SIMILAR PATTERNS OF AMINO ACIDS FOR 3OZU_A_X89A411_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		5 ILE A  60
TYR A 121
ALA A 149
HIS A  97
LEU A 134
 None
 0.66A 3ozuA-1ciaA:
undetectable		 3ozuA-1ciaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsl LEGHEMOGLOBIN A

(Glycine max) 		PF00042
(Globin) 		5 PHE A  29
TYR A  30
HIS A  92
ALA A 132
TYR A 133
 NIO  A 145 ( 4.9A)
NIO  A 145 (-4.6A)
HEM  A 144 (-3.4A)
None
HEM  A 144 (-2.9A)
 0.80A 3ozuA-1fslA:
12.2		 3ozuA-1fslA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 ILE A 135
VAL A 114
ALA A 117
TYR A 101
LEU A 102
 None
None
None
EDO  A1713 (-4.8A)
None
 1.21A 3ozuA-1gqjA:
undetectable		 3ozuA-1gqjA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A  28
TYR A  29
LEU A 102
ALA A 123
TYR A 124
 None
None
None
None
HEM  A1398 ( 4.9A)
 0.62A 3ozuA-1gvhA:
35.7		 3ozuA-1gvhA:
45.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 ILE A  46
LEU A 447
VAL A 415
ALA A 293
TYR A 279
 None
None
None
None
GOL  A1007 ( 4.8A)
 1.06A 3ozuA-1itxA:
2.0		 3ozuA-1itxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 ILE A  36
PHE A  11
ALA A  45
LEU A  49
LEU A 216
 None
 1.03A 3ozuA-1mg5A:
5.0		 3ozuA-1mg5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		5 ILE A 146
ALA A 238
LEU A 241
LEU A 252
ALA A 309
 None
 1.23A 3ozuA-1rfvA:
undetectable		 3ozuA-1rfvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		5 ALA A 103
VAL A  36
LEU A  61
TRP A  56
ALA A  23
 None
 1.32A 3ozuA-1rhcA:
undetectable		 3ozuA-1rhcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2n EXTRACELLULAR
SUBTILISIN-LIKE
SERINE PROTEINASE

(Vibrio sp.
PA-44) 		PF00082
(Peptidase_S8) 		5 ALA A 136
LEU A 137
VAL A 141
LEU A 129
ALA A 125
 None
 1.02A 3ozuA-1s2nA:
2.2		 3ozuA-1s2nA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu9 HYPOTHETICAL PROTEIN
PA3967

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A  84
TYR A  89
ALA A  81
LEU A  82
ALA A  46
 HEM  A 301 (-3.9A)
HEM  A 301 (-4.0A)
None
HEM  A 301 (-4.2A)
None
 1.09A 3ozuA-1tu9A:
13.7		 3ozuA-1tu9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT

(Thermus
thermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA B 246
VAL B 251
LEU B 259
ALA B 321
LEU B 205
 None
 1.28A 3ozuA-1umbB:
4.5		 3ozuA-1umbB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE A  78
ALA A 258
LEU A 257
LEU A  71
LEU A  42
 None
 1.04A 3ozuA-1vmaA:
2.6		 3ozuA-1vmaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 ALA A  67
LEU A  78
VAL A  12
LEU A 264
ALA A 271
 None
 1.26A 3ozuA-1wdtA:
undetectable		 3ozuA-1wdtA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x99 LECTIN

(Xerocomellus
chrysenteron) 		PF07367
(FB_lectin) 		5 ILE A   7
TYR A 130
LEU A  46
VAL A  28
TYR A  99
 None
 1.29A 3ozuA-1x99A:
undetectable		 3ozuA-1x99A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE

(Yersinia
enterocolitica) 		PF00102
(Y_phosphatase) 		5 ILE A 414
VAL A 372
LEU A 285
ALA A 329
LEU A 323
 None
 1.07A 3ozuA-1ytsA:
undetectable		 3ozuA-1ytsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 ILE A 185
PHE A 184
LEU A 171
ALA A 102
LEU A 106
 None
 0.92A 3ozuA-2cevA:
4.0		 3ozuA-2cevA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		5 ALA A  67
LEU A  66
VAL A  71
LEU A  39
ALA A  96
 None
 1.22A 3ozuA-2cwfA:
undetectable		 3ozuA-2cwfA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1q LUCIFERIN
4-MONOOXYGENASE

