SIMILAR PATTERNS OF AMINO ACIDS FOR 3OXC_A_ROCA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		3 ARG A  20
LEU A  24
THR A  79
 SO4  A 202 (-2.8A)
None
None
 0.69A 3oxcA-1b5lA:
undetectable		 3oxcA-1b5lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		3 ARG A 363
LEU A 318
THR A 230
 None
 0.79A 3oxcA-1cj0A:
undetectable		 3oxcA-1cj0A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		3 ARG A  95
LEU A  99
THR A 120
 None
SO4  A 801 ( 4.9A)
None
 0.85A 3oxcA-1dk5A:
undetectable		 3oxcA-1dk5A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ARG A 409
LEU A 311
THR A 398
 None
 0.64A 3oxcA-1g0dA:
undetectable		 3oxcA-1g0dA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		3 ARG A 344
LEU A 346
THR A 205
 None
 0.83A 3oxcA-1hjvA:
undetectable		 3oxcA-1hjvA:
13.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
None
 0.56A 3oxcA-1hvcA:
14.1		 3oxcA-1hvcA:
46.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
None
 0.60A 3oxcA-1hvcA:
14.1		 3oxcA-1hvcA:
46.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 ARG A 339
LEU A 350
THR A 359
 None
 0.81A 3oxcA-1mpxA:
0.1		 3oxcA-1mpxA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ARG A 730
LEU A 732
THR A 753
 None
 0.88A 3oxcA-1ogyA:
undetectable		 3oxcA-1ogyA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 ARG A 368
LEU A 378
THR A 419
 None
 0.80A 3oxcA-1piiA:
undetectable		 3oxcA-1piiA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 578
LEU A 549
THR A 611
 None
 0.91A 3oxcA-1qvrA:
0.0		 3oxcA-1qvrA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 ARG A 369
LEU A 380
THR A 389
 None
 0.66A 3oxcA-1ryyA:
0.0		 3oxcA-1ryyA:
8.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 None
 0.61A 3oxcA-1sivA:
17.7		 3oxcA-1sivA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ss4 GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF13669
(Glyoxalase_4) 		3 ARG A 129
LEU A 147
THR A  99
 None
 0.84A 3oxcA-1ss4A:
undetectable		 3oxcA-1ss4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufv PANTOATE-BETA-ALANIN
E LIGASE

(Thermus
thermophilus) 		PF02569
(Pantoate_ligase) 		3 ARG A  72
LEU A  76
THR A  24
 None
None
GOL  A1300 (-4.4A)
 0.91A 3oxcA-1ufvA:
undetectable		 3oxcA-1ufvA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmg NETRIN RECEPTOR
UNC5H2

(Mus musculus) 		PF00531
(Death) 		3 ARG A 881
LEU A 893
THR A 898
 None
 0.74A 3oxcA-1wmgA:
undetectable		 3oxcA-1wmgA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 ARG A 267
LEU A  91
THR A  96
 None
 0.89A 3oxcA-1ycnA:
undetectable		 3oxcA-1ycnA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu5 CONSERVED
HYPOTHETICAL PROTEIN
TT1486

(Thermus
thermophilus) 		PF01894
(UPF0047) 		3 ARG A 122
LEU A 113
THR A  90
 None
 0.72A 3oxcA-2cu5A:
undetectable		 3oxcA-2cu5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		3 ARG A 181
LEU A 240
THR A 245
 None
 0.87A 3oxcA-2felA:
undetectable		 3oxcA-2felA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fez PROBABLE REGULATORY
PROTEIN EMBR

(Mycobacterium
tuberculosis) 		PF00486
(Trans_reg_C)
PF00498
(FHA)
PF03704
(BTAD) 		3 ARG A 327
LEU A 313
THR A  57
 None
 0.65A 3oxcA-2fezA:
undetectable		 3oxcA-2fezA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Pyrococcus
abyssi) 		PF00814
(Peptidase_M22) 		3 ARG A 261
LEU A 250
THR A 115
 None
 0.79A 3oxcA-2ivpA:
undetectable		 3oxcA-2ivpA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		3 ARG A 372
LEU A 382
THR A 458
 None
 0.77A 3oxcA-2ja2A:
undetectable		 3oxcA-2ja2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kua BCL-2-LIKE PROTEIN
10

