SIMILAR PATTERNS OF AMINO ACIDS FOR 3P2K_C_SAMC6735

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
 None
 1.04A 3p2kC-1c7tA:
undetectable		 3p2kC-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 GLY A 251
GLY A 247
ASN A 242
ALA A 102
LEU A 254
 None
 0.94A 3p2kC-1cg4A:
undetectable		 3p2kC-1cg4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.02A 3p2kC-1cu1A:
undetectable		 3p2kC-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 307
GLY A 183
ALA A 110
ALA A 111
LEU A 188
 None
 1.08A 3p2kC-1eblA:
undetectable		 3p2kC-1eblA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.89A 3p2kC-1epxA:
undetectable		 3p2kC-1epxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.97A 3p2kC-1f2jA:
undetectable		 3p2kC-1f2jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 GLY A 304
GLY A 302
ASN A 301
ALA A 275
LEU A 345
 None
 0.98A 3p2kC-1iuqA:
undetectable		 3p2kC-1iuqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 GLY A  43
ALA A 107
ALA A 104
LEU A  39
LEU A 164
 None
 0.90A 3p2kC-1j0nA:
undetectable		 3p2kC-1j0nA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.02A 3p2kC-1ns3A:
undetectable		 3p2kC-1ns3A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 GLY A  61
GLY A  63
ASN A  96
ALA A  88
PHE A  31
 None
 1.04A 3p2kC-1o9gA:
9.0		 3p2kC-1o9gA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r88 MPT51/MPB51 ANTIGEN

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 GLY A 166
ALA A 216
LEU A 154
PHE A 162
LEU A 219
 None
 1.07A 3p2kC-1r88A:
2.1		 3p2kC-1r88A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjl DNAK SUPPRESSOR
PROTEIN

(Escherichia
coli) 		PF01258
(zf-dskA_traR) 		5 GLY A 112
VAL A 119
ALA A 132
LEU A  37
LEU A 126
 None
 0.93A 3p2kC-1tjlA:
undetectable		 3p2kC-1tjlA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
PRO A  72
ALA A  93
LEU A 107
 SAI  A1300 (-3.5A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.2A)
SAI  A1300 (-3.5A)
None
 1.03A 3p2kC-2avnA:
10.0		 3p2kC-2avnA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bih NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 GLY A 329
ALA A 160
ALA A 161
PHE A  79
LEU A  74
 None
 1.03A 3p2kC-2bihA:
undetectable		 3p2kC-2bihA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bii NITRATE REDUCTASE
[NADPH]

(Ogataea angusta) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 GLY A 329
ALA A 160
ALA A 161
PHE A  79
LEU A  74
 None
GOL  A 702 (-3.7A)
GOL  A 702 ( 4.8A)
None
None
 1.02A 3p2kC-2biiA:
undetectable		 3p2kC-2biiA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 GLY A1094
VAL A1107
ALA A1197
ALA A1196
LEU A1042
 None
 0.98A 3p2kC-2bjiA:
undetectable		 3p2kC-2bjiA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		6 GLY A 254
PRO A 268
VAL A 269
ALA A 287
ALA A  19
LEU A  64
 None
 1.45A 3p2kC-2g4oA:
undetectable		 3p2kC-2g4oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 440
ALA A 515
ALA A 463
LEU A 549
LEU A 460
 None
 1.08A 3p2kC-2i7nA:
undetectable		 3p2kC-2i7nA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		6 GLY A 253
VAL A 284
ASN A 153
ALA A 256
LEU A 250
LEU A 411
 None
None
None
SO4  A 480 (-3.8A)
OCS  A 249 ( 3.7A)
SO4  A 480 (-4.3A)
 1.25A 3p2kC-2iluA:
4.3		 3p2kC-2iluA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9w U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF16842
(RRM_occluded) 		5 GLY A 354
PRO A 318
ASN A 353
LEU A 347
LEU A 332
 None
 0.99A 3p2kC-2l9wA:
undetectable		 3p2kC-2l9wA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		5 GLY A  79
GLY A  47
ALA A  84
ALA A 105
LEU A  77
 ATP  A 281 (-3.2A)
ATP  A 281 (-3.1A)
None
None
None
 0.93A 3p2kC-2ogxA:
2.6		 3p2kC-2ogxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		6 GLY A  68
GLY A  39
VAL A  45
ALA A  80
LEU A  66
LEU A  69
 None
 1.36A 3p2kC-2pcqA:
undetectable		 3p2kC-2pcqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 GLY A  13
GLY A   9
ALA A 306
ALA A 303
LEU A 289
 None
 1.04A 3p2kC-2qtyA:
undetectable		 3p2kC-2qtyA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 GLY A  14
ALA A  16
LEU A 140
TRP A  64
LEU A  63
 None
 0.98A 3p2kC-2rbcA:
undetectable		 3p2kC-2rbcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 108
ALA A 131
ALA A 148
LEU A 135
TRP A 138
 None
 0.89A 3p2kC-2vcyA:
4.7		 3p2kC-2vcyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		5 GLY A 180
ASN A  71
ALA A 188
LEU A 112
LEU A 207
 None
DGL  A1256 (-4.0A)
None
None
None
 1.07A 3p2kC-2w4iA:
undetectable		 3p2kC-2w4iA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A  54
PRO A 420
ASN A  49
ALA A 421
PHE A  81
 None
 0.99A 3p2kC-2wvgA:
3.1		 3p2kC-2wvgA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		6 GLY A  97
GLY A  40
ASN A  13
ALA A 101
PHE A 180
LEU A 154
 None
 1.39A 3p2kC-2yvtA:
undetectable		 3p2kC-2yvtA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Thermus
thermophilus) 		PF01063
(Aminotran_4) 		5 GLY A 160
VAL A 111
ALA A 136
LEU A 180
LEU A 150
 None
None
None
PLP  A 248 (-4.4A)
None
 1.05A 3p2kC-2zgiA:
undetectable		 3p2kC-2zgiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 GLY A 211
GLY A 389
ASN A 391
ALA A 134
LEU A 213
 None
 1.03A 3p2kC-2zukA:
undetectable		 3p2kC-2zukA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		5 GLY A  54
GLY A  56
ALA A 111
LEU A 130
PHE A 131
 GOL  A 302 ( 3.3A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.7A)
SAM  A 301 (-4.8A)
SAM  A 301 (-4.8A)
 0.72A 3p2kC-3ckkA:
14.1		 3p2kC-3ckkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		5 GLY A 130
GLY A 134
ASN A 133
ALA A 188
LEU A 128
 None
 1.07A 3p2kC-3graA:
3.4		 3p2kC-3graA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 GLY A 302
ASN A 303
ALA A 293
ALA A 294
LEU A 310
 None
 0.98A 3p2kC-3hvnA:
undetectable		 3p2kC-3hvnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii6 DNA LIGASE 4

