SIMILAR PATTERNS OF AMINO ACIDS FOR 3P2K_B_SAMB6735_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 GLY A  46
PRO A  86
LEU A  49
THR A  16
LEU A  20
 None
 1.00A 3p2kB-1ao0A:
2.1		 3p2kB-1ao0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
 None
 1.07A 3p2kB-1c7tA:
undetectable		 3p2kB-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2f MALY PROTEIN

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 GLY A 176
ASN A 173
LEU A 323
THR A 300
LEU A 299
 None
PLP  A 400 (-4.0A)
None
None
None
 1.08A 3p2kB-1d2fA:
2.2		 3p2kB-1d2fA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 GLY A 236
GLY A 155
ASN A 168
VAL A  71
ALA A  30
 None
HEC  A 900 (-3.5A)
None
HEC  A 900 (-4.7A)
None
 1.12A 3p2kB-1e2zA:
undetectable		 3p2kB-1e2zA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 GLY A  42
VAL A 110
ALA A 104
LEU A  39
LEU A 164
 None
 1.01A 3p2kB-1j0nA:
undetectable		 3p2kB-1j0nA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 162
VAL A 292
ALA A 186
THR A 243
LEU A 241
 None
NAD  A1250 ( 3.5A)
None
NAD  A1250 (-4.8A)
None
 1.12A 3p2kB-1lluA:
4.9		 3p2kB-1lluA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbm CHYMOTRYPSIN-LIKE
SERINE PROTEASE

(Equine
arteritis virus) 		PF05579
(Peptidase_S32) 		5 GLY A  23
GLY A 121
LEU A  35
THR A  48
LEU A  49
 None
 1.11A 3p2kB-1mbmA:
undetectable		 3p2kB-1mbmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 GLY A 503
GLY A 505
LEU A 528
THR A 484
LEU A 550
 None
 1.08A 3p2kB-1mz5A:
undetectable		 3p2kB-1mz5A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 GLY A 236
GLY A 155
ASN A 168
VAL A  71
ALA A  30
 None
HEM  A 900 (-3.6A)
None
HEM  A 900 (-4.8A)
None
 1.12A 3p2kB-1q90A:
undetectable		 3p2kB-1q90A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjl DNAK SUPPRESSOR
PROTEIN

(Escherichia
coli) 		PF01258
(zf-dskA_traR) 		5 GLY A 112
VAL A 119
ALA A 132
LEU A  37
LEU A 126
 None
 0.96A 3p2kB-1tjlA:
undetectable		 3p2kB-1tjlA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 GLY A  16
GLY A  18
VAL A 212
GLU A 182
THR A 186
 None
 1.10A 3p2kB-1ulsA:
5.0		 3p2kB-1ulsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlm SAM-DEPENDENT
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 GLY A  43
GLY A  45
PRO A  61
ALA A  81
GLU A  82
 NA  A 300 (-4.1A)
None
None
None
None
 0.72A 3p2kB-1vlmA:
9.8		 3p2kB-1vlmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 GLY A 101
GLY A 103
PRO A 124
GLU A 150
TRP A  57
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
SAI  A 401 (-3.8A)
 0.91A 3p2kB-1xtpA:
10.0		 3p2kB-1xtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 GLY A 101
GLY A 103
PRO A 124
VAL A 125
GLU A 150
 SAI  A 401 (-3.4A)
SAI  A 401 (-3.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-4.2A)
SAI  A 401 (-3.3A)
 0.42A 3p2kB-1xtpA:
10.0		 3p2kB-1xtpA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyh NOTCH 1, ANKYRIN
DOMAIN

(Homo sapiens) 		PF12796
(Ank_2) 		5 GLY A 138
VAL A 136
ALA A 160
THR A 126
LEU A 128
 None
 1.17A 3p2kB-1yyhA:
undetectable		 3p2kB-1yyhA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aka DYNAMIN-1

