SIMILAR PATTERNS OF AMINO ACIDS FOR 3OU7_B_SAMB300_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyd | ARABINANENDO-1,5-ALPHA-L-ARABINOSIDASE A (Cellvibriojaponicus) |
PF04616(Glyco_hydro_43) | 5 | GLY B 239GLY B 288SER B 247ALA B 236HIS B 291 | None | 1.14A | 3ou7B-1gydB:undetectable | 3ou7B-1gydB:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htq | GLUTAMINE SYNTHETASE (Mycobacteriumtuberculosis) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | TYR A 171GLY A 170GLY A 156SER A 155HIS A 175 | None | 1.16A | 3ou7B-1htqA:undetectable | 3ou7B-1htqA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1idu | VANADIUMCHLOROPEROXIDASE (Curvulariainaequalis) |
PF01569(PAP2) | 5 | LEU A 241GLY A 409GLY A 552ALA A 341HIS A 239 | None | 1.14A | 3ou7B-1iduA:undetectable | 3ou7B-1iduA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ALA A 134GLY A 132GLY A 432ALA A 176HIS A 424 | None | 0.90A | 3ou7B-1itzA:undetectable | 3ou7B-1itzA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kol | FORMALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 302GLY A 300GLY A 47SER A 48ALA A 192 | NoneNAD A1403 ( 3.7A)NAD A1403 (-3.1A)NAD A1403 (-2.7A)NAD A1403 ( 4.1A) | 1.11A | 3ou7B-1kolA:6.2 | 3ou7B-1kolA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1puj | CONSERVEDHYPOTHETICAL PROTEINYLQF (Bacillussubtilis) |
PF01926(MMR_HSR1) | 5 | LEU A 210TYR A 256ALA A 240GLY A 242LEU A 227 | None | 1.13A | 3ou7B-1pujA:undetectable | 3ou7B-1pujA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rmg | RHAMNOGALACTURONASEA (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 5 | ALA A 148GLY A 114GLY A 170LEU A 176ALA A 127 | None | 1.04A | 3ou7B-1rmgA:undetectable | 3ou7B-1rmgA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp0 | THIAZOLEBIOSYNTHETIC ENZYME (Arabidopsisthaliana) |
PF01946(Thi4) | 5 | GLY A 240GLY A 48SER A 49MET A 259ALA A 195 | AHZ A 600 (-3.5A)AHZ A 600 (-3.4A)AHZ A 600 (-3.5A)AHZ A 600 (-3.3A)None | 1.08A | 3ou7B-1rp0A:2.6 | 3ou7B-1rp0A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sbp | SULFATE-BINDINGPROTEIN (Salmonellaenterica) |
PF13531(SBP_bac_11) | 5 | ALA A 173GLY A 132GLY A 44SER A 45ALA A 191 | SO4 A 311 (-3.4A)SO4 A 311 (-3.1A)SO4 A 311 (-3.5A)SO4 A 311 (-4.4A)None | 0.92A | 3ou7B-1sbpA:undetectable | 3ou7B-1sbpA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 5 | ALA A 553GLY A 603GLY A 555SER A 556ALA A 645 | None | 0.94A | 3ou7B-1sqjA:undetectable | 3ou7B-1sqjA:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA B 232GLY B 185GLY B 336SER B 335ALA B 82 | None | 1.07A | 3ou7B-1tqyB:undetectable | 3ou7B-1tqyB:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | ALA A 112GLY A 109SER A 106LEU A 507ALA A 71 | NoneNoneFAD A1561 ( 4.5A)NoneNone | 1.04A | 3ou7B-1w1kA:undetectable | 3ou7B-1w1kA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xv2 | HYPOTHETICALPROTEIN, SIMILAR TOALPHA-ACETOLACTATEDECARBOXYLASE (Staphylococcusaureus) |
