SIMILAR PATTERNS OF AMINO ACIDS FOR 3OU6_D_SAMD300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)


(Escherichia
coli)
PF00490
(ALAD)
5 LEU A  26
GLU A 319
ALA A 318
ASP A  30
LEU A  28
GOL  A 409 ( 4.7A)
None
None
None
None
1.38A 3ou6D-1b4eA:
undetectable
3ou6D-1b4eA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)


(Proteus
vulgaris)
PF01555
(N6_N4_Mtase)
5 LEU A 330
TYR A  23
GLU A 298
ALA A 301
ASP A 319
None
1.43A 3ou6D-1booA:
3.4
3ou6D-1booA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)


(Ruminiclostridium
thermocellum)
PF01270
(Glyco_hydro_8)
5 LEU A 350
TYR A  41
TRP A 284
GLY A 347
ASP A 349
None
0.99A 3ou6D-1cemA:
undetectable
3ou6D-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus)
PF00581
(Rhodanese)
5 TYR A  98
GLU A 136
GLY A 104
SER A 105
ASP A 102
None
1.17A 3ou6D-1dp2A:
undetectable
3ou6D-1dp2A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta)
PF02763
(Diphtheria_C)
5 GLU A 168
ALA A  77
GLY A  75
SER A  74
ASP A 176
None
1.32A 3ou6D-1dtpA:
undetectable
3ou6D-1dtpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzd FIBRINOGEN-420

(Homo sapiens)
PF00147
(Fibrinogen_C)
5 ALA A 796
GLY A 750
SER A 751
ASP A 745
LEU A 747
None
1.35A 3ou6D-1fzdA:
undetectable
3ou6D-1fzdA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE


(Arabidopsis
thaliana)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 108
TYR A 109
TYR A 125
ALA A 137
LEU A 322
None
1.11A 3ou6D-1ibjA:
1.9
3ou6D-1ibjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
5 LEU A 426
TYR A 576
ALA A 439
ASP A 456
LEU A 417
None
1.15A 3ou6D-1jf5A:
undetectable
3ou6D-1jf5A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE


([Clostridium]
symbiosum)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 GLU A 279
ALA A 276
GLY A 252
SER A 251
LEU A 273
None
1.37A 3ou6D-1kblA:
undetectable
3ou6D-1kblA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans)
PF00069
(Pkinase)
PF07679
(I-set)
5 ALA A6088
GLY A6085
SER A6243
ASP A6063
LEU A6062
None
1.37A 3ou6D-1koaA:
undetectable
3ou6D-1koaA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster)
PF00135
(COesterase)
5 TYR A 447
ALA A 246
SER A 241
MET A 262
LEU A 208
None
1.44A 3ou6D-1qonA:
undetectable
3ou6D-1qonA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r03 MITOCHONDRIAL
FERRITIN


(Homo sapiens)
PF00210
(Ferritin)
5 TYR A  54
TYR A  34
GLY A  96
MET A  37
LEU A  97
None
1.41A 3ou6D-1r03A:
undetectable
3ou6D-1r03A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjc CAMELID HEAVY CHAIN
ANTIBODY


(Camelus
dromedarius)
PF07686
(V-set)
5 LEU A  18
TYR A  94
ALA A   6
TRP A 118
GLY A   8
None
1.44A 3ou6D-1rjcA:
undetectable
3ou6D-1rjcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli)
PF00485
(PRK)
5 LEU A1201
GLU A1295
GLY A1095
SER A1096
LEU A1204
None
1.42A 3ou6D-1sq5A:
undetectable
3ou6D-1sq5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc1 PROTEIN
(HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE)


(Trypanosoma
cruzi)
PF00156
(Pribosyltran)
5 TYR A   5
GLU A  15
GLY A 169
ASP A 112
LEU A 140
None
None
None
MES  A 800 ( 4.0A)
None
1.37A 3ou6D-1tc1A:
2.2
3ou6D-1tc1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
5 TYR A   5
TYR A  12
ALA A  49
MET A  75
ASP A  96
SAH  A1001 (-3.5A)
SAH  A1001 (-4.9A)
SAH  A1001 (-3.4A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.3A)
1.04A 3ou6D-1wznA:
18.9
3ou6D-1wznA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN


(Thermotoga
maritima)
PF08241
(Methyltransf_11)
5 TYR A   9
TYR A  16
TRP A  56
SER A  73
MET A  76
SAI  A1300 (-3.8A)
SAI  A1300 (-4.9A)
None
SAI  A1300 (-4.7A)
SAI  A1300 ( 4.2A)
0.78A 3ou6D-2avnA:
19.0
3ou6D-2avnA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE


