SIMILAR PATTERNS OF AMINO ACIDS FOR 3OZV_B_ECNB411_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ILE A 147
ILE A 148
GLN A 165
ALA A 168
ALA A 516
 None
 0.96A 3ozvB-1d8cA:
undetectable		 3ozvB-1d8cA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxe 2-DEHYDRO-3-DEOXY-GA
LACTARATE ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		5 ILE A 202
ILE A 199
TYR A 226
ALA A 181
LEU A 180
 None
 1.10A 3ozvB-1dxeA:
undetectable		 3ozvB-1dxeA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A 450
ILE A 245
ALA A 197
LEU A 196
LEU A 175
 None
 0.73A 3ozvB-1g8xA:
0.0		 3ozvB-1g8xA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A  95
ILE A 115
ALA A  91
LEU A  92
LEU A  81
 None
 1.10A 3ozvB-1mx3A:
2.9		 3ozvB-1mx3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 ILE B 163
ILE B 162
LEU B 108
LEU B 130
ALA B 168
 None
 1.08A 3ozvB-1n94B:
undetectable		 3ozvB-1n94B:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  47
ALA A   3
LEU A   4
LEU A  39
ALA A  44
 None
 1.02A 3ozvB-1o8cA:
4.0		 3ozvB-1o8cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 ILE A 300
TYR A 330
ALA A 224
LEU A 225
ALA A 299
 None
 1.09A 3ozvB-1q2eA:
undetectable		 3ozvB-1q2eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu9 HYPOTHETICAL PROTEIN
PA3967

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A  24
TYR A  25
ALA A  53
LEU A  96
ALA A  99
 PPI  A 302 (-4.8A)
PPI  A 302 ( 4.4A)
None
None
None
 0.65A 3ozvB-1tu9A:
14.0		 3ozvB-1tu9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvy MYOGLOBIN

(Paramecium
caudatum) 		PF01152
(Bac_globin) 		5 PHE A  19
TYR A  20
ALA A  47
LEU A  85
ALA A  88
 None
 0.57A 3ozvB-1uvyA:
8.2		 3ozvB-1uvyA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 ILE A 171
ALA A 159
LEU A 158
LEU A 178
ALA A 176
 None
 1.02A 3ozvB-1vgmA:
undetectable		 3ozvB-1vgmA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE B 357
GLN B 316
ALA B 319
LEU B 320
LEU B 350
 None
 0.92A 3ozvB-1wa5B:
undetectable		 3ozvB-1wa5B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 175
ALA A 286
LEU A 250
LEU A  77
ALA A  73
 None
 1.00A 3ozvB-1yfmA:
undetectable		 3ozvB-1yfmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		5 ILE A 229
TYR A 262
ALA A  10
LEU A 250
ALA A 265
 None
FAD  A 500 (-4.4A)
None
None
None
 1.10A 3ozvB-2bacA:
undetectable		 3ozvB-2bacA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db0 253AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF02985
(HEAT) 		5 ILE A  59
ILE A  56
ALA A  93
LEU A  24
ALA A  27
 None
 1.11A 3ozvB-2db0A:
undetectable		 3ozvB-2db0A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 ILE A 219
ILE A 221
ALA A 435
LEU A 439
LEU A 285
 None
 1.06A 3ozvB-2dkdA:
undetectable		 3ozvB-2dkdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du9 PREDICTED
TRANSCRIPTIONAL
REGULATORS

(Corynebacterium
glutamicum) 		PF00392
(GntR) 		5 ILE A  13
ILE A   9
ALA A  35
LEU A  34
LEU A  58
 None
 1.11A 3ozvB-2du9A:
undetectable		 3ozvB-2du9A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A 138
ILE A  86
ALA A 148
LEU A  84
LEU A 102
 None
 1.09A 3ozvB-2ew9A:
undetectable		 3ozvB-2ew9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd4 AVIRULENCE PROTEIN
AVRPTOB