(Luciola
cruciata) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE A 314
LEU A 289
VAL A 242
LEU A 279
ALA A  47
 None
 1.17A 3ozuA-2d1qA:
2.6		 3ozuA-2d1qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		5 ILE A  31
ALA A 161
LEU A 160
LEU A 142
LEU A 151
 None
 1.32A 3ozuA-2fnaA:
undetectable		 3ozuA-2fnaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 317
LEU A 290
VAL A 248
ALA A 207
LEU A 210
 GOL  A   6 (-3.8A)
None
None
None
None
 1.37A 3ozuA-2i6tA:
5.6		 3ozuA-2i6tA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is8 MOLYBDOPTERIN
BIOSYNTHESIS ENZYME,
MOAB

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth) 		5 ILE A  26
LEU A 139
VAL A 142
LEU A  65
ALA A 149
 None
 1.20A 3ozuA-2is8A:
undetectable		 3ozuA-2is8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 601
LEU A 600
LEU A 533
ALA A 570
LEU A 571
 None
 1.26A 3ozuA-2ozoA:
undetectable		 3ozuA-2ozoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pql D7R4 PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		5 ILE A  36
TYR A  94
LEU A  43
ALA A 118
LEU A 115
 None
 1.31A 3ozuA-2pqlA:
undetectable		 3ozuA-2pqlA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A  96
LEU A 112
VAL A 464
HIS A  76
TRP A  13
 None
None
None
ZN  A 501 (-3.4A)
None
 1.20A 3ozuA-2qyvA:
undetectable		 3ozuA-2qyvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrt RIBONUCLEASE E

(Escherichia
coli) 		PF00575
(S1)
PF10150
(RNase_E_G) 		5 ILE A  73
ALA A  55
LEU A  68
VAL A  58
ALA A 203
 None
 1.28A 3ozuA-2vrtA:
2.3		 3ozuA-2vrtA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy4 SINGLE DOMAIN
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF00042
(Globin) 		5 PHE A  27
TYR A  28
LEU A 101
ALA A 122
TYR A 123
 None
CYN  A 151 (-4.7A)
None
None
None
 0.29A 3ozuA-2wy4A:
18.2		 3ozuA-2wy4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		5 ALA A 333
LEU A 336
VAL A 420
LEU A 292
ALA A 404
 None
 1.27A 3ozuA-2z1kA:
undetectable		 3ozuA-2z1kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 114
ALA A 133
LEU A 109
LEU A  69
LEU A 101
 None
 1.22A 3ozuA-2z63A:
undetectable		 3ozuA-2z63A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvb PRECORRIN-3
C17-METHYLTRANSFERAS
E