(Paenarthrobacter
nicotinovorans)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 TYR A 293
GLU A 117
ALA A 118
GLY A 122
LEU A 202
None
1.46A 3ou6D-2bvgA:
undetectable
3ou6D-2bvgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324


(Thermus
thermophilus)
PF08241
(Methyltransf_11)
5 TYR A  11
GLU A  43
TRP A  51
SER A  66
MET A  69
None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
0.85A 3ou6D-2gs9A:
16.0
3ou6D-2gs9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqo PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Helicobacter
pylori)
PF00072
(Response_reg)
5 GLU A  82
ALA A  86
GLY A  90
SER A  60
ASP A  92
None
1.42A 3ou6D-2hqoA:
undetectable
3ou6D-2hqoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 TYR A 178
GLU A 172
ALA A 173
SER A 179
LEU A 188
None
1.44A 3ou6D-2ozoA:
undetectable
3ou6D-2ozoA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE


(Thermus
thermophilus)
PF00701
(DHDPS)
5 LEU A  36
GLU A  83
ALA A  84
GLY A  68
LEU A  92
None
1.34A 3ou6D-2pcqA:
undetectable
3ou6D-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ


(Mycobacterium
tuberculosis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 GLU A 102
ALA A 100
GLY A  19
ASP A 184
LEU A 187
None
None
GSP  A 401 (-3.6A)
GSP  A 401 (-3.1A)
None
1.43A 3ou6D-2q1yA:
3.1
3ou6D-2q1yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4i UNCHARACTERIZED
PROTEIN


(Cytophaga
hutchinsonii)
PF14534
(DUF4440)
5 TYR A  53
GLU A  88
ALA A  59
GLY A  56
SER A  55
IPA  A 127 (-4.6A)
None
None
None
None
1.22A 3ou6D-2r4iA:
undetectable
3ou6D-2r4iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus)
PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2)
5 LEU A 359
GLY A 376
SER A 323
LEU A 361
TRP A 338
None
1.24A 3ou6D-2vsaA:
undetectable
3ou6D-2vsaA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE


(Cellvibrio
japonicus)
PF00657
(Lipase_GDSL)
5 LEU A 244
GLU A 257
GLY A 201
SER A 214
ASP A 150
None
1.42A 3ou6D-2w9xA:
undetectable
3ou6D-2w9xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE


(Methylophaga
aminisulfidivorans)
PF00743
(FMO-like)
5 LEU A 229
TYR A 240
ALA A 214
GLY A 218
SER A 219
None
1.19A 3ou6D-2xlrA:
undetectable
3ou6D-2xlrA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN


(Thermus
thermophilus)
PF12697
(Abhydrolase_6)
5 GLU A  12
ALA A  13
GLY A  62
ASP A  59
LEU A  15
None
1.23A 3ou6D-2yysA:
2.2
3ou6D-2yysA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea)
PF00182
(Glyco_hydro_19)
5 TYR A 258
ALA A 289
SER A 266
MET A 264
LEU A 282
None
1.09A 3ou6D-2z37A:
undetectable
3ou6D-2z37A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwf ALKALINE PHOSPHATASE
SYNTHESIS SENSOR
PROTEIN PHOR


(Bacillus
subtilis)
PF16736
(sCache_like)
5 TYR A  90
ALA A  71
GLY A  73
ASP A  76
LEU A  75
None
1.44A 3ou6D-3cwfA:
undetectable
3ou6D-3cwfA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492


(Rhodopseudomonas
palustris)
PF08241
(Methyltransf_11)
5 LEU A  14
TYR A  17
TYR A  24
GLU A  49
GLY A  73
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-4.7A)
None
SAM  A 221 (-3.2A)
1.02A 3ou6D-3e23A:
18.9
3ou6D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492


(Rhodopseudomonas
palustris)
PF08241
(Methyltransf_11)
5 LEU A  14
TYR A  24
GLU A  49
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-4.7A)
None
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.78A 3ou6D-3e23A:
18.9
3ou6D-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnc PUTATIVE
ACETYLTRANSFERASE


(Listeria
innocua)
PF13673
(Acetyltransf_10)
5 LEU A  89
TYR A  88
TYR A  45
ALA A  72
GLY A  70
EDO  A 165 (-4.9A)
EDO  A 167 (-4.1A)
MLI  A 161 (-4.5A)
None
None
1.38A 3ou6D-3fncA:
undetectable
3ou6D-3fncA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fru NEONATAL FC RECEPTOR