(Pseudomonas
syringae) 		PF09046
(AvrPtoB-E3_ubiq) 		5 ILE A 544
ALA A 527
LEU A 526
LEU A 495
ALA A 548
 None
 1.10A 3ozvB-2fd4A:
undetectable		 3ozvB-2fd4A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 199
ILE A 196
TYR A 197
ALA A 184
LEU A 181
 None
MLY  A 193 ( 4.1A)
MLY  A 193 ( 3.9A)
None
None
 1.09A 3ozvB-2g9nA:
undetectable		 3ozvB-2g9nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		5 ILE A2352
ALA A2473
LEU A2470
LEU A2323
ALA A2353
 None
 1.05A 3ozvB-2jswA:
2.5		 3ozvB-2jswA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwe PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF16739
(CARD_2) 		5 ILE A 123
ILE A 124
LEU A 155
LEU A 171
ALA A 174
 None
 1.08A 3ozvB-2lweA:
undetectable		 3ozvB-2lweA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ome C-TERMINAL-BINDING
PROTEIN 2

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 ILE A 101
ILE A 121
ALA A  97
LEU A  98
LEU A  87
 None
 1.06A 3ozvB-2omeA:
2.8		 3ozvB-2omeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		5 ILE A 237
ALA A 206
LEU A 205
LEU A 229
ALA A 123
 None
 1.09A 3ozvB-2oy4A:
undetectable		 3ozvB-2oy4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrw HEMOGLOBIN-LIKE
PROTEIN HBO

(Mycobacterium
tuberculosis) 		PF01152
(Bac_globin) 		5 ILE A  18
PHE A  22
TYR A  23
LEU A  52
ALA A  95
 None
 0.73A 3ozvB-2qrwA:
7.9		 3ozvB-2qrwA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 GLN A  95
ALA A  91
LEU A  94
LEU A  62
ALA A  59
 None
 1.04A 3ozvB-2rafA:
2.3		 3ozvB-2rafA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 ILE A 361
ALA A 255
LEU A 254
LEU A 278
ALA A 357
 None
 1.08A 3ozvB-3bdzA:
undetectable		 3ozvB-3bdzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF01715
(IPPT) 		5 ILE A   8
ALA A  24
LEU A  25
LEU A 316
ALA A 204
 None
 1.09A 3ozvB-3crrA:
undetectable		 3ozvB-3crrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 ILE A 161
GLN A 365
ALA A 362
LEU A 361
ALA A 162
 None
 1.07A 3ozvB-3dm0A:
undetectable		 3ozvB-3dm0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		5 ILE A   6
PHE A   2
ALA A 220
LEU A 237
ALA A 240
 None
 0.92A 3ozvB-3dv9A:
4.7		 3ozvB-3dv9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 150
ALA A 261
LEU A 225
LEU A  51
ALA A  47
 None
 1.05A 3ozvB-3gtdA:
undetectable		 3ozvB-3gtdA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 ILE A 161
GLN A 365
ALA A 362
LEU A 361
ALA A 162
 None
 1.08A 3ozvB-3h4zA:
undetectable		 3ozvB-3h4zA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lh5 TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 ILE A 560
ILE A 562
PHE A 543
LEU A 535
ALA A 559
 None
 1.10A 3ozvB-3lh5A:
undetectable		 3ozvB-3lh5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE A 118
ILE A 122
LEU A  11
LEU A  21
ALA A  24
 None
 1.05A 3ozvB-3n3wA:
undetectable		 3ozvB-3n3wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A  47
ALA A   3
LEU A   4
LEU A  39
ALA A  44
 None
 1.05A 3ozvB-3nx4A:
4.5		 3ozvB-3nx4A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 ILE B 118
ILE B 122
LEU B  11
LEU B  21
ALA B  24
 None
 1.05A 3ozvB-3o2rB:
undetectable		 3ozvB-3o2rB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 ILE N 161
GLN N 365
ALA N 362
LEU N 361
ALA N 162
 None
 1.10A 3ozvB-3o3uN:
undetectable		 3ozvB-3o3uN:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 ILE A 100
ALA A  58
LEU A  57
LEU A  96
ALA A  99
 None
 1.07A 3ozvB-3oc7A:
undetectable		 3ozvB-3oc7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		5 ILE A 412
GLN A 302
ALA A 305
LEU A 306
LEU A 407
 None
 0.98A 3ozvB-3pmkA:
undetectable		 3ozvB-3pmkA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
 None
 1.08A 3ozvB-3py7A:
undetectable		 3ozvB-3py7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qll CITRATE LYASE

(Yersinia pestis) 		PF03328
(HpcH_HpaI) 		5 ILE A 140
ALA A 188
LEU A 150
LEU A 108
ALA A 105
 None
 1.10A 3ozvB-3qllA:
undetectable		 3ozvB-3qllA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r07 PUTATIVE
LIPOATE-PROTEIN
LIGASE A SUBUNIT 2