PF03306(AAL_decarboxy) | 5 | LEU A 5ALA A 74GLY A 9ALA A 23HIS A 31 | None | 1.00A | 3ou7B-1xv2A:undetectable | 3ou7B-1xv2A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yy5 | FMS1 PROTEIN (Saccharomycescerevisiae) |
PF01593(Amino_oxidase) | 5 | TYR A 450ALA A 489GLY A 491LEU A 74HIS A 67 | FAD A 803 (-4.6A)FAD A 803 (-3.7A)NoneNoneFAD A 803 (-3.8A) | 1.18A | 3ou7B-1yy5A:2.4 | 3ou7B-1yy5A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbs | HYPOTHETICAL PROTEINPG1100 (Porphyromonasgingivalis) |
PF01869(BcrAD_BadFG) | 5 | LEU A 274ALA A 95GLY A 67GLY A 100ALA A 75 | None | 1.15A | 3ou7B-1zbsA:undetectable | 3ou7B-1zbsA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ak3 | ADENYLATE KINASEISOENZYME-3 (Bos taurus) |
PF00406(ADK)PF05191(ADK_lid) | 5 | LEU A 39GLY A 89SER A 35LEU A 77ALA A 97 | NoneAMP A 226 (-4.7A)NoneNoneNone | 1.15A | 3ou7B-2ak3A:undetectable | 3ou7B-2ak3A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | TYR A 16GLY A 52TRP A 56SER A 73MET A 76 | SAI A1300 (-4.9A)SAI A1300 (-3.5A)NoneSAI A1300 (-4.7A)SAI A1300 ( 4.2A) | 0.46A | 3ou7B-2avnA:19.1 | 3ou7B-2avnA:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | TYR A 59ALA A 50GLY A 41LEU A 15ALA A 376 | None | 1.15A | 3ou7B-2bb0A:undetectable | 3ou7B-2bb0A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dgk | GLUTAMATEDECARBOXYLASE BETA (Escherichiacoli) |
PF00282(Pyridoxal_deC) | 5 | ALA A 245GLY A 248TRP A 286GLY A 210HIS A 241 | PLP A1500 (-3.4A)NoneNoneNoneNone | 1.05A | 3ou7B-2dgkA:undetectable | 3ou7B-2dgkA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dph | FORMALDEHYDEDISMUTASE (Pseudomonasputida) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 301GLY A 299GLY A 46SER A 47ALA A 192 | NoneNAD A1403 ( 3.7A)NAD A1403 (-3.2A)NAD A1403 (-2.6A)NAD A1403 ( 3.6A) | 1.06A | 3ou7B-2dphA:6.2 | 3ou7B-2dphA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gs9 | HYPOTHETICAL PROTEINTT1324 (Thermusthermophilus) |
PF08241(Methyltransf_11) | 5 | TYR A 11GLY A 47TRP A 51SER A 66MET A 69 | NoneSAH A 301 (-3.5A)SAH A 301 (-4.6A)SAH A 301 (-4.5A)SAH A 301 (-4.2A) | 0.71A | 3ou7B-2gs9A:15.9 | 3ou7B-2gs9A:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h3g | BIOSYNTHETIC PROTEIN (Bacillusanthracis) |
PF03309(Pan_kinase) | 5 | LEU X 246ALA X 12GLY X 8SER X 63LEU X 14 | NoneNoneEDO X 501 (-3.6A)NoneNone | 1.12A | 3ou7B-2h3gX:undetectable | 3ou7B-2h3gX:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibn | INOSITOL OXYGENASE (Homo sapiens) |
PF05153(MIOX) | 5 | LEU A 79ALA A 130GLY A 133LEU A 83ALA A 138 | None | 1.11A | 3ou7B-2ibnA:undetectable | 3ou7B-2ibnA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m9p | SERINE PROTEASESUBUNIT NS2B, SERINEPROTEASE NS3 (Dengue virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | LEU A 210TYR A 222GLY A 194GLY A 197SER A 196 | None | 1.06A | 3ou7B-2m9pA:undetectable | 3ou7B-2m9pA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ox4 | PUTATIVE MANDELATERACEMASE (Zymomonasmobilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 38GLY A 290GLY A 92LEU A 53ALA A 41 | None | 1.17A | 3ou7B-2ox4A:undetectable | 3ou7B-2ox4A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2px0 | FLAGELLARBIOSYNTHESIS PROTEINFLHF (Bacillussubtilis) |