(Rattus
norvegicus)
PF00129
(MHC_I)
PF07654
(C1-set)
5 LEU A 242
GLU A 257
GLY A 222
SER A 223
LEU A 215
None
1.28A 3ou6D-3fruA:
undetectable
3ou6D-3fruA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE


(Trypanosoma
brucei)
PF01156
(IU_nuc_hydro)
5 TYR A  57
ALA A  19
MET A  24
ASP A   9
LEU A 131
None
1.42A 3ou6D-3fz0A:
2.5
3ou6D-3fz0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt7 SENSOR PROTEIN

(Syntrophus
aciditrophicus)
PF00072
(Response_reg)
5 LEU A  83
GLU A  46
ALA A  47
SER A  52
LEU A  15
None
1.22A 3ou6D-3gt7A:
2.1
3ou6D-3gt7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae)
PF11715
(Nup160)
5 LEU A 205
TYR A 204
GLY A 181
LEU A 183
TRP A 246
None
1.28A 3ou6D-3h7nA:
undetectable
3ou6D-3h7nA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2


(Homo sapiens)
PF00415
(RCC1)
5 LEU A4132
GLU A4065
ALA A4066
GLY A4069
LEU A4071
None
1.34A 3ou6D-3kciA:
undetectable
3ou6D-3kciA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5


(Homo sapiens)
PF01094
(ANF_receptor)
5 TYR A 481
GLU A 320
ALA A 321
GLY A 323
LEU A 301
None
1.15A 3ou6D-3lmkA:
undetectable
3ou6D-3lmkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
ALPHA


(Bos taurus)
PF06957
(COPI_C)
5 LEU B1001
ALA B1050
SER B1035
ASP B1005
LEU B1003
None
1.43A 3ou6D-3mkrB:
undetectable
3ou6D-3mkrB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2


(Homo sapiens)
no annotation 5 LEU B 585
ALA B 543
GLY B 545
SER B 528
TRP B 604
None
1.36A 3ou6D-3nr8B:
undetectable
3ou6D-3nr8B:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE


(Taxus
canadensis)
PF00221
(Lyase_aromatic)
5 TYR A 245
ALA A 247
SER A 241
ASP A 473
LEU A 476
None
1.20A 3ou6D-3nz4A:
undetectable
3ou6D-3nz4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on2 PROBABLE
TRANSCRIPTIONAL
REGULATOR


(Rhodococcus
jostii)
PF00440
(TetR_N)
PF13305
(WHG)
5 LEU A 107
GLU A  76
GLY A  67
SER A  66
LEU A  71
None
1.42A 3ou6D-3on2A:
undetectable
3ou6D-3on2A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptomyces
luridus)
PF13649
(Methyltransf_25)
12 LEU A  12
TYR A  15
TYR A  22
GLU A  52
ALA A  54
TRP A  60
GLY A  76
SER A  77
MET A  80
ASP A  98
LEU A  99
TRP A 116
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-4.4A)
None
SAM  A 300 (-3.4A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
None
0.19A 3ou6D-3ou6A:
39.5
3ou6D-3ou6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa8 TOXIN B

(Clostridioides
difficile)
PF11713
(Peptidase_C80)
5 LEU A  26
ALA A  50
GLY A 207
SER A 205
LEU A  54
None
621  A 300 ( 4.1A)
None
None
None
1.38A 3ou6D-3pa8A:
undetectable
3ou6D-3pa8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
6 TYR A  14
TYR A  22
ALA A  58
SER A  81
MET A  84
ASP A 101
SAH  A 263 ( 3.9A)
SAH  A 263 (-4.6A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.5A)
0.99A 3ou6D-3px2A:
17.1
3ou6D-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE


(Acinetobacter
baumannii)
PF00701
(DHDPS)
5 ALA A 221
GLY A   4
SER A   5
MET A 214
ASP A 200
None
1.38A 3ou6D-3tdfA:
undetectable
3ou6D-3tdfA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tth SPERMIDINE
N1-ACETYLTRANSFERASE


(Coxiella
burnetii)
PF13302
(Acetyltransf_3)
5 LEU A  75
TYR A 136
GLU A 103
ALA A 104
LEU A   9
None
1.06A 3ou6D-3tthA:
undetectable
3ou6D-3tthA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]