(Thermoplasma
acidophilum) 		PF10437
(Lip_prot_lig_C) 		5 ILE C  62
ILE C  63
PHE C  66
TYR C  67
ALA C  84
 None
 0.79A 3ozvB-3r07C:
undetectable		 3ozvB-3r07C:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r07 PUTATIVE
LIPOATE-PROTEIN
LIGASE A SUBUNIT 2

(Thermoplasma
acidophilum) 		PF10437
(Lip_prot_lig_C) 		5 ILE C  63
PHE C  66
TYR C  67
ALA C  84
LEU C  85
 None
 1.08A 3ozvB-3r07C:
undetectable		 3ozvB-3r07C:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 147
ALA A 259
LEU A 222
LEU A  55
ALA A  51
 None
 0.94A 3ozvB-3rd8A:
undetectable		 3ozvB-3rd8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 ILE A 273
ILE A 270
PHE A 274
LEU A 165
LEU A 277
 None
 1.01A 3ozvB-3rp9A:
undetectable		 3ozvB-3rp9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		6 ILE A 163
ILE A 162
PHE A 159
LEU A  73
LEU A  33
ALA A  36
 None
 1.07A 3ozvB-3s1sA:
3.6		 3ozvB-3s1sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shw TIGHT JUNCTION
PROTEIN ZO-1

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 ILE A 560
ILE A 562
PHE A 543
LEU A 535
ALA A 559
 None
 1.04A 3ozvB-3shwA:
undetectable		 3ozvB-3shwA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		5 ILE A 354
ILE A 353
ALA A 298
LEU A 297
LEU A 305
 None
 0.96A 3ozvB-3thcA:
undetectable		 3ozvB-3thcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm9 BACTERIAL HEMOGLOBIN

(Vitreoscilla
stercoraria) 		PF00042
(Globin) 		5 ILE A  24
PHE A  28
ALA A  63
LEU A  62
ALA A 105
 None
 1.01A 3ozvB-3tm9A:
18.5		 3ozvB-3tm9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A3845
ALA A3562
LEU A3563
LEU A3838
ALA A3841
 None
 0.89A 3ozvB-3vkgA:
undetectable		 3ozvB-3vkgA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vp7 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 30

(Saccharomyces
cerevisiae) 		PF04111
(APG6) 		5 ILE A 447
ILE A 446
ALA A 368
LEU A 367
LEU A 522
 None
 1.09A 3ozvB-3vp7A:
undetectable		 3ozvB-3vp7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  85
ALA A  98
LEU A  96
LEU A 128
ALA A 131
 None
 1.10A 3ozvB-4a73A:
2.7		 3ozvB-4a73A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akv SORTING NEXIN-33

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		5 ILE A 486
ILE A 485
PHE A 482
ALA A 526
LEU A 527
 None
 0.89A 3ozvB-4akvA:
undetectable		 3ozvB-4akvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 ILE A 149
ALA A 261
LEU A 224
LEU A  57
ALA A  53
 None
 0.97A 3ozvB-4apbA:
undetectable		 3ozvB-4apbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
 None
 1.08A 3ozvB-4edqA:
undetectable		 3ozvB-4edqA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej4 DELTA-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Mus musculus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ILE A1058
ALA A1042
LEU A1046
LEU A1066
ALA A1063
 None
 1.10A 3ozvB-4ej4A:
undetectable		 3ozvB-4ej4A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A 309
ALA A 317
LEU A 314
LEU A 161
ALA A 345
 None
 0.96A 3ozvB-4ewtA:
undetectable		 3ozvB-4ewtA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A 767
TYR A 768
GLN A 807
ALA A 804
LEU A 803
 None
 1.08A 3ozvB-4f4cA:
undetectable		 3ozvB-4f4cA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A  24
PHE A  28
TYR A  29
LEU A 102
ALA A 105
 ECN  A 403 (-4.5A)
ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
ECN  A 403 (-3.8A)
ECN  A 403 ( 4.5A)
 0.40A 3ozvB-4g1bA:
46.5		 3ozvB-4g1bA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkg PHOSPHOPANTETHEINE
ATTACHMENT SITE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF00550
(PP-binding) 		5 ILE A  12
ILE A  11
TYR A   7
LEU A  76
ALA A  73
 None
 0.91A 3ozvB-4hkgA:
undetectable		 3ozvB-4hkgA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ILE A  78
ILE A  99
ALA A  74
LEU A  75
LEU A  64
 None
 1.05A 3ozvB-4hy3A:
undetectable		 3ozvB-4hy3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		6 ILE A 187
ILE A 184
ALA A 230
LEU A 226
LEU A 195
ALA A 192
 None
 1.46A 3ozvB-4hykA:
undetectable		 3ozvB-4hykA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
 None
 1.09A 3ozvB-4ifpA:
undetectable		 3ozvB-4ifpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 5 ILE A 517
ILE A 467
ALA A 382
LEU A 381
ALA A 513
 None
None
None
K  A 912 ( 4.9A)
None
 1.03A 3ozvB-4iruA:
2.0		 3ozvB-4iruA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jl0 REGULATORY PROTEIN
PCRH