(Homo sapiens) 		PF00533
(BRCT)
PF11411
(DNA_ligase_IV) 		5 GLY X 866
ALA X 839
ALA X 842
LEU X 889
LEU X 820
 None
 1.07A 3p2kC-3ii6X:
undetectable		 3p2kC-3ii6X:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		5 GLY A 225
GLY A 252
VAL A 228
ALA A 318
PHE A 424
 None
 0.95A 3p2kC-3ij3A:
undetectable		 3p2kC-3ij3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 GLY A 103
GLY A  48
VAL A  34
ALA A  99
ALA A  98
LEU A 109
 None
 1.44A 3p2kC-3ik4A:
undetectable		 3p2kC-3ik4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 474
ASN A 529
ALA A 463
LEU A 432
LEU A 468
 None
 1.04A 3p2kC-3l6yA:
undetectable		 3p2kC-3l6yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ltj ALPHAREP-4

(synthetic
construct) 		PF02985
(HEAT)
PF03130
(HEAT_PBS)
PF13646
(HEAT_2) 		5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 1.09A 3p2kC-3ltjA:
undetectable		 3p2kC-3ltjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 GLY A 268
VAL A 266
ALA A 243
ALA A 244
LEU A 271
 None
None
None
SO4  A 401 ( 4.5A)
None
 0.94A 3p2kC-3majA:
undetectable		 3p2kC-3majA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		5 GLY A  32
GLY A  34
ALA A  87
LEU A 102
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
SAH  A 216 (-3.5A)
SAH  A 216 (-4.6A)
SAH  A 216 (-4.0A)
 0.25A 3p2kC-3mq2A:
27.4		 3p2kC-3mq2A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 5 GLY A 788
GLY A 786
VAL A 781
ALA A 790
LEU A 757
 GOL  A 101 ( 3.8A)
GOL  A 101 (-4.4A)
GOL  A 103 (-3.7A)
None
None
 1.05A 3p2kC-3p06A:
undetectable		 3p2kC-3p06A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3d NUCLEOPORIN 53

(Meyerozyma
guilliermondii) 		PF05172
(Nup35_RRM) 		5 GLY A 350
GLY A 272
VAL A 347
ALA A 342
LEU A 269
 None
 1.04A 3p2kC-3p3dA:
undetectable		 3p2kC-3p3dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		5 GLY A 239
GLY A 229
ALA A 143
ALA A 208
LEU A 139
 None
 1.02A 3p2kC-3pkmA:
undetectable		 3p2kC-3pkmA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 PRO A  51
ALA A  73
ALA A  74
LEU A  41
LEU A  23
 None
 1.01A 3p2kC-3pkoA:
undetectable		 3p2kC-3pkoA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q13 SPONDIN-1

(Homo sapiens) 		PF06468
(Spond_N) 		5 GLY A 263
PRO A 265
VAL A 266
ALA A 233
ALA A 287
 None
 1.06A 3p2kC-3q13A:
undetectable		 3p2kC-3q13A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.96A 3p2kC-3srzA:
undetectable		 3p2kC-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		5 GLY A 140
GLY A 143
ASN A 144
LEU A 166
PHE A 163
 None
 0.85A 3p2kC-3sxpA:
5.3		 3p2kC-3sxpA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)