(Saccharomyces
cerevisiae)
PF05222
(AlaDh_PNT_N)
5 ALA A 144
GLY A 208
SER A 205
ASP A 211
LEU A 212
None
1.36A 3ou6D-3ugkA:
undetectable
3ou6D-3ugkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 LEU A  25
GLU A 351
GLY A 403
SER A 402
ASP A 414
None
None
None
None
CA  A 603 (-2.8A)
1.30A 3ou6D-3v4pA:
undetectable
3ou6D-3v4pA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2


(Thermus
thermophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 GLU A 243
ALA A 244
GLY A 325
ASP A 330
LEU A 329
None
1.43A 3ou6D-3viuA:
undetectable
3ou6D-3viuA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vjz PUTATIVE
UNCHARACTERIZED
PROTEIN


(Neisseria
meningitidis)
PF14300
(DUF4375)
5 TYR A  53
GLU A 111
ALA A  68
ASP A 119
LEU A 123
None
1.44A 3ou6D-3vjzA:
undetectable
3ou6D-3vjzA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1


(Toxoplasma
gondii)
PF01150
(GDA1_CD39)
5 LEU A 453
GLU A 277
ALA A 283
SER A 332
MET A 329
None
MG  A 701 (-4.7A)
None
None
ANP  A 700 (-4.8A)
1.38A 3ou6D-4a5aA:
undetectable
3ou6D-4a5aA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0y DACB

(Streptococcus
pneumoniae)
PF02557
(VanY)
5 GLU A 152
ALA A  76
SER A  65
ASP A  62
LEU A  82
None
None
None
ZN  A1241 ( 2.4A)
None
1.45A 3ou6D-4d0yA:
undetectable
3ou6D-4d0yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
None
1.11A 3ou6D-4fl3A:
undetectable
3ou6D-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 LEU A 365
TYR A 364
GLU A 420
ALA A 421
LEU A 446
None
1.17A 3ou6D-4fl3A:
undetectable
3ou6D-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Bacillus
anthracis)
PF00144
(Beta-lactamase)
5 TYR A 246
TYR A 352
GLY A 249
SER A 250
LEU A 208
NO3  A 601 (-4.3A)
None
None
None
None
1.45A 3ou6D-4gb7A:
undetectable
3ou6D-4gb7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1


(Danio rerio)
PF00183
(HSP90)
PF13589
(HATPase_c_3)
5 LEU A 113
GLU A 255
GLY A 252
SER A 251
TRP A 246
None
1.25A 3ou6D-4ipeA:
undetectable
3ou6D-4ipeA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE


(Kribbella
flavida)
PF00583
(Acetyltransf_1)
5 LEU A 254
TYR A 142
GLU A  77
GLY A 248
LEU A  74
None
1.38A 3ou6D-4iusA:
undetectable
3ou6D-4iusA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE


(Nocardia
farcinica)
PF00067
(p450)
5 TYR A 176
SER A 159
MET A 155
ASP A 214
LEU A 215
None
1.17A 3ou6D-4j6cA:
undetectable
3ou6D-4j6cA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj3 MAMP

(Magnetococcus
marinus)
PF13180
(PDZ_2)
5 LEU A 116
GLU A 156
ALA A 141
GLY A 118
LEU A 139
None
1.41A 3ou6D-4jj3A:
undetectable
3ou6D-4jj3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 236
TRP A 241
GLY A 191
SER A 192
MET A 196
None
1.45A 3ou6D-4l52A:
undetectable
3ou6D-4l52A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n77 UNCHARACTERIZED
PROTEIN


(Thermus
thermophilus)
PF09704
(Cas_Cas5d)
5 LEU A 130
GLU A 180
ALA A 178
GLY A 129
LEU A   5
None
1.42A 3ou6D-4n77A:
undetectable
3ou6D-4n77A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt9 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
no annotation 5 GLU B 152
ALA B  76
SER B  65
ASP B  62
LEU B  82
None
1.44A 3ou6D-4nt9B:
undetectable
3ou6D-4nt9B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens)
PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
5 LEU A1182
GLU A1110
ALA A1158
GLY A1139
ASP A1615
None
1.44A 3ou6D-4o9xA:
undetectable
3ou6D-4o9xA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofq PUTATIVE CELL
SURFACE PROTEIN


(Streptococcus
pyogenes)
PF16364
(Antigen_C)
5 TYR A1288
ALA A1270
TRP A1184
ASP A1234
LEU A1235
None
1.37A 3ou6D-4ofqA:
undetectable
3ou6D-4ofqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF14262
(Cthe_2159)
5 GLU A 120
ALA A 122
GLY A  98
SER A  74
ASP A 126
None
0.98A 3ou6D-4phbA:
undetectable
3ou6D-4phbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE


