SIMILAR PATTERNS OF AMINO ACIDS FOR 3OYA_A_RLTA398

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 ASP A 105
GLN A 154
PRO A 134
GLU A  94
 None
 0.89A 3oyaA-1bs9A:
undetectable		 3oyaA-1bs9A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 ASP A 337
PRO A 376
TYR A 364
GLN A 373
 None
 1.11A 3oyaA-1dj3A:
undetectable		 3oyaA-1dj3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5v SURVIVAL MOTOR
NEURON PROTEIN 1

(Homo sapiens) 		PF06003
(SMN) 		4 PRO A 110
TYR A 109
GLN A 136
GLU A 134
 None
 1.13A 3oyaA-1g5vA:
5.1		 3oyaA-1g5vA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		4 ASP A 120
GLN A 121
PRO A 116
GLU A 117
 None
 0.86A 3oyaA-1iufA:
undetectable		 3oyaA-1iufA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 PRO A 564
PRO A 566
GLN A 569
GLU A 568
 None
 1.05A 3oyaA-1l0wA:
undetectable		 3oyaA-1l0wA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 ASP A 259
PRO A 261
PRO A 286
GLU A 284
 None
 1.11A 3oyaA-1oznA:
0.0		 3oyaA-1oznA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 216
ASP A 248
PRO A 253
GLU A 119
 CA  A 909 ( 2.6A)
CA  A 908 ( 3.1A)
None
CA  A 909 ( 3.2A)
 0.31A 3oyaA-1q5aA:
undetectable		 3oyaA-1q5aA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 216
ASP A 248
PRO A 253
GLU A 182
 CA  A 909 ( 2.6A)
CA  A 908 ( 3.1A)
None
CA  A 909 ( 2.5A)
 0.21A 3oyaA-1q5aA:
undetectable		 3oyaA-1q5aA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ASP A 435
ASP A 463
PRO A 466
GLU A 397
 CA  A 913 ( 2.3A)
CA  A 914 ( 3.4A)
None
CA  A 916 ( 1.9A)
 0.89A 3oyaA-1q5aA:
undetectable		 3oyaA-1q5aA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9k NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 2

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 GLN C 669
PRO C 670
TYR C 659
GLN C 583
 None
 1.03A 3oyaA-1s9kC:
undetectable		 3oyaA-1s9kC:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 113
PRO A 111
GLN A  50
GLU A 110
 None
 1.10A 3oyaA-1spjA:
undetectable		 3oyaA-1spjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 GLN A 259
PRO A 125
TYR A 161
PRO A 159
 None
 1.13A 3oyaA-1tklA:
0.0		 3oyaA-1tklA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 ASP A 186
ASP A 185
PRO A 184
GLN A 192
 None
 1.13A 3oyaA-1ua7A:
undetectable		 3oyaA-1ua7A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxa AFADIN

(Mus musculus) 		PF00788
(RA) 		4 PRO A  24
TYR A  25
GLN A 104
GLU A  73
 None
 1.00A 3oyaA-1wxaA:
undetectable		 3oyaA-1wxaA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ASP A 476
PRO A 479
GLN A 393
GLU A 394
 None
 0.98A 3oyaA-1y4uA:
undetectable		 3oyaA-1y4uA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		4 GLN 1  63
TYR 1 484
GLN 1 432
GLU 1 431
 None
 0.98A 3oyaA-1y791:
undetectable		 3oyaA-1y791:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 GLN A  23
PRO A  24
TYR A 113
PRO A 115
 None
 1.11A 3oyaA-2c2qA:
undetectable		 3oyaA-2c2qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckk KIN17

(Homo sapiens) 		no annotation 4 ASP A 122
GLN A  16
TYR A  13
GLU A 121
 None
 1.11A 3oyaA-2ckkA:
4.4		 3oyaA-2ckkA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8k SYNAPTOTAGMIN VII

(Homo sapiens) 		PF00168
(C2) 		4 ASP A 103
ASP A 109
PRO A 110
GLN A  98
 None
 1.13A 3oyaA-2d8kA:
undetectable		 3oyaA-2d8kA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8k SYNAPTOTAGMIN VII

