SIMILAR PATTERNS OF AMINO ACIDS FOR 3OWX_A_XRAA233

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 GLY A  91
GLY A 183
MET A 187
VAL A 190
ILE A 433
 PTT  A 800 (-3.2A)
PTT  A 800 (-3.4A)
None
None
None
 1.49A 3owxA-1b25A:
undetectable		 3owxA-1b25A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 716
GLY A 717
TYR A 733
VAL A 773
GLU A 715
 None
None
None
None
MGD  A1001 (-3.9A)
 1.17A 3owxA-1eu1A:
2.4		 3owxA-1eu1A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 359
GLY A 358
TYR A 356
VAL A 328
GLU A 363
 None
 1.25A 3owxA-1kczA:
undetectable		 3owxA-1kczA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 TRP A 157
GLY A 104
GLY A 105
VAL A 188
ILE A 136
 CAA  A 501 (-3.6A)
CAA  A 501 (-3.5A)
CAA  A 501 (-3.9A)
CAA  A 501 (-4.8A)
None
 1.32A 3owxA-1q51A:
undetectable		 3owxA-1q51A:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
 FAD  A 501 (-4.5A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.0A)
None
FAD  A 501 (-4.9A)
 0.60A 3owxA-1qbgA:
32.9		 3owxA-1qbgA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		6 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
VAL A 160
 DQN  A 276 ( 3.6A)
CBD  A 275 ( 3.7A)
FAD  A 274 (-3.7A)
CBD  A 275 ( 4.4A)
None
None
 0.55A 3owxA-1qrdA:
29.6		 3owxA-1qrdA:
41.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 GLY A 126
GLY A 128
VAL A 176
GLU A  65
ILE A  81
 ACT  A1301 ( 4.3A)
None
None
ACT  A1301 (-3.6A)
None
 1.13A 3owxA-1wxdA:
5.0		 3owxA-1wxdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zki HYPOTHETICAL PROTEIN
PA5202

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 GLY A  50
GLY A  49
VAL A  46
ASN A  42
ILE A  81
 None
 1.49A 3owxA-1zkiA:
undetectable		 3owxA-1zkiA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0d COLICIN-E7 IMMUNITY
PROTEIN

(Escherichia
coli) 		PF01320
(Colicin_Pyocin) 		5 GLY X  69
GLY X  70
ASN X  64
GLU X  78
ILE X  75
 None
 1.23A 3owxA-2k0dX:
undetectable		 3owxA-2k0dX:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqb PROBABLE
BETA-LACTAMASE

(Staphylococcus
aureus) 		PF16229
(DUF4888) 		5 GLY A  50
GLY A  26
VAL A  76
ASN A  29
ILE A  19
 None
 1.15A 3owxA-2mqbA:
undetectable		 3owxA-2mqbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 378
GLY A 379
MET A 407
VAL A 409
ILE A 236
 None
 1.17A 3owxA-2okjA:
2.8		 3owxA-2okjA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		5 GLY A 220
GLY A 221
VAL A 306
ASN A 224
ILE A 218
 None
 1.31A 3owxA-2qr6A:
undetectable		 3owxA-2qr6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6u UNCHARACTERIZED
PROTEIN

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		5 TRP A 121
GLY A  60
GLY A  61
VAL A  68
ILE A  30
 None
 1.37A 3owxA-2r6uA:
undetectable		 3owxA-2r6uA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 156
TYR A 343
ASN A 344
GLU A 220
ILE A 151
 None
 1.31A 3owxA-2wtzA:
3.1		 3owxA-2wtzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		5 GLY A  36
GLY A  38
ASN A  13
GLU A 153
ILE A 184
 None
 1.41A 3owxA-3d31A:
undetectable		 3owxA-3d31A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loq UNIVERSAL STRESS
PROTEIN