(Borreliella
burgdorferi) 		PF04069
(OpuAC) 		5 GLY A  77
ALA A 234
LEU A 222
PHE A  98
LEU A 227
 None
 1.02A 3p2kC-3tmgA:
undetectable		 3p2kC-3tmgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii) 		PF07475
(Hpr_kinase_C) 		5 GLY A  79
ASN A  78
LEU A  94
PHE A  95
LEU A  97
 None
 1.01A 3p2kC-3tqfA:
undetectable		 3p2kC-3tqfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 254
ASN A 253
ALA A 294
LEU A 263
LEU A 288
 None
 0.96A 3p2kC-3tqpA:
undetectable		 3p2kC-3tqpA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5t 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A 131
VAL A  85
ALA A 124
ALA A 125
LEU A 170
 None
 0.96A 3p2kC-3u5tA:
5.1		 3p2kC-3u5tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		6 GLY A 823
GLY A 820
ALA A 794
ALA A 797
LEU A 855
LEU A 826
 None
 1.31A 3p2kC-3un9A:
undetectable		 3p2kC-3un9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		5 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 0.90A 3p2kC-3uoeA:
undetectable		 3p2kC-3uoeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 GLY A 101
GLY A  11
ALA A  97
ALA A 140
PHE A  92
 None
 1.09A 3p2kC-3v3tA:
4.0		 3p2kC-3v3tA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		5 GLY A  94
VAL A 107
ALA A 197
ALA A 196
LEU A  42
 PO4  A 401 (-3.4A)
None
None
None
None
 0.96A 3p2kC-4as5A:
undetectable		 3p2kC-4as5A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 GLY A 618
VAL A 545
ALA A 666
ALA A 667
PHE A 623
 None
None
None
NAG  A1542 (-3.6A)
None
 1.08A 3p2kC-4ccdA:
undetectable		 3p2kC-4ccdA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cok PYRUVATE
DECARBOXYLASE

(Gluconacetobacter
diazotrophicus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A  54
PRO A 416
ASN A  49
ALA A 417
PHE A  81
 None
 0.96A 3p2kC-4cokA:
undetectable		 3p2kC-4cokA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
GLY A 121
VAL A 151
ALA A 159
ALA A 138
 None
 1.06A 3p2kC-4d9iA:
2.2		 3p2kC-4d9iA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		5 GLY A  49
GLY A  57
LEU A  51
PHE A 183
LEU A 107
 None
 1.02A 3p2kC-4dveA:
undetectable		 3p2kC-4dveA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fso PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLY A 222
GLY A 199
VAL A 196
ASN A 197
ALA A 220
 C8E  A 506 (-3.4A)
None
None
None
C8E  A 506 ( 3.9A)
 1.06A 3p2kC-4fsoA:
undetectable		 3p2kC-4fsoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		5 GLY A 400
VAL A 490
ALA A 482
ALA A 481
LEU A 434
 None
 1.07A 3p2kC-4g25A:
undetectable		 3p2kC-4g25A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw2 A3 ARTIFICIAL
PROTEIN

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A  39
GLY A  42
VAL A  47
ALA A  65
ALA A  64
 None
 1.08A 3p2kC-4jw2A:
undetectable		 3p2kC-4jw2A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A 163
GLY A 141
ALA A 160
ALA A 157
LEU A 133
 None
 1.07A 3p2kC-4k2bA:
undetectable		 3p2kC-4k2bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 GLY A 399
ALA A 302
ALA A 280
LEU A 296
LEU A 289
 None
 1.04A 3p2kC-4kv7A:
undetectable		 3p2kC-4kv7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lf0 ALIPHATIC AMIDASE

(Bacillus sp.
(in: Bacteria)) 		PF00795
(CN_hydrolase) 		5 GLY A  64
ALA A  76
ALA A  77
PHE A  57
LEU A 102
 None
 0.99A 3p2kC-4lf0A:
undetectable		 3p2kC-4lf0A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		5 GLY A 243
GLY A 247
ALA A 241
PHE A 270
LEU A 272
 None
 0.98A 3p2kC-4lg9A:
undetectable		 3p2kC-4lg9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 306
GLY A 183
ALA A 110
ALA A 111
LEU A 188
 None
None
None
SCY  A 112 ( 2.7A)
None
 1.04A 3p2kC-4nhdA:
undetectable		 3p2kC-4nhdA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		11 GLY Y  32
GLY Y  34
PRO Y  56
VAL Y  57
ASN Y  60
ALA Y  86
ALA Y  87
LEU Y 104
PHE Y 105
LEU Y 110
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
G  A1486 ( 3.9A)
SFG  Y 301 ( 4.1A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-4.8A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.5A)
 0.64A 3p2kC-4ox9Y:
31.6		 3p2kC-4ox9Y:
98.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		5 GLY A 123
GLY A  60
VAL A 126
ALA A  39
LEU A 167
 None
 1.09A 3p2kC-4p0dA:
undetectable		 3p2kC-4p0dA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		6 GLY A 262
VAL A 455
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
 1.34A 3p2kC-4r04A:
undetectable		 3p2kC-4r04A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rx1 PUTATIVE RRNA
METHYLTRANSFERASE