(Mus musculus) 		PF00452
(Bcl-2) 		3 ARG A 113
LEU A 115
THR A  29
 None
 0.78A 3oxcA-2kuaA:
undetectable		 3oxcA-2kuaA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ky4 PHYCOBILISOME LINKER
POLYPEPTIDE

(Nostoc sp. PCC
7120) 		PF00427
(PBS_linker_poly) 		3 ARG A  30
LEU A  67
THR A  74
 None
 0.71A 3oxcA-2ky4A:
undetectable		 3oxcA-2ky4A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n2n TARGET OF MYB
PROTEIN 1

(Homo sapiens) 		PF03127
(GAT) 		3 ARG A 305
LEU A 238
THR A 309
 None
 0.73A 3oxcA-2n2nA:
undetectable		 3oxcA-2n2nA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 ARG A 441
LEU A 297
THR A 285
 None
 0.88A 3oxcA-2ocaA:
undetectable		 3oxcA-2ocaA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ARG A 189
LEU A 194
THR A 200
 None
 0.81A 3oxcA-2on5A:
undetectable		 3oxcA-2on5A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		3 ARG A 533
LEU A 539
THR A 548
 None
 0.85A 3oxcA-2r6fA:
undetectable		 3oxcA-2r6fA:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 AB1  A 501 ( 4.7A)
None
None
 0.51A 3oxcA-2rkfA:
20.2		 3oxcA-2rkfA:
82.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		3 ARG A  59
LEU A  38
THR A 328
 None
 0.89A 3oxcA-2vhhA:
undetectable		 3oxcA-2vhhA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmx SERINE
HYDROXYMETHYLTRANSFE
RASE

(Geobacillus
stearothermophilus) 		PF00464
(SHMT) 		3 ARG A 357
LEU A 312
THR A 227
 ALO  A 502 (-3.0A)
None
None
 0.77A 3oxcA-2vmxA:
undetectable		 3oxcA-2vmxA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 ARG B 245
LEU B 215
THR B 299
 None
 0.64A 3oxcA-2y7cB:
undetectable		 3oxcA-2y7cB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A 383
LEU A 384
THR A 318
 None
None
NAG  A 801 (-3.5A)
 0.85A 3oxcA-2yp2A:
undetectable		 3oxcA-2yp2A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		3 ARG A 353
LEU A 161
THR A 173
 None
 0.68A 3oxcA-2yxlA:
undetectable		 3oxcA-2yxlA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A  64
LEU A   8
THR A 360
 None
 0.87A 3oxcA-2zc8A:
undetectable		 3oxcA-2zc8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 ARG A 273
LEU A 246
THR A 253
 None
 0.80A 3oxcA-3a8kA:
undetectable		 3oxcA-3a8kA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 3 ARG C 332
LEU C 405
THR C 217
 None
 0.72A 3oxcA-3amjC:
undetectable		 3oxcA-3amjC:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		3 ARG B 181
LEU B 184
THR B 177
 None
 0.81A 3oxcA-3bg0B:
undetectable		 3oxcA-3bg0B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk5 PUTATIVE OUTER
MEMBRANE
LIPOPROTEIN-SORTING
PROTEIN

(Vibrio
parahaemolyticus) 		PF17131
(LolA_like) 		3 ARG A 194
LEU A 216
THR A 220
 None
 0.86A 3oxcA-3bk5A:
undetectable		 3oxcA-3bk5A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brx ANNEXIN