(Geobacillus
kaustophilus)
PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C)
5 LEU A 403
ALA A 314
SER A 393
LEU A 318
TRP A 205
None
1.45A 3ou6D-4r1pA:
undetectable
3ou6D-4r1pA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)


(Agrobacterium
vitis)
PF01547
(SBP_bac_1)
5 LEU A 101
GLU A  88
ALA A  89
MET A  82
LEU A 123
None
1.45A 3ou6D-4ryaA:
undetectable
3ou6D-4ryaA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 252
GLY A 129
SER A 155
MET A 267
LEU A  87
None
1.26A 3ou6D-4tvoA:
4.5
3ou6D-4tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE


(Clostridium
acetobutylicum)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 377
GLU A 198
GLY A 354
SER A 353
LEU A 358
None
1.28A 3ou6D-4wyrA:
undetectable
3ou6D-4wyrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 TYR A 288
ALA A 223
SER A 229
ASP A 199
LEU A 197
None
None
None
GOL  A 915 (-2.9A)
None
1.40A 3ou6D-4xmvA:
undetectable
3ou6D-4xmvA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaa FDC1

(Aspergillus
niger)
PF01977
(UbiD)
5 GLU A 233
ALA A 234
TRP A 166
GLY A 238
LEU A 245
MN  A 603 ( 2.7A)
None
None
None
None
1.25A 3ou6D-4zaaA:
undetectable
3ou6D-4zaaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 928
GLU A 923
ALA A 925
GLY A 580
LEU A 577
None
1.41A 3ou6D-4zdnA:
undetectable
3ou6D-4zdnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqu CDIA-CT TOXIN,
CONSERVED DOMAIN
PROTEIN
CDII TOXIN


(Yersinia
pseudotuberculosis;
Salmonella
enterica)
no annotation
PF07262
(CdiI)
5 ALA B  67
GLY A 187
SER A 188
ASP B  86
LEU B  82
None
1.45A 3ou6D-4zquB:
undetectable
3ou6D-4zquB:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB


(Bordetella
pertussis)
PF02537
(CRCB)
5 TYR A 104
ALA A  42
GLY A  47
SER A 112
LEU A  79
None
1.45A 3ou6D-5a40A:
undetectable
3ou6D-5a40A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE


(Mycolicibacterium
smegmatis)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 375
GLU A  30
ALA A  31
GLY A  35
ASP A  37
None
1.42A 3ou6D-5bp1A:
undetectable
3ou6D-5bp1A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus)
PF06048
(DUF927)
5 LEU A 119
TYR A 125
ALA A 360
GLY A 117
LEU A 129
None
1.34A 3ou6D-5dgkA:
undetectable
3ou6D-5dgkA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis)
no annotation 5 TYR A 327
GLU A 360
ALA A 359
GLY A 329
LEU A 365
None
None
None
ADP  A 403 (-3.6A)
None
1.26A 3ou6D-5ec0A:
undetectable
3ou6D-5ec0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eio N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE/N-ACET
YL-GAMMA-AMINOADIPYL
-PHOSPHATE REDUCTASE


(Thermus
thermophilus)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
5 LEU A  75
GLU A  18
ALA A  15
ASP A  96
LEU A  97
NAP  A 401 (-4.6A)
None
NAP  A 401 (-3.3A)
None
NAP  A 401 (-4.9A)
1.24A 3ou6D-5eioA:
2.9
3ou6D-5eioA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE


(Methanohalophilus
portucalensis)
PF13649
(Methyltransf_25)
5 ALA A  67
GLY A  89
SER A  90
MET A  93
ASP A 114
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
0.48A 3ou6D-5h02A:
16.8
3ou6D-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb1 NUCLEOPORIN NUP170

(Chaetomium
thermophilum)
PF03177
(Nucleoporin_C)
5 TYR A 905
GLU A 867
ALA A 865
SER A 907
LEU A 875
None
1.20A 3ou6D-5hb1A:
undetectable
3ou6D-5hb1A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM


(Pseudomonas
aeruginosa)
PF01323
(DSBA)
5 TYR A   8
GLU A  29
ALA A  27
LEU A 207
TRP A 203
TYR  A   8 ( 1.3A)
GLU  A  29 ( 0.6A)
ALA  A  27 ( 0.0A)
LEU  A 207 ( 0.6A)
TRP  A 203 ( 0.5A)
1.41A 3ou6D-5hfiA:
undetectable
3ou6D-5hfiA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu6 HAPTOGLOBIN-HEMOGLOB
IN RECEPTOR