(Homo sapiens) 		PF00168
(C2) 		4 ASP A 103
ASP A 109
PRO A 138
GLN A  98
 None
 0.79A 3oyaA-2d8kA:
undetectable		 3oyaA-2d8kA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 PRO A 182
PRO A 187
GLN A 190
GLU A 189
 None
 1.05A 3oyaA-2de2A:
undetectable		 3oyaA-2de2A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ASP A  48
PRO A  50
PRO A  46
GLU A  45
 None
 1.05A 3oyaA-2f9gA:
undetectable		 3oyaA-2f9gA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ASP A 487
PRO A 188
TYR A 187
GLU A 489
 None
 1.14A 3oyaA-2g3nA:
2.0		 3oyaA-2g3nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7i COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		4 ASP A1220
PRO A1166
TYR A1142
GLU A1145
 None
 1.10A 3oyaA-2g7iA:
undetectable		 3oyaA-2g7iA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 ASP A 295
GLN A 462
GLN A 236
GLU A 335
 None
 1.10A 3oyaA-2gmhA:
undetectable		 3oyaA-2gmhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 ASP A 476
PRO A 479
GLN A 393
GLU A 394
 None
 0.90A 3oyaA-2gq0A:
undetectable		 3oyaA-2gq0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		4 ASP A 254
PRO A 222
TYR A 183
PRO A 185
 None
 1.11A 3oyaA-2gryA:
undetectable		 3oyaA-2gryA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu9 TETRACENOMYCIN
POLYKETIDE SYNTHESIS
PROTEIN

(Xanthomonas
campestris) 		PF07883
(Cupin_2) 		4 ASP A  45
TYR A  96
PRO A  98
GLN A  20
 None
 1.15A 3oyaA-2gu9A:
undetectable		 3oyaA-2gu9A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 PRO A  48
PRO A  50
GLN A  53
GLU A  52
 None
 1.13A 3oyaA-2jfwA:
2.5		 3oyaA-2jfwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6r FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 ASP A  49
PRO A  46
TYR A  47
GLN A  82
 None
 0.96A 3oyaA-2m6rA:
undetectable		 3oyaA-2m6rA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 ASP A 270
GLN A 225
PRO A 264
GLN A 262
 None
 1.14A 3oyaA-2om5A:
undetectable		 3oyaA-2om5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 PRO A 165
PRO A 135
GLN A 144
GLU A 139
 None
 1.11A 3oyaA-2vxyA:
undetectable		 3oyaA-2vxyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjr PROBABLE
N-ACETYLNEURAMINIC
ACID OUTER MEMBRANE
CHANNEL PROTEIN NANC

(Escherichia
coli) 		PF06178
(KdgM) 		4 ASP A 188
TYR A 133
GLN A 174
GLU A 186
 None
 1.11A 3oyaA-2wjrA:
undetectable		 3oyaA-2wjrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ASP A 421
GLN A 422
TYR A 258
PRO A 235
 None
 0.96A 3oyaA-3a24A:
undetectable		 3oyaA-3a24A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 ASP A 274
GLN A 193
PRO A 192
TYR A 191
 None
 1.10A 3oyaA-3aqiA:
undetectable		 3oyaA-3aqiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		4 ASP A1563
GLN A1559
PRO A1583
GLN A1160
 None
 1.08A 3oyaA-3av6A:
2.4		 3oyaA-3av6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 ASP A 459
GLN A 458
PRO A 462
GLN A   3
 None
 0.94A 3oyaA-3c8vA:
undetectable		 3oyaA-3c8vA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 PRO A 121
TYR A 296
PRO A 125
GLN A  39
 None
 1.09A 3oyaA-3ctzA:
2.8		 3oyaA-3ctzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 141
PRO A 135
GLN A 145
GLU A 144
 None
 1.08A 3oyaA-3ddrA:
undetectable		 3oyaA-3ddrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		4 GLN A 234
PRO A 101
TYR A 136
PRO A 134
 None
 1.05A 3oyaA-3e8jA:
undetectable		 3oyaA-3e8jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF01359
(Transposase_1) 		5 ASP A  38
ASP A 130
PRO A 156
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
None
 0.69A 3oyaA-3f2kA:
9.5		 3oyaA-3f2kA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		4 ASP A 367
ASP A 368
GLN A  73
GLU A  72
 None
 0.99A 3oyaA-3h1tA:
undetectable		 3oyaA-3h1tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ASP A  65
ASP A 122
PRO A 148
TYR A 149
 None
 0.92A 3oyaA-3jcaA:
11.3		 3oyaA-3jcaA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 ASP A 657
GLN A 621
TYR A 623
GLN A 629
 None
None
U  B   9 ( 4.5A)
A  B   8 ( 3.1A)
 1.14A 3oyaA-3k49A:
undetectable		 3oyaA-3k49A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9v PUTATIVE
THIOL-DISULFIDE
ISOMERASE OR
THIOREDOXIN

