SIMILAR PATTERNS OF AMINO ACIDS FOR 3OZK_A_T44A128_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 MET A 339
THR A 312
ALA A  43
SER A 365
VAL A 111
 None
 1.49A 3ozkA-1flcA:
0.1		 3ozkA-1flcA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		7 MET A  13
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
VAL A 121
 None
 0.57A 3ozkA-1gkeA:
22.0		 3ozkA-1gkeA:
82.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		6 MET A  13
LYS A  15
THR A 106
ALA A 108
THR A 119
VAL A 121
 None
 0.73A 3ozkA-1gkeA:
22.0		 3ozkA-1gkeA:
82.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LYS A 496
LEU A 492
THR A 499
ALA A 495
LEU A 322
 None
 1.36A 3ozkA-1gz4A:
undetectable		 3ozkA-1gz4A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN

(Rattus
norvegicus) 		PF06399
(GFRP) 		5 LEU A   4
THR A  75
SER A  68
THR A  70
VAL A  72
 None
 1.07A 3ozkA-1jg5A:
undetectable		 3ozkA-1jg5A:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		7 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
VAL A 121
 None
 0.55A 3ozkA-1sn2A:
20.7		 3ozkA-1sn2A:
53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		8 LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
SER A 117
THR A 119
VAL A 121
 None
 0.60A 3ozkA-1tfpA:
19.8		 3ozkA-1tfpA:
73.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 LYS A 218
ALA A 217
LEU A 221
THR A 154
VAL A  26
 None
 1.41A 3ozkA-1v9pA:
0.2		 3ozkA-1v9pA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		5 THR J 336
ALA J 334
SER J 332
THR J 207
VAL J 205
 None
 0.83A 3ozkA-1wcdJ:
0.1		 3ozkA-1wcdJ:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		5 MET A 161
LEU A  63
ALA A  34
LEU A  45
VAL A  96
 None
 1.48A 3ozkA-1xfgA:
undetectable		 3ozkA-1xfgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 MET A 161
LEU A  63
ALA A  34
LEU A  45
VAL A  96
 None
 1.50A 3ozkA-2j6hA:
undetectable		 3ozkA-2j6hA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 201
ALA A 199
LEU A 203
SER A 207
THR A 205
 None
 1.47A 3ozkA-2jisA:
undetectable		 3ozkA-2jisA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 MET A  14
LEU A  21
ALA A 225
LEU A 227
VAL A 210
 None
 1.26A 3ozkA-2rghA:
undetectable		 3ozkA-2rghA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LYS G1358
THR G1407
SER G1397
THR G1395
VAL G1393
 None
 1.14A 3ozkA-2uv8G:
undetectable		 3ozkA-2uv8G:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2k D-MANDELATE
DEHYDROGENASE

(Rhodotorula
graminis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU B 335
ALA B 107
LEU B 319
SER B 109
VAL B  83
 None
 1.43A 3ozkA-2w2kB:
undetectable		 3ozkA-2w2kB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		5 LEU A 269
THR A 293
ALA A 291
LEU A 289
THR A 386
 None
 1.43A 3ozkA-2wfdA:
undetectable		 3ozkA-2wfdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 THR A 249
ALA A 251
SER A 262
THR A 264
VAL A 266
 None
 1.25A 3ozkA-2yocA:
3.2		 3ozkA-2yocA:
8.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		5 MET A  13
LEU A  17
ALA A 108
LEU A 110
THR A 118
 None
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
None
 1.47A 3ozkA-3fc8A:
24.0		 3ozkA-3fc8A:
99.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		8 MET A  13
LYS A  15
LEU A  17
THR A 106
ALA A 108
LEU A 110
THR A 119
VAL A 121
 None
IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-4.9A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
IFA  A3000 ( 4.9A)
None
 0.56A 3ozkA-3fc8A:
24.0		 3ozkA-3fc8A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		5 LEU A 144
ALA A 175
LEU A 169
SER A 173
THR A 188
 None
 1.39A 3ozkA-3fhcA:
undetectable		 3ozkA-3fhcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LYS A 179
LEU A 175
THR A 209
ALA A 178
LEU A 174
 None
 1.22A 3ozkA-3gd5A:
undetectable		 3ozkA-3gd5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A  34
THR A  38
LEU A  78
SER A  85
THR A  87
 None
 1.32A 3ozkA-3h7lA:
4.6		 3ozkA-3h7lA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oit OS07G0271500 PROTEIN