(Rattus
norvegicus) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 GLY B 233
GLY B 273
ALA B 177
LEU B 268
LEU B 207
 None
 1.11A 3p2kB-2akaB:
undetectable		 3p2kB-2akaB:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		6 GLY A  50
GLY A  52
PRO A  72
ALA A  93
GLU A  94
LEU A 107
 SAI  A1300 (-3.5A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.2A)
SAI  A1300 (-3.5A)
SAI  A1300 (-3.0A)
None
 1.13A 3p2kB-2avnA:
9.9		 3p2kB-2avnA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 GLY A 326
GLY A 331
ASN A 309
ALA A   9
THR A 152
 None
None
None
None
PLP  A1361 (-2.7A)
 1.04A 3p2kB-2bi3A:
undetectable		 3p2kB-2bi3A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dia FILAMIN-B

(Homo sapiens) 		PF00630
(Filamin) 		5 GLY A  24
GLY A  30
PRO A  74
VAL A  73
ALA A  77
 None
 1.17A 3p2kB-2diaA:
undetectable		 3p2kB-2diaA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 GLY A 347
GLY A  74
VAL A  76
ALA A 327
GLU A 171
 None
 1.17A 3p2kB-2epgA:
undetectable		 3p2kB-2epgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbb PUTATIVE CHORISMATE
MUTASE

(Yersinia pestis) 		PF01817
(CM_2) 		5 GLY A  82
ALA A  74
LEU A 145
THR A 135
LEU A 138
 None
 1.15A 3p2kB-2gbbA:
undetectable		 3p2kB-2gbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 157
GLY A 283
ALA A 162
LEU A 134
THR A 226
 None
 1.06A 3p2kB-2hjrA:
5.1		 3p2kB-2hjrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		5 GLY A  40
GLY A  37
ALA A  68
GLU A  69
THR A  29
 None
 1.13A 3p2kB-2i99A:
3.9		 3p2kB-2i99A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 GLY B 235
GLY B 157
ASN B 170
VAL B  71
GLU B  32
 None
HEC  B 250 (-3.4A)
None
HEC  B 250 (-4.1A)
None
 1.11A 3p2kB-2jxmB:
undetectable		 3p2kB-2jxmB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		5 VAL A 128
ALA A 181
LEU A 194
THR A 184
LEU A 187
 None
 1.13A 3p2kB-2nunA:
undetectable		 3p2kB-2nunA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 GLY A 259
ASN A 339
PRO A  72
LEU A 402
LEU A 261
 None
 1.15A 3p2kB-2pi5A:
undetectable		 3p2kB-2pi5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		6 GLY A  14
ALA A  16
LEU A 140
TRP A  64
THR A  87
LEU A  63
 None
 1.30A 3p2kB-2rbcA:
3.2		 3p2kB-2rbcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 GLY A 497
GLY A 491
ASN A 107
GLU A 333
TRP A 115
 None
 1.17A 3p2kB-2v7gA:
4.5		 3p2kB-2v7gA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpw ORF14

(Streptomyces
clavuligerus) 		PF00583
(Acetyltransf_1) 		5 GLY A 250
GLY A 239
ASN A 288
VAL A 241
LEU A 200
 None
 1.09A 3p2kB-2wpwA:
undetectable		 3p2kB-2wpwA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 GLY A 178
GLY A 124
ALA A 310
THR A 241
LEU A 240
 None
 1.02A 3p2kB-2x4gA:
3.9		 3p2kB-2x4gA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.01A 3p2kB-2yneA:
undetectable		 3p2kB-2yneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 GLY A  12
GLY A  10
LEU A  14
THR A  36
LEU A  40
 None
 1.16A 3p2kB-2zvbA:
undetectable		 3p2kB-2zvbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		5 GLY B 400
GLY B 467
ASN B 481
VAL B 405
LEU B 440
 None
 1.10A 3p2kB-3aq1B:
undetectable		 3p2kB-3aq1B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aut GLUCOSE
1-DEHYDROGENASE 4