(Sorangium
cellulosum) 		no annotation 5 GLY A  32
GLY A  34
PRO A  56
PHE A 105
LEU A 110
 GOL  A 303 (-3.7A)
None
None
None
None
 0.72A 3p2kC-4rx1A:
25.0		 3p2kC-4rx1A:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 295
GLY A  88
ALA A 170
ALA A 171
LEU A 122
 None
 0.94A 3p2kC-4v2pA:
undetectable		 3p2kC-4v2pA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		6 GLY C  39
GLY C  42
VAL C  16
ALA C  34
ALA C  35
LEU C  50
 None
 1.26A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C 163
GLY C 166
VAL C 171
ALA C 189
ALA C 188
 None
 1.08A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xl5 BGFP-A

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 GLY C 225
GLY C 228
VAL C 202
ALA C 220
ALA C 221
 None
 1.09A 3p2kC-4xl5C:
undetectable		 3p2kC-4xl5C:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 295
GLY A  88
ALA A 170
ALA A 171
LEU A 122
 None
 1.02A 3p2kC-4yufA:
undetectable		 3p2kC-4yufA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 306
GLY A 183
ALA A 110
ALA A 111
LEU A 188
 None
None
None
SCY  A 112 ( 2.7A)
None
 1.06A 3p2kC-4z19A:
undetectable		 3p2kC-4z19A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		5 GLY A 194
GLY A 197
VAL A 202
ALA A 220
ALA A 219
 None
 1.02A 3p2kC-4zv6A:
undetectable		 3p2kC-4zv6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 299
ALA A  93
PHE A 319
LEU A 302
TRP A 270
 None
 1.09A 3p2kC-5avmA:
undetectable		 3p2kC-5avmA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 6 GLY A  38
GLY A  40
PRO A  62
ALA A  92
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 ( 4.3A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.44A 3p2kC-5bw4A:
25.5		 3p2kC-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 161
GLY A 283
ASN A 282
ALA A  31
LEU A  46
 None
 1.09A 3p2kC-5by7A:
undetectable		 3p2kC-5by7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by7 3-OXOACYL-ACP
SYNTHASE III

(Verrucosispora
maris) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 163
GLY A 131
ASN A 282
ALA A 165
ALA A  -9
 None
 1.07A 3p2kC-5by7A:
undetectable		 3p2kC-5by7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		5 GLY A 415
ALA A 490
ALA A 438
LEU A 524
LEU A 435
 ADP  A 601 (-3.5A)
None
None
None
None
 0.86A 3p2kC-5e26A:
2.8		 3p2kC-5e26A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		5 GLY A 117
ALA A 139
ALA A 140
PHE A  68
TRP A  69
 GOL  A1280 ( 3.7A)
DAO  A1285 ( 4.0A)
None
None
None
 1.05A 3p2kC-5fusA:
undetectable		 3p2kC-5fusA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		5 GLY A 157
GLY A 153
VAL A 135
ASN A 133
ALA A 123
 None
 0.96A 3p2kC-5h6sA:
undetectable		 3p2kC-5h6sA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 GLY A 341
GLY A 344
ALA A 334
ALA A 333
LEU A 352
 None
 0.97A 3p2kC-5i5lA:
undetectable		 3p2kC-5i5lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 GLY A  85
GLY A  90
ALA A 115
ALA A 114
LEU A 221
 FAD  A 700 (-3.6A)
None
FAD  A 700 ( 4.0A)
FAD  A 700 (-3.6A)
None
 1.01A 3p2kC-5mq6A:
2.8		 3p2kC-5mq6A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		5 PRO A 607
VAL A 606
ALA A 566
PHE A 534
LEU A 537
 None
 1.02A 3p2kC-5mswA:
2.9		 3p2kC-5mswA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 5 GLY A  82
GLY A  85
VAL A  52
ALA A  77
ALA A  78
 None
 1.09A 3p2kC-5n3uA:
undetectable		 3p2kC-5n3uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 6 GLY A  27
GLY A 101
ALA A 289
ALA A  25
LEU A 233
TRP A 232
 FAD  A 601 ( 4.8A)
None
FAD  A 601 (-3.6A)
None
None
None
 1.39A 3p2kC-5nitA:
5.5		 3p2kC-5nitA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 5 GLY A  54
PRO A 421
ASN A  49
ALA A 422
PHE A  81
 None
 1.07A 3p2kC-5npuA:
3.6		 3p2kC-5npuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o67 FAPF

