m PESTICIDAL CRYSTAL
PROTEIN CRY5BA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PRO A 350
ILE A 368
ILE A 533
ASN A 306
 None
 0.92A 3p50A-4d8mA:
4.5		 3p50A-4d8mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evw NUCLEOSIDE-DIPHOSPHA
TE-SUGAR
PYROPHOSPHORYLASE

(Vibrio cholerae) 		no annotation 4 PRO A   5
ILE A 205
LEU A 208
THR A  90
 None
 0.94A 3p50A-4evwA:
undetectable		 3p50A-4evwA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 LEU C 208
THR C 343
ILE C 344
ASN C 134
 None
 0.94A 3p50A-4f4oC:
undetectable		 3p50A-4f4oC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		4 PRO A  84
LEU A 183
TYR A 339
THR A 341
 None
 0.89A 3p50A-4fmcA:
undetectable		 3p50A-4fmcA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.93A 3p50A-4g8dA:
undetectable		 3p50A-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		4 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50A-4gf8A:
undetectable		 3p50A-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Staphylococcus
aureus) 		PF01255
(Prenyltransf) 		4 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.95A 3p50A-4h8eA:
undetectable		 3p50A-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbu VIRULENCE-ASSOCIATED
V ANTIGEN

(Yersinia pestis) 		PF04792
(LcrV) 		4 ILE A 186
LEU A 240
TYR A 259
ILE A 174
 None
 0.98A 3p50A-4jbuA:
undetectable		 3p50A-4jbuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 PRO A 197
LEU A 174
TYR A 196
THR A 195
ILE A 194
 None
 1.28A 3p50A-4mioA:
undetectable		 3p50A-4mioA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		4 PRO A 271
LEU A 190
THR A 269
ILE A 268
 None
 0.87A 3p50A-4mnpA:
undetectable		 3p50A-4mnpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 PRO B 464
ILE B 250
LEU B 252
ILE B 315
 None
 0.97A 3p50A-4mrmB:
undetectable		 3p50A-4mrmB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 ILE A 325
LEU A 321
THR A  77
ILE A  56
 None
 0.98A 3p50A-4n7tA:
undetectable		 3p50A-4n7tA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Mesorhizobium
japonicum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.89A 3p50A-4om8A:
undetectable		 3p50A-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 502
LEU A 483
THR A 451
ILE A 452
 None
 0.93A 3p50A-4om9A:
undetectable		 3p50A-4om9A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		4 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.91A 3p50A-4rltA:
undetectable		 3p50A-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ILE A 161
LEU A 158
THR A 491
ASN A 539
 None
 0.84A 3p50A-4u16A:
3.6		 3p50A-4u16A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1r ALPHA-1,6-MANNANASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		4 ILE A  57
LEU A 374
TYR A  91
THR A  90
 None
 0.94A 3p50A-4v1rA:
undetectable		 3p50A-4v1rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 4 LEU C 263
THR C 398
ILE C 399
ASN C 189
 None
 0.91A 3p50A-4wjgC:
undetectable		 3p50A-4wjgC:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 PRO A 104
ILE A 156
THR A 102
ILE A 101
 None
 0.98A 3p50A-4wvaA:
undetectable		 3p50A-4wvaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.90A 3p50A-4x0lC:
undetectable		 3p50A-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfs INTERLEUKIN-18

(Homo sapiens) 		PF00340
(IL1) 		4 PRO A  88
ILE A  48
THR A  63
ILE A  64
 None
 0.87A 3p50A-4xfsA:
undetectable		 3p50A-4xfsA:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 ILE A 209
LEU A 213
TYR A 261
THR A 262
ILE A 265
ASN A 314
 None
 0.59A 3p50A-4yeuA:
20.0		 3p50A-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 PRO A 120
ILE A 209
LEU A 213
TYR A 261
THR A 262
ILE A 265
 None
 0.82A 3p50A-4yeuA:
20.0		 3p50A-4yeuA:
52.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 ILE C  30
LEU C  23
THR C  76
ILE C 130
 None
 0.95A 3p50A-4z42C:
undetectable		 3p50A-4z42C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.74A 3p50A-5a31A:
5.2		 3p50A-5a31A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdc VP1, STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF08762
(CRPV_capsid) 		4 PRO A 135
TYR A 134
THR A 133
ILE A 132
 None
 0.78A 3p50A-5cdcA:
undetectable		 3p50A-5cdcA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chn ANTIBODY 5M16 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 PRO H  53
LEU H 109
THR H  51
ILE H  50
 None
 0.94A 3p50A-5chnH:
undetectable		 3p50A-5chnH:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5w HEMAGGLUTININ-ESTERA
SE

