SIMILAR PATTERNS OF AMINO ACIDS FOR 3P4W_E_DSFE319_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edy ALPHA
1-MACROGLOBULIN

(Rattus
norvegicus) 		PF07677
(A2M_recep) 		5 ILE A  30
VAL A  32
TYR A 115
ILE A  45
ILE A  84
 None
 1.18A 3p4wE-1edyA:
2.5		 3p4wE-1edyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9a HYPOTHETICAL PROTEIN
MJ0541

(Methanocaldococcus
jannaschii) 		PF01467
(CTP_transf_like) 		5 TYR A  68
ILE A  31
ILE A  32
ILE A  20
ILE A  23
 None
 0.93A 3p4wE-1f9aA:
0.0		 3p4wE-1f9aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5c BETA-CARBONIC
ANHYDRASE

(Methanothermobacter
thermautotrophicus) 		PF00484
(Pro_CA) 		5 ILE A  67
ILE A 145
VAL A  62
ILE A  82
ILE A  30
 None
 1.13A 3p4wE-1g5cA:
0.0		 3p4wE-1g5cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		5 MET A 124
VAL A 139
TYR A 104
ILE A 107
ILE A 111
 None
 1.14A 3p4wE-1gnsA:
undetectable		 3p4wE-1gnsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE B 352
ILE B 356
VAL B 349
ILE B 270
ILE B 268
 None
 1.19A 3p4wE-1hr7B:
0.0		 3p4wE-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 TYR B 455
ILE B 456
MET B 441
VAL B 353
ILE B 268
 None
 1.18A 3p4wE-1hr7B:
0.0		 3p4wE-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		PF07827
(KNTase_C) 		5 TYR A 110
ILE A  34
ILE A 109
MET A  53
ILE A  19
 None
 1.21A 3p4wE-1knyA:
2.4		 3p4wE-1knyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF13302
(Acetyltransf_3) 		5 ILE A 110
ILE A  82
VAL A 144
ILE A  96
ILE A 132
 CL  A 184 ( 4.2A)
None
None
None
None
 1.04A 3p4wE-1nslA:
0.0		 3p4wE-1nslA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ILE A 237
ILE A 245
VAL A 198
ILE A 212
ILE A 211
 None
 1.00A 3p4wE-1ps9A:
0.0		 3p4wE-1ps9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 PRO A 285
ILE A 104
ILE A 282
THR A 227
ILE A 231
 None
None
HEA  A 602 ( 4.7A)
None
None
 1.15A 3p4wE-1qleA:
2.0		 3p4wE-1qleA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE

(Staphylococcus
aureus) 		PF00557
(Peptidase_M24) 		5 ILE A  68
VAL A  90
THR A  30
ILE A  34
ILE A  84
 None
 0.79A 3p4wE-1qxyA:
0.0		 3p4wE-1qxyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 ILE C 729
ILE C 374
VAL C 748
ILE C 755
ILE C 752
 None
 1.17A 3p4wE-1w36C:
3.1		 3p4wE-1w36C:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		5 ILE A 221
ILE A 215
VAL A 141
ILE A 137
ILE A 231
 None
 1.21A 3p4wE-1y7eA:
undetectable		 3p4wE-1y7eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A  67
ILE A  62
TYR A  87
ILE A  89
ILE A  76
 None
 0.89A 3p4wE-1z68A:
undetectable		 3p4wE-1z68A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE

(Bacillus
subtilis) 		PF12710
(HAD) 		5 ILE A  22
MET A 102
VAL A  52
ILE A 131
ILE A 133
 EDO  A1306 ( 3.8A)
None
None
None
None
 1.20A 3p4wE-2feaA:
undetectable		 3p4wE-2feaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		5 PRO A  46
ILE A  94
VAL A 121
ILE A  30
ILE A  28
 None
 1.23A 3p4wE-2gnoA:
undetectable		 3p4wE-2gnoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		5 ILE A  88
ILE A  89
VAL A  49
ILE A  33
ILE A  99
 None
 1.15A 3p4wE-2gx8A:
undetectable		 3p4wE-2gx8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF00121
(TIM) 		5 ILE A  24
ILE A  21
VAL A  28
ILE A   5
ILE A  36
 None
 1.09A 3p4wE-2h6rA:
undetectable		 3p4wE-2h6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 ILE A 497
ILE A 432
VAL A 508
THR A 387
ILE A 393
 None
 0.91A 3p4wE-2hj0A:
undetectable		 3p4wE-2hj0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqr PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 ILE A 172
VAL A 151
TYR A 212
ILE A 188
ILE A 191
 None
 1.15A 3p4wE-2hqrA:
undetectable		 3p4wE-2hqrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdf GAMMA CRYSTALLIN B