(Pseudomonas
aeruginosa) 		PF07720
(TPR_3) 		5 PHE A 108
GLN A  81
ALA A  78
LEU A 143
ALA A 130
 None
 1.06A 3ozvB-4jl0A:
undetectable		 3ozvB-4jl0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 ILE A 517
ILE A 467
ALA A 382
LEU A 381
ALA A 513
 None
 0.89A 3ozvB-4jw1A:
3.2		 3ozvB-4jw1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 ILE A 256
GLN A 320
ALA A 323
LEU A 324
ALA A 297
 None
 1.04A 3ozvB-4kf7A:
undetectable		 3ozvB-4kf7A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 ILE A  65
PHE A  69
ALA A 159
LEU A 160
ALA A 188
 None
 1.01A 3ozvB-4knaA:
2.4		 3ozvB-4knaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 110
ILE A 111
ALA A 215
LEU A 118
ALA A 294
 None
GOL  A 402 ( 4.6A)
None
None
None
 1.00A 3ozvB-4lg4A:
undetectable		 3ozvB-4lg4A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nlm LMO1340 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 ILE A 236
GLN A 225
ALA A 227
LEU A 234
ALA A 261
 None
 1.03A 3ozvB-4nlmA:
undetectable		 3ozvB-4nlmA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqk PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF16739
(CARD_2) 		5 ILE A 123
ILE A 124
LEU A 155
LEU A 171
ALA A 174
 None
 1.07A 3ozvB-4nqkA:
2.3		 3ozvB-4nqkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		6 ILE A 967
ILE A 931
GLN A 994
ALA A 993
LEU A 991
ALA A 963
 None
 1.34A 3ozvB-4r04A:
undetectable		 3ozvB-4r04A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 ILE A 281
ILE A 274
ALA A 244
LEU A 260
ALA A 257
 None
 1.09A 3ozvB-4r7uA:
undetectable		 3ozvB-4r7uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		5 ILE A  84
ILE A  96
ALA A 335
LEU A  88
ALA A  85
 None
 1.10A 3ozvB-4s13A:
undetectable		 3ozvB-4s13A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		5 ILE A1151
ILE A1236
ALA A1270
LEU A1148
ALA A1174
 None
 1.08A 3ozvB-4w4tA:
2.3		 3ozvB-4w4tA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wct FRUCTOSYL
AMINE:OXYGEN
OXIDOREDUCTASE

(Aspergillus
fumigatus) 		PF01266
(DAO) 		5 ILE A  12
ILE A 219
ALA A 387
LEU A 388
ALA A 215
 None
 1.01A 3ozvB-4wctA:
undetectable		 3ozvB-4wctA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrr PUTATIVE
DIACYLGLYCEROL
KINASE

(Bacillus
anthracis) 		PF00781
(DAGK_cat) 		5 ILE A 170
ILE A 239
TYR A 238
LEU A 167
LEU A 196
 None
 1.07A 3ozvB-4wrrA:
undetectable		 3ozvB-4wrrA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		6 ILE A 471
ILE A 484
TYR C 795
LEU A 491
LEU A 480
ALA A 474
 None
 1.32A 3ozvB-5a5tA:
undetectable		 3ozvB-5a5tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A 476
ILE A 475
PHE A 473
LEU A 503
LEU A 469
 None
 0.99A 3ozvB-5brqA:
undetectable		 3ozvB-5brqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1v GLOBIN

