SIMILAR PATTERNS OF AMINO ACIDS FOR 3P4W_D_DSFD319_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edy ALPHA
1-MACROGLOBULIN


(Rattus
norvegicus)
PF07677
(A2M_recep)
5 ILE A  30
VAL A  32
TYR A 115
ILE A  45
ILE A  84
None
1.18A 3p4wD-1edyA:
2.5
3p4wD-1edyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5c BETA-CARBONIC
ANHYDRASE


(Methanothermobacter
thermautotrophicus)
PF00484
(Pro_CA)
5 ILE A  67
ILE A 145
VAL A  62
ILE A  82
ILE A  30
None
1.14A 3p4wD-1g5cA:
0.0
3p4wD-1g5cA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens)
PF00082
(Peptidase_S8)
5 MET A 124
VAL A 139
TYR A 104
ILE A 107
ILE A 111
None
1.14A 3p4wD-1gnsA:
0.0
3p4wD-1gnsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT


(Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 ILE B 352
ILE B 356
VAL B 349
ILE B 270
ILE B 268
None
1.18A 3p4wD-1hr7B:
0.0
3p4wD-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT


(Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 TYR B 455
ILE B 456
MET B 441
VAL B 353
ILE B 268
None
1.20A 3p4wD-1hr7B:
0.0
3p4wD-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE


(Staphylococcus
aureus)
PF07827
(KNTase_C)
5 TYR A 110
ILE A  34
ILE A 109
MET A  53
ILE A  19
None
1.19A 3p4wD-1knyA:
2.5
3p4wD-1knyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsl PROBABLE
ACETYLTRANSFERASE


(Bacillus
subtilis)
PF13302
(Acetyltransf_3)
5 ILE A 110
ILE A  82
VAL A 144
ILE A  96
ILE A 132
CL  A 184 ( 4.2A)
None
None
None
None
1.05A 3p4wD-1nslA:
0.0
3p4wD-1nslA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli)
no annotation 5 ILE B  98
ILE B  97
THR B 145
ILE B 146
ILE B 175
None
1.15A 3p4wD-1p3wB:
0.0
3p4wD-1p3wB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE


(Escherichia
coli)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
5 ILE A 237
ILE A 245
VAL A 198
ILE A 212
ILE A 211
None
1.00A 3p4wD-1ps9A:
0.0
3p4wD-1ps9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
5 PRO A 285
ILE A 104
ILE A 282
THR A 227
ILE A 231
None
None
HEA  A 602 ( 4.7A)
None
None
1.16A 3p4wD-1qleA:
undetectable
3p4wD-1qleA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu9 YJGF PROTEIN

(Escherichia
coli)
PF01042
(Ribonuc_L-PSP)
5 ILE A  71
VAL A  61
THR A  29
ILE A  28
ILE A  27
None
1.02A 3p4wD-1qu9A:
undetectable
3p4wD-1qu9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00557
(Peptidase_M24)
5 ILE A  68
VAL A  90
THR A  30
ILE A  34
ILE A  84
None
0.79A 3p4wD-1qxyA:
undetectable
3p4wD-1qxyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN


(Escherichia
coli)
PF04257
(Exonuc_V_gamma)
5 ILE C 729
ILE C 374
VAL C 748
ILE C 755
ILE C 752
None
1.17A 3p4wD-1w36C:
3.1
3p4wD-1w36C:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Borreliella
burgdorferi)
PF02127
(Peptidase_M18)
5 ILE A 221
ILE A 215
VAL A 141
ILE A 137
ILE A 231
None
1.22A 3p4wD-1y7eA:
undetectable
3p4wD-1y7eA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 TYR A  67
ILE A  62
TYR A  87
ILE A  89
ILE A  76
None
0.90A 3p4wD-1z68A:
undetectable
3p4wD-1z68A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fea 2-HYDROXY-3-KETO-5-M
ETHYLTHIOPENTENYL-1-
PHOSPHATE
PHOSPHATASE


(Bacillus
subtilis)
PF12710
(HAD)
5 ILE A  22
MET A 102
VAL A  52
ILE A 131
ILE A 133
EDO  A1306 ( 3.8A)
None
None
None
None
1.20A 3p4wD-2feaA:
undetectable
3p4wD-2feaA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN


(Thermotoga
maritima)
PF13177
(DNA_pol3_delta2)
5 PRO A  46
ILE A  94
VAL A 121
ILE A  30
ILE A  28
None
1.22A 3p4wD-2gnoA:
undetectable
3p4wD-2gnoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus)
PF01784
(NIF3)
5 ILE A  88
ILE A  89
VAL A  49
ILE A  33
ILE A  99
None
1.14A 3p4wD-2gx8A:
undetectable
3p4wD-2gx8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE


(Streptococcus
pneumoniae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 ILE A 317
ILE A 258
MET A 319
VAL A 269
ILE A 273
None
1.11A 3p4wD-2gz3A:
undetectable
3p4wD-2gz3A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6r TRIOSEPHOSPHATE
ISOMERASE


(Methanocaldococcus
jannaschii)
PF00121
(TIM)
5 ILE A  24
ILE A  21
VAL A  28
ILE A   5
ILE A  36
None
1.10A 3p4wD-2h6rA:
undetectable
3p4wD-2h6rA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT


(Streptococcus
mutans)
PF04223
(CitF)
5 ILE A 497
ILE A 432
VAL A 508
THR A 387
ILE A 393
None
0.91A 3p4wD-2hj0A:
undetectable
3p4wD-2hj0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqr PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Helicobacter
pylori)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 ILE A 172
VAL A 151
TYR A 212
ILE A 188
ILE A 191
None
1.16A 3p4wD-2hqrA:
undetectable
3p4wD-2hqrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdf GAMMA CRYSTALLIN B

(Homo sapiens)
PF00030
(Crystall)
5 PRO A 148
ILE A  81
MET A  43
VAL A 170
ILE A 132
None
1.12A 3p4wD-2jdfA:
undetectable
3p4wD-2jdfA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE


(Plasmodium
falciparum)
PF00069
(Pkinase)
5 ILE X  12
VAL X 113
TYR X  28
ILE X 116
ILE X 115
None
1.14A 3p4wD-2pmoX:
undetectable
3p4wD-2pmoX:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 TYR B 327
ILE B 324
ILE B 323
VAL B 139
ILE B 184
None
1.11A 3p4wD-2v4jB:
undetectable
3p4wD-2v4jB:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va1 URIDYLATE KINASE

(Ureaplasma
parvum)
PF00696
(AA_kinase)
5 ILE A  38
ILE A 220
VAL A  44
ILE A  10
ILE A  46
None
1.22A 3p4wD-2va1A:
undetectable
3p4wD-2va1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE


(Streptococcus
pneumoniae)
PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1)
5 PRO A 323
ILE A 288
TYR A 358
ILE A 271
ILE A 272
None
1.06A 3p4wD-2wwdA:
undetectable
3p4wD-2wwdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA


(Salmonella
enterica)
PF00771
(FHIPEP)
5 ILE A 601
ILE A 654
MET A 657
VAL A 600
ILE A 628
None
1.15A 3p4wD-2x49A:
undetectable
3p4wD-2x49A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus)
no annotation 5 TYR A  37
ILE A  27
ILE A  35
VAL A 157
ILE A  15
None
1.05A 3p4wD-2x5qA:
undetectable
3p4wD-2x5qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE


(Oceanicola
granulosus)
PF07555
(NAGidase)
5 PRO A 255
ILE A 266
MET A  31
THR A 253
ILE A 252
None
1.17A 3p4wD-2xsbA:
3.6
3p4wD-2xsbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE


(Bifidobacterium
breve)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 ILE A 432
ILE A 497
TYR A 418
ILE A 422
ILE A 423
None
0.90A 3p4wD-3ahiA:
undetectable
3p4wD-3ahiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 ILE A 432
TYR A 418
THR A 419
ILE A 422
ILE A 423
None
1.21A 3p4wD-3ai7A:
undetectable
3p4wD-3ai7A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjm PUTATIVE
BETA-LACTAMASE