(Pseudomonas sp.
UK4) 		no annotation 5 ASN B  97
ALA B 374
ALA B 375
PHE B 110
LEU B 379
 None
 1.03A 3p2kC-5o67B:
undetectable		 3p2kC-5o67B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suh MSM0271 PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  75
GLY A  38
PRO A  41
ALA A  47
LEU A  77
 None
 0.89A 3p2kC-5suhA:
undetectable		 3p2kC-5suhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		5 GLY A  52
PRO A  54
VAL A  55
ASN A  57
LEU A 688
 None
None
None
83M  A 801 ( 4.0A)
None
 1.09A 3p2kC-5ubkA:
undetectable		 3p2kC-5ubkA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		6 GLY A   9
VAL A  97
ALA A   6
LEU A  16
PHE A  44
LEU A  10
 None
 1.39A 3p2kC-5vipA:
undetectable		 3p2kC-5vipA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 GLY A 141
ALA A 111
ALA A   7
LEU A  36
PHE A  43
 None
 1.07A 3p2kC-5wdxA:
undetectable		 3p2kC-5wdxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 GLY A 278
GLY A 441
ALA A 274
LEU A 328
LEU A 282
 None
 0.97A 3p2kC-5zb3A:
undetectable		 3p2kC-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 GLY D  73
ALA D  45
ALA D  42
LEU D  80
LEU G  31
 None
 1.02A 3p2kC-6cfwD:
undetectable		 3p2kC-6cfwD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 5 GLY R 121
ALA R 298
ALA R 295
LEU R 119
TRP R 126
 None
 1.08A 3p2kC-6cmoR:
undetectable		 3p2kC-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft5 -

(-) 		no annotation 5 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
GOL  A 502 (-3.7A)
 1.06A 3p2kC-6ft5A:
undetectable		 3p2kC-6ft5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 ASN A  29
ASP A 307
GLU A 264
SER A  27
 None
 1.21A 3p2kC-1b4eA:
undetectable		 3p2kC-1b4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 ASN A 202
ASP A 219
THR A 295
SER A 225
 PLP  A 955 (-4.6A)
None
None
PLP  A 955 ( 3.9A)
 1.01A 3p2kC-1c4kA:
undetectable		 3p2kC-1c4kA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		4 ASN B 212
ASP B 198
THR B 235
SER B 169
 None
 1.40A 3p2kC-1ccwB:
undetectable		 3p2kC-1ccwB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4e VANCOMYCIN/TEICOPLAN
IN A-TYPE RESISTANCE
PROTEIN VANA

(Enterococcus
faecium) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 ASP B  18
GLU B  60
THR B  44
SER B 177
 None
None
None
PHY  B 355 ( 3.6A)
 1.45A 3p2kC-1e4eB:
undetectable		 3p2kC-1e4eB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		4 ASN A 206
ASP A 210
THR A 219
SER A 205
 None
 1.12A 3p2kC-1f5vA:
undetectable		 3p2kC-1f5vA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 ASP A  42
GLU A 384
THR A 382
SER A 186
 None
 1.35A 3p2kC-1fi4A:
undetectable		 3p2kC-1fi4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 ASN A 238
ASP A 306
GLU A 282
SER A 249
 None
None
A  B 524 ( 3.2A)
None
 1.38A 3p2kC-1g59A:
undetectable		 3p2kC-1g59A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		4 ASN A  15
ASP A  37
GLU A  85
SER A  14
 None
 1.08A 3p2kC-1i60A:
undetectable		 3p2kC-1i60A:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ASN A 312
ASP A 255
THR A 361
SER A 218
 None
ZN  A 488 (-2.5A)
None
None
 1.47A 3p2kC-1lamA:
undetectable		 3p2kC-1lamA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 ASN C 118
ASP C 124
THR C 195
SER C  36
 FAD  C3932 (-4.1A)
FAD  C3932 (-3.8A)
None
FAD  C3932 (-2.6A)
 1.13A 3p2kC-1n61C:
undetectable		 3p2kC-1n61C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		4 ASN A 261
GLU A 476
THR A 244
SER A 260
 None
None
NAD  A1501 (-4.1A)
None
 1.34A 3p2kC-1o9jA:
4.6		 3p2kC-1o9jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ASN A 110
ASP A 141
THR A 240
SER A   7
 ANP  A1285 (-3.7A)
CDM  A1284 (-2.9A)
CDM  A1284 ( 4.8A)
None
 1.46A 3p2kC-1oj4A:
undetectable		 3p2kC-1oj4A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 ASN A  99
ASP A  90
GLU A 161
SER A  37
 None
 1.13A 3p2kC-1rtrA:
undetectable		 3p2kC-1rtrA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		4 ASP A 946
GLU A 851
THR A 863
SER A  82
 None
 1.14A 3p2kC-1uf2A:
undetectable		 3p2kC-1uf2A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 ASN A  16
ASP A  97
GLU A 103
SER A  14
 None
 1.50A 3p2kC-1v72A:
undetectable		 3p2kC-1v72A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 ASN A  40
ASP A  31
GLU A 209
SER A  43
 None
 1.49A 3p2kC-1w55A:
2.1		 3p2kC-1w55A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 3
DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens;
Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3)
PF00364
(Biotin_lipoyl) 		4 ASN A 157
GLU B 168
THR B 175
SER A 160
 None
 1.38A 3p2kC-1y8pA:
undetectable		 3p2kC-1y8pA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 136
ASP A 154
THR A  24
SER A 135
 None
 1.19A 3p2kC-1z1wA:
undetectable		 3p2kC-1z1wA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ASN A 136
ASP A 154
THR A  26
SER A 135
 None
 0.95A 3p2kC-1z1wA:
undetectable		 3p2kC-1z1wA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ASN A 200
GLU A 121
THR A 182
SER A 199
 None
 0.99A 3p2kC-2dfsA:
undetectable		 3p2kC-2dfsA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 ASN X 496
ASP X 464
THR X 610
SER X 471
 None
 1.47A 3p2kC-2epkX:
undetectable		 3p2kC-2epkX:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6a COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05737
(Collagen_bind) 		4 ASN A 193
ASP A 179
GLU A  86
SER A 276
 None
 1.43A 3p2kC-2f6aA:
undetectable		 3p2kC-2f6aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASN A 357
ASP A 175
THR A 215
SER A 335
 None
 1.20A 3p2kC-2oejA:
undetectable		 3p2kC-2oejA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ols PHOSPHOENOLPYRUVATE
SYNTHASE