(Archaeoglobus
fulgidus) 		PF00582
(Usp) 		5 GLY A 175
GLY A 174
VAL A  24
GLU A 205
ILE A 204
 None
 1.27A 3owxA-3loqA:
undetectable		 3owxA-3loqA:
23.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		9 TRP A 105
GLY A 149
GLY A 150
MET A 154
TYR A 155
VAL A 160
ASN A 161
GLU A 193
ILE A 194
 FAD  A 232 ( 4.3A)
FAD  A 232 (-3.6A)
FAD  A 232 (-3.6A)
None
FAD  A 232 (-4.6A)
None
None
FAD  A 232 ( 3.1A)
None
 0.31A 3owxA-3te7A:
38.9		 3owxA-3te7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		5 GLY A 137
GLY A 138
VAL A 146
ASN A 109
GLU A 178
 None
 1.49A 3owxA-3vovA:
undetectable		 3owxA-3vovA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 318
GLY A 317
VAL A 314
GLU A 320
ILE A 222
 None
 1.38A 3owxA-4b45A:
6.2		 3owxA-4b45A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 GLY A 349
GLY B 293
VAL A 406
GLU A 315
ILE B 304
 None
 1.13A 3owxA-4cakA:
undetectable		 3owxA-4cakA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLY A  21
GLY A  22
TYR A  32
GLU A  59
ILE A  19
 None
 1.48A 3owxA-4cnsA:
undetectable		 3owxA-4cnsA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 GLY A  19
GLY A  18
VAL A  93
ASN A  95
ILE A  54
 None
 1.44A 3owxA-4dryA:
4.3		 3owxA-4dryA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		5 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.39A 3owxA-4gi5A:
30.3		 3owxA-4gi5A:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN

(Micromonospora
viridifaciens) 		PF13088
(BNR_2) 		5 GLY A 382
TYR A 393
ASN A 395
GLU A 208
ILE A 315
 None
 1.48A 3owxA-4j9tA:
undetectable		 3owxA-4j9tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 5 GLY A 157
GLY A 158
ASN A 160
GLU A  57
ILE A  58
 None
 1.36A 3owxA-4q38A:
undetectable		 3owxA-4q38A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 GLY A 398
GLY A 399
TYR A 164
GLU A 185
ILE A 184
 None
 1.07A 3owxA-4q6rA:
undetectable		 3owxA-4q6rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 180
GLY A 181
VAL A 471
ASN A 472
ILE A 239
 FAD  A 603 (-3.6A)
FAD  A 603 (-3.2A)
None
FAD  A 603 (-3.7A)
FAD  A 603 (-3.8A)
 1.43A 3owxA-5d79A:
undetectable		 3owxA-5d79A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 TRP A 276
GLY A 315
TYR A  55
GLU A 339
ILE A 291
 None
 1.39A 3owxA-5mscA:
3.2		 3owxA-5mscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5p APHRODISIN

(Mesocricetus
auratus) 		PF00061
(Lipocalin) 		4 PHE A  33
ILE A  47
PHE A  49
PHE A  31
 None
 1.05A 3owxB-1e5pA:
undetectable		 3owxB-1e5pA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		4 VAL A 187
PHE A 231
ILE A 193
PHE A 320
 None
 1.06A 3owxB-1ea6A:
0.0		 3owxB-1ea6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 VAL A 580
PHE A 656
ILE A 608
PHE A 556
 None
 1.07A 3owxB-1k1xA:
0.0		 3owxB-1k1xA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		4 VAL A  34
PHE A  70
ILE A 103
PHE A 112
 None
 1.09A 3owxB-1k5cA:
undetectable		 3owxB-1k5cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		4 PHE A 205
ILE A 212
PHE A 231
PHE A 233
 None
 1.12A 3owxB-1lpcA:
undetectable		 3owxB-1lpcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 VAL A  43
PHE A 101
ILE A  93
PHE A 102
 None
BCP  A 401 ( 4.9A)
BCP  A 401 (-4.0A)
None
 1.13A 3owxB-1m66A:
5.3		 3owxB-1m66A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		4 VAL A  37
ILE A  40
PHE A  47
PHE A  62
 None
 1.04A 3owxB-1p6pA:
undetectable		 3owxB-1p6pA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prx HORF6