(Bacillus
megaterium) 		PF13561
(adh_short_C2) 		5 GLY A 123
ASN A 142
VAL A  73
ALA A  79
LEU A  86
 None
 1.17A 3p2kB-3autA:
5.0		 3p2kB-3autA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLY A 297
GLY A 396
ALA A 267
LEU A 366
LEU A 302
 None
 1.02A 3p2kB-3b40A:
undetectable		 3p2kB-3b40A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cex UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF04978
(DUF664) 		5 ASN A  60
ALA A 152
LEU A 114
THR A  10
LEU A  11
 None
 1.15A 3p2kB-3cexA:
undetectable		 3p2kB-3cexA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		5 GLY A 165
VAL A 115
ALA A 143
GLU A 146
LEU A 155
 None
None
None
CIT  A 302 (-3.4A)
None
 0.94A 3p2kB-3cswA:
undetectable		 3p2kB-3cswA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7l LIN1944 PROTEIN

(Listeria
innocua) 		PF13561
(adh_short_C2) 		5 GLY A 112
ALA A 176
GLU A 159
THR A  11
LEU A  12
 None
 1.03A 3p2kB-3d7lA:
3.7		 3p2kB-3d7lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 GLY A  41
GLY A  43
PRO A  63
ALA A  84
GLU A  85
 EDO  A 261 (-3.2A)
EDO  A 261 ( 3.9A)
EDO  A 261 ( 4.9A)
None
None
 0.71A 3p2kB-3egeA:
10.6		 3p2kB-3egeA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 GLY A 322
GLY A 320
VAL A 328
ALA A 106
LEU A 103
 None
 1.11A 3p2kB-3ek1A:
3.2		 3p2kB-3ek1A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE

(Haemophilus
influenzae) 		PF03767
(Acid_phosphat_B) 		5 GLY A 118
ASN A 114
ALA A  47
THR A 212
LEU A 177
 None
 1.05A 3p2kB-3et5A:
undetectable		 3p2kB-3et5A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 GLY A 353
ALA A 441
LEU A 382
THR A 362
LEU A 359
 None
 1.11A 3p2kB-3fcrA:
undetectable		 3p2kB-3fcrA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		5 GLY A 201
PRO A 196
VAL A 199
GLU A  58
TRP A 278
 None
 1.06A 3p2kB-3ff1A:
undetectable		 3p2kB-3ff1A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		5 GLY A 205
ALA A 286
LEU A 319
THR A 309
LEU A 312
 None
 1.09A 3p2kB-3gonA:
undetectable		 3p2kB-3gonA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		5 GLY A 310
GLY A 314
ALA A 306
LEU A 262
THR A 253
 None
 1.17A 3p2kB-3hd6A:
undetectable		 3p2kB-3hd6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 GLY A 236
PRO A 198
VAL A 199
ALA A 257
LEU A 244
 None
 1.17A 3p2kB-3i4jA:
undetectable		 3p2kB-3i4jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		5 GLY A 207
PRO A 202
VAL A 205
GLU A  59
TRP A 284
 None
 1.15A 3p2kB-3ifsA:
undetectable		 3p2kB-3ifsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
MYA  A1001 (-4.1A)
None
None
 1.03A 3p2kB-3iu1A:
undetectable		 3p2kB-3iu1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		5 GLY A  59
GLY A  72
LEU A  79
THR A  35
LEU A  36
 None
 1.04A 3p2kB-3lkuA:
undetectable		 3p2kB-3lkuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A  84
GLY A  46
ALA A 156
LEU A  48
LEU A 113
 None
 1.16A 3p2kB-3m1lA:
4.4		 3p2kB-3m1lA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		5 VAL A  33
ALA A 301
LEU A 347
THR A 326
LEU A 327
 None
 1.02A 3p2kB-3mpnA:
undetectable		 3p2kB-3mpnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE

(Streptoalloteichus
tenebrarius) 		PF02390
(Methyltransf_4) 		6 GLY A  32
GLY A  34
ALA A  87
GLU A  88
LEU A 102
LEU A 108
 SAH  A 216 (-3.5A)
SAH  A 216 (-3.4A)
SAH  A 216 (-3.5A)
SAH  A 216 (-2.9A)
SAH  A 216 (-4.6A)
SAH  A 216 (-4.0A)
 0.46A 3p2kB-3mq2A:
27.2		 3p2kB-3mq2A:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Ruegeria sp.
TM1040) 		PF04952
(AstE_AspA) 		5 GLY A 326
GLY A 305
LEU A 307
THR A 249
LEU A 250
 None
 1.09A 3p2kB-3na6A:
undetectable		 3p2kB-3na6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 GLY A 110
GLY A 114
GLU A 198
THR A 438
LEU A 441
 None
 1.08A 3p2kB-3nd0A:
undetectable		 3p2kB-3nd0A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p06 VP4 PROTEIN

(Tellina virus) 		no annotation 5 GLY A 788
GLY A 786
VAL A 781
ALA A 790
LEU A 757
 GOL  A 101 ( 3.8A)
GOL  A 101 (-4.4A)
GOL  A 103 (-3.7A)
None
None
 1.10A 3p2kB-3p06A:
undetectable		 3p2kB-3p06A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		5 GLY A1609
ALA A1661
GLU A1660
THR A1656
LEU A1657
 None
 1.08A 3p2kB-3ppxA:
undetectable		 3p2kB-3ppxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		6 GLY A  68
ASN A  72
ALA A   9
LEU A  71
THR A 106
LEU A 105
 SAM  A 670 (-3.2A)
SAM  A 670 ( 3.7A)
None
SAM  A 670 (-3.8A)
None
None
 1.50A 3p2kB-3ps9A:
7.8		 3p2kB-3ps9A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 106
ALA A 186
GLU A 185
LEU A 111
LEU A 100
 None
 1.10A 3p2kB-3qdkA:
undetectable		 3p2kB-3qdkA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 GLY A 233
GLY A 273
ALA A 177
LEU A 268
LEU A 207
 None
 1.08A 3p2kB-3snhA:
undetectable		 3p2kB-3snhA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		5 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.11A 3p2kB-3srzA:
undetectable		 3p2kB-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 GLY A  73
ASN A  36
ALA A  81
LEU A   8
TRP A   6
 None
 1.15A 3p2kB-3t5bA:
undetectable		 3p2kB-3t5bA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcl CH04 HEAVY CHAIN FAB

(Homo sapiens) 		no annotation 5 GLY H  33
GLY H 100
ASN H  53
ALA H  93
TRP H 100
 None
 1.06A 3p2kB-3tclH:
undetectable		 3p2kB-3tclH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trd ALPHA/BETA HYDROLASE

(Coxiella
burnetii) 		PF00561
(Abhydrolase_1) 		5 GLY A 108
GLY A 112
LEU A 106
THR A  51
LEU A  52
 None
 1.04A 3p2kB-3trdA:
2.5		 3p2kB-3trdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		5 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 0.88A 3p2kB-3uoeA:
undetectable		 3p2kB-3uoeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6o DYNAMIN-1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 GLY A 243
GLY A 281
ALA A 187
LEU A 276
LEU A 217
 None
 1.14A 3p2kB-3w6oA:
undetectable		 3p2kB-3w6oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 2

(Mus musculus) 		PF07528
(DZF) 		5 GLY A 249
ALA A 267
LEU A 245
THR A 219
LEU A 223
 None
 1.09A 3p2kB-4atbA:
undetectable		 3p2kB-4atbA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 GLY A 224
GLY A 213
LEU A 248
THR A 174
LEU A 175
 None
None
NHW  A1000 (-4.0A)
None
None
 1.02A 3p2kB-4c2xA:
undetectable		 3p2kB-4c2xA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db3 N-ACETYL-D-GLUCOSAMI
NE KINASE