(Neisseria
meningitidis) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 ASN A 685
ASP A 705
GLU A 587
SER A 684
 None
 1.25A 3p2kC-2olsA:
undetectable		 3p2kC-2olsA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT

(Methanosarcina
mazei) 		PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 ASN A 512
ASP A 246
GLU A 603
SER A 508
 None
ZN  A1639 (-2.7A)
None
None
 1.45A 3p2kC-2xr1A:
undetectable		 3p2kC-2xr1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ASN A 134
ASP A 183
GLU A 217
THR A 321
 None
ZN  A 700 (-2.4A)
None
SO4  A 801 (-3.2A)
 1.50A 3p2kC-2yheA:
undetectable		 3p2kC-2yheA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 ASN A 911
ASP A 878
GLU A 694
SER A 910
 None
 1.36A 3p2kC-2yocA:
undetectable		 3p2kC-2yocA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASN A 359
ASP A 178
THR A 218
SER A 337
 None
 1.29A 3p2kC-2zviA:
undetectable		 3p2kC-2zviA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		4 ASN A 194
ASP A 593
THR A 625
SER A 162
 None
 1.27A 3p2kC-3abzA:
undetectable		 3p2kC-3abzA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdb NOVEL IMMUNE-TYPE
RECEPTOR 11

(Ictalurus
punctatus) 		PF07686
(V-set) 		4 ASN A  79
ASP A  87
GLU A 112
SER A  68
 None
 1.33A 3p2kC-3bdbA:
undetectable		 3p2kC-3bdbA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ASN A  67
ASP A  54
GLU A 449
THR A 452
 None
 1.40A 3p2kC-3ehmA:
undetectable		 3p2kC-3ehmA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 297
GLU A 247
THR A 168
SER A  65
 None
MG  A 501 (-3.2A)
None
None
 1.29A 3p2kC-3fxgA:
undetectable		 3p2kC-3fxgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmi PUTATIVE MEMBRANE
PROTEIN COG4129

(Clostridioides
difficile) 		PF11728
(ArAE_1_C) 		4 ASP A 167
GLU A 160
THR A 187
SER A 236
 None
 1.42A 3p2kC-3kmiA:
undetectable		 3p2kC-3kmiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		4 ASN A 100
ASP A  91
GLU A 163
SER A  38
 None
 1.41A 3p2kC-3krcA:
undetectable		 3p2kC-3krcA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mql FIBRONECTIN 1

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		4 ASN A 354
GLU A 467
THR A 370
SER A 355
 None
 1.47A 3p2kC-3mqlA:
undetectable		 3p2kC-3mqlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 ASN A  99
ASP A  90
GLU A 160
SER A  36
 None
 1.21A 3p2kC-3p8lA:
undetectable		 3p2kC-3p8lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2j ALPHA/BETA-HYDROLASE
-LIKE PROTEIN

(Leishmania
infantum) 		PF00857
(Isochorismatase) 		4 ASP A  73
GLU A 131
THR A 120
SER A  43
 ZN  A 301 ( 2.5A)
None
None
None
 1.45A 3p2kC-3r2jA:
undetectable		 3p2kC-3r2jA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ASN A 740
ASP A 743
THR A 746
SER A 791
 None
 1.46A 3p2kC-3szeA:
undetectable		 3p2kC-3szeA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 ASN A 451
ASP A 526
GLU A 600
SER A 453
 NAG  A 901 (-2.4A)
None
None
None
 1.00A 3p2kC-3t6qA:
undetectable		 3p2kC-3t6qA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		4 ASN A 941
ASP A 711
GLU A 820
THR A 698
 None
 1.18A 3p2kC-3vkwA:
undetectable		 3p2kC-3vkwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ASN A 590
ASP A 532
GLU A 543
SER A 585
 None
 1.48A 3p2kC-3wdjA:
undetectable		 3p2kC-3wdjA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		4 ASN A 200
ASP A  84
THR A 136
SER A 197
 None
 1.39A 3p2kC-4d1tA:
undetectable		 3p2kC-4d1tA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzh AMIDOHYDROLASE