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 201
LEU A 203
SER A 143
THR A 141
VAL A 139
 None
 1.33A 3ozkA-3oitA:
undetectable		 3ozkA-3oitA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 290
ALA A 286
LEU A 292
THR A 283
VAL A 467
 EDO  A 491 (-4.2A)
None
None
None
None
 1.47A 3ozkA-3peiA:
undetectable		 3ozkA-3peiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd5 PUTATIVE
RIBOSE-5-PHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF02502
(LacAB_rpiB) 		5 MET A  74
ALA A  12
SER A  38
THR A  40
VAL A  42
 None
 0.97A 3ozkA-3qd5A:
undetectable		 3ozkA-3qd5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		5 LEU A 215
THR A 235
ALA A 233
LEU A 231
THR A 115
 None
 1.37A 3ozkA-3shoA:
undetectable		 3ozkA-3shoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex9 ALNA

(Streptomyces
sp. CM020) 		PF04227
(Indigoidine_A) 		5 LEU A 286
ALA A 289
LEU A 285
THR A 122
VAL A  26
 None
 1.43A 3ozkA-4ex9A:
undetectable		 3ozkA-4ex9A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		5 MET A 248
LEU A 319
LEU A 320
THR A 244
VAL A 231
 None
 1.35A 3ozkA-4ghnA:
undetectable		 3ozkA-4ghnA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1

(Homo sapiens) 		PF07686
(V-set) 		5 LEU A 115
LEU A  54
SER A  44
THR A  41
VAL A  39
 None
 1.06A 3ozkA-4gosA:
3.4		 3ozkA-4gosA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpc HEME OXYGENASE

(Corynebacterium
diphtheriae) 		PF01126
(Heme_oxygenase) 		5 LEU A 193
ALA A 197
LEU A 194
SER A  15
THR A 198
 None
 1.46A 3ozkA-4gpcA:
undetectable		 3ozkA-4gpcA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		5 LEU A 267
THR A 158
ALA A 260
LEU A 271
THR A 259
 None
 1.46A 3ozkA-4isaA:
undetectable		 3ozkA-4isaA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzy 40S RIBOSOMAL
PROTEIN S2

(Oryctolagus
cuniculus) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 LEU C  92
THR C 225
ALA C 222
LEU C 218
VAL C 178
 None
 1.43A 3ozkA-4kzyC:
undetectable		 3ozkA-4kzyC:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qd9 THIOESTERASE PA1618

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 LEU A  10
THR A 101
ALA A  39
LEU A  13
VAL A 103
 None
 1.37A 3ozkA-4qd9A:
undetectable		 3ozkA-4qd9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rih GLYCOSYL TRANSFERASE
HOMOLOG,GLYCOSYL
TRANSFERASE

(Streptomyces
cyanogenus;
Streptomyces
fradiae) 		PF06722
(DUF1205) 		5 LYS A 225
LEU A 221
THR A 227
ALA A 224
THR A 248
 None
 1.45A 3ozkA-4rihA:
undetectable		 3ozkA-4rihA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		5 LEU A 793
THR A 842
SER A 833
THR A 837
VAL A 841
 None
 1.30A 3ozkA-4v36A:
undetectable		 3ozkA-4v36A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp2 PUTATIVE MRNA EXPORT
PROTEIN

(Chaetomium
thermophilum) 		PF03943
(TAP_C) 		5 MET A 615
LEU A 624
THR A 613
LEU A 605
VAL A 657
 CAS  A 623 ( 3.6A)
CAS  A 623 ( 4.2A)
None
None
None
 1.39A 3ozkA-4wp2A:
undetectable		 3ozkA-4wp2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 THR A 214
ALA A 216
SER A 202
THR A 204
VAL A 206
 FDA  A 501 ( 4.2A)
None
None
None
None
 1.43A 3ozkA-4x28A:
undetectable		 3ozkA-4x28A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 LEU A 176
ALA A 174
SER A 157
THR A 153
VAL A 151
 None
 1.45A 3ozkA-5g4lA:
undetectable		 3ozkA-5g4lA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 LEU B 125
THR B  87
ALA B 121
LEU B 127
THR B 118
 None
LLP  B  86 ( 4.4A)
None
None
None
 1.20A 3ozkA-5kzmB:
undetectable		 3ozkA-5kzmB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Aggregatibacter
actinomycetemcomitans) 		no annotation 5 LEU A 448
THR A 362
ALA A 364
LEU A 366
SER A 350
 None
 1.31A 3ozkA-5lj6A:
undetectable		 3ozkA-5lj6A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 LEU O  83
THR O 174
LEU O  86
SER O  95
THR O 136
 None
 1.44A 3ozkA-5mpdO:
undetectable		 3ozkA-5mpdO:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 5 LEU D 148
THR D 100
SER D  33
THR D  29
VAL D  27
 None
 1.49A 3ozkA-5n03D:
undetectable		 3ozkA-5n03D:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET A1009
THR A1012
ALA A1196
LEU A1135
VAL A1192
 None
 1.34A 3ozkA-5weoA:
undetectable		 3ozkA-5weoA:
9.97