(Gossypium
hirsutum) 		PF00191
(Annexin) 		3 ARG A 271
LEU A  96
THR A 105
 None
 0.76A 3oxcA-3brxA:
undetectable		 3oxcA-3brxA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		3 ARG A 106
LEU A  84
THR A  92
 None
 0.89A 3oxcA-3cknA:
undetectable		 3oxcA-3cknA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhg N-GLYCOSYLASE/DNA
LYASE

(Sulfolobus
solfataricus) 		PF00730
(HhH-GPD) 		3 ARG A  18
LEU A 195
THR A 202
 None
 0.80A 3oxcA-3fhgA:
undetectable		 3oxcA-3fhgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 ARG A  61
LEU A  31
THR A 252
 None
 0.67A 3oxcA-3hbjA:
undetectable		 3oxcA-3hbjA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3C

(Saccharomyces
cerevisiae) 		PF00203
(Ribosomal_S19) 		3 ARG p 716
LEU p 627
THR p 724
 None
 0.91A 3oxcA-3japp:
undetectable		 3oxcA-3japp:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		3 ARG A1182
LEU A1185
THR A1178
 None
 0.70A 3oxcA-3jroA:
undetectable		 3oxcA-3jroA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		3 ARG A  81
LEU A 292
THR A 329
 ACR  A 405 (-3.0A)
None
None
 0.79A 3oxcA-3jzjA:
undetectable		 3oxcA-3jzjA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		3 ARG A 262
LEU A 263
THR A 255
 None
 0.81A 3oxcA-3k9yA:
undetectable		 3oxcA-3k9yA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		3 ARG A 156
LEU A 115
THR A  33
 None
 0.84A 3oxcA-3lhlA:
undetectable		 3oxcA-3lhlA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1c ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
2) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 ARG A 527
LEU A 640
THR A 551
 None
 0.70A 3oxcA-3m1cA:
undetectable		 3oxcA-3m1cA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1x INTERLEUKIN
ENHANCER-BINDING
FACTOR 3

(Homo sapiens) 		PF00035
(dsrm) 		3 ARG A 536
LEU A 532
THR A 592
 None
 0.91A 3oxcA-3p1xA:
undetectable		 3oxcA-3p1xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ARG A 471
LEU A  77
THR A  23
 None
 0.76A 3oxcA-3ptkA:
undetectable		 3oxcA-3ptkA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 118
LEU A  42
THR A   2
 None
 0.84A 3oxcA-3s5sA:
undetectable		 3oxcA-3s5sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tth SPERMIDINE
N1-ACETYLTRANSFERASE

(Coxiella
burnetii) 		PF13302
(Acetyltransf_3) 		3 ARG A 162
LEU A 124
THR A  76
 None
 0.59A 3oxcA-3tthA:
undetectable		 3oxcA-3tthA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 017  A 201 ( 4.8A)
None
None
 0.43A 3oxcA-3ttpA:
18.9		 3oxcA-3ttpA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 None
 0.39A 3oxcA-3u7sA:
19.2		 3oxcA-3u7sA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9i MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Roseiflexus sp.
RS-1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ARG A 119
LEU A  44
THR A   4
 None
 0.74A 3oxcA-3u9iA:
undetectable		 3oxcA-3u9iA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		3 ARG A 533
LEU A 539
THR A 548
 None
 0.74A 3oxcA-3ux8A:
undetectable		 3oxcA-3ux8A:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		3 ARG A 549
LEU A 555
THR A 564
 None
 0.73A 3oxcA-3zqjA:
undetectable		 3oxcA-3zqjA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		3 ARG A  94
LEU A 312
THR A 383
 None
 0.82A 3oxcA-3zzuA:
undetectable		 3oxcA-3zzuA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 ARG A  23
LEU A 236
THR A 148
 None
 0.84A 3oxcA-4e0bA:
undetectable		 3oxcA-4e0bA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecn LEUCINE-RICH REPEAT
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14660
(DUF4458) 		3 ARG A 392
LEU A 393
THR A 320
 None
 0.82A 3oxcA-4ecnA:
undetectable		 3oxcA-4ecnA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd2 CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 578
LEU A 549
THR A 611
 None
 0.87A 3oxcA-4fd2A:
undetectable		 3oxcA-4fd2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fek PUTATIVE DIFLAVIN
FLAVOPROTEIN A 5