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 ALA A 134
VAL A 178
LEU A 154
ALA A 196
LEU A 230
 None
 1.29A 3ozuA-2zvbA:
undetectable		 3ozuA-2zvbA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aay PUTATIVE THIOSULFATE
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		5 ALA A 193
VAL A 163
LEU A 246
ALA A 201
LEU A 217
 None
CSO  A 233 ( 4.9A)
None
None
None
 1.15A 3ozuA-3aayA:
3.1		 3ozuA-3aayA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 ILE A 159
PHE A 121
VAL A 128
LEU A 104
ALA A  90
 None
 1.32A 3ozuA-3daqA:
2.1		 3ozuA-3daqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 ILE A 183
LEU A 186
VAL A 135
ALA A 259
LEU A 353
 None
 1.31A 3ozuA-3fdhA:
undetectable		 3ozuA-3fdhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		5 ILE A 146
ALA A 238
LEU A 241
LEU A 252
ALA A 309
 None
 1.24A 3ozuA-3fhxA:
undetectable		 3ozuA-3fhxA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 ILE A  88
LEU A   8
VAL A   6
LEU A 156
ALA A 161
 None
 1.34A 3ozuA-3k53A:
2.7		 3ozuA-3k53A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Yersinia pestis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 PHE A 269
TYR A 271
LEU A  76
VAL A  80
LEU A   4
 None
 1.32A 3ozuA-3mjfA:
2.9		 3ozuA-3mjfA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 LEU A 221
VAL A 117
HIS A  72
ALA A  50
LEU A  54
 None
 1.29A 3ozuA-3nf2A:
undetectable		 3ozuA-3nf2A:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 11 ILE B  25
PHE B  28
TYR B  29
ALA B  56
LEU B  57
VAL B  61
HIS B  85
TRP B 122
ALA B 125
TYR B 126
LEU B 129
 ECN  B 411 (-4.5A)
ECN  B 411 (-4.0A)
None
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
HEM  B 404 (-3.3A)
None
DGG  B 406 ( 3.8A)
HEM  B 404 ( 3.9A)
HEM  B 404 ( 4.3A)
 0.31A 3ozuA-3ozvB:
46.1		 3ozuA-3ozvB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 11 PHE B  28
TYR B  29
ALA B  56
LEU B  57
VAL B  61
HIS B  85
LEU B 102
TRP B 122
ALA B 125
TYR B 126
LEU B 129
 ECN  B 411 (-4.0A)
None
ECN  B 411 (-3.5A)
ECN  B 411 (-4.1A)
DGG  B 406 ( 4.8A)
HEM  B 404 (-3.3A)
ECN  B 411 (-3.2A)
None
DGG  B 406 ( 3.8A)
HEM  B 404 ( 3.9A)
HEM  B 404 ( 4.3A)
 0.24A 3ozuA-3ozvB:
46.1		 3ozuA-3ozvB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyc E3 UBIQUITIN-PROTEIN
LIGASE SMURF1

(Homo sapiens) 		PF00168
(C2) 		5 ILE A 105
LEU A 100
VAL A  98
LEU A  17
ALA A  38
 None
 1.00A 3ozuA-3pycA:
undetectable		 3ozuA-3pycA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdt BOLETUS EDULIS
LECTIN

(Boletus edulis) 		PF07367
(FB_lectin) 		5 ILE A   4
TYR A 127
LEU A  43
VAL A  25
TYR A  96
 None
 1.29A 3ozuA-3qdtA:
undetectable		 3ozuA-3qdtA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		5 ILE A 152
ALA A 117
LEU A 118
VAL A 122
LEU A 142
 None
 1.10A 3ozuA-3rk6A:
undetectable		 3ozuA-3rk6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 5 ILE A  65
LEU A  39
VAL A  42
LEU A  93
TYR A  52
 None
 1.35A 3ozuA-3t8kA:
undetectable		 3ozuA-3t8kA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm9 BACTERIAL HEMOGLOBIN

(Vitreoscilla
stercoraria) 		PF00042
(Globin) 		5 PHE A  28
LEU A 102
TRP A 122
ALA A 125
TYR A 126
 None
None
None
None
HEM  A 201 (-3.5A)
 0.36A 3ozuA-3tm9A:
18.6		 3ozuA-3tm9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 PHE A  28
HIS A  82
LEU A  99
TRP A 119
TYR A 123
 None
HEM  A 201 (-3.2A)
None
None
HEM  A 201 (-4.4A)
 0.64A 3ozuA-3ubcA:
17.6		 3ozuA-3ubcA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 PHE A  28
TYR A  29
HIS A  82
LEU A  99
TYR A 123
 None
None
HEM  A 201 (-3.2A)
None
HEM  A 201 (-4.4A)
 0.71A 3ozuA-3ubcA:
17.6		 3ozuA-3ubcA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		5 ILE A 290
LEU A 287
LEU A 147
ALA A 175
LEU A 178
 None
 1.22A 3ozuA-3v1zA:
undetectable		 3ozuA-3v1zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v57 PHYCOERYTHRIN BETA
SUBUNIT

