SIMILAR PATTERNS OF AMINO ACIDS FOR 3OU7_C_SAMC300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		3 GLY A  65
ASP A  84
ASP A 113
 None
 0.25A 3ou7C-1dusA:
13.2		 3ou7C-1dusA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 198
ASP A 219
ASP A 239
 SAH  A1699 ( 3.9A)
SAH  A1699 (-2.9A)
SAH  A1699 (-3.8A)
 0.45A 3ou7C-1fp2A:
15.2		 3ou7C-1fp2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 219
ASP A 240
ASP A 260
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-3.8A)
 0.37A 3ou7C-1fpqA:
15.5		 3ou7C-1fpqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		3 GLY A  11
ASP A  33
ASP A  59
 NAD  A2001 ( 4.1A)
NAD  A2001 (-2.8A)
NAD  A2001 (-3.6A)
 0.45A 3ou7C-1gegA:
5.5		 3ou7C-1gegA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF01135
(PCMT) 		3 GLY A  87
ASP A 109
ASP A 141
 SAH  A 300 (-3.6A)
SAH  A 300 (-2.9A)
SAH  A 300 (-3.7A)
 0.39A 3ou7C-1kr5A:
7.7		 3ou7C-1kr5A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 210
ASP A 231
ASP A 251
 None
 0.47A 3ou7C-1kywA:
14.5		 3ou7C-1kywA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3i PRECORRIN-6Y
METHYLTRANSFERASE/PU
TATIVE DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF13847
(Methyltransf_31) 		3 GLY A  43
ASP A  62
ASP A  90
 SAH  A 801 (-3.2A)
SAH  A 801 (-2.6A)
SAH  A 801 (-3.8A)
 0.34A 3ou7C-1l3iA:
14.1		 3ou7C-1l3iA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 GLY A  81
ASP A 101
ASP A 158
 SAH  A2002 (-3.0A)
SAH  A2002 (-3.1A)
SAH  A2002 (-3.6A)
 0.43A 3ou7C-1n7jA:
16.9		 3ou7C-1n7jA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne2 HYPOTHETICAL PROTEIN
TA1320

(Thermoplasma
acidophilum) 		PF06325
(PrmA) 		3 GLY A  58
ASP A  78
ASP A 100
 None
 0.35A 3ou7C-1ne2A:
13.5		 3ou7C-1ne2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 GLY A 252
ASP A 271
ASP A  46
 SAM  A 401 (-3.3A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.6A)
 0.46A 3ou7C-1nw5A:
4.1		 3ou7C-1nw5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri3 MRNA CAPPING ENZYME

(Encephalitozoon
cuniculi) 		PF03291
(Pox_MCEL) 		3 GLY A  74
ASP A  94
ASP A 122
 SAH  A 299 (-3.5A)
SAH  A 299 (-2.9A)
SAH  A 299 (-3.2A)
 0.29A 3ou7C-1ri3A:
14.9		 3ou7C-1ri3A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 GLY A  48
ASP A  67
ASP A  93
 SAM  A 302 (-3.6A)
SAM  A 302 (-2.8A)
SAM  A 302 (-3.4A)
 0.42A 3ou7C-1ve3A:
17.2		 3ou7C-1ve3A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		3 GLY A  52
ASP A  71
ASP A  98
 None
 0.40A 3ou7C-1vl5A:
16.7		 3ou7C-1vl5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		3 GLY A  51
ASP A  70
ASP A  96
 SAH  A1001 (-3.1A)
SAH  A1001 (-2.7A)
SAH  A1001 (-3.3A)
 0.35A 3ou7C-1wznA:
19.0		 3ou7C-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		3 GLY A  48
ASP A  67
ASP A  93
 None
 0.24A 3ou7C-1y8cA:
18.3		 3ou7C-1y8cA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 209
ASP A 230
ASP A 250
 SAH  A3994 ( 4.0A)
SAH  A3994 (-2.8A)
SAH  A3994 (-3.4A)
 0.41A 3ou7C-1zgjA:
13.3		 3ou7C-1zgjA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 GLY A  65
ASP A  85
ASP A 142
 SAH  A4001 (-3.0A)
SAH  A4001 (-2.7A)
SAH  A4001 (-3.7A)
 0.41A 3ou7C-2a14A:
17.1		 3ou7C-2a14A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3t PROTEIN
METHYLTRANSFERASE
HEMK