PF00448(SRP54) | 5 | LEU A 288GLY A 187GLY A 182SER A 183ALA A 193 | NoneGNP A 1 ( 3.2A)NoneNoneNone | 1.10A | 3ou7B-2px0A:undetectable | 3ou7B-2px0A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 206ALA A 380GLY A 228GLY A 383ALA A 154 | None | 1.12A | 3ou7B-2qo3A:undetectable | 3ou7B-2qo3A:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 5 | LEU A 455ALA A 467GLY A 443GLY A 465ALA A 469 | None | 0.87A | 3ou7B-2qzpA:2.6 | 3ou7B-2qzpA:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5f | TRANSCRIPTIONALREGULATOR, PUTATIVE (Pseudomonassyringae groupgenomosp. 3) |
PF04198(Sugar-bind) | 5 | ALA A 296GLY A 255GLY A 300LEU A 302ALA A 292 | None | 1.10A | 3ou7B-2r5fA:2.9 | 3ou7B-2r5fA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r66 | GLYCOSYLTRANSFERASE, GROUP 1 (Halothermothrixorenii) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | TYR A 352ALA A 385GLY A 435LEU A 397ALA A 363 | None | 1.09A | 3ou7B-2r66A:2.9 | 3ou7B-2r66A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzz | N-METHYL-L-TRYPTOPHAN OXIDASE (Escherichiacoli) |
PF01266(DAO) | 5 | ALA A 16GLY A 18GLY A 11SER A 10MET A 30 | NoneNoneFAD A1373 (-3.4A)NoneNone | 1.05A | 3ou7B-2uzzA:undetectable | 3ou7B-2uzzA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wvg | PYRUVATEDECARBOXYLASE (Zymomonasmobilis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 63GLY A 59GLY A 65ALA A 426HIS A 20 | None | 1.17A | 3ou7B-2wvgA:undetectable | 3ou7B-2wvgA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z01 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Geobacilluskaustophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 5 | GLY A 96GLY A 243LEU A 305ALA A 229HIS A 246 | None | 1.06A | 3ou7B-2z01A:undetectable | 3ou7B-2z01A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2n | VIRGINIAMYCIN BLYASE (Staphylococcusaureus) |
no annotation | 5 | LEU A 196ALA A 153GLY A 149SER A 150LEU A 154 | None | 1.00A | 3ou7B-2z2nA:undetectable | 3ou7B-2z2nA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z37 | CHITINASE (Brassica juncea) |
PF00182(Glyco_hydro_19) | 5 | ALA A 289GLY A 261SER A 266MET A 264LEU A 282 | None | 1.07A | 3ou7B-2z37A:undetectable | 3ou7B-2z37A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zo4 | METALLO-BETA-LACTAMASE FAMILY PROTEIN (Thermusthermophilus) |
PF00753(Lactamase_B) | 5 | ALA A 172GLY A 174GLY A 99ALA A 191HIS A 75 | NoneNoneNoneNone ZN A 319 (-3.2A) | 1.16A | 3ou7B-2zo4A:undetectable | 3ou7B-2zo4A:24.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0g | HEMOGLOBIN SUBUNITBETA (Cavia porcellus) |
PF00042(Globin) | 5 | ALA B 27GLY B 29GLY B 64LEU B 68HIS B 117 | None | 1.10A | 3ou7B-3a0gB:undetectable | 3ou7B-3a0gB:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3br8 | PROBABLEACYLPHOSPHATASE (Bacillussubtilis) |
PF00708(Acylphosphatase) | 5 | ALA A 31GLY A 48GLY A 82MET A 1ALA A 25 | None | 1.17A | 3ou7B-3br8A:undetectable | 3ou7B-3br8A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c02 | AQUAGLYCEROPORIN (Plasmodiumfalciparum) |