(Homo sapiens) 		PF00030
(Crystall) 		5 PRO A 148
ILE A  81
MET A  43
VAL A 170
ILE A 132
 None
 1.13A 3p4wE-2jdfA:
undetectable		 3p4wE-2jdfA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ILE X  12
VAL X 113
TYR X  28
ILE X 116
ILE X 115
 None
 1.14A 3p4wE-2pmoX:
undetectable		 3p4wE-2pmoX:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r19 PROTEIN YHBN

(Escherichia
coli) 		PF03968
(OstA) 		5 ILE A  67
ILE A  65
VAL A  72
ILE A  36
ILE A  38
 None
 1.09A 3p4wE-2r19A:
undetectable		 3p4wE-2r19A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum) 		PF00696
(AA_kinase) 		5 ILE A  38
ILE A 220
VAL A  44
ILE A  10
ILE A  46
 None
 1.21A 3p4wE-2va1A:
undetectable		 3p4wE-2va1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		5 PRO A 323
ILE A 288
TYR A 358
ILE A 271
ILE A 272
 None
 1.05A 3p4wE-2wwdA:
undetectable		 3p4wE-2wwdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 5 TYR A  37
ILE A  27
ILE A  35
VAL A 157
ILE A  15
 None
 1.05A 3p4wE-2x5qA:
undetectable		 3p4wE-2x5qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		5 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
 None
 1.20A 3p4wE-2xsbA:
2.7		 3p4wE-2xsbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ILE A  33
ILE A  52
VAL A  88
ILE A 101
ILE A  75
 None
 1.23A 3p4wE-2z17A:
undetectable		 3p4wE-2z17A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 ILE A 432
ILE A 497
TYR A 418
ILE A 422
ILE A 423
 None
 0.92A 3p4wE-3ahiA:
undetectable		 3p4wE-3ahiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 ILE A 432
TYR A 418
THR A 419
ILE A 422
ILE A 423
 None
 1.23A 3p4wE-3ai7A:
2.0		 3p4wE-3ai7A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxz PREPROTEIN
TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF07517
(SecA_DEAD) 		5 ILE A 502
VAL A 465
THR A 559
ILE A 557
ILE A 438
 None
 1.23A 3p4wE-3bxzA:
undetectable		 3p4wE-3bxzA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE

(Enterococcus
faecalis) 		PF13354
(Beta-lactamase2) 		5 TYR A 229
ILE A 232
MET A 236
TYR A 220
ILE A 270
 None
 1.17A 3p4wE-3cjmA:
undetectable		 3p4wE-3cjmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
 None
 1.06A 3p4wE-3cskA:
undetectable		 3p4wE-3cskA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3q TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Staphylococcus
epidermidis) 		PF01715
(IPPT) 		5 ILE A 100
ILE A 101
TYR A 196
ILE A  89
ILE A  92
 None
 0.93A 3p4wE-3d3qA:
undetectable		 3p4wE-3d3qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX

(Lactobacillus
reuteri) 		PF02631
(RecX) 		5 TYR A  24
ILE A  18
VAL A  28
ILE A  49
ILE A  52
 None
 0.99A 3p4wE-3d5lA:
undetectable		 3p4wE-3d5lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eje ACYL CARRIER PROTEIN

