SIMILAR PATTERNS OF AMINO ACIDS FOR 3P2K_D_SAMD6735_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASN A 134
ASP A 183
GLU A 217
THR A 321
 None
ZN  A 700 (-2.4A)
None
SO4  A 801 (-3.2A)
 1.49A 3p2kD-2yheA:
0.0		 3p2kD-2yheA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASN A  67
ASP A  54
GLU A 449
THR A 452
 None
 1.38A 3p2kD-3ehmA:
0.0		 3p2kD-3ehmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		4 ASN A 237
ASP A   9
GLU A 224
THR A 179
 None
MG  A 271 (-2.9A)
None
None
 1.43A 3p2kD-3l7yA:
0.3		 3p2kD-3l7yA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB
CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
PF00229
(TNF) 		4 ASN L  32
ASP T  32
GLU T  57
THR H  31
 None
 1.39A 3p2kD-4ht1L:
0.0		 3p2kD-4ht1L:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		4 ASN Y  38
ASP Y  55
GLU Y  88
THR Y 109
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.3A)
 0.64A 3p2kD-4ox9Y:
30.9		 3p2kD-4ox9Y:
98.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8x URICASE

(Bacillus
fastidiosus) 		PF01014
(Uricase) 		4 ASN A 241
ASP A 195
GLU A 279
THR A 276
 None
 1.48A 3p2kD-4r8xA:
0.0		 3p2kD-4r8xA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASN A 286
ASP A 320
GLU A 392
THR A 185
 SO4  A 704 (-3.4A)
GAL  A 701 (-3.0A)
None
None
 1.16A 3p2kD-5bxpA:
0.0		 3p2kD-5bxpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 4 ASN A 127
ASP A 135
GLU A 204
THR A 115
 None
 1.14A 3p2kD-5mdqA:
undetectable		 3p2kD-5mdqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 ASN B  22
ASP C 174
GLU C 188
THR C  82
 None
 1.27A 3p2kD-6c6lB:
undetectable		 3p2kD-6c6lB:
undetectable