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 VAL A 136
PHE A  25
ILE A  69
PHE A  14
 None
 1.01A 3owxB-1prxA:
0.0		 3owxB-1prxA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		4 PHE A 204
ILE A 211
PHE A 230
PHE A 232
 None
 1.03A 3owxB-1qi7A:
undetectable		 3owxB-1qi7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		5 VAL A 270
PHE A 117
ILE A 113
PHE A 178
PHE A 211
 None
 1.48A 3owxB-1vp4A:
2.6		 3owxB-1vp4A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn4 RIBONUCLEASE MAR1

(Leishmania
major) 		PF00857
(Isochorismatase) 		4 VAL A  37
PHE A  31
ILE A 107
PHE A  24
 None
 1.10A 3owxB-1xn4A:
5.4		 3owxB-1xn4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z82 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 PHE A 216
ILE A 286
PHE A 213
PHE A 217
 None
 1.09A 3owxB-1z82A:
4.9		 3owxB-1z82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 VAL A 462
PHE A 422
ILE A 403
PHE A 472
 None
 1.03A 3owxB-1zpuA:
undetectable		 3owxB-1zpuA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes) 		4 VAL A 594
PHE A 235
ILE A 231
PHE A 232
 None
 1.05A 3owxB-2bw3A:
undetectable		 3owxB-2bw3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du7 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF01409
(tRNA-synt_2d) 		4 PHE A 380
ILE A 491
PHE A 383
PHE A 409
 None
 0.92A 3owxB-2du7A:
undetectable		 3owxB-2du7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		4 VAL A  21
ILE A  71
PHE A 136
PHE A 199
 None
 0.70A 3owxB-2ejaA:
undetectable		 3owxB-2ejaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f73 FATTY ACID-BINDING
PROTEIN, LIVER

(Homo sapiens) 		PF14651
(Lipocalin_7) 		4 PHE A  50
ILE A  41
PHE A  48
PHE A  63
 None
 1.06A 3owxB-2f73A:
undetectable		 3owxB-2f73A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		4 VAL A  38
PHE A  54
ILE A 118
PHE A  61
 None
 1.02A 3owxB-2fw2A:
undetectable		 3owxB-2fw2A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		4 VAL A 205
PHE A 137
ILE A 200
PHE A  16
 None
 0.96A 3owxB-2i0mA:
undetectable		 3owxB-2i0mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jo7 GLYCOSYLPHOSPHATIDYL
INOSITOL-ANCHORED
MEROZOITE SURFACE
PROTEIN

(Babesia
divergens) 		PF11641
(Antigen_Bd37) 		4 VAL A 235
ILE A 254
PHE A 223
PHE A 216
 None
 0.97A 3owxB-2jo7A:
undetectable		 3owxB-2jo7A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kca BACTERIOPHAGE SPP1
COMPLETE NUCLEOTIDE
SEQUENCE

(Bacillus phage
SPP1) 		PF05521
(Phage_H_T_join) 		4 VAL A 122
ILE A 102
PHE A  45
PHE A  66
 None
 1.05A 3owxB-2kcaA:
undetectable		 3owxB-2kcaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph7 UNCHARACTERIZED
PROTEIN AF_2093

(Archaeoglobus
fulgidus) 		no annotation 4 VAL A 201
PHE A 180
ILE A 198
PHE A 183
 None
 0.76A 3owxB-2ph7A:
2.4		 3owxB-2ph7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3q UNCHARACTERIZED
PROTEIN AT1G24000

(Arabidopsis
thaliana) 		PF00407
(Bet_v_1) 		4 VAL A 107
PHE A  20
ILE A  70
PHE A  21
 None
 1.12A 3owxB-2q3qA:
undetectable		 3owxB-2q3qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 VAL A  33
ILE A  82
PHE A 154
PHE A 217
 None
 0.77A 3owxB-2q6zA:
undetectable		 3owxB-2q6zA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo4 LIVER-BASIC FATTY
ACID BINDING PROTEIN