(Escherichia
coli) 		PF00550
(PP-binding) 		5 ILE A  31
ILE A  30
VAL A  85
ILE A  92
ILE A  89
 None
 1.15A 3p4wE-3ejeA:
undetectable		 3p4wE-3ejeA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 ILE A 203
ILE A 189
MET A 160
ILE A 213
ILE A 210
 None
None
BR  A 702 (-4.8A)
None
None
 1.23A 3p4wE-3fysA:
undetectable		 3p4wE-3fysA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		5 ILE A 157
ILE A 155
VAL A  84
ILE A 319
ILE A  88
 None
 1.15A 3p4wE-3gbvA:
undetectable		 3p4wE-3gbvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		5 TYR A 358
ILE A 203
ILE A 357
VAL A 214
ILE A 218
 None
 1.10A 3p4wE-3h1tA:
undetectable		 3p4wE-3h1tA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		5 PRO A 424
ILE A 329
VAL A 367
TYR A 338
ILE A 341
 None
 0.99A 3p4wE-3i6rA:
undetectable		 3p4wE-3i6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.13A 3p4wE-3irvA:
undetectable		 3p4wE-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR

(Chlorobaculum
tepidum) 		PF13185
(GAF_2) 		5 ILE A  40
ILE A  41
VAL A 161
ILE A  43
ILE A 129
 None
 0.94A 3p4wE-3k2nA:
3.1		 3p4wE-3k2nA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktw SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF01922
(SRP19) 		5 VAL A  73
TYR A  81
THR A  82
ILE A  85
ILE A  86
 None
 0.85A 3p4wE-3ktwA:
undetectable		 3p4wE-3ktwA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 203
VAL A 172
TYR A 227
ILE A 249
ILE A 246
 None
 1.07A 3p4wE-3lijA:
2.1		 3p4wE-3lijA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388

(Staphylococcus
aureus) 		PF01784
(NIF3) 		5 ILE A 326
ILE A 328
VAL A 304
ILE A 285
ILE A 283
 None
 1.21A 3p4wE-3lnlA:
undetectable		 3p4wE-3lnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 TYR A 265
ILE A 262
VAL A 271
ILE A  39
ILE A  70
 None
 1.04A 3p4wE-3lwuA:
undetectable		 3p4wE-3lwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		5 ILE A 378
ILE A 376
MET A 412
VAL A  46
ILE A  44
 None
 1.23A 3p4wE-3mpgA:
undetectable		 3p4wE-3mpgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		5 ILE A  34
ILE A  55
VAL A 251
ILE A 262
ILE A 247
 None
 1.23A 3p4wE-3ppoA:
undetectable		 3p4wE-3ppoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		5 ILE A 262
ILE A 247
VAL A 261
ILE A  34
ILE A  55
 None
 1.19A 3p4wE-3ppoA:
undetectable		 3p4wE-3ppoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srt MALTOSE
O-ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		5 ILE A 156
ILE A 166
VAL A 142
ILE A 148
ILE A 144
 None
 1.04A 3p4wE-3srtA:
undetectable		 3p4wE-3srtA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		5 PRO X1706
ILE X1940
VAL X1699
ILE X1990
ILE X1989
 None
 1.19A 3p4wE-3su8X:
undetectable		 3p4wE-3su8X:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		5 ILE M 461
VAL M 380
THR M 441
ILE M 442
ILE M 378
 None
 1.18A 3p4wE-3t63M:
undetectable		 3p4wE-3t63M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tow MULTIVESICULAR BODY
SUBUNIT 12B

(Homo sapiens) 		PF10240
(DUF2464) 		5 ILE A 148
MET A 114
VAL A  53
ILE A 160
ILE A 163
 None
 1.23A 3p4wE-3towA:
undetectable		 3p4wE-3towA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		5 ILE A  53
ILE A 132
MET A  90
ILE A  39
ILE A  35
 None
 1.18A 3p4wE-4a7wA:
undetectable		 3p4wE-4a7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 ILE A  57
VAL A  65
THR A 153
ILE A 145
ILE A 157
 None
 1.18A 3p4wE-4c90A:
4.5		 3p4wE-4c90A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		5 ILE A 195
ILE A 121
VAL A 198
ILE A 149
ILE A 139
 None
 1.17A 3p4wE-4eqmA:
undetectable		 3p4wE-4eqmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3q TRANSCRIPTIONAL
REGULATORY PROTEIN
CBU_1566