PF00230(MIP) | 5 | LEU A 69ALA A 53GLY A 51GLY A 57ALA A 30 | GOL A 663 (-4.1A)NoneNoneNoneNone | 1.03A | 3ou7B-3c02A:undetectable | 3ou7B-3c02A:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c4n | UNCHARACTERIZEDPROTEIN DR_0571 (Deinococcusradiodurans) |
PF01266(DAO) | 5 | ALA A 385GLY A 383TRP A 86MET A 47ALA A 99 | NoneNoneNoneADP A 411 ( 4.9A)None | 1.17A | 3ou7B-3c4nA:3.2 | 3ou7B-3c4nA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czx | PUTATIVEN-ACETYLMURAMOYL-L-ALANINE AMIDASE (Neisseriameningitidis) |
PF01520(Amidase_3) | 5 | LEU A 60ALA A 136GLY A 140LEU A 133ALA A 91 | None | 1.06A | 3ou7B-3czxA:undetectable | 3ou7B-3czxA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtn | PUTATIVEMETHYLTRANSFERASEMM_2633 (Methanosarcinamazei) |
PF13649(Methyltransf_25) | 5 | GLY A 52SER A 75MET A 78ALA A 114HIS A 119 | None | 0.64A | 3ou7B-3dtnA:17.7 | 3ou7B-3dtnA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dyj | TALIN-1 (Mus musculus) |
no annotation | 5 | LEU A2283ALA A2244GLY A2246GLY A2240LEU A2216 | None | 1.17A | 3ou7B-3dyjA:undetectable | 3ou7B-3dyjA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e23 | UNCHARACTERIZEDPROTEIN RPA2492 (Rhodopseudomonaspalustris) |
PF08241(Methyltransf_11) | 5 | LEU A 14TYR A 24GLY A 53GLY A 73SER A 74 | SAM A 221 (-4.4A)SAM A 221 (-4.7A)SAM A 221 (-3.2A)SAM A 221 (-3.2A)SAM A 221 (-4.6A) | 0.64A | 3ou7B-3e23A:19.1 | 3ou7B-3e23A:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e23 | UNCHARACTERIZEDPROTEIN RPA2492 (Rhodopseudomonaspalustris) |
PF08241(Methyltransf_11) | 5 | TYR A 24GLY A 53GLY A 73SER A 74ALA A 110 | SAM A 221 (-4.7A)SAM A 221 (-3.2A)SAM A 221 (-3.2A)SAM A 221 (-4.6A)SAM A 221 (-4.3A) | 1.06A | 3ou7B-3e23A:19.1 | 3ou7B-3e23A:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpz | THIAZOLEBIOSYNTHETIC ENZYME (Saccharomycescerevisiae) |
PF01946(Thi4) | 5 | GLY A 290GLY A 74SER A 75MET A 309ALA A 243 | AHZ A1100 (-3.5A)AHZ A1100 (-3.6A)AHZ A1100 (-3.6A)AHZ A1100 (-3.3A)None | 1.05A | 3ou7B-3fpzA:2.1 | 3ou7B-3fpzA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbx | GLUTAMATEDECARBOXYLASE 1 (Arabidopsisthaliana) |
PF00282(Pyridoxal_deC) | 5 | ALA A 246GLY A 249TRP A 287GLY A 211HIS A 242 | LLP A 277 ( 3.3A)NoneNoneNoneNone | 1.07A | 3ou7B-3hbxA:undetectable | 3ou7B-3hbxA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ALA A 423GLY A 421GLY A 426MET A 128ALA A 449 | None | 1.06A | 3ou7B-3m49A:2.1 | 3ou7B-3m49A:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi9 | CELL DIVISIONPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 165TYR A 194GLY A 214LEU A 134ALA A 220 | None | 1.07A | 3ou7B-3mi9A:undetectable | 3ou7B-3mi9A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 5 | LEU A 472GLY A 495GLY A 490LEU A 488ALA A 511 | None | 0.85A | 3ou7B-3nowA:undetectable | 3ou7B-3nowA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 5 | LEU A 472GLY A 495GLY A 490LEU A 488ALA A 512 | None | 1.13A | 3ou7B-3nowA:undetectable | 3ou7B-3nowA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obz | PHYTANOYL-COADIOXYGENASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF05721(PhyH) | 5 | LEU A 278GLY A 104GLY A 74SER A 73HIS A 263 | NoneNoneNoneNoneAKG A 481 ( 4.8A) | 1.14A | 3ou7B-3obzA:undetectable | 3ou7B-3obzA:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ou6 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptomycesluridus) |
