SIMILAR PATTERNS OF AMINO ACIDS FOR 3OZW_B_KKKB413_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A 127
HIS A 646
LEU A 538
ILE A 150
GLY A 163
 None
 1.05A 3ozwB-1b0kA:
undetectable		 3ozwB-1b0kA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		6 ILE A 357
HIS A 310
GLN A 316
ALA A 319
LEU A 320
LEU A 346
 None
 1.40A 3ozwB-1bk6A:
undetectable		 3ozwB-1bk6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		5 ILE A 110
ALA A  99
LEU A  27
GLY A  71
PRO A  72
 None
 0.99A 3ozwB-1esoA:
undetectable		 3ozwB-1esoA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		5 ILE A 269
GLN A 303
ALA A 298
LEU A 297
GLY A 344
 None
 1.07A 3ozwB-1igwA:
undetectable		 3ozwB-1igwA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii8 RAD50 ABC-ATPASE

(Pyrococcus
furiosus) 		PF13304
(AAA_21)
PF13476
(AAA_23) 		5 ILE A 143
ALA B 803
LEU B 802
LEU B 821
GLY B 749
 None
 1.08A 3ozwB-1ii8A:
undetectable		 3ozwB-1ii8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjt NITRIC-OXIDE
SYNTHASE HOMOLOG

(Staphylococcus
aureus) 		PF02898
(NO_synthase) 		5 ILE A  63
HIS A 289
ALA A 318
LEU A 317
PRO A 323
 None
 1.09A 3ozwB-1mjtA:
undetectable		 3ozwB-1mjtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		5 TYR A 489
LEU A 180
ILE A 227
GLY A 222
PRO A 223
 None
 1.06A 3ozwB-1mqsA:
undetectable		 3ozwB-1mqsA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE B 357
HIS B 310
GLN B 316
ALA B 319
LEU B 320
 None
 1.05A 3ozwB-1wa5B:
undetectable		 3ozwB-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ILE A  54
ALA A  47
LEU A  48
HIS A  11
ILE A 250
 None
None
None
FAD  A 601 (-4.4A)
None
 1.05A 3ozwB-2bc0A:
4.6		 3ozwB-2bc0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		5 HIS A  76
ALA A 193
HIS A 185
LEU A 225
ILE A 137
 TYR  A 701 (-3.7A)
None
None
None
None
 1.14A 3ozwB-2cycA:
undetectable		 3ozwB-2cycA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		5 ILE A  45
GLN A  90
ALA A  61
LEU A  33
ILE A 128
 None
 0.89A 3ozwB-2dfaA:
undetectable		 3ozwB-2dfaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLN A  28
ALA A   8
LEU A   9
ILE A 313
GLY A  26
 None
 1.05A 3ozwB-2eklA:
3.2		 3ozwB-2eklA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A  21
LEU A  23
LEU A  60
GLY A 175
PRO A 176
 None
 1.07A 3ozwB-2fmtA:
4.0		 3ozwB-2fmtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 GLN B 304
GLN B 307
ALA B 308
ILE B 335
GLY B 338
 None
 0.96A 3ozwB-2fpgB:
3.0		 3ozwB-2fpgB:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		5 HIS A 360
GLN A 359
ALA A 480
LEU A 371
GLY A 470
 None
 1.11A 3ozwB-2gduA:
undetectable		 3ozwB-2gduA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1