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		3 GLY A 119
ASP A 140
ASP A 167
 SAH  A 300 (-3.5A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.0A)
 0.32A 3ou7C-2b3tA:
12.3		 3ou7C-2b3tA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		3 GLY A 128
ASP A 154
ASP A 180
 SAM  A 400 (-3.3A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
 0.47A 3ou7C-2f8lA:
9.9		 3ou7C-2f8lA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		3 GLY A  66
ASP A  86
ASP A 143
 SAH  A4001 (-3.2A)
SAH  A4001 (-2.9A)
SAH  A4001 (-4.0A)
 0.42A 3ou7C-2i62A:
17.6		 3ou7C-2i62A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		3 GLY A  65
ASP A  85
ASP A 142
 SAH  A4001 (-3.0A)
SAH  A4001 (-2.6A)
SAH  A4001 (-3.7A)
 0.35A 3ou7C-2iipA:
17.3		 3ou7C-2iipA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 GLY A 177
ASP A 198
ASP A 225
 None
 0.25A 3ou7C-2ip2A:
15.5		 3ou7C-2ip2A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		3 GLY A 107
ASP A 128
ASP A 175
 None
 0.43A 3ou7C-2ob1A:
11.2		 3ou7C-2ob1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 GLY A 180
ASP A 214
ASP A 243
 SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
SAM  A 500 (-3.3A)
 0.45A 3ou7C-2okcA:
9.4		 3ou7C-2okcA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		3 GLY A  40
ASP A  61
ASP A  83
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.2A)
 0.30A 3ou7C-2p35A:
14.5		 3ou7C-2p35A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 GLY A  68
ASP A  88
ASP A 113
 SAH  A 301 ( 3.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.1A)
 0.40A 3ou7C-2pxxA:
16.2		 3ou7C-2pxxA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		3 GLY A  86
ASP A 110
ASP A 135
 SAM  A 400 ( 3.2A)
SAM  A 400 (-2.7A)
SAM  A 400 (-3.4A)
 0.33A 3ou7C-2qe6A:
13.2		 3ou7C-2qe6A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 203
ASP A 224
ASP A 244
 SAH  A 601 ( 3.8A)
SAH  A 601 (-2.9A)
SAH  A 601 (-3.5A)
 0.46A 3ou7C-2qyoA:
14.4		 3ou7C-2qyoA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		3 GLY A  40
ASP A  59
ASP A  86
 SFG  A1198 (-3.2A)
SFG  A1198 (-2.8A)
SFG  A1198 (-3.9A)
 0.16A 3ou7C-2xvaA:
15.1		 3ou7C-2xvaA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		3 GLY A 318
ASP A 334
ASP A 346
 SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
SAH  A 900 (-3.6A)
 0.36A 3ou7C-2zfuA:
10.2		 3ou7C-2zfuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 GLY A 117
ASP A 146
ASP A 196
 SAH  A 801 (-3.4A)
SAH  A 801 (-2.9A)
SAH  A 801 (-4.1A)
 0.33A 3ou7C-2zwaA:
11.1		 3ou7C-2zwaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 GLY A 205
ASP A 223
ASP A 251
 ADN  A 401 ( 4.0A)
ADN  A 401 (-2.6A)
ADN  A 401 (-3.8A)
 0.39A 3ou7C-3ay0A:
12.4		 3ou7C-3ay0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		3 GLY A 113
ASP A 131
ASP A 157
 5GP  A 500 ( 4.5A)
5GP  A 500 (-3.1A)
5GP  A 500 (-2.7A)
 0.43A 3ou7C-3b89A:
13.6		 3ou7C-3b89A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		3 GLY A  52
ASP A  72
ASP A  96
 None
 0.32A 3ou7C-3bkwA:
16.9		 3ou7C-3bkwA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		3 GLY A  48
ASP A  67
ASP A  89
 None
 0.44A 3ou7C-3ccfA:
16.6		 3ou7C-3ccfA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		3 GLY A  42
ASP A  60
ASP A  86
 None
 0.40A 3ou7C-3d2lA:
17.4		 3ou7C-3d2lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF13489
(Methyltransf_23) 		3 GLY A 292
ASP A 311
ASP A 330
 None
 0.38A 3ou7C-3dliA:
15.8		 3ou7C-3dliA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633