(Vibrio
vulnificus) 		PF00480
(ROK) 		5 GLY A 191
GLY A 133
ALA A 208
LEU A 189
LEU A 255
 None
 1.08A 3p2kB-4db3A:
undetectable		 3p2kB-4db3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 247
ASN A 283
VAL A 522
ALA A 244
LEU A 239
 None
 1.16A 3p2kB-4fsfA:
undetectable		 3p2kB-4fsfA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 GLY A1109
ALA A1025
LEU A1073
THR A1086
LEU A1085
 None
 1.14A 3p2kB-4guaA:
undetectable		 3p2kB-4guaA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		5 GLY A 111
GLY A 127
ALA A 108
LEU A 113
THR A 184
 None
 1.11A 3p2kB-4guzA:
undetectable		 3p2kB-4guzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 PRO A 338
ALA A 390
LEU A 286
THR A 455
LEU A 402
 None
 1.14A 3p2kB-4lq1A:
undetectable		 3p2kB-4lq1A:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ox9 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		11 GLY Y  32
GLY Y  34
ASN Y  38
PRO Y  56
VAL Y  57
ALA Y  87
GLU Y  88
LEU Y 104
THR Y 109
LEU Y 110
TRP Y 197
 SFG  Y 301 (-3.9A)
SFG  Y 301 (-3.1A)
SFG  Y 301 ( 4.5A)
SFG  Y 301 (-4.4A)
U  A1485 ( 4.7A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.6A)
SFG  Y 301 (-4.6A)
SFG  Y 301 (-3.3A)
SFG  Y 301 (-4.0A)
SFG  Y 301 (-3.5A)
 0.73A 3p2kB-4ox9Y:
31.4		 3p2kB-4ox9Y:
98.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		5 GLY A 123
GLY A  60
VAL A 126
ALA A  39
LEU A 167
 None
 1.06A 3p2kB-4p0dA:
undetectable		 3p2kB-4p0dA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 GLY A  44
ASN A  47
VAL A  42
ALA A  64
LEU A  31
 None
 1.11A 3p2kB-4r6lA:
undetectable		 3p2kB-4r6lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE

(Mycobacterium
tuberculosis) 		no annotation 5 GLY B  16
GLY B  14
ALA B  47
THR B 205
LEU B 208
 FAD  B 401 (-3.4A)
FAD  B 401 (-3.3A)
None
None
None
 0.99A 3p2kB-4rphB:
undetectable		 3p2kB-4rphB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 123
ASN A 452
LEU A 451
THR A 117
LEU A 118
 None
 1.12A 3p2kB-4ruhA:
undetectable		 3p2kB-4ruhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		5 GLY A 105
GLY A 367
LEU A 448
THR A 432
LEU A 433
 None
 1.04A 3p2kB-4wgxA:
undetectable		 3p2kB-4wgxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 PRO C  48
ALA C 331
LEU C 342
THR C 349
LEU C 348
 None
 0.89A 3p2kB-4xgcC:
undetectable		 3p2kB-4xgcC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 195
VAL A 204
LEU A  77
THR A 216
LEU A 215
 None
 1.00A 3p2kB-4ye5A:
undetectable		 3p2kB-4ye5A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLY B 903
ASN B 925
VAL B 905
ALA B 952
GLU B 954
 None
 1.08A 3p2kB-4zktB:
undetectable		 3p2kB-4zktB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 6 GLY A  38
GLY A  40
PRO A  62
GLU A  94
LEU A 110
LEU A 116
 SAM  A 301 (-3.4A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.5A)
SAM  A 301 (-3.2A)
SAM  A 301 (-4.7A)
SAM  A 301 (-4.0A)
 0.45A 3p2kB-5bw4A:
25.4		 3p2kB-5bw4A:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 GLY A 353
GLY A 357
ALA A 349
THR A 363
LEU A 303
 None
 1.15A 3p2kB-5cslA:
2.5		 3p2kB-5cslA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3q DYNAMIN-1,DYNAMIN-1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 GLY A 233
GLY A 273
ALA A 177
LEU A 268
LEU A 207
 None
 1.09A 3p2kB-5d3qA:
undetectable		 3p2kB-5d3qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 GLY A 507
GLY A 505
ALA A 535
LEU A 524
LEU A 533
 None
 1.15A 3p2kB-5e02A:
2.6		 3p2kB-5e02A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7g IPT/TIG
DOMAIN-CONTAINING
PROTEIN BACOVA_02650