(Chloroflexus
aurantiacus) 		PF01152
(Bac_globin) 		5 ILE A  19
PHE A  23
TYR A  24
LEU A  52
ALA A  95
 None
 0.75A 3ozvB-5d1vA:
8.2		 3ozvB-5d1vA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ILE a 125
ILE a 126
ALA a 537
LEU a 539
ALA a 447
 None
 0.96A 3ozvB-5gw5a:
undetectable		 3ozvB-5gw5a:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		5 ILE b 193
ILE b 195
ALA b 380
LEU b 384
LEU b 208
 None
 1.10A 3ozvB-5gw5b:
undetectable		 3ozvB-5gw5b:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ILE A 162
GLN A 366
ALA A 363
LEU A 362
ALA A 163
 None
 1.11A 3ozvB-5h7nA:
undetectable		 3ozvB-5h7nA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ILE A 528
GLN A 732
ALA A 729
LEU A 728
ALA A 529
 None
 1.07A 3ozvB-5hzvA:
undetectable		 3ozvB-5hzvA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 ILE A3828
GLN A4032
ALA A4029
LEU A4028
ALA A3829
 None
 1.08A 3ozvB-5ii5A:
undetectable		 3ozvB-5ii5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		5 ILE A  67
ILE A  68
ALA A 162
LEU A 163
ALA A 191
 None
 1.05A 3ozvB-5izdA:
4.9		 3ozvB-5izdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ILE A 439
ILE A 443
ALA A 417
LEU A 421
ALA A 438
 None
 1.09A 3ozvB-5ldfA:
undetectable		 3ozvB-5ldfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lji FLAVODOXIN

(Streptococcus
pneumoniae) 		PF00258
(Flavodoxin_1) 		5 ILE A  84
ILE A  51
ALA A 139
LEU A 142
ALA A 114
 None
 1.10A 3ozvB-5ljiA:
3.8		 3ozvB-5ljiA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE A 634
ILE A 638
TYR A 666
ALA A 709
LEU A 673
 None
None
EDO  A 808 (-4.2A)
None
None
 1.09A 3ozvB-5lmgA:
undetectable		 3ozvB-5lmgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 ILE A3766
ALA A3477
LEU A3478
LEU A3753
ALA A3752
 None
 1.10A 3ozvB-5nugA:
undetectable		 3ozvB-5nugA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ILE A1058
ALA A1042
LEU A1046
LEU A1066
ALA A1063
 None
 1.00A 3ozvB-5t1aA:
undetectable		 3ozvB-5t1aA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 ILE A 161
GLN A 365
ALA A 362
LEU A 361
ALA A 162
 None
 1.10A 3ozvB-5tj2A:
undetectable		 3ozvB-5tj2A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 ILE A  70
PHE A  73
ALA A 163
LEU A 164
ALA A 192
 None
 0.91A 3ozvB-5u0lA:
4.5		 3ozvB-5u0lA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ILE A 336
ILE A 269
ALA A 192
LEU A 190
LEU A 116
 None
 1.07A 3ozvB-5um2A:
undetectable		 3ozvB-5um2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		5 ILE A 359
ILE A 357
ALA A 331
LEU A 332
LEU A 297
 None
 0.89A 3ozvB-5vc2A:
undetectable		 3ozvB-5vc2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 5 ILE A 280
ILE A 303
PHE A 306
ALA A 271
LEU A 273
 None
 1.06A 3ozvB-5yv5A:
undetectable		 3ozvB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ILE A 110
ILE A 111
ALA A 215
LEU A 118
ALA A 294
 None
 1.06A 3ozvB-6ao5A:
undetectable		 3ozvB-6ao5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arr ACETYL-COA
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		no annotation 5 ILE A  99
ILE A 100
LEU A 393
LEU A 264
ALA A 116
 None
 1.09A 3ozvB-6arrA:
undetectable		 3ozvB-6arrA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft -

(-) 		no annotation 5 ILE A 263
GLN A 239
ALA A 236
LEU A 235
LEU A 324
 None
 1.02A 3ozvB-6dftA:
3.2		 3ozvB-6dftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 5 ILE B  97
ILE B  96
LEU B  27
LEU B 135
ALA B 138
 None
 1.02A 3ozvB-6gplB:
5.8		 3ozvB-6gplB:
undetectable