(Nostoc sp. PCC
7120) 		no annotation 3 ARG A 236
LEU A 226
THR A  18
 None
 0.90A 3oxcA-4fekA:
undetectable		 3oxcA-4fekA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		3 ARG B 182
LEU B  70
THR A  56
 EDO  A 507 (-4.2A)
None
EDO  A 507 (-4.5A)
 0.85A 3oxcA-4hjlB:
undetectable		 3oxcA-4hjlB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		3 ARG A 226
LEU A 168
THR A  84
 None
 0.84A 3oxcA-4jipA:
undetectable		 3oxcA-4jipA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 3 ARG A 123
LEU A 122
THR A 128
 None
 0.89A 3oxcA-4mfzA:
undetectable		 3oxcA-4mfzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndw NUCLEOID-ASSOCIATED
PROTEIN ESPR

(Mycobacterium
tuberculosis) 		no annotation 3 ARG A  49
LEU A   9
THR A  15
 None
 0.89A 3oxcA-4ndwA:
undetectable		 3oxcA-4ndwA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 RIT  A 500 (-3.2A)
None
None
 0.53A 3oxcA-4njvA:
19.8		 3oxcA-4njvA:
84.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 3 ARG B 361
LEU B 244
THR B 297
 None
 0.82A 3oxcA-4p37B:
undetectable		 3oxcA-4p37B:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Rhodoferax
ferrireducens) 		PF00903
(Glyoxalase) 		3 ARG A  98
LEU A 107
THR A  65
 None
 0.79A 3oxcA-4qb5A:
undetectable		 3oxcA-4qb5A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		3 ARG A 327
LEU A 334
THR A 383
 None
 0.85A 3oxcA-4qlbA:
undetectable		 3oxcA-4qlbA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qs9 HEXOKINASE-1

(Arabidopsis
thaliana) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ARG A 405
LEU A 409
THR A 255
 None
 0.78A 3oxcA-4qs9A:
undetectable		 3oxcA-4qs9A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvm CITRATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		3 ARG A 202
LEU A 194
THR A 114
 None
 0.90A 3oxcA-4tvmA:
undetectable		 3oxcA-4tvmA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		3 ARG A 871
LEU A 929
THR A 858
 None
 0.90A 3oxcA-4uwaA:
undetectable		 3oxcA-4uwaA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		3 ARG B 182
LEU B 185
THR B 178
 None
 0.69A 3oxcA-4xmmB:
undetectable		 3oxcA-4xmmB:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		3 ARG A 166
LEU A 120
THR A 174
 GOL  A 505 (-4.8A)
None
None
 0.80A 3oxcA-4yr1A:
undetectable		 3oxcA-4yr1A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		3 ARG A 247
LEU A 251
THR A 201
 None
 0.90A 3oxcA-4zmiA:
undetectable		 3oxcA-4zmiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2z EXFOLIATIVE TOXIN D2

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		3 ARG A  99
LEU A 100
THR A  93
 None
 0.87A 3oxcA-5c2zA:
undetectable		 3oxcA-5c2zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		3 ARG A  95
LEU A  87
THR A 374
 None
 0.72A 3oxcA-5djsA:
undetectable		 3oxcA-5djsA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 3 ARG A 322
LEU A  58
THR A  63
 None
 0.90A 3oxcA-5dz2A:
undetectable		 3oxcA-5dz2A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		3 ARG A 525
LEU A 222
THR A 261
 ADP  A 601 (-4.1A)
ADP  A 601 (-3.9A)
None
 0.87A 3oxcA-5e26A:
undetectable		 3oxcA-5e26A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 ARG B 116
LEU B  37
THR B 125
 None
 0.87A 3oxcA-5g5gB:
undetectable		 3oxcA-5g5gB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		3 ARG A  52
LEU A  29
THR A  64
 None
 0.56A 3oxcA-5gkvA:
undetectable		 3oxcA-5gkvA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ir6 BD-TYPE QUINOL
OXIDASE SUBUNIT I