(Salmonella
enterica) 		PF01323
(DSBA) 		4 ASP A  40
PRO A  28
PRO A 148
GLU A  21
 None
PE8  A   1 (-4.2A)
None
None
 0.99A 3oyaA-3l9vA:
undetectable		 3oyaA-3l9vA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv0 NUCLEAR RNA EXPORT
FACTOR 2

(Caenorhabditis
elegans) 		no annotation 4 ASP A 342
PRO A 344
PRO A 311
GLN A 233
 NA  A 460 (-4.0A)
EDO  A1003 (-3.7A)
None
None
 1.10A 3oyaA-3nv0A:
undetectable		 3oyaA-3nv0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN

(Homo sapiens) 		PF13927
(Ig_3) 		4 ASP B  58
ASP B  56
GLN B  55
GLU B  60
 None
None
NAG  B 338 (-4.3A)
None
 1.03A 3oyaA-3o4oB:
undetectable		 3oyaA-3o4oB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 ASP A 544
GLN A 568
PRO A 534
GLN A 563
 None
ADP  A3001 (-4.0A)
None
None
 1.10A 3oyaA-3o98A:
2.3		 3oyaA-3o98A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omd UNCHARACTERIZED
PROTEIN

(Leptospirillum
rubarum) 		PF16798
(DUF5069) 		4 ASP A  72
GLN A  71
PRO A  68
GLN A  -1
 None
 1.11A 3oyaA-3omdA:
undetectable		 3oyaA-3omdA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oyn PFV INTEGRASE

(Simian foamy
virus) 		PF00665
(rve) 		8 ASP A 128
ASP A 185
GLN A 186
PRO A 211
TYR A 212
PRO A 214
GLN A 215
GLU A 221
 MG  A 396 (-2.6A)
MG  A 396 ( 2.7A)
None
None
ZZX  A 398 ( 4.0A)
ZZX  A 398 (-4.1A)
ZZX  A 398 (-3.9A)
MG  A 397 ( 1.8A)
 0.46A 3oyaA-3oynA:
44.9		 3oyaA-3oynA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkm CAS6 PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		4 PRO A 156
TYR A 153
GLN A 206
GLU A 232
 None
 1.07A 3oyaA-3pkmA:
undetectable		 3oyaA-3pkmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ASP A 686
ASP A 764
PRO A 766
PRO A 763
 None
 1.12A 3oyaA-3s4dA:
undetectable		 3oyaA-3s4dA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sw0 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		4 ASP X1220
PRO X1166
TYR X1142
GLU X1145
 None
 1.02A 3oyaA-3sw0X:
undetectable		 3oyaA-3sw0X:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1x PUTATIVE GLYCOSYL
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		4 ASP A 143
GLN A 114
PRO A 148
GLN A 162
 None
None
None
PGE  A 260 (-4.2A)
 1.10A 3oyaA-3u1xA:
undetectable		 3oyaA-3u1xA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 ASP A 597
TYR A 626
PRO A 601
GLN A 602
 None
 1.08A 3oyaA-3vmnA:
2.6		 3oyaA-3vmnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 ASP A 240
PRO A 244
PRO A 238
GLU A 237
 None
 1.06A 3oyaA-3zgjA:
undetectable		 3oyaA-3zgjA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 TYR A 216
PRO A 215
GLN A 269
GLU A 265
 None
 1.01A 3oyaA-4e8dA:
undetectable		 3oyaA-4e8dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eis POLYSACCHARIDE
MONOOXYGENASE-3

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		4 GLN B 169
PRO B  41
PRO B 172
GLU B 155
 HIC  B   1 ( 4.3A)
HIC  B   1 ( 4.6A)
None
None
 1.04A 3oyaA-4eisB:
undetectable		 3oyaA-4eisB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 ASP A 160
PRO A 163
GLN A  57
GLU A  54
 None
 1.11A 3oyaA-4gfjA:
undetectable		 3oyaA-4gfjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		4 ASP A 115
GLN A 112
PRO A 272
GLU A 118
 None
 1.11A 3oyaA-4haoA:
undetectable		 3oyaA-4haoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrr THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Legionella
pneumophila) 		PF01323
(DSBA) 		4 GLN A 128
PRO A  67
PRO A 184
GLU A  60
 None
 0.98A 3oyaA-4jrrA:
undetectable		 3oyaA-4jrrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 179
PRO A 166
GLN A 169
GLU A 167
 None
 1.12A 3oyaA-4jsoA:
undetectable		 3oyaA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6x DISULFIDE
OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF13462
(Thioredoxin_4) 		4 PRO A 215
PRO A  90
GLN A 162
GLU A 165
 None
EPE  A 301 (-3.5A)
None
None
 1.03A 3oyaA-4k6xA:
undetectable		 3oyaA-4k6xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)