(Saccharomyces
cerevisiae;
synthetic
construct) 		PF13499
(EF-hand_7) 		5 ILE A 135
GLN A 138
GLN A 139
ALA A 142
LEU A 143
 None
 0.91A 3ozwB-2lhiA:
undetectable		 3ozwB-2lhiA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 325
HIS A 414
ALA A 369
LEU A 364
LEU A 419
 None
 1.10A 3ozwB-2o3jA:
4.1		 3ozwB-2o3jA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 5 GLN A  75
ALA A  72
LEU A  71
HIS A  20
ILE A  97
 None
 1.08A 3ozwB-2qgsA:
2.1		 3ozwB-2qgsA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 ALA A  11
LEU A 175
LEU A 162
ILE A  52
GLY A  26
 None
 1.12A 3ozwB-2v82A:
undetectable		 3ozwB-2v82A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 ILE A 676
LEU A  78
HIS A 153
ILE A  92
GLY A  68
 None
 1.08A 3ozwB-2yr5A:
3.6		 3ozwB-2yr5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 306
LEU A 305
LEU A 319
ILE A 264
GLY A 175
 None
 1.07A 3ozwB-2z01A:
undetectable		 3ozwB-2z01A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		5 ILE A   5
GLN A 290
ALA A  56
LEU A  57
GLY A 250
 None
None
None
None
AMP  A 501 (-3.4A)
 1.14A 3ozwB-3b1rA:
4.5		 3ozwB-3b1rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 368
LEU A 358
LEU A 373
ILE A 262
GLY A 264
 None
 1.14A 3ozwB-3ce6A:
4.4		 3ozwB-3ce6A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		5 ILE 1  90
ALA 1 241
LEU 1 240
GLY 1 168
PRO 1 167
 None
None
SC4  1 999 ( 4.7A)
None
None
 1.11A 3ozwB-3epf1:
undetectable		 3ozwB-3epf1:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ILE A  15
ALA A 310
LEU A 311
LEU A 128
GLY A 300
 None
 1.09A 3ozwB-3gweA:
undetectable		 3ozwB-3gweA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 TYR A 314
ALA A 238
HIS A 100
LEU A 222
GLY A 205
 None
None
ACT  A1900 (-4.1A)
None
None
 1.12A 3ozwB-3h09A:
undetectable		 3ozwB-3h09A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 ILE A 387
ALA A 368
LEU A 367
LEU A 317
GLY A 440
 None
 1.10A 3ozwB-3hi0A:
undetectable		 3ozwB-3hi0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		5 ALA 2 152
LEU 2 154
LEU 2  80
GLY 2 170
PRO 2 169
 None
 0.92A 3ozwB-3i9v2:
undetectable		 3ozwB-3i9v2:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  58
ALA A 158
HIS A 342
ILE A 374
GLY A  64
 None
 0.90A 3ozwB-3ip1A:
6.3		 3ozwB-3ip1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 374
GLN A 424
ALA A 353
LEU A 338
ILE A 461
 None
 1.12A 3ozwB-3iveA:
undetectable		 3ozwB-3iveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		5 ILE A 260
GLN A 257
ALA A 254
LEU A 253
LEU A 183
 None
 1.09A 3ozwB-3ju1A:
undetectable		 3ozwB-3ju1A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A   5
ALA A  17
LEU A  21
LEU A 327
GLY A 301
 None
None
None
None
FAD  A 401 (-3.4A)
 1.11A 3ozwB-3kkjA:
4.3		 3ozwB-3kkjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 GLN A  69
ALA A 110
HIS A  14
LEU A 115
ILE A 100
 None
 1.12A 3ozwB-3la4A:
undetectable		 3ozwB-3la4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		5 ILE A 220
ALA A 218
LEU A 219
ILE A 255
GLY A 253
 PHE  A 601 (-4.0A)
None
None
None
None
 0.97A 3ozwB-3lkvA:
3.8		 3ozwB-3lkvA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 272
GLN A 117
LEU A 182
HIS A  79
ILE A 194
 None
None
None
XUL  A7778 (-4.0A)
None
 1.12A 3ozwB-3ll3A:
undetectable		 3ozwB-3ll3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ILE A 359
GLN A 354
LEU A 442
LEU A 379
GLY A 348
 None
 1.01A 3ozwB-3n5mA:
undetectable		 3ozwB-3n5mA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		5 ILE A 356
GLN A 360
ALA A 361
LEU A 357
LEU A 346
 None
 1.15A 3ozwB-3nraA:
undetectable		 3ozwB-3nraA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ILE A  21
TYR A 270
ALA A   5
LEU A  28
GLY A  91
 None
 1.05A 3ozwB-3oa2A:
4.0		 3ozwB-3oa2A:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 10 ILE B  25
TYR B  29
HIS B  47
GLN B  52
GLN B  53
ALA B  56
LEU B  57
HIS B  85
LEU B 102
ILE B 371
 ECN  B 411 (-4.5A)
None
None
None
HEM  B 404 (-3.9A)
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
 0.74A 3ozwB-3ozvB:
63.6		 3ozwB-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 11 ILE B  25
TYR B  29
HIS B  47
GLN B  53
ALA B  56
LEU B  57
HIS B  85
LEU B 102
ILE B 371
GLY B 397
PRO B 398
 ECN  B 411 (-4.5A)
None
None
HEM  B 404 (-3.9A)
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
FAD  B 405 ( 4.4A)
HEM  B 404 (-4.4A)
 0.64A 3ozwB-3ozvB:
63.6		 3ozwB-3ozvB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 HIS A  99
ALA A 124
LEU A 123
LEU A 138
ILE A 102
 None
EDO  A 270 (-4.1A)
None
None
EDO  A 270 ( 4.3A)
 0.99A 3ozwB-3r0oA:
undetectable		 3ozwB-3r0oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 TYR A 194
GLN A 257
ALA A 181
LEU A 183
GLY A 139
 None
 1.06A 3ozwB-3rpwA:
undetectable		 3ozwB-3rpwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		5 ALA A 246
LEU A  21
ILE A 226
GLY A 222
PRO A 221
 None
 1.11A 3ozwB-3u0hA:
undetectable		 3ozwB-3u0hA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		6 ILE A  86
GLN A 498
ALA A 496
LEU A 495
LEU A 539
ILE A 104
 None
 1.16A 3ozwB-3ux8A:
undetectable		 3ozwB-3ux8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		5 ILE A 354
ALA A 327
LEU A 328
LEU A  15
GLY A 298
 None
 0.91A 3ozwB-3wkhA:
undetectable		 3ozwB-3wkhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq2 HOMOGENTISATE
1,2-DIOXYGENASE