PF13649(Methyltransf_25) | 12 | LEU A 12TYR A 22ALA A 54GLY A 56TRP A 60GLY A 76SER A 77MET A 80LEU A 99ALA A 114TRP A 116HIS A 119 | SAM A 300 ( 3.9A)SAM A 300 (-4.4A)SAM A 300 (-3.4A)SAM A 300 (-3.1A)NoneSAM A 300 (-3.3A)SAM A 300 (-4.5A)SAM A 300 (-4.0A)SAM A 300 (-3.9A)SAM A 300 (-3.6A)NoneSO4 A 301 (-4.0A) | 0.16A | 3ou7B-3ou6A:38.6 | 3ou7B-3ou6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3px2 | N-METHYLTRANSFERASE (Streptomycesfradiae) |
PF13649(Methyltransf_25) | 5 | TYR A 22ALA A 58GLY A 60SER A 81MET A 84 | SAH A 263 (-4.6A)SAH A 263 (-3.5A)SAH A 263 (-3.3A)SAH A 263 (-4.7A)SAH A 263 (-4.5A) | 0.43A | 3ou7B-3px2A:17.3 | 3ou7B-3px2A:28.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q98 | TRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | LEU A 159ALA A 118GLY A 63GLY A 120SER A 65 | None | 1.10A | 3ou7B-3q98A:undetectable | 3ou7B-3q98A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvq | PHOSPHODIESTERASEOLEI02445 (Oleispiraantarctica) |
PF03009(GDPD) | 5 | LEU A 155GLY A 168SER A 148LEU A 182ALA A 173 | NoneNoneG3P A 301 ( 4.4A)NoneNone | 1.10A | 3ou7B-3qvqA:undetectable | 3ou7B-3qvqA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uog | ALCOHOLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 306GLY A 182LEU A 299ALA A 157TRP A 155 | None | 1.09A | 3ou7B-3uogA:4.8 | 3ou7B-3uogA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v4y | SERINE/THREONINE-PROTEIN PHOSPHATASEPP1-ALPHA CATALYTICSUBUNIT (Homo sapiens) |
PF00149(Metallophos)PF16891(STPPase_N) | 5 | LEU A 75TYR A 255ALA A 279GLY A 254SER A 268 | None | 1.13A | 3ou7B-3v4yA:undetectable | 3ou7B-3v4yA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w15 | PEROXISOMALTARGETING SIGNAL 2RECEPTOR (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | LEU A 216ALA A 223GLY A 240GLY A 220SER A 219 | NO3 A 401 (-4.4A)NoneNoneNoneNone | 0.99A | 3ou7B-3w15A:undetectable | 3ou7B-3w15A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d65 | PORIN 2 (Providenciastuartii) |
PF00267(Porin_1) | 5 | GLY A 191GLY A 175SER A 193LEU A 149ALA A 179 | LDA A1370 ( 4.6A)LDA A1383 ( 4.2A)NoneLDA A1365 ( 4.3A)None | 1.06A | 3ou7B-4d65A:undetectable | 3ou7B-4d65A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emi | TODA (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | LEU A 394ALA A 350GLY A 349GLY A 344LEU A 352 | None | 1.13A | 3ou7B-4emiA:2.5 | 3ou7B-4emiA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 303GLY A 301GLY A 48SER A 49ALA A 193 | NoneNAD A 403 ( 3.7A)NAD A 403 (-3.0A)NAD A 403 ( 3.0A)NAD A 403 ( 4.1A) | 1.13A | 3ou7B-4jlwA:6.2 | 3ou7B-4jlwA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kry | ACETYL ESTERASE (Escherichiacoli) |