(Enterococcus
faecalis)
PF13354
(Beta-lactamase2)
5 TYR A 229
ILE A 232
MET A 236
TYR A 220
ILE A 270
None
1.17A 3p4wD-3cjmA:
undetectable
3p4wD-3cjmA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
5 PRO A 111
TYR A 163
ILE A 158
ILE A  62
ILE A  65
None
1.07A 3p4wD-3cskA:
undetectable
3p4wD-3cskA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3q TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE


(Staphylococcus
epidermidis)
PF01715
(IPPT)
5 ILE A 100
ILE A 101
TYR A 196
ILE A  89
ILE A  92
None
0.93A 3p4wD-3d3qA:
undetectable
3p4wD-3d3qA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX


(Lactobacillus
reuteri)
PF02631
(RecX)
5 TYR A  24
ILE A  18
VAL A  28
ILE A  49
ILE A  52
None
0.99A 3p4wD-3d5lA:
undetectable
3p4wD-3d5lA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
5 ILE A 203
ILE A 189
MET A 160
ILE A 213
ILE A 210
None
None
BR  A 702 (-4.8A)
None
None
1.23A 3p4wD-3fysA:
undetectable
3p4wD-3fysA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Bacteroides
fragilis)
PF13407
(Peripla_BP_4)
5 ILE A 157
ILE A 155
VAL A  84
ILE A 319
ILE A  88
None
1.17A 3p4wD-3gbvA:
undetectable
3p4wD-3gbvA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT


(Vibrio
vulnificus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2)
5 TYR A 358
ILE A 203
ILE A 357
VAL A 214
ILE A 218
None
1.11A 3p4wD-3h1tA:
undetectable
3p4wD-3h1tA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL


(Plasmodium
falciparum)
PF01180
(DHO_dh)
5 PRO A 424
ILE A 329
VAL A 367
TYR A 338
ILE A 341
None
0.99A 3p4wD-3i6rA:
undetectable
3p4wD-3i6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi)
PF00857
(Isochorismatase)
5 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
None
1.12A 3p4wD-3irvA:
undetectable
3p4wD-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2n SIGMA-54-DEPENDENT
TRANSCRIPTIONAL
REGULATOR


(Chlorobaculum
tepidum)
PF13185
(GAF_2)
5 ILE A  40
ILE A  41
VAL A 161
ILE A  43
ILE A 129
None
0.94A 3p4wD-3k2nA:
3.1
3p4wD-3k2nA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktw SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN


(Sulfolobus
solfataricus)
PF01922
(SRP19)
5 VAL A  73
TYR A  81
THR A  82
ILE A  85
ILE A  86
None
0.85A 3p4wD-3ktwA:
undetectable
3p4wD-3ktwA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnl UPF0135 PROTEIN
SA1388


(Staphylococcus
aureus)
PF01784
(NIF3)
5 ILE A 326
ILE A 328
VAL A 304
ILE A 285
ILE A 283
None
1.21A 3p4wD-3lnlA:
undetectable
3p4wD-3lnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE


(Shewanella
frigidimarina)
PF04952
(AstE_AspA)
5 TYR A 265
ILE A 262
VAL A 271
ILE A  39
ILE A  70
None
1.04A 3p4wD-3lwuA:
undetectable
3p4wD-3lwuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis)
PF01979
(Amidohydro_1)
5 ILE A 378
ILE A 376
MET A 412
VAL A  46
ILE A  44
None
1.22A 3p4wD-3mpgA:
undetectable
3p4wD-3mpgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN


(Bacillus
subtilis)
PF04069
(OpuAC)
5 ILE A 262
ILE A 247
VAL A 261
ILE A  34
ILE A  55
None
1.18A 3p4wD-3ppoA:
undetectable
3p4wD-3ppoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
5 ILE L 222
ILE L 219
VAL L 253
ILE L 108
ILE L 105
None
1.12A 3p4wD-3rgwL:
1.2
3p4wD-3rgwL:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rys ADENOSINE DEAMINASE
1


(Paenarthrobacter
aurescens)
PF00962
(A_deaminase)
5 PRO A 104
ILE A 165
VAL A 121
ILE A 139
ILE A 100
None
1.15A 3p4wD-3rysA:
undetectable
3p4wD-3rysA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srt MALTOSE
O-ACETYLTRANSFERASE