(Methanosarcina
mazei) 		PF13649
(Methyltransf_25) 		3 GLY A  52
ASP A  73
ASP A  98
 None
 0.42A 3ou7C-3dtnA:
17.5		 3ou7C-3dtnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 GLY A 700
ASP A 719
ASP A 747
 ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.4A)
 0.34A 3ou7C-3egiA:
11.6		 3ou7C-3egiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 GLY A 700
ASP A 719
ASP A 747
 SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
 0.41A 3ou7C-3gdhA:
12.0		 3ou7C-3gdhA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		3 GLY A  65
ASP A  84
ASP A 108
 SAH  A 248 (-3.2A)
SAH  A 248 (-2.9A)
SAH  A 248 (-3.7A)
 0.36A 3ou7C-3ggdA:
16.7		 3ou7C-3ggdA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		3 GLY A  87
ASP A 111
ASP A 138
 SAH  A 277 (-3.1A)
SAH  A 277 (-2.7A)
SAH  A 277 (-3.5A)
 0.24A 3ou7C-3go4A:
12.6		 3ou7C-3go4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu3 METHYLTRANSFERASE

(Bacillus cereus) 		PF13847
(Methyltransf_31) 		3 GLY A  49
ASP A  71
ASP A  97
 SAH  A 401 (-3.3A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.3A)
 0.28A 3ou7C-3gu3A:
15.4		 3ou7C-3gu3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		3 GLY A 164
ASP A  94
ASP A  89
 AGT  A 366 ( 3.5A)
AGT  A 366 ( 3.0A)
None
 0.47A 3ou7C-3h7kA:
undetectable		 3ou7C-3h7kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8d METHYLTRANSFERASE

(Bacillus
thuringiensis) 		PF08241
(Methyltransf_11) 		3 GLY A  63
ASP A  82
ASP A 106
 None
 0.33A 3ou7C-3l8dA:
14.2		 3ou7C-3l8dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcc PUTATIVE METHYL
CHLORIDE TRANSFERASE

(Arabidopsis
thaliana) 		PF05724
(TPMT) 		3 GLY A  76
ASP A  95
ASP A 123
 SAH  A 300 (-3.5A)
SAH  A 300 (-2.8A)
SAH  A 300 (-3.8A)
 0.43A 3ou7C-3lccA:
15.7		 3ou7C-3lccA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		3 GLY B 135
ASP B 156
ASP B 182
 SAM  B 301 ( 4.1A)
SAM  B 301 (-2.9A)
SAM  B 301 (-3.1A)
 0.38A 3ou7C-3lcvB:
11.8		 3ou7C-3lcvB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		3 GLY A 191
ASP A 212
ASP A 237
 SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.6A)
 0.35A 3ou7C-3lstA:
11.3		 3ou7C-3lstA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		3 GLY A 130
ASP A 149
ASP A 175
 None
 0.28A 3ou7C-3m70A:
14.9		 3ou7C-3m70A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 GLY A 100
ASP A 122
ASP A 171
 SAM  A 801 ( 3.7A)
SAM  A 801 (-2.7A)
SAM  A 801 (-3.8A)
 0.37A 3ou7C-3o7wA:
9.9		 3ou7C-3o7wA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		3 GLY A 125
ASP A 147
ASP A 175
 None
 0.34A 3ou7C-3ocjA:
14.6		 3ou7C-3ocjA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		3 GLY A  56
ASP A  75
ASP A  98
 SAM  A 300 (-3.1A)
SAM  A 300 (-2.8A)
SAM  A 300 (-4.0A)
 0.10A 3ou7C-3ou6A:
39.2		 3ou7C-3ou6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9c CAFFEIC ACID
O-METHYLTRANSFERASE