(Danio rerio) 		PF14651
(Lipocalin_7) 		4 VAL A  37
ILE A  40
PHE A  47
PHE A  62
 None
None
None
IPA  A 142 ( 4.4A)
 1.05A 3owxB-2qo4A:
undetectable		 3owxB-2qo4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 VAL A 291
PHE A 307
ILE A 315
PHE A 365
 None
 1.01A 3owxB-2qpmA:
undetectable		 3owxB-2qpmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		4 PHE A 669
ILE A 731
PHE A 733
PHE A 646
 None
 1.02A 3owxB-2wd6A:
undetectable		 3owxB-2wd6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnf MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 25

(Homo sapiens) 		PF11232
(Med25) 		4 VAL A 510
PHE A 473
PHE A 522
PHE A 475
 None
 1.07A 3owxB-2xnfA:
undetectable		 3owxB-2xnfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 VAL A  33
PHE A  62
ILE A 251
PHE A  43
 None
 1.12A 3owxB-2yxxA:
undetectable		 3owxB-2yxxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 VAL A  87
ILE A 250
PHE A 298
PHE A  68
 None
 1.09A 3owxB-2zktA:
1.9		 3owxB-2zktA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwr METALLO-BETA-LACTAMA
SE SUPERFAMILY
PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		4 VAL A  74
PHE A 132
ILE A  27
PHE A 141
 None
 1.09A 3owxB-2zwrA:
undetectable		 3owxB-2zwrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au0 CLUMPING FACTOR B

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 PHE A 309
ILE A 285
PHE A 307
PHE A 257
 None
 0.97A 3owxB-3au0A:
undetectable		 3owxB-3au0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 VAL A 220
ILE A 195
PHE A 281
PHE A 284
 None
 1.04A 3owxB-3b9eA:
undetectable		 3owxB-3b9eA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 4 VAL A 165
ILE A 198
PHE A 415
PHE A 419
 None
EDO  A 484 ( 4.5A)
None
EDO  A 484 (-3.7A)
 1.02A 3owxB-3c8vA:
undetectable		 3owxB-3c8vA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		4 VAL A 228
PHE A 173
ILE A 185
PHE A 139
 None
 1.09A 3owxB-3g6sA:
undetectable		 3owxB-3g6sA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqi PHOSPHOLIPASE
C-GAMMA-1

(Rattus
norvegicus) 		PF00017
(SH2) 		4 VAL B 735
PHE B 691
ILE B 704
PHE B 706
 None
 1.12A 3owxB-3gqiB:
undetectable		 3owxB-3gqiB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A  26
PHE A  12
ILE A  15
PHE A   6
 None
 1.09A 3owxB-3k4xA:
undetectable		 3owxB-3k4xA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 VAL A 293
PHE A 279
ILE A 282
PHE A 273
 None
 0.99A 3owxB-3k4xA:
undetectable		 3owxB-3k4xA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 262
PHE A 166
ILE A 159
PHE A  74
 None
 1.08A 3owxB-3l8kA:
undetectable		 3owxB-3l8kA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		4 VAL A  13
PHE A  33
ILE A  38
PHE A 286
 None
 0.97A 3owxB-3le2A:
undetectable		 3owxB-3le2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc9 UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Entamoeba
histolytica) 		PF01704
(UDPGP) 		4 VAL A 182
PHE A 308
PHE A 307
PHE A 309
 None
 1.07A 3owxB-3oc9A:
undetectable		 3owxB-3oc9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PHE A 273
ILE A 368
PHE A 276
PHE A 221
 None
 1.06A 3owxB-3oceA:
undetectable		 3owxB-3oceA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyn PFV INTEGRASE