(Pseudomonas
putida) 		PF04209
(HgmA) 		5 GLN A 101
ALA A 358
LEU A 408
ILE A 342
GLY A 196
 None
 1.03A 3ozwB-4aq2A:
undetectable		 3ozwB-4aq2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		5 ILE A 172
ALA A  73
LEU A  76
LEU A 209
ILE A  97
 None
 1.03A 3ozwB-4co6A:
undetectable		 3ozwB-4co6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		5 TYR A 338
HIS A 380
LEU A 384
LEU A 319
PRO A 292
 None
 1.14A 3ozwB-4cswA:
undetectable		 3ozwB-4cswA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 ILE A 395
ALA A 349
LEU A 346
LEU A  63
ILE A 278
 None
 0.94A 3ozwB-4dykA:
undetectable		 3ozwB-4dykA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE

(Lechevalieria
aerocolonigenes) 		PF01494
(FAD_binding_3) 		5 ILE A  11
ALA A  20
LEU A  21
HIS A 299
ILE A  67
 None
 0.90A 3ozwB-4eipA:
2.3		 3ozwB-4eipA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 ILE A 121
GLN A  72
LEU A 113
LEU A  94
ILE A  34
 None
 1.14A 3ozwB-4h5uA:
undetectable		 3ozwB-4h5uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 ILE B 183
ALA B 252
LEU B 192
ILE B  62
GLY B 173
 None
None
EDO  B 901 (-4.5A)
None
None
 1.04A 3ozwB-4hdsB:
2.6		 3ozwB-4hdsB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfo BIOGENIC
AMINE-BINDING
PROTEIN

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		5 ILE A  73
HIS A  47
GLN A  48
LEU A 186
GLY A  21
 None
 0.94A 3ozwB-4hfoA:
undetectable		 3ozwB-4hfoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 ILE A 113
LEU A  32
LEU A  11
ILE A 206
GLY A 199
 None
 1.13A 3ozwB-4ifqA:
2.1		 3ozwB-4ifqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 ILE A  27
TYR A  31
ALA A 107
LEU A 106
ILE A 143
 None
 1.11A 3ozwB-4infA:
undetectable		 3ozwB-4infA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 174
GLN A 177
HIS A  25
ILE A 367
PRO A 351
 None
None
TLA  A 502 (-4.1A)
None
None
 1.08A 3ozwB-4it1A:
undetectable		 3ozwB-4it1A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		6 ILE A 155
TYR A 187
GLN A 200
ALA A 261
LEU A 153
LEU A 139
 None
 1.44A 3ozwB-4iv8A:
3.2		 3ozwB-4iv8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA

(Escherichia
coli) 		PF01081
(Aldolase)
PF01346
(FKBP_N) 		5 ALA A  11
LEU A 175
LEU A 162
ILE A  52
GLY A  26
 None
 1.12A 3ozwB-4qccA:
undetectable		 3ozwB-4qccA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A 340
ALA A 502
HIS A 431
GLY A 498
PRO A 499
 None
 1.06A 3ozwB-4qiwA:
2.6		 3ozwB-4qiwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ILE A 340
ALA A 502
LEU A 450
GLY A 498
PRO A 499
 None
 0.97A 3ozwB-4qiwA:
2.6		 3ozwB-4qiwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 5 ILE A 282
HIS A  93
LEU A 291
GLY A 208
PRO A 207
 None
 1.14A 3ozwB-4rh0A:
undetectable		 3ozwB-4rh0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ILE A 126
HIS A 182
ALA A 151
LEU A 154
GLY A 144
 None
UNL  A 506 ( 4.6A)
None
None
None
 1.01A 3ozwB-4rvoA:
2.2		 3ozwB-4rvoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		5 ALA A 253
LEU A 144
LEU A 378
ILE A 395
GLY A 288
 None
 1.11A 3ozwB-4umzA:
undetectable		 3ozwB-4umzA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 ILE A 205
ALA A 278
LEU A 279
ILE A 264
GLY A 255
 None
None
None
TPO  A 252 ( 4.9A)
None
 1.09A 3ozwB-4wb7A:
undetectable		 3ozwB-4wb7A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wm0 XYLOSIDE
XYLOSYLTRANSFERASE 1