(Clostridioides
difficile)
PF12464
(Mac)
PF14602
(Hexapep_2)
5 ILE A 156
ILE A 166
VAL A 142
ILE A 148
ILE A 144
None
1.04A 3p4wD-3srtA:
undetectable
3p4wD-3srtA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens)
PF08337
(Plexin_cytopl)
5 PRO X1706
ILE X1940
VAL X1699
ILE X1990
ILE X1989
None
1.17A 3p4wD-3su8X:
undetectable
3p4wD-3su8X:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN


(Pseudomonas
putida)
PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N)
5 ILE M 461
VAL M 380
THR M 441
ILE M 442
ILE M 378
None
1.18A 3p4wD-3t63M:
undetectable
3p4wD-3t63M:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tow MULTIVESICULAR BODY
SUBUNIT 12B


(Homo sapiens)
PF10240
(DUF2464)
5 ILE A 148
MET A 114
VAL A  53
ILE A 160
ILE A 163
None
1.23A 3p4wD-3towA:
undetectable
3p4wD-3towA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori)
PF00696
(AA_kinase)
5 ILE A  53
ILE A 132
MET A  90
ILE A  39
ILE A  35
None
1.19A 3p4wD-4a7wA:
undetectable
3p4wD-4a7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
5 ILE A  57
VAL A  65
THR A 153
ILE A 145
ILE A 157
None
1.19A 3p4wD-4c90A:
4.5
3p4wD-4c90A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus)
PF00069
(Pkinase)
5 ILE A 195
ILE A 121
VAL A 198
ILE A 149
ILE A 139
None
1.17A 3p4wD-4eqmA:
undetectable
3p4wD-4eqmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3q TRANSCRIPTIONAL
REGULATORY PROTEIN
CBU_1566


(Coxiella
burnetii)
PF01709
(Transcrip_reg)
5 ILE A 183
ILE A 140
VAL A 158
ILE A 151
ILE A 154
None
1.16A 3p4wD-4f3qA:
undetectable
3p4wD-4f3qA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 PRO A 145
ILE A 105
ILE A 128
ILE A 142
ILE A 119
None
1.16A 3p4wD-4fs7A:
undetectable
3p4wD-4fs7A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN


(Escherichia
coli)
no annotation 5 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
None
1.21A 3p4wD-4gd3S:
undetectable
3p4wD-4gd3S:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl6 HYPOTHETICAL PROTEIN

([Ruminococcus]
gnavus)
PF16440
(DUF5037)
5 TYR A 203
ILE A 169
TYR A 186
ILE A 115
ILE A 124
None
None
None
None
GOL  A 301 ( 4.0A)
1.19A 3p4wD-4gl6A:
undetectable
3p4wD-4gl6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11)
PF00692
(dUTPase)
5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
None
1.07A 3p4wD-4gv8A:
undetectable
3p4wD-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II


(Porphyromonas
gingivalis)
PF03060
(NMO)
5 PRO A  70
VAL A  91
TYR A  73
ILE A  79
ILE A  83
FMN  A 401 ( 4.5A)
None
NDP  A 403 (-4.4A)
None
None
1.23A 3p4wD-4iqlA:
undetectable
3p4wD-4iqlA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1


(Arabidopsis
thaliana)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 PRO A 564
ILE A 646
VAL A 651
ILE A 655
ILE A 675
None
1.03A 3p4wD-4j0mA:
undetectable
3p4wD-4j0mA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k59 RNA BINDING PROTEIN
RSMF


(Pseudomonas
aeruginosa)
PF02599
(CsrA)
5 ILE A  39
ILE A  41
VAL A  61
ILE A  17
ILE A  63
None
1.22A 3p4wD-4k59A:
undetectable
3p4wD-4k59A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9)
PF01979
(Amidohydro_1)
5 ILE A   5
ILE A 395
VAL A  21
ILE A  51
ILE A 385
ILE  A   5 ( 0.6A)
ILE  A 395 ( 0.4A)
VAL  A  21 ( 0.5A)
ILE  A  51 ( 0.7A)
ILE  A 385 ( 0.7A)
1.13A 3p4wD-4kqnA:
undetectable
3p4wD-4kqnA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfn GALACTOSE-6-PHOSPHAT
E ISOMERASE SUBUNIT
B