PF07859(Abhydrolase_3) | 5 | LEU A 209ALA A 259GLY A 258TRP A 194HIS A 292 | NoneNoneNoneNoneSEB A 165 ( 4.1A) | 1.15A | 3ou7B-4kryA:3.4 | 3ou7B-4kryA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myw | ENVELOPEGLYCOPROTEIN D (Humanalphaherpesvirus2) |
PF01537(Herpes_glycop_D) | 5 | ALA A 155SER A 142LEU A 236ALA A 65TRP A 241 | None | 1.03A | 3ou7B-4mywA:undetectable | 3ou7B-4mywA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q05 | ESTERASE E25 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 183GLY A 213SER A 185LEU A 276ALA A 209 | None | 1.16A | 3ou7B-4q05A:2.9 | 3ou7B-4q05A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 81GLY A 83TRP A 407LEU A 72ALA A 55 | None | 1.07A | 3ou7B-4q9dA:undetectable | 3ou7B-4q9dA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 83TRP A 407GLY A 79LEU A 72ALA A 55 | None | 0.83A | 3ou7B-4q9dA:undetectable | 3ou7B-4q9dA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qi7 | CELLOBIOSEDEHYDROGENASE (Neurosporacrassa) |
PF00732(GMC_oxred_N)PF00734(CBM_1)PF05199(GMC_oxred_C)PF16010(CDH-cyt) | 5 | LEU A 419ALA A 239GLY A 241GLY A 315ALA A 755 | NoneFAD A 902 (-3.3A)NoneNoneNone | 1.07A | 3ou7B-4qi7A:2.4 | 3ou7B-4qi7A:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qme | AMINOPEPTIDASE N (Neisseriameningitidis) |
PF01433(Peptidase_M1)PF11940(DUF3458)PF17432(DUF3458_C) | 5 | LEU A 833ALA A 796GLY A 801LEU A 630HIS A 836 | None | 1.12A | 3ou7B-4qmeA:undetectable | 3ou7B-4qmeA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmk | TYPE III SECRETIONSYSTEM EFFECTORPROTEIN EXOU (Pseudomonasfluorescens) |
PF01734(Patatin) | 5 | ALA A 95GLY A 90GLY A 61SER A 60ALA A 261 | None | 1.12A | 3ou7B-4qmkA:undetectable | 3ou7B-4qmkA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | LEU A 640GLY A 55GLY A 599SER A 598ALA A 61 | None | 1.15A | 3ou7B-4rvwA:undetectable | 3ou7B-4rvwA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-VINTEGRIN BETA-6 (Homo sapiens;Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2)PF00362(Integrin_beta)PF17205(PSI_integrin) | 6 | GLY A 157GLY A 175SER A 176LEU B 265ALA A 109HIS A 113 | None | 1.45A | 3ou7B-4um8A:undetectable | 3ou7B-4um8A:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdt | FAD:PROTEIN FMNTRANSFERASE (Treponemapallidum) |
PF02424(ApbE) | 5 | LEU A 45ALA A 164GLY A 166LEU A 52ALA A 162 | NoneFAD A 401 (-2.6A)NoneFAD A 401 ( 3.9A)FAD A 401 ( 3.2A) | 1.12A | 3ou7B-4xdtA:undetectable | 3ou7B-4xdtA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yqy | PUTATIVEDEHYDROGENASE (Sulfitobactersp. NAS-14.1) |
PF13561(adh_short_C2) | 5 | ALA A 143GLY A 156GLY A 149ALA A 140HIS A 192 | None | 1.15A | 3ou7B-4yqyA:5.7 | 3ou7B-4yqyA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu4 | HEMOGLOBIN (Helogaleparvula) |