(Porphyridium
purpureum) 		PF00502
(Phycobilisome) 		5 ALA B  99
LEU B  98
VAL B  41
ALA B  48
LEU B  90
 None
 1.27A 3ozuA-3v57B:
5.7		 3ozuA-3v57B:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		5 PHE A 254
ALA A 215
VAL A 371
LEU A 281
ALA A 335
 None
 1.06A 3ozuA-3vacA:
undetectable		 3ozuA-3vacA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 ALA A 336
VAL A 311
LEU A 321
ALA A 288
LEU A 292
 None
CA0  A 602 (-3.7A)
None
None
None
 1.27A 3ozuA-3vexA:
undetectable		 3ozuA-3vexA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 ILE A 101
PHE A 359
VAL A  64
LEU A 105
LEU A  83
 None
 0.98A 3ozuA-3vzbA:
undetectable		 3ozuA-3vzbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfx HEMOGLOBIN-LIKE
FLAVOPROTEIN FUSED
TO ROADBLOCK/LC7
DOMAIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 HIS A  81
LEU A  98
TRP A 118
ALA A 121
TYR A 122
 HEM  A 201 (-3.3A)
None
None
None
HEM  A 201 ( 4.3A)
 0.96A 3ozuA-3wfxA:
7.3		 3ozuA-3wfxA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		5 ILE A1248
PHE A1153
LEU A1245
VAL A1215
LEU A1171
 None
 1.21A 3ozuA-4a4zA:
undetectable		 3ozuA-4a4zA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 115
ALA A  82
LEU A 137
VAL A 135
ALA A  89
 R4L  A1394 (-4.9A)
R4L  A1394 ( 3.7A)
R4L  A1394 (-3.9A)
None
None
 1.04A 3ozuA-4b99A:
undetectable		 3ozuA-4b99A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		5 ILE A 455
PHE A 427
LEU A 462
VAL A 500
ALA A 508
 None
 0.71A 3ozuA-4c4aA:
4.5		 3ozuA-4c4aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 513
LEU H 511
VAL H 485
LEU H 543
LEU H 492
 None
 1.28A 3ozuA-4c8qH:
undetectable		 3ozuA-4c8qH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ca9 39 KDA FK506-BINDING
NUCLEAR PROTEIN

(Drosophila
melanogaster) 		no annotation 5 ILE A  29
LEU A  87
VAL A  85
ALA A  80
TYR A  78
 None
 1.26A 3ozuA-4ca9A:
undetectable		 3ozuA-4ca9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		5 ALA A 136
LEU A 137
VAL A 141
LEU A 129
ALA A 125
 None
 1.00A 3ozuA-4dztA:
2.1		 3ozuA-4dztA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 ILE A 262
ALA A 100
LEU A 260
LEU A 116
ALA A 142
 None
 1.14A 3ozuA-4effA:
undetectable		 3ozuA-4effA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		5 ILE A 404
ALA A 292
LEU A 291
VAL A 272
LEU A 551
 None
 1.17A 3ozuA-4ep6A:
undetectable		 3ozuA-4ep6A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		no annotation 5 TYR A  76
ALA A  80
LEU A  79
VAL A  84
LEU A  54
 None
 1.00A 3ozuA-4ezgA:
undetectable		 3ozuA-4ezgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 ILE A  11
PHE A 263
LEU A 457
ALA A 373
LEU A 380
 0SF  A 610 (-3.2A)
0SF  A 610 ( 4.1A)
2OB  A 606 (-4.5A)
2OB  A 606 ( 3.8A)
None
 0.99A 3ozuA-4f2aA:
undetectable		 3ozuA-4f2aA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fno PEPTIDYL-TRNA
HYDROLASE

(Pseudomonas
aeruginosa) 		PF01195
(Pept_tRNA_hydro) 		5 ILE A  85
PHE A  83
LEU A   6
VAL A   8
LEU A  40
 None
 0.96A 3ozuA-4fnoA:
undetectable		 3ozuA-4fnoA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ALA A  56
LEU A  57
VAL A  61
TRP A 122
ALA A 125
 ECN  A 403 (-3.8A)
ECN  A 403 (-2.7A)
ECN  A 403 ( 4.7A)
None
None
 0.65A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A  28
TYR A  29
LEU A 102
ALA A 125
TYR A 126
 ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
ECN  A 403 (-3.8A)
None
ECN  A 403 (-4.7A)
 0.52A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g1b FLAVOHEMOGLOBIN