(Xanthomonas
campestris) 		PF01979
(Amidohydro_1) 		4 ASN A 290
GLU A 126
THR A  84
SER A 295
 None
 1.46A 3p2kC-4dzhA:
undetectable		 3p2kC-4dzhA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esw PYRIMIDINE
BIOSYNTHESIS ENZYME
THI13

(Candida
albicans) 		PF09084
(NMT1) 		4 ASN A  44
GLU A 151
THR A 153
SER A  46
 None
 1.36A 3p2kC-4eswA:
undetectable		 3p2kC-4eswA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etm LOW MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YFKJ

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 ASP A 122
GLU A 134
THR A 129
SER A  95
 None
 1.39A 3p2kC-4etmA:
2.5		 3p2kC-4etmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 ASN A 240
GLU A 458
THR A 224
SER A 239
 None
None
NAD  A 601 (-4.2A)
None
 1.36A 3p2kC-4go4A:
4.5		 3p2kC-4go4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		4 ASN A 421
ASP A 418
GLU A 296
SER A 264
 None
NA  A 702 (-2.3A)
None
None
 0.99A 3p2kC-4gwnA:
undetectable		 3p2kC-4gwnA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 CHIMERIC ANTIBODY
FAB
CHIMERIC ANTIBODY
FAB
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set)
PF00229
(TNF) 		4 ASN L  32
ASP T  32
GLU T  57
THR H  31
 None
 1.42A 3p2kC-4ht1L:
undetectable		 3p2kC-4ht1L:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 ASN A 473
GLU A 554
THR A 576
SER A 474
 None
 1.43A 3p2kC-4j3bA:
undetectable		 3p2kC-4j3bA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 ASN B  93
ASP B 172
THR B 202
SER B  92
 None
ACT  B 902 (-3.5A)
None
PYC  B 904 (-3.0A)
 1.44A 3p2kC-4k7gB:
undetectable		 3p2kC-4k7gB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw2 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 ASN A 197
ASP A 183
GLU A  58
THR A 128
 None
 1.38A 3p2kC-4kw2A:
undetectable		 3p2kC-4kw2A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwg ALDEHYDE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 ASN A 261
GLU A 476
THR A 244
SER A 260
 None
 1.39A 3p2kC-4kwgA:
4.5		 3p2kC-4kwgA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		4 ASN A  74
ASP A  63
GLU A 102
SER A  29
 None
 1.42A 3p2kC-4m1rA:
2.0		 3p2kC-4m1rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 ASN A 266
ASP A  13
GLU A  85
THR A  94
 None
MN  A 501 (-2.0A)
None
None
 1.39A 3p2kC-4n7tA:
undetectable		 3p2kC-4n7tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 ASN A 386
ASP A 332
THR A 279
SER A   2
 None
 1.43A 3p2kC-4n7tA:
undetectable		 3p2kC-4n7tA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		4 ASN A  31
ASP A  71
THR A 253
SER A  26
 None
 1.02A 3p2kC-4nnqA:
undetectable		 3p2kC-4nnqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 ASP A 659
GLU A 579
THR A 677
SER A 334
 None
 1.32A 3p2kC-4o5pA:
undetectable		 3p2kC-4o5pA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o94 TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 ASN A 213
ASP A 235
THR A 264
SER A 212
 SIN  A 403 (-3.3A)
None
None
None
 1.34A 3p2kC-4o94A:
undetectable		 3p2kC-4o94A:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		5 ASN Y  38
ASP Y  55
GLU Y  88
THR Y 109
SER Y 195
 SFG  Y 301 ( 4.5A)
SFG  Y 301 (-2.8A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 ( 3.7A)
 0.81A 3p2kC-4ox9Y:
31.6		 3p2kC-4ox9Y:
98.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ASN A 290
ASP A 371
GLU A 454
SER A 292
 None
 1.14A 3p2kC-4r6gA:
undetectable		 3p2kC-4r6gA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		4 ASN A 121
ASP A   8
GLU A 202
SER A 118
 None
 1.49A 3p2kC-4uarA:
2.0		 3p2kC-4uarA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		4 ASN A 468
ASP A 379
THR A 386
SER A 471
 None
 1.28A 3p2kC-4wzwA:
undetectable		 3p2kC-4wzwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		4 ASN A 183
ASP A  84
THR A 133
SER A 180
 None
 1.42A 3p2kC-5a87A:
undetectable		 3p2kC-5a87A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 ASN A 261
GLU A 476
THR A 244
SER A 260
 None
 1.34A 3p2kC-5abmA:
4.5		 3p2kC-5abmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		4 ASN A 286
ASP A 320
GLU A 392
THR A 185
 SO4  A 704 (-3.4A)
GAL  A 701 (-3.0A)
None
None
 1.17A 3p2kC-5bxpA:
undetectable		 3p2kC-5bxpA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE

(Rhizomucor
miehei) 		PF00291
(PALP) 		4 ASN A 186
GLU A 279
THR A 233
SER A 244
 None
PLP  A 401 ( 4.0A)
None
None
 1.29A 3p2kC-5c3uA:
2.4		 3p2kC-5c3uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewn STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF03115
(Astro_capsid_N) 		4 ASN A 214
ASP A 375
GLU A 316
SER A 216
 None
 1.45A 3p2kC-5ewnA:
undetectable		 3p2kC-5ewnA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 ASN A 273
GLU A 488
THR A 256
SER A 272
 None
 1.36A 3p2kC-5fhzA:
4.6		 3p2kC-5fhzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Arabidopsis
thaliana;
Oryza sativa) 		PF12697
(Abhydrolase_6)
no annotation 		4 ASP A  31
GLU B 693
THR B 664
SER A 187
 None
 1.05A 3p2kC-5hzgA:
2.8		 3p2kC-5hzgA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 242
ASP A 258
GLU A 142
SER A 240
 None
None
GAL  A4001 (-2.7A)
None
 1.44A 3p2kC-5ihrA:
undetectable		 3p2kC-5ihrA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw PUTATIVE
ANGIOTENSINOGEN
C-TERMINAL PEPTIDE
OF PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis;
Lampetra
fluviatilis) 		PF00079
(Serpin)
PF00079
(Serpin) 		4 ASN A 268
ASP C 427
THR A 295
SER A 269
 None
 1.14A 3p2kC-5inwA:
undetectable		 3p2kC-5inwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ASN A 953
GLU A 618
THR A 621
SER A 882
 None
 1.49A 3p2kC-5ip9A:
undetectable		 3p2kC-5ip9A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		4 ASN A 139
ASP A 136
GLU A 265
SER A  60
 None
 1.48A 3p2kC-5jqxA:
undetectable		 3p2kC-5jqxA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 ASN A 137
GLU A 498
THR A 383
SER A 134
 NAP  A 801 ( 3.6A)
None
None
MLT  A 802 (-2.6A)
 1.40A 3p2kC-5kvuA:
undetectable		 3p2kC-5kvuA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdq CHITOPORIN

(Vibrio harveyi) 		no annotation 4 ASN A 127
ASP A 135
GLU A 204
THR A 115
 None
 1.11A 3p2kC-5mdqA:
undetectable		 3p2kC-5mdqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Archaeoglobus
fulgidus) 		no annotation 4 ASN A  82
ASP A  85
GLU A 249
THR A 281
 None
 1.46A 3p2kC-5mqzA:
undetectable		 3p2kC-5mqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 ASN A 236
ASP A 282
THR A  61
SER A 223
 None
None
NH3  A 504 ( 2.8A)
None
 1.31A 3p2kC-5msyA:
undetectable		 3p2kC-5msyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3u PTS SYSTEM, IIA
COMPONENT

(Streptococcus
pneumoniae) 		PF03610
(EIIA-man) 		4 ASN A  66
ASP A  60
GLU A  52
SER A  65
 None
 1.41A 3p2kC-5t3uA:
undetectable		 3p2kC-5t3uA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata) 		no annotation 4 ASN A 224
ASP A 162
GLU A 180
SER A 145
 None
 1.44A 3p2kC-5u84A:
undetectable		 3p2kC-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve2 ENOYL-COA HYDRATASE

(Pseudoalteromonas
atlantica) 		PF00378
(ECH_1) 		4 ASN A  43
GLU A 137
THR A 109
SER A  42
 ASN  A  43 ( 0.6A)
GLU  A 137 ( 0.6A)
THR  A 109 ( 0.8A)
SER  A  42 (-0.0A)
 1.14A 3p2kC-5ve2A:
undetectable		 3p2kC-5ve2A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 ASN A 516
GLU A 677
THR A 607
SER A 486
 None
 1.34A 3p2kC-5whsA:
undetectable		 3p2kC-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 ASN A 284
ASP A 275
GLU A 260
SER A 282
 None
 1.47A 3p2kC-5yemA:
2.3		 3p2kC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 4 ASN A 279
GLU A 494
THR A 262
SER A 278
 None
 1.36A 3p2kC-6b5iA:
4.6		 3p2kC-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT D
V-TYPE PROTON ATPASE
SUBUNIT C''

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 ASN B  22
ASP C 174
GLU C 188
THR C  82
 None
 1.31A 3p2kC-6c6lB:
undetectable		 3p2kC-6c6lB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 ASN A 354
ASP A 318
GLU A 782
SER A 569
 None
G39  A 908 ( 4.2A)
None
None
 1.30A 3p2kC-6eksA:
undetectable		 3p2kC-6eksA:
14.81