(Coxiella
burnetii) 		PF01709
(Transcrip_reg) 		5 ILE A 183
ILE A 140
VAL A 158
ILE A 151
ILE A 154
 None
 1.16A 3p4wE-4f3qA:
undetectable		 3p4wE-4f3qA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 PRO A 145
ILE A 105
ILE A 128
ILE A 142
ILE A 119
 None
 1.15A 3p4wE-4fs7A:
undetectable		 3p4wE-4fs7A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 5 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.21A 3p4wE-4gd3S:
undetectable		 3p4wE-4gd3S:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus) 		PF16440
(DUF5037) 		5 TYR A 203
ILE A 169
TYR A 186
ILE A 115
ILE A 124
 None
None
None
None
GOL  A 301 ( 4.0A)
 1.19A 3p4wE-4gl6A:
undetectable		 3p4wE-4gl6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11) 		PF00692
(dUTPase) 		5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.08A 3p4wE-4gv8A:
undetectable		 3p4wE-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 ILE A 319
ILE A 321
VAL A 258
ILE A 200
ILE A 224
 None
 1.23A 3p4wE-4injA:
undetectable		 3p4wE-4injA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PRO A 564
ILE A 646
VAL A 651
ILE A 655
ILE A 675
 None
 1.03A 3p4wE-4j0mA:
undetectable		 3p4wE-4j0mA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k59 RNA BINDING PROTEIN
RSMF

(Pseudomonas
aeruginosa) 		PF02599
(CsrA) 		5 ILE A  39
ILE A  41
VAL A  61
ILE A  17
ILE A  63
 None
 1.21A 3p4wE-4k59A:
undetectable		 3p4wE-4k59A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 ILE A   5
ILE A 395
VAL A  21
ILE A  51
ILE A 385
 ILE  A   5 ( 0.6A)
ILE  A 395 ( 0.4A)
VAL  A  21 ( 0.5A)
ILE  A  51 ( 0.7A)
ILE  A 385 ( 0.7A)
 1.14A 3p4wE-4kqnA:
undetectable		 3p4wE-4kqnA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B

(Lactobacillus
rhamnosus) 		PF02502
(LacAB_rpiB) 		5 ILE B  62
ILE B   5
MET B  64
VAL B 120
ILE B 116
 None
 1.07A 3p4wE-4lfnB:
undetectable		 3p4wE-4lfnB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 347
ILE A 349
VAL A 337
ILE A 367
ILE A 375
 None
 1.05A 3p4wE-4lvcA:
undetectable		 3p4wE-4lvcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 375
ILE A 367
MET A 377
ILE A 349
ILE A 347
 None
 0.90A 3p4wE-4lvcA:
undetectable		 3p4wE-4lvcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 PRO A 102
VAL A  27
TYR A  99
ILE A  76
ILE A   6
 None
 1.18A 3p4wE-4mptA:
undetectable		 3p4wE-4mptA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Drosophila
melanogaster) 		no annotation 5 PRO A 461
ILE A 430
ILE A 433
VAL A 456
ILE A 405
 None
 1.15A 3p4wE-4nk7A:
undetectable		 3p4wE-4nk7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 TYR A  19
ILE A  30
TYR A  76
ILE A 112
ILE A 116
 None
 1.11A 3p4wE-4payA:
2.9		 3p4wE-4payA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		8 PRO A 120
ILE A 208
ILE A 209
MET A 212
TYR A 261
THR A 262
ILE A 265
ILE A 266
 None
 0.74A 3p4wE-4yeuA:
19.9		 3p4wE-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 266
 None
 0.79A 3p4wE-4yeuA:
19.9		 3p4wE-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
MET A 212
VAL A 249
 None
 1.16A 3p4wE-4yeuA:
19.9		 3p4wE-4yeuA:
52.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 PRO A 164
ILE A 181
ILE A 174
VAL A 263
ILE A 159
 None
 1.17A 3p4wE-4zqgA:
undetectable		 3p4wE-4zqgA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila) 		no annotation 5 TYR A  20
ILE A  31
TYR A  77
ILE A 113
ILE A 117
 None
 1.17A 3p4wE-4zuzA:
4.7		 3p4wE-4zuzA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 ILE A 795
ILE A 793
VAL A 831
ILE A 838
ILE A 835
 None
 1.19A 3p4wE-5a0zA:
undetectable		 3p4wE-5a0zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.05A 3p4wE-5a4mS:
undetectable		 3p4wE-5a4mS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejb FUSION GLYCOPROTEIN
F0