(Bacteroides
ovatus) 		no annotation 5 GLY A  60
VAL A  57
GLU A 162
THR A 106
LEU A 105
 None
 1.14A 3p2kB-5e7gA:
undetectable		 3p2kB-5e7gA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqd UDP-GALACTOPYRANOSE
MUTASE

(Mycolicibacterium
smegmatis) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A  25
GLY A  23
ALA A  56
THR A 214
LEU A 217
 FAD  A 501 (-3.3A)
FAD  A 501 (-3.1A)
FAD  A 501 ( 4.4A)
None
None
 0.91A 3p2kB-5eqdA:
undetectable		 3p2kB-5eqdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 GLY e 443
GLY e 511
VAL e 448
THR e 482
LEU e 483
 None
 1.10A 3p2kB-5gw5e:
undetectable		 3p2kB-5gw5e:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		5 GLY A 235
PRO A 238
VAL A 237
GLU A 243
THR A 280
 None
 1.08A 3p2kB-5karA:
undetectable		 3p2kB-5karA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 5 ASN A 342
LEU A 371
THR A 382
LEU A 383
TRP A 373
 None
 1.14A 3p2kB-5ny0A:
undetectable		 3p2kB-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suh MSM0271 PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 GLY A  75
GLY A  38
PRO A  41
ALA A  47
LEU A  77
 None
 0.86A 3p2kB-5suhA:
undetectable		 3p2kB-5suhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 6 GLY A 135
GLY A 133
ASN A 194
ALA A 165
LEU A 137
THR A 174
 None
SAH  A 414 (-2.8A)
TRS  A 415 ( 2.3A)
None
SAH  A 414 ( 3.7A)
IOD  A 405 ( 4.3A)
 1.44A 3p2kB-5u4tA:
7.4		 3p2kB-5u4tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 GLY A 569
GLY A 571
ALA A 444
THR A 490
LEU A 582
 None
 1.17A 3p2kB-5ubmA:
undetectable		 3p2kB-5ubmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 287
ASN A 280
VAL A 268
ALA A 292
LEU A 289
 None
 1.12A 3p2kB-5xgcA:
undetectable		 3p2kB-5xgcA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 GLY A 176
ASN A 197
VAL A 434
TRP A 171
THR A 173
 None
 0.98A 3p2kB-5yl7A:
2.0		 3p2kB-5yl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 GLY A 128
ALA A 136
LEU A 160
TRP A 163
LEU A 133
 None
 1.12A 3p2kB-6avyA:
2.3		 3p2kB-6avyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqc CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Escherichia
coli) 		no annotation 5 GLY A  54
GLY A  57
PRO A 279
LEU A  51
LEU A  96
 LOP  A 402 ( 4.2A)
None
None
None
None
 1.06A 3p2kB-6bqcA:
10.7		 3p2kB-6bqcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db5 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY TA6 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 GLY H 106
GLY H 104
VAL H   5
ALA H   9
THR H 151
 None
 1.07A 3p2kB-6db5H:
undetectable		 3p2kB-6db5H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 5 GLY C 197
GLY C 195
ALA C 139
LEU C 154
LEU C 201
 None
 1.17A 3p2kB-6eicC:
2.6		 3p2kB-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 GLY A 114
GLY A  75
ALA A 203
GLU A 168
THR A  54
 None
FAD  A 600 (-3.4A)
None
None
None
 1.15A 3p2kB-6fydA:
undetectable		 3p2kB-6fydA:
undetectable