(Trypanosoma
brucei)
no annotation 5 TYR D  66
ALA D 155
GLY D 159
SER D 161
LEU D 239
None
1.45A 3ou6D-5hu6D:
undetectable
3ou6D-5hu6D:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN


(Bacteroides
cellulosilyticus)
no annotation 5 LEU A 260
TYR A 259
TRP A 363
GLY A 304
LEU A 300
None
1.45A 3ou6D-5jvkA:
undetectable
3ou6D-5jvkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
5 LEU A 635
GLU A 717
ALA A 716
ASP A 703
LEU A 668
None
1.32A 3ou6D-5kqiA:
undetectable
3ou6D-5kqiA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE


(Vibrio
vulnificus)
PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C)
5 TYR A 232
ALA A 324
TRP A 237
ASP A 361
LEU A 364
None
1.44A 3ou6D-5ks1A:
undetectable
3ou6D-5ks1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocr KAPPA-CARRAGEENASE

(Zobellia
galactanivorans)
no annotation 5 LEU A 208
GLU A 241
ALA A 243
ASP A 182
LEU A 183
None
1.31A 3ou6D-5ocrA:
undetectable
3ou6D-5ocrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
no annotation 5 GLU A 193
ALA A 194
TRP A 179
GLY A 196
SER A 172
IMD  A 402 (-3.6A)
None
IMD  A 402 (-3.5A)
None
None
1.44A 3ou6D-5t9xA:
undetectable
3ou6D-5t9xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 LEU 4 623
GLU 4 647
GLY 4 619
SER 4 618
LEU 4 601
None
1.41A 3ou6D-5u8s4:
undetectable
3ou6D-5u8s4:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc0 UNCHARACTERIZED
PROTEIN COG5400


(Brucella
abortus)
PF06577
(DUF1134)
5 LEU A  99
TYR A 100
GLU A  45
GLY A  77
LEU A 130
None
1.44A 3ou6D-5uc0A:
undetectable
3ou6D-5uc0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H


(Human
betaherpesvirus
5)
PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
5 ALA A 351
GLY A 185
SER A 184
ASP A 146
LEU A 309
None
1.22A 3ou6D-5vocA:
undetectable
3ou6D-5vocA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wql TAIL-SPECIFIC
PROTEASE


(Escherichia
coli)
no annotation 5 TYR C 438
ALA C 467
GLY C 465
SER C 561
ASP C 463
None
1.43A 3ou6D-5wqlC:
undetectable
3ou6D-5wqlC:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens)
PF06702
(Fam20C)
5 LEU A 486
GLU A 326
GLY A 338
SER A 339
LEU A 336
None
1.32A 3ou6D-5wrrA:
undetectable
3ou6D-5wrrA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR


(Aplysia
californica)
no annotation 5 TYR A 186
GLY A 149
SER A 148
ASP A 153
LEU A 154
None
1.40A 3ou6D-5xglA:
undetectable
3ou6D-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN
OS02G0668100 PROTEIN


(Oryza sativa;
Oryza sativa)
PF00348
(polyprenyl_synt)
PF00348
(polyprenyl_synt)
5 GLU C 150
ALA C 152
GLY C 156
SER C 157
ASP A 116
None
1.31A 3ou6D-5xn6C:
undetectable
3ou6D-5xn6C:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 ALA B 407
GLY B 238
SER B 239
ASP B  48
LEU B  49
None
1.22A 3ou6D-5xogB:
undetectable
3ou6D-5xogB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae)
no annotation 5 TYR A 583
GLY A 481
SER A 482
LEU A 479
TRP A 633
None
1.42A 3ou6D-6arxA:
undetectable
3ou6D-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10


(Homo sapiens)
no annotation 5 LEU B  75
GLU B  46
ALA B  45
MET B  14
LEU B  86
None
1.31A 3ou6D-6c9mB:
undetectable
3ou6D-6c9mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MBH13 NADH
DEHYDROGENASE
SUBUNIT


(Pyrococcus
furiosus;
Pyrococcus
furiosus)
no annotation
no annotation
5 TYR M 125
GLU M 211
ALA M 215
GLY J  61
SER J  62
None
1.44A 3ou6D-6cfwM:
undetectable
3ou6D-6cfwM:
undetectable