(Mus musculus) 		PF01501
(Glyco_transf_8) 		5 TYR A 230
GLN A 223
LEU A 138
LEU A 125
ILE A 203
 None
 1.02A 3ozwB-4wm0A:
undetectable		 3ozwB-4wm0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A  68
TYR A  56
HIS A 146
LEU A  49
GLY A 137
 None
 1.14A 3ozwB-4xhlA:
undetectable		 3ozwB-4xhlA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0l PUTATIVE MEMBRANE
PROTEIN MMPL11

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 448
HIS A 441
ALA A 473
LEU A 475
GLY A 435
 None
 1.08A 3ozwB-4y0lA:
undetectable		 3ozwB-4y0lA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 ALA A 738
LEU A 737
LEU A 706
GLY A 886
PRO A 885
 None
 1.11A 3ozwB-5b7iA:
undetectable		 3ozwB-5b7iA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by8 RPF2
RRS1

(Aspergillus
nidulans) 		PF04427
(Brix)
PF04939
(RRS1) 		5 ILE A 103
LEU A 171
LEU A  32
ILE B  94
PRO B  96
 None
 1.15A 3ozwB-5by8A:
undetectable		 3ozwB-5by8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		5 TYR A 406
LEU A 388
LEU A 374
ILE A 276
GLY A 256
 None
 1.14A 3ozwB-5ebbA:
undetectable		 3ozwB-5ebbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE

(Clostridium
sardiniense) 		PF13561
(adh_short_C2) 		5 ALA A 224
LEU A 228
LEU A   4
ILE A 191
GLY A  17
 None
None
None
NAP  A 301 (-3.9A)
NAP  A 301 (-3.3A)
 1.07A 3ozwB-5epoA:
5.8		 3ozwB-5epoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		5 TYR A 312
HIS A 448
ALA A 385
LEU A 382
LEU A 282
 LLP  A 311 ( 4.8A)
None
None
None
None
 1.13A 3ozwB-5eueA:
2.2		 3ozwB-5eueA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 108
GLN A  97
HIS A  93
ILE A 394
GLY A 392
 FRU  A3001 ( 4.3A)
FRU  A3001 ( 3.5A)
None
None
None
 0.96A 3ozwB-5fkcA:
undetectable		 3ozwB-5fkcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE C  76
TYR C  64
ALA C  44
LEU C  57
GLY C  94
 None
 1.13A 3ozwB-5fqdC:
undetectable		 3ozwB-5fqdC:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1
VP2

(Deformed wing
virus) 		PF00073
(Rhv)
PF08762
(CRPV_capsid) 		5 ILE B 207
HIS B 163
ALA B 174
LEU B  83
GLY A   1
 None
 1.05A 3ozwB-5g52B:
undetectable		 3ozwB-5g52B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gri ISOCITRATE
DEHYDROGENASE [NAD]
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		PF00180
(Iso_dh) 		5 ILE A  19
ALA A 279
LEU A 280
ILE A 240
GLY A 242
 None
 1.03A 3ozwB-5griA:
2.8		 3ozwB-5griA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		5 ILE A  44
LEU A  42
LEU A 496
GLY A 200
PRO A 201
 None
 1.12A 3ozwB-5isuA:
undetectable		 3ozwB-5isuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 ILE A 149
GLN A 180
ALA A 181
HIS A 373
ILE A  65
 None
 1.14A 3ozwB-5jkjA:
undetectable		 3ozwB-5jkjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ALA A 567
LEU A 544
LEU A 522
GLY A 571
PRO A 570
 None
 1.14A 3ozwB-5ju6A:
undetectable		 3ozwB-5ju6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ILE A 127
ALA A 258
LEU A 257
HIS A 207
GLY A 271
 None
 1.01A 3ozwB-5ks8A:
3.7		 3ozwB-5ks8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		5 TYR A 147
ALA A 130
LEU A 131
LEU A 104
ILE A 170
 None
 1.15A 3ozwB-5ly3A:
2.8		 3ozwB-5ly3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mll DNA PROCESSING CHAIN
A (DPRA)