(Lolium perenne) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 207
ASP A 228
ASP A 248
 SAH  A 401 (-3.6A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.6A)
 0.36A 3ou7C-3p9cA:
15.1		 3ou7C-3p9cA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		3 GLY A 331
ASP A 355
ASP A 388
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.8A)
SAH  A 900 (-4.1A)
 0.20A 3ou7C-3s1sA:
8.5		 3ou7C-3s1sA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 GLY A 194
ASP A 216
ASP A 243
 None
 0.46A 3ou7C-3tmaA:
12.4		 3ou7C-3tmaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		3 GLY A 146
ASP A 430
ASP A 456
 None
 0.45A 3ou7C-3vgfA:
undetectable		 3ou7C-3vgfA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wye DIACETYL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING],L-2,3-BUTAN
EDIOL
DEHYDROGENASE,DIACET
YL REDUCTASE
[(S)-ACETOIN
FORMING]

(Klebsiella
pneumoniae;
Corynebacterium
glutamicum) 		PF13561
(adh_short_C2) 		3 GLY A  11
ASP A  33
ASP A  59
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.7A)
 0.48A 3ou7C-3wyeA:
5.4		 3ou7C-3wyeA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 GLY A 189
ASP A 210
ASP A 236
 SAM  A1349 ( 3.8A)
SAM  A1349 (-2.9A)
SAM  A1349 (-3.5A)
 0.29A 3ou7C-4a6eA:
16.4		 3ou7C-4a6eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cql ESTRADIOL
17-BETA-DEHYDROGENAS
E 8

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 GLY A  20
ASP A  42
ASP A  75
 NAD  A 301 ( 3.9A)
NAD  A 301 (-2.4A)
NAD  A 301 (-3.4A)
 0.44A 3ou7C-4cqlA:
5.3		 3ou7C-4cqlA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		3 GLY A   8
ASP A  32
ASP A  37
 None
 0.46A 3ou7C-4ezbA:
3.5		 3ou7C-4ezbA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		3 GLY A 234
ASP A 254
ASP A 281
 SAH  A 501 (-3.6A)
SAH  A 501 (-2.6A)
SAH  A 501 (-3.5A)
 0.32A 3ou7C-4ineA:
16.7		 3ou7C-4ineA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv8 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
knowlesi) 		PF08241
(Methyltransf_11) 		3 GLY A  63
ASP A  83
ASP A 108
 SAM  A 301 ( 3.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.37A 3ou7C-4iv8A:
16.1		 3ou7C-4iv8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		3 GLY A 230
ASP A 250
ASP A 277
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.7A)
SAH  A 701 (-3.4A)
 0.26A 3ou7C-4kriA:
17.0		 3ou7C-4kriA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		3 GLY A 168
ASP A 189
ASP A 217
 SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 ( 3.7A)
 0.34A 3ou7C-4m73A:
14.4		 3ou7C-4m73A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		3 GLY A  62
ASP A  82
ASP A 107
 SAM  A 301 ( 3.8A)
SAM  A 301 (-2.8A)
SAM  A 301 (-3.5A)
 0.34A 3ou7C-4mwzA:
17.0		 3ou7C-4mwzA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		3 GLY A  49
ASP A  68
ASP A  94
 SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 ( 3.6A)
 0.35A 3ou7C-4necA:
15.7		 3ou7C-4necA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 208
ASP A 229
ASP A 249
 SAM  A 401 ( 4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-3.2A)
 0.47A 3ou7C-4pghA:
15.4		 3ou7C-4pghA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		3 GLY A  72
ASP A  91
ASP A 120
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.8A)
 0.39A 3ou7C-4qdkA:
17.1		 3ou7C-4qdkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		3 GLY B  57
ASP B  77
ASP B  99
 SAM  B 301 (-3.3A)
SAM  B 301 (-2.6A)
SAM  B 301 (-3.7A)
 0.38A 3ou7C-4qtuB:
15.5		 3ou7C-4qtuB:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		3 GLY A  65
ASP A  85
ASP A 110
 SAH  A 302 (-3.6A)
SAH  A 302 (-2.6A)
SAH  A 302 (-3.6A)
 0.33A 3ou7C-4r6wA:
17.8		 3ou7C-4r6wA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uy6 HISTIDINE-SPECIFIC
METHYLTRANSFERASE
EGTD