(Hendra
henipavirus) 		no annotation 5 TYR B 275
ILE B 277
ILE B 276
ILE B  90
ILE B  94
 None
 1.09A 3p4wE-5ejbB:
undetectable		 3p4wE-5ejbB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ILE A 256
ILE A 193
VAL A 258
THR A 272
ILE A 275
 None
 1.15A 3p4wE-5g37A:
undetectable		 3p4wE-5g37A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 5 ILE Y  82
ILE Y  73
VAL Y  49
ILE Y  31
ILE Y  33
 None
 1.09A 3p4wE-5gaiY:
undetectable		 3p4wE-5gaiY:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		5 ILE A 538
ILE A 465
VAL A 611
ILE A 642
ILE A 571
 None
 1.18A 3p4wE-5j72A:
undetectable		 3p4wE-5j72A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
 None
 0.98A 3p4wE-5j8qA:
undetectable		 3p4wE-5j8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 TYR A 237
ILE A 238
VAL A 201
ILE A  40
ILE A  41
 None
 1.23A 3p4wE-5khaA:
undetectable		 3p4wE-5khaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 354
ILE A 377
VAL A 411
THR A 416
ILE A 338
 None
 1.21A 3p4wE-5ks8A:
undetectable		 3p4wE-5ks8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB

(Pseudomonas
stutzeri) 		no annotation 5 ILE A 208
VAL A  66
TYR A  35
ILE A 225
ILE A 222
 None
 1.16A 3p4wE-5me4A:
undetectable		 3p4wE-5me4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		5 ILE A 361
ILE A 365
VAL A 339
THR A 381
ILE A 324
 None
 0.88A 3p4wE-5n8oA:
undetectable		 3p4wE-5n8oA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 5 ILE A 300
ILE A 304
VAL A 333
ILE A 314
ILE A 317
 None
 1.17A 3p4wE-5obuA:
undetectable		 3p4wE-5obuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.22A 3p4wE-5ojsT:
undetectable		 3p4wE-5ojsT:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 5 ILE A 106
TYR A 251
THR A 252
ILE A 255
ILE A 309
 None
 1.15A 3p4wE-5olkA:
2.3		 3p4wE-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 5 ILE A  44
ILE A  43
VAL A  57
ILE A   4
ILE A   7
 None
 1.10A 3p4wE-5oqrA:
2.9		 3p4wE-5oqrA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 10 PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
VAL C 242
TYR C 254
THR C 255
ILE C 258
ILE C 259
 None
 0.37A 3p4wE-5v6nC:
36.2		 3p4wE-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft 26S PROTEASOME
REGULATORY SUBUNIT 8

(Homo sapiens) 		no annotation 5 ILE C 292
ILE C 245
VAL C 186
ILE C 165
ILE C 161
 None
 1.16A 3p4wE-5vftC:
2.6		 3p4wE-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 ILE A 162
ILE A 152
VAL A 132
TYR A 192
ILE A 218
 None
 1.18A 3p4wE-5w5jA:
undetectable		 3p4wE-5w5jA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 TYR A 533
ILE A 529
THR A 609
ILE A 612
ILE A 613
 None
 1.17A 3p4wE-5welA:
4.0		 3p4wE-5welA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 TYR A1334
ILE A1376
VAL A1294
ILE A1361
ILE A1360
 None
 1.17A 3p4wE-5wlhA:
1.7		 3p4wE-5wlhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 311
VAL A 287
THR A 279
ILE A 278
ILE A 277
 None
 1.19A 3p4wE-6aphA:
undetectable		 3p4wE-6aphA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza

() 		no annotation 5 ILE A 269
TYR B 234
THR A 353
ILE A 357
ILE A 354
 None
 1.08A 3p4wE-6czaA:
undetectable		 3p4wE-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN

(Salmonella
enterica) 		no annotation 5 ILE A  65
VAL A  93
TYR A 114
ILE A  80
ILE A  79
 None
None
None
MPD  A 506 (-4.5A)
None
 0.98A 3p4wE-6dusA:
undetectable		 3p4wE-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 5 ILE A 296
VAL A 278
TYR A 347
ILE A 370
ILE A 367
 None
 1.20A 3p4wE-6fylA:
undetectable		 3p4wE-6fylA:
undetectable