(Candida
albicans) 		PF01965
(DJ-1_PfpI) 		4 ASP A 127
ASP A 147
PRO A 153
GLN A 119
 None
 1.00A 3oyaA-4lruA:
undetectable		 3oyaA-4lruA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		4 GLN A 238
PRO A 112
TYR A 113
GLN A 329
 None
 1.05A 3oyaA-4n91A:
undetectable		 3oyaA-4n91A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN

(Streptococcus
pyogenes) 		PF16364
(Antigen_C) 		4 ASP A1108
ASP A1006
GLN A 975
TYR A1139
 None
 1.14A 3oyaA-4ofqA:
undetectable		 3oyaA-4ofqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		4 GLN A 184
PRO A 364
GLN A 356
GLU A 365
 None
 1.04A 3oyaA-4oo3A:
undetectable		 3oyaA-4oo3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3y THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Acinetobacter
baumannii) 		PF01323
(DSBA) 		4 GLN B  96
PRO B  35
PRO B 151
GLU B  28
 None
 1.12A 3oyaA-4p3yB:
undetectable		 3oyaA-4p3yB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		4 ASP A 238
PRO A 298
TYR A 299
PRO A 233
 None
 1.15A 3oyaA-4q6tA:
undetectable		 3oyaA-4q6tA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r71 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		4 ASP E  34
PRO E  49
GLN E  52
GLU E  51
 None
 1.15A 3oyaA-4r71E:
undetectable		 3oyaA-4r71E:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN B CHAIN
GLOBIN C CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 PRO C  86
PRO B  58
GLN B  61
GLU B  59
 None
 1.03A 3oyaA-4u8uC:
undetectable		 3oyaA-4u8uC:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wa8 FLAP ENDONUCLEASE 1

(Methanopyrus
kandleri) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ASP A 172
ASP A 170
GLN A 169
TYR A  34
 None
 1.14A 3oyaA-4wa8A:
undetectable		 3oyaA-4wa8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 ASP A 136
ASP A 134
GLN A  91
GLU A 139
 None
None
CIT  A 602 ( 3.3A)
None
 1.14A 3oyaA-4wbdA:
undetectable		 3oyaA-4wbdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		4 ASP A 118
PRO A 176
PRO A 121
GLN A 126
 None
 1.13A 3oyaA-4xscA:
undetectable		 3oyaA-4xscA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbg ACETYLTRANSFERASE

(Brucella
abortus) 		PF13527
(Acetyltransf_9) 		4 GLN A  88
PRO A  85
GLN A  56
GLU A  53
 ACO  A 201 (-3.6A)
None
None
None
 0.93A 3oyaA-4zbgA:
undetectable		 3oyaA-4zbgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X

(synthetic
construct) 		PF01498
(HTH_Tnp_Tc3_2)
PF13358
(DDE_3) 		4 ASP A  43
ASP A 134
PRO A 163
GLU A 169
 GOL  A 317 (-4.2A)
SO4  A 309 ( 3.9A)
GOL  A 317 (-3.8A)
GOL  A 317 (-4.0A)
 0.67A 3oyaA-5cr4A:
11.1		 3oyaA-5cr4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djo KINESIN-LIKE PROTEIN

(Mus musculus) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		4 ASP A  90
GLN A  96
PRO A 104
GLN A 103
 None
 1.13A 3oyaA-5djoA:
undetectable		 3oyaA-5djoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 ASP B 969
GLN B 968
GLN B 907
GLU B 904
 None
 1.03A 3oyaA-5dlqB:
undetectable		 3oyaA-5dlqB:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejk GAG-PRO-POL
POLYPROTEIN

(Rous sarcoma
virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ASP A  64
ASP A 121
PRO A 147
GLU A 157
 None
 0.52A 3oyaA-5ejkA:
19.1		 3oyaA-5ejkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 GLN A 242
PRO A 109
TYR A 144
PRO A 142
 None
 1.05A 3oyaA-5eo6A:
undetectable		 3oyaA-5eo6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
 1.12A 3oyaA-5erpA:
undetectable		 3oyaA-5erpA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8r PROTOCADHERIN
GAMMA-B3