(Saccharomyces
cerevisiae) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 PHE A  28
TYR A  29
TRP A 122
ALA A 125
TYR A 126
 ECN  A 403 (-3.6A)
ECN  A 403 (-4.8A)
None
None
ECN  A 403 (-4.7A)
 0.39A 3ozuA-4g1bA:
34.9		 3ozuA-4g1bA:
37.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9q 4-CARBOXYMUCONOLACTO
NE DECARBOXYLASE

(Sinorhizobium
meliloti) 		PF02627
(CMD) 		5 ALA A 223
LEU A 222
VAL A 218
ALA A 205
LEU A 202
 None
 0.95A 3ozuA-4g9qA:
undetectable		 3ozuA-4g9qA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		5 ILE A 242
PHE A 239
TYR A 238
LEU A 246
HIS A 151
 None
 1.05A 3ozuA-4grxA:
undetectable		 3ozuA-4grxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		5 ILE A 155
TYR A 187
ALA A 261
LEU A 153
LEU A 139
 None
 1.36A 3ozuA-4iv8A:
3.3		 3ozuA-4iv8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD/NADP
TRANSHYDROGENASE
ALPHA SUBUNIT 1

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ALA A  68
VAL A   6
LEU A  27
ALA A 327
LEU A 330
 None
 1.26A 3ozuA-4j16A:
undetectable		 3ozuA-4j16A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 ILE A 873
LEU A 940
VAL A 936
ALA A 887
LEU A 888
 None
 0.96A 3ozuA-4k6jA:
undetectable		 3ozuA-4k6jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 ALA A 266
LEU A 265
VAL A 261
LEU A 205
ALA A 305
 None
 1.31A 3ozuA-4k70A:
undetectable		 3ozuA-4k70A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3f INTERNALIN K

(Listeria
monocytogenes) 		no annotation 5 TYR A  83
ALA A  87
LEU A  86
VAL A  91
LEU A  61
 None
 1.05A 3ozuA-4l3fA:
undetectable		 3ozuA-4l3fA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 ILE A 190
TYR A 160
ALA A 198
ALA A 182
TYR A 177
 None
 1.00A 3ozuA-4lsbA:
2.2		 3ozuA-4lsbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsb LYASE/MUTASE

(Burkholderia
cenocepacia) 		PF13714
(PEP_mutase) 		5 ILE A 190
TYR A 160
ALA A 198
VAL A 203
ALA A 182
 None
 1.32A 3ozuA-4lsbA:
2.2		 3ozuA-4lsbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 ALA A  76
LEU A  87
VAL A  85
LEU A  42
ALA A  82
 None
 1.11A 3ozuA-4oj5A:
undetectable		 3ozuA-4oj5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 ALA A 184
LEU A 183
VAL A 179
ALA A 201
LEU A 172
 None
 1.30A 3ozuA-4ou2A:
4.8		 3ozuA-4ou2A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		5 ILE A 157
TYR A 189
ALA A 263
LEU A 155
LEU A 141
 None
 1.34A 3ozuA-4r6wA:
3.6		 3ozuA-4r6wA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT
PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ALA S 130
VAL S 133
HIS L  36
ALA S  72
LEU S  12
 None
 1.14A 3ozuA-4u9iS:
undetectable		 3ozuA-4u9iS:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT

(Pseudomonas
mendocina) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A 180
LEU A 175
VAL A 163
LEU A 122
ALA A 151
 None
None
FAD  A 402 (-3.3A)
None
None
 1.20A 3ozuA-4wqmA:
12.9		 3ozuA-4wqmA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 ALA A 232
HIS A 113
LEU A 271
ALA A 246
LEU A 252
 NDP  A 401 (-4.0A)
None
None
None
None
 1.03A 3ozuA-4xcvA:
2.7		 3ozuA-4xcvA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxx DTOR_6X35L

