SIMILAR PATTERNS OF AMINO ACIDS FOR 3P4W_A_DSFA319

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 TYR A 194
ILE A 205
ILE A 182
TYR A 216
ILE A 146
 None
 1.36A 3p4wA-1dq3A:
0.0		 3p4wA-1dq3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 TYR A  85
ILE A 181
ILE A 154
VAL A 169
THR A 137
 None
 1.31A 3p4wA-1jjiA:
0.0		 3p4wA-1jjiA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE B  94
VAL B 120
TYR B 125
THR B 124
ILE B  79
 None
 1.40A 3p4wA-1l1oB:
undetectable		 3p4wA-1l1oB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		5 TYR A  52
ILE A  92
ILE A  93
VAL A  90
ILE A   8
 None
 1.32A 3p4wA-1o60A:
0.0		 3p4wA-1o60A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		5 TYR A 854
ILE A 816
ILE A 813
TYR A 768
ILE A 802
 None
 1.26A 3p4wA-1q1oA:
0.0		 3p4wA-1q1oA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 PRO A 444
ILE A 448
VAL A 403
THR A 602
ILE A 599
 None
 1.45A 3p4wA-1suvA:
0.0		 3p4wA-1suvA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uci GUANYL-SPECIFIC
RIBONUCLEASE SA

(Kitasatospora
aureofaciens) 		PF00545
(Ribonuclease) 		5 TYR A  81
ILE A  92
TYR A  55
THR A  18
ILE A  22
 None
 1.35A 3p4wA-1uciA:
0.0		 3p4wA-1uciA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 TYR B  55
TYR B  69
ILE B 366
THR B  60
ILE B  63
 None
 1.28A 3p4wA-1wdwB:
0.0		 3p4wA-1wdwB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A  79
TYR A  67
ILE A  62
TYR A  87
ILE A  89
 None
 1.20A 3p4wA-1z68A:
0.0		 3p4wA-1z68A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE B 430
ILE B 420
VAL B 402
TYR B 454
ILE B 477
 None
 1.29A 3p4wA-2a1aB:
2.1		 3p4wA-2a1aB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 TYR A 279
ILE A 263
VAL A 205
TYR A 250
ILE A 234
 None
 1.45A 3p4wA-2g1sA:
undetectable		 3p4wA-2g1sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2b STICHOLYSIN-2

(Stichodactyla
helianthus) 		PF06369
(Anemone_cytotox) 		5 TYR A  90
ILE A 171
ILE A 173
VAL A 100
ILE A 119
 None
 1.07A 3p4wA-2l2bA:
undetectable		 3p4wA-2l2bA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9p UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF08327
(AHSA1) 		5 TYR A  47
TYR A  69
ILE A  67
ILE A  61
THR A  45
 None
 1.32A 3p4wA-2l9pA:
undetectable		 3p4wA-2l9pA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 415
ILE A 479
VAL A 419
TYR A 472
ILE A 450
 None
 1.28A 3p4wA-2qyvA:
undetectable		 3p4wA-2qyvA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay8 GLUTATHIONE
S-TRANSFERASE

(Bombyx mori) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 TYR A  74
TYR A  79
ILE A  27
ILE A  25
ILE A 158
 None
 1.38A 3p4wA-3ay8A:
undetectable		 3p4wA-3ay8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		5 TYR A 118
ILE A  94
VAL A  90
THR A 217
ILE A 215
 None
None
SO4  A 361 (-3.5A)
None
None
 1.37A 3p4wA-3ffhA:
undetectable		 3p4wA-3ffhA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		5 TYR A  83
ILE A  66
VAL A  68
TYR A  86
THR A  24
 None
 1.34A 3p4wA-3fsxA:
undetectable		 3p4wA-3fsxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7f ASPARTYL-TRNA
SYNTHETASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.37A 3p4wA-3i7fA:
undetectable		 3p4wA-3i7fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 ILE A  53
ILE A 169
VAL A  55
THR A 183
ILE A 184
 None
 1.13A 3p4wA-3irvA:
undetectable		 3p4wA-3irvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20) 		5 TYR A 125
ILE A 129
VAL A   6
TYR A 458
THR A 455
 None
 1.41A 3p4wA-3khzA:
undetectable		 3p4wA-3khzA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lho PUTATIVE HYDROLASE

(Shewanella
frigidimarina) 		PF07063
(DUF1338) 		5 TYR A 160
ILE A 115
ILE A 111
VAL A  51
THR A  45
 None
 1.43A 3p4wA-3lhoA:
undetectable		 3p4wA-3lhoA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster) 		PF00028
(Cadherin) 		5 TYR A 685
ILE A 699
ILE A 705
VAL A 727
ILE A 671
 None
 1.32A 3p4wA-3ubgA:
undetectable		 3p4wA-3ubgA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 TYR A   3
ILE A  64
ILE A  67
VAL A  61
THR A  33
 None
 1.44A 3p4wA-3vf1A:
2.1		 3p4wA-3vf1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Pyrococcus
furiosus) 		PF01269
(Fibrillarin) 		5 TYR E 102
ILE E 125
ILE E 124
TYR E  79
ILE E  82
 None
 1.43A 3p4wA-4by9E:
undetectable		 3p4wA-4by9E:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 5 PRO A 252
TYR A 228
ILE A 162
VAL A 186
ILE A 164
 None
 1.48A 3p4wA-4ehcA:
undetectable		 3p4wA-4ehcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 TYR A 518
ILE A 507
ILE A 510
VAL A 493
ILE A 557
 None
 1.44A 3p4wA-4fm9A:
1.7		 3p4wA-4fm9A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv8 DUTPASE