(Influenza D
virus) 		PF00509
(Hemagglutinin)
PF08720
(Hema_stalk) 		4 ILE B 100
LEU B  97
ILE B  64
ASN B  68
 None
 0.94A 3p50A-5e5wB:
3.9		 3p50A-5e5wB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 PRO D 359
TYR D 357
THR D 356
ILE D 355
 None
 0.81A 3p50A-5exrD:
undetectable		 3p50A-5exrD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 PRO A  31
ILE A 153
LEU A 155
THR A  44
 None
 0.83A 3p50A-5f7cA:
undetectable		 3p50A-5f7cA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO L 126
ILE L 137
LEU L 196
THR L 220
 None
 0.95A 3p50A-5fhxL:
undetectable		 3p50A-5fhxL:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		4 ILE A 287
LEU A 285
THR A 308
ILE A 311
 None
 0.95A 3p50A-5foeA:
undetectable		 3p50A-5foeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 616
TYR A 618
THR A 619
ILE A 620
 None
 0.82A 3p50A-5fr8A:
undetectable		 3p50A-5fr8A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		4 PRO A 103
ILE A  97
THR A 357
ILE A 125
 None
 0.97A 3p50A-5g5zA:
undetectable		 3p50A-5g5zA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 177
TYR A 209
ILE A 125
ASN A 413
 None
 0.91A 3p50A-5gr1A:
undetectable		 3p50A-5gr1A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 PRO A 321
ILE A 308
LEU A 305
ILE A 284
 None
 0.95A 3p50A-5gz8A:
2.3		 3p50A-5gz8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 PRO A 155
ILE A  92
THR A 100
ILE A 101
 None
 0.92A 3p50A-5j5pA:
undetectable		 3p50A-5j5pA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.85A 3p50A-5lcwA:
5.1		 3p50A-5lcwA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A 409
LEU A 223
THR A 258
ILE A 246
 None
 0.96A 3p50A-5lggA:
undetectable		 3p50A-5lggA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.96A 3p50A-5lp4A:
undetectable		 3p50A-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 4 ILE A 106
TYR A 251
THR A 252
ILE A 255
 None
 0.85A 3p50A-5olkA:
2.3		 3p50A-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.85A 3p50A-5ot0A:
undetectable		 3p50A-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA

(Yersinia pestis) 		PF01297
(ZnuA) 		4 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.91A 3p50A-5uygA:
undetectable		 3p50A-5uygA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 7 PRO C 120
ILE C 202
LEU C 206
TYR C 254
THR C 255
ILE C 258
ASN C 307
 None
 0.45A 3p50A-5v6nC:
36.2		 3p50A-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 2
ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		PF04084
(ORC2)
no annotation 		4 ILE B 401
LEU B 402
THR C 113
ILE C 116
 None
 0.99A 3p50A-5v8fB:
undetectable		 3p50A-5v8fB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 PRO A1826
LEU A1793
THR A1828
ILE A1786
 None
 0.99A 3p50A-5wchA:
undetectable		 3p50A-5wchA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 PRO A  73
ILE A 140
LEU A 136
ILE A  69
 None
 0.98A 3p50A-5xa5A:
8.0		 3p50A-5xa5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 4 PRO A  67
ILE A 120
LEU A  91
THR A 116
 None
 0.92A 3p50A-5zbyA:
undetectable		 3p50A-5zbyA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh5 LYSINE--TRNA LIGASE

(Plasmodium
falciparum) 		no annotation 4 ILE A 258
LEU A 261
THR A 561
ILE A 560
 None
 0.87A 3p50A-5zh5A:
undetectable		 3p50A-5zh5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 4 ILE A 363
LEU A 361
THR A 256
ILE A 259
 None
 0.94A 3p50A-6b3bA:
2.1		 3p50A-6b3bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 4 ILE A  78
TYR A 433
THR A 434
ILE A 437
 None
 0.84A 3p50A-6bf6A:
undetectable		 3p50A-6bf6A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 ILE 1  51
TYR 1  66
THR 1  68
ASN 1  33
 None
 0.93A 3p50A-6c261:
4.6		 3p50A-6c261:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 184
LEU C 185
THR C 169
ASN C 100
 None
 0.88A 3p50A-6c6lC:
3.5		 3p50A-6c6lC:
13.65