(Lactobacillus
rhamnosus)
PF02502
(LacAB_rpiB)
5 ILE B  62
ILE B   5
MET B  64
VAL B 120
ILE B 116
None
1.06A 3p4wD-4lfnB:
undetectable
3p4wD-4lfnB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 347
ILE A 349
VAL A 337
ILE A 367
ILE A 375
None
1.05A 3p4wD-4lvcA:
undetectable
3p4wD-4lvcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)


(Bradyrhizobium
elkanii)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 375
ILE A 367
MET A 377
ILE A 349
ILE A 347
None
0.90A 3p4wD-4lvcA:
undetectable
3p4wD-4lvcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN


(Bordetella
pertussis)
PF13458
(Peripla_BP_6)
5 PRO A 102
VAL A  27
TYR A  99
ILE A  76
ILE A   6
None
1.18A 3p4wD-4mptA:
undetectable
3p4wD-4mptA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Xanthobacter
autotrophicus)
PF03480
(DctP)
5 ILE A 317
ILE A 320
MET A 316
VAL A 308
ILE A 128
None
1.16A 3p4wD-4ovrA:
undetectable
3p4wD-4ovrA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila)
no annotation 5 TYR A  19
ILE A  30
TYR A  76
ILE A 112
ILE A 116
None
1.11A 3p4wD-4payA:
undetectable
3p4wD-4payA:
19.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
8 PRO A 120
ILE A 208
ILE A 209
MET A 212
TYR A 261
THR A 262
ILE A 265
ILE A 266
None
0.74A 3p4wD-4yeuA:
19.9
3p4wD-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
7 TYR A 204
ILE A 208
ILE A 209
MET A 212
THR A 262
ILE A 265
ILE A 266
None
0.76A 3p4wD-4yeuA:
19.9
3p4wD-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL


(Dickeya
chrysanthemi;
Gloeobacter
violaceus)
PF02931
(Neur_chan_LBD)
5 TYR A 204
ILE A 208
ILE A 209
MET A 212
VAL A 249
None
1.14A 3p4wD-4yeuA:
19.9
3p4wD-4yeuA:
52.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Moraxella
catarrhalis)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 PRO A 164
ILE A 181
ILE A 174
VAL A 263
ILE A 159
None
1.17A 3p4wD-4zqgA:
undetectable
3p4wD-4zqgA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zuz SIDC

(Legionella
pneumophila)
no annotation 5 TYR A  20
ILE A  31
TYR A  77
ILE A 113
ILE A 117
None
1.17A 3p4wD-4zuzA:
4.8
3p4wD-4zuzA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE


(Klebsiella
pneumoniae)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 ILE A 795
ILE A 793
VAL A 831
ILE A 838
ILE A 835
None
1.20A 3p4wD-5a0zA:
2.7
3p4wD-5a0zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN


(Escherichia
coli)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
None
1.05A 3p4wD-5a4mS:
undetectable
3p4wD-5a4mS:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejb FUSION GLYCOPROTEIN
F0


(Hendra
henipavirus)
no annotation 5 TYR B 275
ILE B 277
ILE B 276
ILE B  90
ILE B  94
None
1.10A 3p4wD-5ejbB:
undetectable
3p4wD-5ejbB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN


(Lysinibacillus
sphaericus)
PF05431
(Toxin_10)
5 ILE A 256
ILE A 193
VAL A 258
THR A 272
ILE A 275
None
1.14A 3p4wD-5g37A:
undetectable
3p4wD-5g37A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22)
no annotation 5 ILE Y  82
ILE Y  73
VAL Y  49
ILE Y  31
ILE Y  33
None
1.08A 3p4wD-5gaiY:
undetectable
3p4wD-5gaiY:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6


(Clostridioides
difficile)
PF01520
(Amidase_3)
PF04122
(CW_binding_2)
5 ILE A 538
ILE A 465
VAL A 611
ILE A 642
ILE A 571
None
1.17A 3p4wD-5j72A:
undetectable
3p4wD-5j72A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS


(Bacillus
subtilis)
PF00266
(Aminotran_5)
5 ILE A   3
ILE A   6
MET A   1
TYR A 380
ILE A 299
None
0.99A 3p4wD-5j8qA:
undetectable
3p4wD-5j8qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA


(Methylobacillus
flagellatus)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A 354
ILE A 377
VAL A 411
THR A 416
ILE A 338
None
1.23A 3p4wD-5ks8A:
undetectable
3p4wD-5ks8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me4 PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN HTXB


(Pseudomonas
stutzeri)
no annotation 5 ILE A 208
VAL A  66
TYR A  35
ILE A 225
ILE A 222
None
1.15A 3p4wD-5me4A:
undetectable
3p4wD-5me4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n41 POLB1 BINDING
PROTEIN 2


(Sulfolobus
solfataricus)
no annotation 5 ILE A  59
MET A  56
VAL A  49
ILE A  20
ILE A  16
None
1.23A 3p4wD-5n41A:
undetectable
3p4wD-5n41A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK


(Mycoplasma
genitalium)
no annotation 5 ILE A 300
ILE A 304
VAL A 333
ILE A 314
ILE A 317
None
1.17A 3p4wD-5obuA:
undetectable
3p4wD-5obuA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1


(Leeuwenhoekiella
blandensis)
no annotation 5 ILE A 106
TYR A 251
THR A 252
ILE A 255
ILE A 309
None
1.16A 3p4wD-5olkA:
undetectable
3p4wD-5olkA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 5 ILE A  44
ILE A  43
VAL A  57
ILE A   4
ILE A   7
None
1.10A 3p4wD-5oqrA:
undetectable
3p4wD-5oqrA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL


(Gloeobacter
violaceus)
no annotation 10 PRO C 120
TYR C 197
ILE C 201
ILE C 202
MET C 205
VAL C 242
TYR C 254
THR C 255
ILE C 258
ILE C 259
None
0.34A 3p4wD-5v6nC:
36.1
3p4wD-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vft 26S PROTEASOME
REGULATORY SUBUNIT 8


(Homo sapiens)
no annotation 5 ILE C 292
ILE C 245
VAL C 186
ILE C 165
ILE C 161
None
1.15A 3p4wD-5vftC:
2.6
3p4wD-5vftC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 5 ILE A 162
ILE A 152
VAL A 132
TYR A 192
ILE A 218
None
1.18A 3p4wD-5w5jA:
undetectable
3p4wD-5w5jA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica)
no annotation 5 ILE M 254
VAL M 334
THR M 345
ILE M 348
ILE M 352
None
1.16A 3p4wD-5wc8M:
undetectable
3p4wD-5wc8M:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN


(Mus musculus;
Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd)
5 TYR A 533
ILE A 529
THR A 609
ILE A 612
ILE A 613
None
1.17A 3p4wD-5welA:
4.0
3p4wD-5welA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)


(Lachnospiraceae
bacterium
NK4A179)
no annotation 5 TYR A1334
ILE A1376
VAL A1294
ILE A1361
ILE A1360
None
1.15A 3p4wD-5wlhA:
1.9
3p4wD-5wlhA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE


(Elizabethkingia
anophelis)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 311
VAL A 287
THR A 279
ILE A 278
ILE A 277
None
1.17A 3p4wD-6aphA:
undetectable
3p4wD-6aphA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza

()
no annotation 5 ILE A 269
TYR B 234
THR A 353
ILE A 357
ILE A 354
None
1.07A 3p4wD-6czaA:
undetectable
3p4wD-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dus TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN


(Salmonella
enterica)
no annotation 5 ILE A  65
VAL A  93
TYR A 114
ILE A  80
ILE A  79
None
None
None
MPD  A 506 (-4.5A)
None
0.98A 3p4wD-6dusA:
undetectable
3p4wD-6dusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN


(Azotobacter
vinelandii)
no annotation 5 ILE A 279
VAL A 254
TYR A 223
ILE A 291
ILE A 294
None
1.22A 3p4wD-6feaA:
undetectable
3p4wD-6feaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2


(Homo sapiens)
no annotation 5 ILE A 296
VAL A 278
TYR A 347
ILE A 370
ILE A 367
None
1.20A 3p4wD-6fylA:
undetectable
3p4wD-6fylA:
undetectable