(Helicobacter
pylori) 		no annotation 5 ILE A 155
ALA A  88
LEU A 182
ILE A 119
GLY A  80
 None
 1.08A 3ozwB-5mllA:
4.0		 3ozwB-5mllA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 ILE M 347
ALA M 196
LEU M 193
ILE M 212
PRO M 215
 None
 1.12A 3ozwB-5mpaM:
undetectable		 3ozwB-5mpaM:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbk IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE A 342
HIS A 295
GLN A 301
ALA A 304
LEU A 305
 None
 1.04A 3ozwB-5tbkA:
undetectable		 3ozwB-5tbkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 GLN A 388
GLN A 386
ALA A 410
LEU A 412
HIS A 340
 None
 1.14A 3ozwB-5tqrA:
undetectable		 3ozwB-5tqrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A  22
LEU A  24
LEU A  61
GLY A 176
PRO A 177
 None
 1.08A 3ozwB-5uaiA:
4.3		 3ozwB-5uaiA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		5 ILE 3 381
HIS 3 374
ALA 3 368
LEU 3 367
ILE 3 561
 None
 1.14A 3ozwB-5udb3:
undetectable		 3ozwB-5udb3:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 5 ILE A 456
GLN A 415
ALA A 418
LEU A 419
ILE A 377
 None
 1.14A 3ozwB-5ve8A:
2.7		 3ozwB-5ve8A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 5 ILE B 351
HIS B 304
GLN B 310
ALA B 313
LEU B 314
 None
 0.97A 3ozwB-5vqiB:
undetectable		 3ozwB-5vqiB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 ILE A 428
TYR A 425
ALA A 332
ILE A 376
GLY A 335
 None
 1.13A 3ozwB-5w4xA:
2.9		 3ozwB-5w4xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 ILE A 399
GLN A 410
LEU A 407
ILE A 219
GLY A 364
 None
 0.91A 3ozwB-5wyaA:
undetectable		 3ozwB-5wyaA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3q ENVELOPE
GLYCOPROTEIN

(Talaromyces
marneffei) 		no annotation 5 ILE A 259
GLN A 256
LEU A 258
LEU A 278
GLY A 103
 None
 1.08A 3ozwB-5x3qA:
undetectable		 3ozwB-5x3qA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe9 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA

(Streptococcus
mutans) 		PF03412
(Peptidase_C39) 		5 ILE A  54
HIS A  96
ALA A  20
LEU A  22
LEU A 138
 None
 1.00A 3ozwB-5xe9A:
undetectable		 3ozwB-5xe9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 LIGHT CHAIN OF FAB
1D5

(Mus musculus) 		PF07686
(V-set) 		5 TYR L  42
HIS L 116
GLN L 106
GLN L 105
ALA L  38
 None
 1.04A 3ozwB-5xs7L:
undetectable		 3ozwB-5xs7L:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		5 ILE J 116
ALA J 153
LEU J 155
ILE J 200
GLY J 187
 None
 0.87A 3ozwB-5xtdJ:
undetectable		 3ozwB-5xtdJ:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 5 GLN A 360
ALA A 361
LEU A 359
LEU A 345
ILE A 457
 None
 1.15A 3ozwB-6au1A:
undetectable		 3ozwB-6au1A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 ILE B 352
GLN B 304
ALA B 307
LEU B 308
HIS B 279
 None
 0.93A 3ozwB-6btmB:
2.9		 3ozwB-6btmB:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 6 ALA A 392
LEU A 393
HIS A  72
ILE A 426
GLY A 420
PRO A 421
 None
 1.37A 3ozwB-6bz0A:
undetectable		 3ozwB-6bz0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 5 ILE A 133
ALA A 188
LEU A 187
ILE A  27
GLY A 173
 None
 1.06A 3ozwB-6cc4A:
undetectable		 3ozwB-6cc4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evg MULTI-COPPER OXIDASE
CUEO

(Ochrobactrum) 		no annotation 5 ILE A 121
GLN A 123
LEU A  70
LEU A  78
GLY A 251
 None
 0.90A 3ozwB-6evgA:
undetectable		 3ozwB-6evgA:
12.24