(Simian foamy
virus) 		PF00665
(rve) 		4 VAL A 142
PHE A 190
ILE A 127
PHE A 195
 None
 1.02A 3owxB-3oynA:
undetectable		 3owxB-3oynA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 VAL A 194
PHE A 214
ILE A 191
PHE A 206
 None
 0.85A 3owxB-3q9cA:
undetectable		 3owxB-3q9cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		4 VAL A 151
PHE A  81
ILE A 154
PHE A 126
 None
 0.90A 3owxB-3rnsA:
undetectable		 3owxB-3rnsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 VAL A 247
PHE A 408
ILE A  75
PHE A 114
 None
 1.06A 3owxB-3t02A:
undetectable		 3owxB-3t02A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3te7 RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE]

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		5 VAL A  69
PHE A 126
ILE A 128
PHE A 131
PHE A 178
 None
TE7  A   1 (-4.3A)
None
None
TE7  A   1 (-3.6A)
 0.32A 3owxB-3te7A:
39.8		 3owxB-3te7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 VAL A  27
ILE A 150
PHE A 121
PHE A 166
 None
 1.13A 3owxB-3v5rA:
undetectable		 3owxB-3v5rA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 VAL A 478
PHE A 415
PHE A 418
PHE A 414
 None
 1.10A 3owxB-3v5rA:
undetectable		 3owxB-3v5rA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx6 UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF05638
(T6SS_HCP) 		4 PHE A 146
ILE A  59
PHE A 110
PHE A  85
 None
 1.11A 3owxB-3wx6A:
undetectable		 3owxB-3wx6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 VAL A 511
PHE A 517
ILE A 494
PHE A 429
 None
 0.92A 3owxB-4a5qA:
undetectable		 3owxB-4a5qA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 VAL A 392
ILE A 411
PHE A 357
PHE A 376
 AU  A1752 ( 4.6A)
None
AU  A1755 (-4.6A)
None
 1.12A 3owxB-4b8bA:
undetectable		 3owxB-4b8bA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		4 VAL A 118
PHE A  17
ILE A  65
PHE A  21
 None
 1.07A 3owxB-4bnqA:
undetectable		 3owxB-4bnqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci7 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		4 VAL A 489
PHE A 358
ILE A 428
PHE A 360
 None
 1.07A 3owxB-4ci7A:
undetectable		 3owxB-4ci7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d59 CELL SURFACE PROTEIN
(PUTATIVE CELL
SURFACE-ASSOCIATED
CYSTEINE PROTEASE)

(Clostridioides
difficile) 		PF00112
(Peptidase_C1) 		4 VAL A 489
PHE A 358
ILE A 428
PHE A 360
 None
 1.07A 3owxB-4d59A:
undetectable		 3owxB-4d59A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dix PLECTIN-RELATED
PROTEIN

(Arabidopsis
thaliana) 		PF16709
(SCAB-IgPH) 		4 VAL A 377
PHE A 384
PHE A 404
PHE A 459
 None
 1.00A 3owxB-4dixA:
undetectable		 3owxB-4dixA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 VAL A 198
ILE A 167
PHE A 145
PHE A  22
 None
 0.94A 3owxB-4dziA:
undetectable		 3owxB-4dziA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4w DNA MISMATCH REPAIR
PROTEIN MLH1

(Saccharomyces
cerevisiae) 		PF16413
(Mlh1_C) 		4 VAL A 754
PHE A 533
ILE A 749
PHE A 743
 None
 1.02A 3owxB-4e4wA:
undetectable		 3owxB-4e4wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2e CUPA