(Homo sapiens) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 ASP A 131
ASP A  95
GLN A  94
PRO A   8
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
None
CA  A 503 ( 2.3A)
 1.49A 3oyaA-5k8rA:
undetectable		 3oyaA-5k8rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		4 GLN D 266
PRO D 286
GLN D 306
GLU D 303
 None
 1.13A 3oyaA-5lc5D:
undetectable		 3oyaA-5lc5D:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 ASP A  45
GLN A 200
PRO A 242
PRO A 244
 None
 1.06A 3oyaA-5lunA:
undetectable		 3oyaA-5lunA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0q INTEGRASE

(Visna-maedi
virus) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		4 ASP A  66
ASP A 118
PRO A 144
GLU A 154
 None
 0.89A 3oyaA-5m0qA:
17.4		 3oyaA-5m0qA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 410
PRO A 417
TYR A 419
PRO A 422
 None
 1.15A 3oyaA-5mewA:
undetectable		 3oyaA-5mewA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2x GLYCOSIDE HYDROLASE
FAMILY 61

(Trichoderma
reesei) 		PF03443
(Glyco_hydro_61) 		4 GLN A 172
PRO A 175
GLN A 176
GLU A 158
 SO4  A 319 (-3.3A)
None
None
None
 1.15A 3oyaA-5o2xA:
undetectable		 3oyaA-5o2xA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 ASP A 131
ASP A  95
GLN A  94
PRO A   8
GLU A  63
 CA  A 603 ( 3.5A)
CA  A 602 (-3.4A)
None
None
CA  A 602 ( 2.4A)
 1.50A 3oyaA-5t9tA:
undetectable		 3oyaA-5t9tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 PRO A  33
PRO A  30
GLN A  23
GLU A  29
 None
 1.09A 3oyaA-5tu4A:
undetectable		 3oyaA-5tu4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1c HIV-1 INTEGRASE,
SSO7D CHIMERA

(Human
immunodeficiency
virus 1;
Sulfolobus
solfataricus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		6 ASP A  64
ASP A 116
PRO A 142
TYR A 143
PRO A 145
GLN A 146
 MG  A 501 (-1.8A)
MG  A 501 (-2.8A)
None
None
None
None
 0.78A 3oyaA-5u1cA:
18.0		 3oyaA-5u1cA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM

(Brucella
abortus) 		PF04069
(OpuAC) 		4 ASP A 234
GLN A 239
PRO A 240
GLN A 243
 None
 1.13A 3oyaA-5uveA:
undetectable		 3oyaA-5uveA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4

(Homo sapiens) 		no annotation 4 ASP I 140
PRO I 104
GLN I 109
GLU I 108
 None
 1.15A 3oyaA-5vfrI:
undetectable		 3oyaA-5vfrI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE

(Escherichia
coli) 		no annotation 4 GLN C  40
PRO C 499
PRO C 496
GLN C 492
 None
 1.08A 3oyaA-5wqlC:
undetectable		 3oyaA-5wqlC:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsz LPMO10A

(Bacillus
thuringiensis) 		PF03067
(LPMO_10) 		4 PRO A  24
TYR A  27
PRO A  29
GLN A  30
 None
 1.15A 3oyaA-5wszA:
undetectable		 3oyaA-5wszA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		4 GLN C  92
PRO C  59
GLN C 171
GLU C  60
 None
 1.08A 3oyaA-5xbpC:
undetectable		 3oyaA-5xbpC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydn GENE PRODUCT J

(Escherichia
virus Mu) 		no annotation 4 ASP A  33
PRO A  24
PRO A  31
GLN A  30
 None
 0.90A 3oyaA-5ydnA:
undetectable		 3oyaA-5ydnA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 ASP A 472
GLN A 489
PRO A 490
GLU A 469
 CA  A 704 (-3.1A)
None
None
CA  A 704 (-2.5A)
 0.87A 3oyaA-6bdzA:
undetectable		 3oyaA-6bdzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 GLN A 312
PRO A 310
GLN A 522
GLU A 520
 None
 1.04A 3oyaA-6cddA:
undetectable		 3oyaA-6cddA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgb CADHERIN-11,
CADHERIN-6 CHIMERA

(Mus musculus) 		no annotation 4 ASP A 134
ASP A  98
GLN A  97
GLU A  66
 CA  A 303 ( 3.3A)
CA  A 301 (-3.2A)
None
CA  A 301 ( 2.3A)
 1.11A 3oyaA-6cgbA:
undetectable		 3oyaA-6cgbA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 4 ASP A 439
ASP A 442
GLN A 444
GLN A 392
 None
 1.15A 3oyaA-6ftlA:
undetectable		 3oyaA-6ftlA:
11.92