PF00042(Globin) | 5 | GLY A 22GLY A 18SER A 19ALA A 28HIS A 112 | None | 1.15A | 3ou7B-4yu4A:undetectable | 3ou7B-4yu4A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z26 | PUTATIVE GMC-TYPEOXIDOREDUCTASE R135 (Acanthamoebapolyphagamimivirus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 100GLY A 233LEU A 237ALA A 38HIS A 40 | FAD A 901 (-3.3A)NoneNoneFAD A 901 (-3.6A)None | 1.14A | 3ou7B-4z26A:undetectable | 3ou7B-4z26A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3n | PUTATIVE DRUG/SODIUMANTIPORTER (Escherichiacoli) |
PF01554(MatE) | 5 | LEU A 314GLY A 260GLY A 93SER A 94ALA A 83 | NoneNoneNoneNoneOLC A 507 ( 3.9A) | 1.14A | 3ou7B-4z3nA:undetectable | 3ou7B-4z3nA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpi | PUTATIVEOXIDASE/HYDROXYLASE (Streptomyceshygroscopicus) |
PF05721(PhyH) | 5 | LEU A 36ALA A 221GLY A 88GLY A 90LEU A 219 | None | 1.18A | 3ou7B-4zpiA:undetectable | 3ou7B-4zpiA:24.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp8 | ENT-COPALYLDIPHOSPHATE SYNTHASE (Streptomycesplatensis) |
PF00432(Prenyltrans)PF13243(SQHop_cyclase_C) | 5 | LEU A 101GLY A 51GLY A 57LEU A 59ALA A 46 | NoneSO4 A 704 (-3.3A)NoneNoneNone | 1.03A | 3ou7B-5bp8A:undetectable | 3ou7B-5bp8A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 5 | ALA A 239TRP A 96SER A 152LEU A 148ALA A 234 | None | 1.04A | 3ou7B-5dm3A:undetectable | 3ou7B-5dm3A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyt | ADENYLOSUCCINATELYASE (Schistosomamansoni) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | LEU A 206ALA A 193GLY A 195GLY A 103LEU A 40 | None | 1.06A | 3ou7B-5eytA:undetectable | 3ou7B-5eytA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0q | BETA-GLUCURONIDASE (Acidobacteriumcapsulatum) |
PF03662(Glyco_hydro_79n) | 5 | LEU A 307ALA A 394GLY A 469LEU A 356ALA A 383 | None | 0.91A | 3ou7B-5g0qA:undetectable | 3ou7B-5g0qA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 5 | LEU A 449GLY A 348GLY A 170SER A 175ALA A 429 | None | 1.03A | 3ou7B-5g5zA:undetectable | 3ou7B-5g5zA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gp4 | GLUTAMATEDECARBOXYLASE (Lactobacillusbrevis) |
no annotation | 5 | ALA C 248GLY C 251TRP C 289GLY C 213HIS C 244 | PLP C 501 (-3.1A)NoneNoneNoneNone | 1.07A | 3ou7B-5gp4C:undetectable | 3ou7B-5gp4C:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h02 | GLYCINE SARCOSINEN-METHYLTRANSFERASE (Methanohalophilusportucalensis) |
PF13649(Methyltransf_25) | 5 | ALA A 67GLY A 69GLY A 89SER A 90MET A 93 | SAH A 301 (-3.9A)SAH A 301 (-3.3A)SAH A 301 (-3.4A)SAH A 301 ( 4.9A)SAH A 301 (-3.9A) | 0.48A | 3ou7B-5h02A:17.4 | 3ou7B-5h02A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxs | SODIUM,CALCIUMEXCHANGER (Methanocaldococcusjannaschii) |
PF01699(Na_Ca_ex) | 5 | LEU A 254ALA A 244GLY A 248SER A 249ALA A 239 | None | 1.13A | 3ou7B-5hxsA:undetectable | 3ou7B-5hxsA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5je3 | METHYL TRANSFERASE (Burkholderiaglumae) |
PF13847(Methyltransf_31) | 5 | ALA A 47GLY A 49SER A 71MET A 74ALA A 111 | SAH A 301 (-3.2A)SAH A 301 (-3.6A)SAH A 301 ( 4.8A)SAH A 301 ( 4.5A)SAH A 301 (-3.8A) | 0.43A | 3ou7B-5je3A:16.0 | 3ou7B-5je3A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp7 | ACETYL-COAACETYLTRANSFERASE (Bacillussubtilis) |