(Streptococcus
pneumoniae) 		PF13473
(Cupredoxin_1) 		4 VAL A  65
PHE A  80
ILE A  99
PHE A  83
 None
 1.02A 3owxB-4f2eA:
undetectable		 3owxB-4f2eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A 421
PHE A 371
ILE A 407
PHE A 392
 None
 0.88A 3owxB-4flnA:
undetectable		 3owxB-4flnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		4 VAL A 133
PHE A 153
ILE A 136
PHE A 358
 None
 1.06A 3owxB-4gnrA:
2.6		 3owxB-4gnrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A1149
ILE A1003
PHE A1004
PHE A1067
 None
 1.07A 3owxB-4grvA:
undetectable		 3owxB-4grvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 4 VAL A 378
PHE A 510
ILE A 477
PHE A 507
 None
 0.99A 3owxB-4iruA:
undetectable		 3owxB-4iruA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqr HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF14717
(DUF4465) 		4 VAL A  30
PHE A  33
ILE A 113
PHE A  60
 None
None
EDO  A 310 (-4.2A)
None
 1.12A 3owxB-4jqrA:
undetectable		 3owxB-4jqrA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 317
ILE A 471
PHE A 320
PHE A 316
 None
 1.00A 3owxB-4kq8A:
undetectable		 3owxB-4kq8A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN

(Vibrio cholerae) 		PF00165
(HTH_AraC) 		4 VAL A 131
PHE A 148
ILE A  86
PHE A 152
 None
 0.99A 3owxB-4mloA:
undetectable		 3owxB-4mloA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 VAL A 120
PHE A 363
ILE A 183
PHE A 142
 None
 1.12A 3owxB-4pxdA:
2.2		 3owxB-4pxdA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 VAL A 442
PHE A 414
ILE A 421
PHE A 413
 None
 1.01A 3owxB-4uvkA:
undetectable		 3owxB-4uvkA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 PHE A 317
ILE A 274
PHE A 320
PHE A 266
 None
 1.05A 3owxB-4v2xA:
undetectable		 3owxB-4v2xA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		4 VAL A  23
ILE A  74
PHE A 145
PHE A 208
 None
 0.74A 3owxB-4wshA:
undetectable		 3owxB-4wshA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		4 PHE A 127
ILE A  89
PHE A 120
PHE A 134
 None
 1.13A 3owxB-4wy9A:
undetectable		 3owxB-4wy9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoh DIVISION MAL FOUTUE
1 PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 PHE C  60
ILE C  13
PHE C  11
PHE C  66
 None
 0.83A 3owxB-4xohC:
undetectable		 3owxB-4xohC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 VAL A 304
PHE A 240
ILE A 232
PHE A 289
 None
 1.13A 3owxB-4y9vA:
undetectable		 3owxB-4y9vA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 VAL A 170
ILE A  24
PHE A  25
PHE A  88
 None
 1.10A 3owxB-4yxcA:
undetectable		 3owxB-4yxcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlr BRAIN TUMOR PROTEIN

(Drosophila
melanogaster) 		PF01436
(NHL) 		4 VAL A 888
PHE A 898
ILE A 885
PHE A 866
 None
 0.86A 3owxB-4zlrA:
undetectable		 3owxB-4zlrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		4 VAL A 158
PHE A 189
ILE A 176
PHE A 214
 None
 1.11A 3owxB-4znjA:
undetectable		 3owxB-4znjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af2 VP3

(Rotavirus A) 		PF05213
(Corona_NS2A) 		4 VAL A 770
PHE A 788
ILE A 701
PHE A 781
 None
 1.09A 3owxB-5af2A:
undetectable		 3owxB-5af2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyf PUTATIVE URIDINE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 VAL A  44
PHE A  23
PHE A  20
PHE A  25
 None
 1.01A 3owxB-5cyfA:
2.9		 3owxB-5cyfA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		4 VAL A 575
PHE A  86
PHE A  83
PHE A  87
 None
 1.00A 3owxB-5dqqA:
undetectable		 3owxB-5dqqA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du3 PLASMA PROTEASE C1
INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A 424
PHE A 457
ILE A 379
PHE A 455
 None
 1.11A 3owxB-5du3A:
undetectable		 3owxB-5du3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 PHE A 292
ILE A 249
PHE A 295
PHE A 241
 None
 1.05A 3owxB-5e0cA:
undetectable		 3owxB-5e0cA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h11 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07393
(Sec10) 		4 VAL A 530
PHE A 493
ILE A 525
PHE A 496
 None
 1.10A 3owxB-5h11A:
undetectable		 3owxB-5h11A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihs ENDOGLUCANASE,
GLYCOSIDE HYDROLASE
FAMILY 5 PROTEIN