(Geobacillus
stearothermophilus) 		PF01654
(Cyt_bd_oxida_I) 		3 ARG A 217
LEU A 207
THR A 223
 None
 0.82A 3oxcA-5ir6A:
undetectable		 3oxcA-5ir6A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxu DYP-TYPE PEROXIDASE
FAMILY

(Thermomonospora
curvata) 		PF04261
(Dyp_perox) 		3 ARG A  86
LEU A  90
THR A 190
 None
 0.90A 3oxcA-5jxuA:
undetectable		 3oxcA-5jxuA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzl HEME OXYGENASE

(Leptospira
interrogans) 		PF01126
(Heme_oxygenase) 		3 ARG A 171
LEU A 127
THR A  11
 None
HEM  A 301 ( 4.4A)
None
 0.63A 3oxcA-5kzlA:
undetectable		 3oxcA-5kzlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		3 ARG A 654
LEU A 585
THR A 692
 None
 0.88A 3oxcA-5ltaA:
undetectable		 3oxcA-5ltaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		3 ARG A 601
LEU A 645
THR A 635
 None
 0.54A 3oxcA-5mqoA:
undetectable		 3oxcA-5mqoA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA
COATOMER SUBUNIT
DELTA-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01217
(Clat_adaptor_s)
PF01602
(Adaptin_N) 		3 ARG B 122
LEU A 221
THR A 256
 None
 0.84A 3oxcA-5mu7B:
undetectable		 3oxcA-5mu7B:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 3 ARG A  64
LEU A  16
THR A  29
 GOL  A 405 (-4.3A)
None
None
 0.82A 3oxcA-5niiA:
undetectable		 3oxcA-5niiA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 3 ARG A 433
LEU A 375
THR A 388
 None
 0.90A 3oxcA-5oltA:
undetectable		 3oxcA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S18,
PUTATIVE
RIBOSOMAL PROTEIN
S25, PUTATIVE

(Trypanosoma
cruzi) 		no annotation 3 ARG u  25
LEU a  81
THR a  52
 C  E2067 ( 4.2A)
None
None
 0.89A 3oxcA-5optu:
undetectable		 3oxcA-5optu:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		3 ARG A   8
LEU A  23
THR A  80
 None
 0.40A 3oxcA-5t2zA:
19.2		 3oxcA-5t2zA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 ARG A 425
LEU A 381
THR A 281
 8Z1  A 601 ( 3.8A)
None
LLP  A 280 ( 3.9A)
 0.73A 3oxcA-5v7iA:
undetectable		 3oxcA-5v7iA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 3 ARG A 444
LEU A  63
THR A  10
 None
 0.84A 3oxcA-5wkaA:
undetectable		 3oxcA-5wkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		3 ARG A 557
LEU A 554
THR A 905
 None
 0.79A 3oxcA-5wveA:
undetectable		 3oxcA-5wveA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xil PUTATIVE PROLYL-TRNA
SYNTHETASE

(Leishmania
major) 		no annotation 3 ARG A 663
LEU A 751
THR A 462
 None
 0.87A 3oxcA-5xilA:
undetectable		 3oxcA-5xilA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 3 ARG B 154
LEU B 158
THR B  99
 None
 0.72A 3oxcA-5zvtB:
undetectable		 3oxcA-5zvtB:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 3 ARG A   7
LEU A 130
THR A 122
 None
 0.75A 3oxcA-6b3bA:
undetectable		 3oxcA-6b3bA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 3 ARG h  20
LEU h  24
THR M 435
 None
 0.82A 3oxcA-6g2jh:
undetectable		 3oxcA-6g2jh:
20.00