no annotation | 5 | ALA H 356GLY H 113GLY H 352MET H 53ALA H 9 | None | 1.13A | 3ou7B-5lp7H:undetectable | 3ou7B-5lp7H:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m95 | DIVALENT METALCATION TRANSPORTERMNTH (Staphylococcuscapitis) |
PF01566(Nramp) | 5 | LEU A 323ALA A 126GLY A 130SER A 131LEU A 385 | None | 1.11A | 3ou7B-5m95A:undetectable | 3ou7B-5m95A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n8o | DNA HELICASE I (Escherichiacoli) |
PF07057(TraI)PF08751(TrwC)PF13604(AAA_30) | 5 | ALA A 800GLY A 804GLY A 538SER A 537ALA A 796 | None | 1.00A | 3ou7B-5n8oA:2.8 | 3ou7B-5n8oA:8.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxn | PORIN 1 (Providenciastuartii) |
no annotation | 5 | GLY A 193GLY A 177SER A 195LEU A 152ALA A 181 | None | 1.02A | 3ou7B-5nxnA:undetectable | 3ou7B-5nxnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5onu | OUTER MEMBRANEPROTEIN OMPU (Vibrio cholerae) |
no annotation | 5 | LEU A 138ALA A 219GLY A 231GLY A 233LEU A 217 | None | 1.16A | 3ou7B-5onuA:undetectable | 3ou7B-5onuA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7x | NOD FACTOR BINDINGLECTIN-NUCLEOTIDEPHOSPHOHYDROLASE (Vignaunguiculata) |
PF01150(GDA1_CD39) | 5 | LEU F 94ALA F 87GLY F 14SER F 49LEU F 103 | NoneNonePO4 F 502 (-3.4A)NoneNone | 0.98A | 3ou7B-5u7xF:undetectable | 3ou7B-5u7xF:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um2 | ABC TRANSPORTERSULFATE BINDINGPROTEIN (Xanthomonascitri) |
PF13531(SBP_bac_11) | 5 | ALA A 225GLY A 184GLY A 95SER A 96ALA A 243 | SO4 A 401 (-3.4A)SO4 A 401 (-3.3A)SO4 A 401 (-3.6A)SO4 A 401 (-4.4A)None | 0.90A | 3ou7B-5um2A:undetectable | 3ou7B-5um2A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yp3 | DIPEPTIDYLAMINOPEPTIDASE 4 (Pseudoxanthomonasmexicana) |
no annotation | 5 | ALA A 635GLY A 611GLY A 633LEU A 681ALA A 637 | None | 1.10A | 3ou7B-5yp3A:undetectable | 3ou7B-5yp3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6az0 | MITOCHONDRIAL INNERMEMBRANE I-AAAPROTEASESUPERCOMPLEX SUBUNITYME1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 678TYR A 606GLY A 543LEU A 688HIS A 686 | None | 1.02A | 3ou7B-6az0A:undetectable | 3ou7B-6az0A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 5 | LEU A1177ALA A1230GLY A1226GLY A1217MET A1221 | None | 1.13A | 3ou7B-6bq1A:undetectable | 3ou7B-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c2h | CYSTATHIONINEBETA-SYNTHASE (Saccharomycescerevisiae) |
no annotation | 5 | ALA A 90GLY A 93GLY A 120LEU A 116ALA A 57 | NoneNone NA A 404 (-4.0A)NoneNone | 1.16A | 3ou7B-6c2hA:2.3 | 3ou7B-6c2hA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5z | 24-STEROLC-METHYLTRANSFERASE (Haloferaxvolcanii) |
no annotation | 5 | GLY A 48TRP A 108GLY A 70SER A 71MET A 74 | SAH A 301 ( 3.7A)NoneSAH A 301 (-3.6A)NoneSAH A 301 (-4.0A) | 1.16A | 3ou7B-6f5zA:17.9 | 3ou7B-6f5zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 5 | ALA A 262GLY A 255SER A 278LEU A 133ALA A 227 | NoneEDO A 505 ( 4.9A)NoneNoneNone | 1.08A | 3ou7B-6gu8A:undetectable | 3ou7B-6gu8A:undetectable |