(Cytophaga
hutchinsonii) 		PF00150
(Cellulase) 		4 VAL A 191
PHE A 139
ILE A 121
PHE A 138
 None
 1.12A 3owxB-5ihsA:
undetectable		 3owxB-5ihsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 VAL A 466
PHE A 456
ILE A 789
PHE A 521
 None
 1.04A 3owxB-5mtzA:
undetectable		 3owxB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 VAL A 491
PHE A 456
ILE A 469
PHE A 521
 None
 0.99A 3owxB-5mtzA:
undetectable		 3owxB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndz LYSOZYME,PROTEINASE-
ACTIVATED RECEPTOR
2,SOLUBLE CYTOCHROME
B562,PROTEINASE-ACTI
VATED RECEPTOR 2

(Escherichia
coli;
Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF07361
(Cytochrom_B562) 		4 VAL A1149
ILE A1003
PHE A1004
PHE A1067
 None
 1.09A 3owxB-5ndzA:
undetectable		 3owxB-5ndzA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 4 PHE A1126
ILE A1144
PHE A1128
PHE A1112
 None
 0.96A 3owxB-5ng6A:
undetectable		 3owxB-5ng6A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 VAL A 328
PHE A 308
ILE A 311
PHE A 307
 None
 0.89A 3owxB-5nvrA:
undetectable		 3owxB-5nvrA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 VAL A 273
ILE A 315
PHE A 326
PHE A 392
 None
 0.90A 3owxB-5szsA:
undetectable		 3owxB-5szsA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 VAL A 151
PHE A 184
ILE A 171
PHE A 187
 73X  A 704 ( 3.8A)
None
None
None
 1.04A 3owxB-5t0lA:
undetectable		 3owxB-5t0lA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1p ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 VAL A 226
PHE A 197
ILE A 161
PHE A 196
 None
 0.91A 3owxB-5t1pA:
undetectable		 3owxB-5t1pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 VAL A 144
PHE A 183
ILE A 178
PHE A 180
 None
 0.91A 3owxB-5vc2A:
undetectable		 3owxB-5vc2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 VAL A 254
ILE A 233
PHE A 208
PHE A 212
 None
 1.05A 3owxB-5wtnA:
undetectable		 3owxB-5wtnA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 4 VAL A 149
ILE A   3
PHE A   4
PHE A  67
 None
 1.11A 3owxB-5yqrA:
undetectable		 3owxB-5yqrA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 4 VAL A 283
ILE A 239
PHE A 308
PHE A 312
 None
 0.95A 3owxB-6b2yA:
undetectable		 3owxB-6b2yA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 4 VAL A 365
PHE A 205
ILE A 226
PHE A 201
 None
 1.02A 3owxB-6c8sA:
2.8		 3owxB-6c8sA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE BETA
SUBUNIT

(Rhodococcus
jostii) 		no annotation 4 VAL B 159
ILE B 101
PHE B 149
PHE B 215
 None
 1.11A 3owxB-6co9B:
2.0		 3owxB-6co9B:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A 672
PHE A 734
ILE A 679
PHE A 732
PHE A 744
 None
 1.46A 3owxB-6eojA:
undetectable		 3owxB-6eojA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL G  28
PHE G 102
ILE G 109
PHE G 103
 None
 0.89A 3owxB-6eznG:
3.8		 3owxB-6eznG:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g94 PROBABLE
NI/FE-HYDROGENASE 1
B-TYPE CYTOCHROME
SUBUNIT

(Escherichia
coli) 		no annotation 4 VAL A  69
PHE A 148
ILE A 144
PHE A 163
 None
HEM  A 301 (-3.7A)
HEM  A 301 ( 4.4A)
None
 1.02A 3owxB-6g94A:
undetectable		 3owxB-6g94A:
18.06