(Staphylococcus
virus 11) 		PF00692
(dUTPase) 		5 TYR A 126
ILE A 110
ILE A 128
VAL A  67
ILE A  90
 None
 1.07A 3p4wA-4gv8A:
undetectable		 3p4wA-4gv8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		5 ILE A 447
ILE A 449
VAL A 433
TYR A 457
ILE A 427
 None
 1.39A 3p4wA-4hpfA:
undetectable		 3p4wA-4hpfA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 TYR A 341
PRO A 342
VAL A 317
THR A 344
ILE A 345
 None
 1.23A 3p4wA-4itaA:
undetectable		 3p4wA-4itaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jys PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 ILE A  99
ILE A 150
VAL A 183
TYR A  88
ILE A 148
 None
 1.28A 3p4wA-4jysA:
undetectable		 3p4wA-4jysA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 TYR A 746
PRO A 513
TYR A 293
VAL A 466
TYR A 741
 None
 1.41A 3p4wA-4rbnA:
1.6		 3p4wA-4rbnA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 PRO A 163
TYR A 148
ILE A  98
VAL A 146
THR A 165
 None
 1.46A 3p4wA-4xk1A:
undetectable		 3p4wA-4xk1A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B
NORC-LIKE PROTEIN

(Roseobacter
denitrificans) 		PF00034
(Cytochrom_C)
PF00115
(COX1) 		5 PRO A 253
TYR B  35
ILE B  36
TYR A 247
ILE A 250
 None
 1.34A 3p4wA-4xydA:
1.7		 3p4wA-4xydA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		6 PRO A 120
ILE A 208
ILE A 209
TYR A 261
THR A 262
ILE A 265
 None
 0.76A 3p4wA-4yeuA:
19.9		 3p4wA-4yeuA:
52.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 TYR A 204
ILE A 208
ILE A 209
THR A 262
ILE A 265
 None
 0.80A 3p4wA-4yeuA:
19.9		 3p4wA-4yeuA:
52.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 PRO A 154
TYR A 186
ILE A 190
ILE A 187
VAL A 151
 None
 1.32A 3p4wA-5a7mA:
undetectable		 3p4wA-5a7mA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cag UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF17145
(DUF5119) 		5 TYR A  84
PRO A  58
VAL A  79
TYR A  57
ILE A  55
 None
 1.17A 3p4wA-5cagA:
undetectable		 3p4wA-5cagA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 ILE A 258
VAL A 261
TYR A 251
THR A 269
ILE A 270
 None
 1.35A 3p4wA-5dteA:
undetectable		 3p4wA-5dteA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g37 41.9 KDA
INSECTICIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 ILE A 256
ILE A 193
VAL A 258
THR A 272
ILE A 275
 None
 1.16A 3p4wA-5g37A:
undetectable		 3p4wA-5g37A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.42A 3p4wA-5k8dB:
undetectable		 3p4wA-5k8dB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ILE A  12
ILE A 609
VAL A 506
THR A 487
ILE A 485
 None
 1.30A 3p4wA-5lggA:
undetectable		 3p4wA-5lggA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6

(Schizosaccharomyces
pombe) 		no annotation 5 ILE B 629
ILE B 646
VAL B 559
TYR B 673
ILE B 571
 None
 1.28A 3p4wA-5mg8B:
undetectable		 3p4wA-5mg8B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(Methanotorris
formicicus) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 TYR B 334
TYR C 102
TYR C 108
THR C 117
ILE C 126
 None
 1.44A 3p4wA-5n28B:
undetectable		 3p4wA-5n28B:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 TYR T 313
ILE T 354
ILE T 310
VAL T 325
TYR T 238
 None
 1.23A 3p4wA-5ojsT:
undetectable		 3p4wA-5ojsT:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		5 TYR A 149
ILE A 127
ILE A 162
VAL A 139
ILE A 284
 None
 1.49A 3p4wA-5tumA:
1.7		 3p4wA-5tumA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 TYR A 281
ILE A 110
ILE A 111
VAL A   4
ILE A  86
 None
 1.46A 3p4wA-5twbA:
undetectable		 3p4wA-5twbA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 9 TYR C 119
PRO C 120
TYR C 197
ILE C 201
ILE C 202
VAL C 242
TYR C 254
THR C 255
ILE C 258
 None
 0.38A 3p4wA-5v6nC:
36.2		 3p4wA-5v6nC:
98.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 ILE A 162
ILE A 152
VAL A 132
TYR A 192
ILE A 218
 None
 1.19A 3p4wA-5w5jA:
undetectable		 3p4wA-5w5jA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 5 TYR A  89
ILE A 316
ILE A 315
VAL A 161
TYR A  86
 None
 1.21A 3p4wA-5xbjA:
3.3		 3p4wA-5xbjA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwz UNPLACED GENOMIC
SCAFFOLD
SUPERCONT1.36, WHOLE
GENOME SHOTGUN
SEQUENCE

(Cladophialophora
bantiana) 		no annotation 5 PRO A 127
ILE A 236
ILE A 234
VAL A 213
ILE A 228
 None
 1.36A 3p4wA-5xwzA:
undetectable		 3p4wA-5xwzA:
11.88