(Mycolicibacterium
smegmatis) 		PF10017
(Methyltransf_33) 		3 GLY A  88
ASP A 113
ASP A 141
 SAH  A 801 (-3.2A)
SAH  A 801 (-3.0A)
SAH  A 801 (-3.7A)
 0.30A 3ou7C-4uy6A:
15.4		 3ou7C-4uy6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		3 GLY A  47
ASP A  67
ASP A  95
 SAH  A 301 (-3.5A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.3A)
 0.40A 3ou7C-5bp7A:
13.0		 3ou7C-5bp7A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE

(Yarrowia
lipolytica) 		PF08241
(Methyltransf_11) 		3 GLY Z  66
ASP Z  83
ASP Z 105
 None
 0.36A 3ou7C-5cm2Z:
15.7		 3ou7C-5cm2Z:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvv (ISO)EUGENOL
O-METHYLTRANSFERASE

(Clarkia breweri) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 213
ASP A 234
ASP A 254
 SAH  A 401 ( 3.7A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.5A)
 0.38A 3ou7C-5cvvA:
14.6		 3ou7C-5cvvA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 GLY A 207
ASP A 227
ASP A 261
 SAH  A 501 (-3.4A)
SAH  A 501 (-2.5A)
SAH  A 501 (-3.5A)
 0.41A 3ou7C-5e9jA:
14.2		 3ou7C-5e9jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		3 GLY A 207
ASP A 227
ASP A 261
 SAH  A 500 (-3.5A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.6A)
 0.25A 3ou7C-5e9wA:
14.4		 3ou7C-5e9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epe SAM-DEPENDENT
METHYLTRANSFERASE

(Thiobacillus
denitrificans) 		PF13847
(Methyltransf_31) 		3 GLY A  46
ASP A  66
ASP A  94
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.38A 3ou7C-5epeA:
11.6		 3ou7C-5epeA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		3 GLY A 181
ASP A 202
ASP A 229
 SAH  A 400 (-3.4A)
SAH  A 400 (-1.6A)
SAH  A 400 (-4.1A)
 0.27A 3ou7C-5f8eA:
15.2		 3ou7C-5f8eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		3 GLY A 205
ASP A 208
ASP A 236
 None
 0.38A 3ou7C-5gggA:
undetectable		 3ou7C-5gggA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		3 GLY A 205
ASP A 208
ASP A 236
 None
 0.46A 3ou7C-5ggkA:
undetectable		 3ou7C-5ggkA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		3 GLY A  69
ASP A  88
ASP A 114
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.7A)
 0.23A 3ou7C-5h02A:
17.1		 3ou7C-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jc8 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Paraburkholderia
xenovorans) 		PF13561
(adh_short_C2) 		3 GLY A  18
ASP A  45
ASP A  71
 None
 0.44A 3ou7C-5jc8A:
5.8		 3ou7C-5jc8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae) 		PF13847
(Methyltransf_31) 		3 GLY A  49
ASP A  69
ASP A  95
 SAH  A 301 (-3.6A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.7A)
 0.27A 3ou7C-5je3A:
16.4		 3ou7C-5je3A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		3 GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.46A 3ou7C-5m58A:
13.8		 3ou7C-5m58A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		3 GLY A  49
ASP A  70
ASP A  96
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.44A 3ou7C-5mgzA:
13.9		 3ou7C-5mgzA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		3 GLY A  15
ASP A  13
ASP A 231
 CL  A 311 (-3.4A)
None
None
 0.47A 3ou7C-5n05A:
undetectable		 3ou7C-5n05A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens) 		no annotation 3 GLY B 207
ASP B 230
ASP B 255
 SAH  B 501 (-3.3A)
SAH  B 501 (-2.7A)
SAH  B 501 (-3.9A)
 0.29A 3ou7C-5thzB:
15.5		 3ou7C-5thzB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 3 GLY A 133
ASP A 152
ASP A 179
 SAH  A 414 (-2.8A)
SAH  A 414 (-2.1A)
SAH  A 414 (-2.9A)
 0.31A 3ou7C-5u4tA:
9.6		 3ou7C-5u4tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uk5 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1