(synthetic
construct) 		no annotation 5 ALA A   6
LEU A   3
LEU A 174
ALA A 167
LEU A 185
 None
 1.31A 3ozuA-4yxxA:
undetectable		 3ozuA-4yxxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 LEU A 269
VAL A 125
LEU A 292
ALA A 242
LEU A 245
 None
 1.17A 3ozuA-5ah1A:
undetectable		 3ozuA-5ah1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 ILE A 100
ALA A  67
LEU A  59
VAL A  57
LEU A  72
 None
 1.04A 3ozuA-5c1bA:
2.4		 3ozuA-5c1bA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 ALA E 357
LEU E 354
LEU E 317
ALA E 371
LEU E 383
 None
None
None
None
BQR  E 803 ( 4.3A)
 1.15A 3ozuA-5c4gE:
undetectable		 3ozuA-5c4gE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		5 LEU E 354
VAL E 386
LEU E 317
ALA E 371
LEU E 383
 None
None
None
None
BQR  E 803 ( 4.3A)
 1.30A 3ozuA-5c4gE:
undetectable		 3ozuA-5c4gE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ILE A1479
ALA A1493
LEU A1497
LEU A1408
LEU A1403
 None
 1.02A 3ozuA-5cwvA:
undetectable		 3ozuA-5cwvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		5 ILE A  76
ALA A 138
VAL A 169
ALA A 207
LEU A 212
 None
 1.17A 3ozuA-5exkA:
undetectable		 3ozuA-5exkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 ILE A 708
TYR A 692
LEU A 756
VAL A 763
ALA A 614
 None
 1.29A 3ozuA-5gl7A:
2.6		 3ozuA-5gl7A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ILE B1479
ALA B1493
LEU B1497
LEU B1408
LEU B1403
 None
 1.10A 3ozuA-5hb4B:
undetectable		 3ozuA-5hb4B:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 ILE A 113
ALA A 132
LEU A 108
LEU A  68
LEU A 100
 None
 1.21A 3ozuA-5ijbA:
undetectable		 3ozuA-5ijbA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 PHE A 314
TYR A 313
LEU A 482
ALA A 490
LEU A 391
 None
 1.23A 3ozuA-5j6sA:
undetectable		 3ozuA-5j6sA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei) 		PF00117
(GATase) 		5 ILE A 361
PHE A 329
TYR A 363
LEU A 359
ALA A 560
 None
 1.18A 3ozuA-5n29A:
undetectable		 3ozuA-5n29A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 ALA A 138
LEU A 139
VAL A 143
LEU A 131
ALA A 127
 SO4  A 304 (-3.3A)
None
None
None
None
 1.01A 3ozuA-5wslA:
2.0		 3ozuA-5wslA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4l TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 ILE A 100
ALA A  67
LEU A  59
VAL A  57
LEU A  72
 None
 1.00A 3ozuA-5x4lA:
undetectable		 3ozuA-5x4lA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		5 ALA A 281
LEU A 280
VAL A 285
HIS A 331
ALA A 341
 None
 1.23A 3ozuA-5xgsA:
undetectable		 3ozuA-5xgsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6j NUCLEOPROTEIN

(Tomato spotted
wilt
orthotospovirus) 		PF01533
(Tospo_nucleocap) 		5 ALA A 189
LEU A 190
VAL A 164
ALA A 216
LEU A 219
 None
 1.03A 3ozuA-5y6jA:
2.8		 3ozuA-5y6jA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ILE A 258
TYR A 196
ALA A 286
LEU A 337
ALA A 382
 None
 1.26A 3ozuA-5ydjA:
2.5		 3ozuA-5ydjA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ILE A 258
TYR A 196
ALA A 286
LEU A 337
ALA A 382
 None
 1.22A 3ozuA-6arxA:
undetectable		 3ozuA-6arxA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 TYR A 281
VAL A 129
HIS A 134
ALA A  31
LEU A 117
 FAD  A 501 (-4.8A)
None
None
None
None
 1.02A 3ozuA-6bz0A:
2.1		 3ozuA-6bz0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 5 ILE A 130
LEU A  94
VAL A  96
LEU A 287
LEU A 151
 None
 1.24A 3ozuA-6h20A:
undetectable		 3ozuA-6h20A:
undetectable