(Rattus
norvegicus) 		PF00008
(EGF)
PF07645
(EGF_CA) 		3 GLY A 364
ASP A 374
ASP A 388
 None
 0.44A 3ou7C-5uk5A:
undetectable		 3ou7C-5uk5A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 3 GLY A  56
ASP A  82
ASP A 109
 SAH  A 301 (-3.4A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
 0.41A 3ou7C-5w7kA:
15.4		 3ou7C-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 3 GLY A  56
ASP A  82
ASP A 109
 SAH  A 301 (-3.3A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.8A)
 0.36A 3ou7C-5w7mA:
15.2		 3ou7C-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 GLY A  63
ASP A  82
ASP A 107
 SAH  A 701 (-3.5A)
SAH  A 701 (-2.9A)
SAH  A 701 (-3.2A)
 0.35A 3ou7C-5wp4A:
19.3		 3ou7C-5wp4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 GLY A 292
ASP A 312
ASP A 338
 SAH  A 703 ( 3.7A)
SAH  A 703 (-2.6A)
SAH  A 703 (-3.3A)
 0.39A 3ou7C-5wp4A:
19.3		 3ou7C-5wp4A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 3 GLY A  63
ASP A  82
ASP A 107
 SAH  A 502 (-3.5A)
SAH  A 502 (-2.9A)
SAH  A 502 (-3.2A)
 0.40A 3ou7C-5wp5A:
18.5		 3ou7C-5wp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 3 GLY A 292
ASP A 312
ASP A 338
 SAH  A 501 (-3.6A)
SAH  A 501 (-2.8A)
SAH  A 501 (-3.4A)
 0.39A 3ou7C-5wp5A:
18.5		 3ou7C-5wp5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 3 GLY A  15
ASP A  37
ASP A  63
 None
 0.43A 3ou7C-5x8hA:
5.3		 3ou7C-5x8hA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoh BERGAPTOL
O-METHYLTRANSFERASE

(Peucedanum
praeruptorum) 		no annotation 3 GLY A 205
ASP A 226
ASP A 246
 SAH  A 401 ( 3.7A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.7A)
 0.38A 3ou7C-5xohA:
12.8		 3ou7C-5xohA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 3 GLY A 184
ASP A 205
ASP A 232
 SAH  A 501 (-3.3A)
SAH  A 501 (-2.9A)
SAH  A 501 (-3.5A)
 0.18A 3ou7C-6c5bA:
14.9		 3ou7C-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 3 GLY A  48
ASP A  69
ASP A  93
 SAH  A 301 ( 3.7A)
SAH  A 301 (-2.7A)
SAH  A 301 (-3.8A)
 0.44A 3ou7C-6f5zA:
17.8		 3ou7C-6f5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdf TRNA
(CYTOSINE(38)-C(5))-
METHYLTRANSFERASE

(Schizosaccharomyces
pombe) 		no annotation 3 GLY A  15
ASP A  37
ASP A  58
 SAH  A 401 (-3.4A)
SAH  A 401 (-2.7A)
SAH  A 401 (-3.8A)
 0.36A 3ou7C-6fdfA:
7.8		 3ou7C-6fdfA:
undetectable