SIMILAR PATTERNS OF AMINO ACIDS FOR 3OU6_B_SAMB300_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)


(Homo sapiens)
PF00168
(C2)
PF01735
(PLA2_B)
5 ALA A 396
GLY A 394
GLY A 551
SER A 550
LEU A 421
None
1.16A 3ou6B-1cjyA:
undetectable
3ou6B-1cjyA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cxa CYTOCHROME C2

(Rhodobacter
sphaeroides)
PF00034
(Cytochrom_C)
5 LEU A  87
TYR A  90
ALA A  48
TRP A  71
HIS A  75
None
None
HEM  A 126 (-4.4A)
HEM  A 126 (-4.0A)
None
1.03A 3ou6B-1cxaA:
undetectable
3ou6B-1cxaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE


(Escherichia
coli)
PF00080
(Sod_Cu)
5 LEU A  85
ALA A 143
GLY A 145
ALA A  55
HIS A 118
None
None
None
None
CU  A 150 ( 3.2A)
1.14A 3ou6B-1esoA:
undetectable
3ou6B-1esoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
5 GLY B 239
GLY B 288
SER B 247
ALA B 236
HIS B 291
None
1.14A 3ou6B-1gydB:
undetectable
3ou6B-1gydB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE


(Curvularia
inaequalis)
PF01569
(PAP2)
5 LEU A 241
GLY A 409
GLY A 552
ALA A 341
HIS A 239
None
1.10A 3ou6B-1iduA:
undetectable
3ou6B-1iduA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA A 134
GLY A 132
GLY A 432
ALA A 176
HIS A 424
None
0.93A 3ou6B-1itzA:
2.4
3ou6B-1itzA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmg RHAMNOGALACTURONASE
A


(Aspergillus
aculeatus)
PF00295
(Glyco_hydro_28)
5 ALA A 148
GLY A 114
GLY A 170
LEU A 176
ALA A 127
None
1.06A 3ou6B-1rmgA:
undetectable
3ou6B-1rmgA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp0 THIAZOLE
BIOSYNTHETIC ENZYME


(Arabidopsis
thaliana)
PF01946
(Thi4)
5 GLY A 240
GLY A  48
SER A  49
MET A 259
ALA A 195
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.4A)
AHZ  A 600 (-3.5A)
AHZ  A 600 (-3.3A)
None
1.08A 3ou6B-1rp0A:
2.6
3ou6B-1rp0A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN


(Salmonella
enterica)
PF13531
(SBP_bac_11)
5 ALA A 173
GLY A 132
GLY A  44
SER A  45
ALA A 191
SO4  A 311 (-3.4A)
SO4  A 311 (-3.1A)
SO4  A 311 (-3.5A)
SO4  A 311 (-4.4A)
None
0.91A 3ou6B-1sbpA:
undetectable
3ou6B-1sbpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbp SULFATE-BINDING
PROTEIN


(Salmonella
enterica)
PF13531
(SBP_bac_11)
5 TYR A  10
ALA A 173
GLY A 132
GLY A  44
ALA A 191
SO4  A 311 (-4.8A)
SO4  A 311 (-3.4A)
SO4  A 311 (-3.1A)
SO4  A 311 (-3.5A)
None
1.10A 3ou6B-1sbpA:
undetectable
3ou6B-1sbpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 ALA B 232
GLY B 185
GLY B 336
SER B 335
ALA B  82
None
1.06A 3ou6B-1tqyB:
undetectable
3ou6B-1tqyB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE


(Penicillium
simplicissimum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
5 ALA A 112
GLY A 109
SER A 106
LEU A 507
ALA A  71
None
None
FAD  A1561 ( 4.5A)
None
None
1.04A 3ou6B-1w1kA:
undetectable
3ou6B-1w1kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv2 HYPOTHETICAL
PROTEIN, SIMILAR TO
ALPHA-ACETOLACTATE
DECARBOXYLASE


(Staphylococcus
aureus)
PF03306
(AAL_decarboxy)
5 LEU A   5
ALA A  74
GLY A   9
ALA A  23
HIS A  31
None
0.98A 3ou6B-1xv2A:
undetectable
3ou6B-1xv2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9k IAA
ACETYLTRANSFERASE


(Bacillus cereus)
PF00583
(Acetyltransf_1)
5 LEU A  81
TYR A  50
GLY A  48
GLY A  77
HIS A  83
None
1.03A 3ou6B-1y9kA:
undetectable
3ou6B-1y9kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE


(Rattus
norvegicus)
PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C)
5 LEU A 317
ALA A 290
GLY A 252
SER A 251
ALA A 339
None
1.13A 3ou6B-1yjkA:
undetectable
3ou6B-1yjkA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbs HYPOTHETICAL PROTEIN
PG1100


(Porphyromonas
gingivalis)
PF01869
(BcrAD_BadFG)
5 LEU A 274
ALA A  95
GLY A  67
GLY A 100
ALA A  75
None
1.14A 3ou6B-1zbsA:
undetectable
3ou6B-1zbsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ak3 ADENYLATE KINASE
ISOENZYME-3


(Bos taurus)
PF00406
(ADK)
PF05191
(ADK_lid)
5 LEU A  39
GLY A  89
SER A  35
LEU A  77
ALA A  97
None
AMP  A 226 (-4.7A)
None
None
None
1.14A 3ou6B-2ak3A:
undetectable
3ou6B-2ak3A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)


(Actinobacillus
pleuropneumoniae)
PF00080
(Sod_Cu)
5 LEU A 110
ALA A 162
GLY A 164
LEU A  52
HIS A 141
None
None
None
None
CU  A 402 ( 3.1A)
1.15A 3ou6B-2apsA:
undetectable
3ou6B-2apsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN


(Thermotoga
maritima)
PF08241
(Methyltransf_11)
5 TYR A   9
GLY A  52
TRP A  56
SER A  73
MET A  76
SAI  A1300 (-3.8A)
SAI  A1300 (-3.5A)
None
SAI  A1300 (-4.7A)
SAI  A1300 ( 4.2A)
0.72A 3ou6B-2avnA:
19.1
3ou6B-2avnA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA


(Escherichia
coli)
PF00282
(Pyridoxal_deC)
5 ALA A 245
GLY A 248
TRP A 286
GLY A 210
HIS A 241
PLP  A1500 (-3.4A)
None
None
None
None
1.01A 3ou6B-2dgkA:
undetectable
3ou6B-2dgkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV


(Stenotrophomonas
maltophilia)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 LEU A 620
ALA A 632
GLY A 608
GLY A 630
ALA A 634
None
0.99A 3ou6B-2ecfA:
undetectable
3ou6B-2ecfA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis)
PF03309
(Pan_kinase)
5 LEU X 246
ALA X  12
GLY X   8
SER X  63
LEU X  14
None
None
EDO  X 501 (-3.6A)
None
None
1.15A 3ou6B-2h3gX:
undetectable
3ou6B-2h3gX:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens)
PF05153
(MIOX)
5 LEU A  79
ALA A 130
GLY A 133
LEU A  83
ALA A 138
None
1.12A 3ou6B-2ibnA:
undetectable
3ou6B-2ibnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jpd DNA EXCISION REPAIR
PROTEIN ERCC-1


(Homo sapiens)
PF03834
(Rad10)
5 LEU A 209
TYR A 212
GLY A 133
LEU A 139
ALA A 165
None
1.08A 3ou6B-2jpdA:
undetectable
3ou6B-2jpdA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE


(Thermus
thermophilus)
PF00701
(DHDPS)
5 LEU A  36
ALA A  84
GLY A  68
LEU A  92
ALA A  86
None
1.03A 3ou6B-2pcqA:
undetectable
3ou6B-2pcqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Mycobacterium
tuberculosis)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 308
TYR A 310
ALA A 113
GLY A 303
GLY A 305
None
None
None
None
DFD  A 760 (-3.6A)
1.12A 3ou6B-2qnyA:
undetectable
3ou6B-2qnyA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 206
ALA A 380
GLY A 228
GLY A 383
ALA A 154
None
1.13A 3ou6B-2qo3A:
undetectable
3ou6B-2qo3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME


(Aeropyrum
pernix)
PF00326
(Peptidase_S9)
5 LEU A 455
ALA A 467
GLY A 443
GLY A 465
ALA A 469
None
0.84A 3ou6B-2qzpA:
2.7
3ou6B-2qzpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5f TRANSCRIPTIONAL
REGULATOR, PUTATIVE


(Pseudomonas
syringae group
genomosp. 3)
PF04198
(Sugar-bind)
5 ALA A 296
GLY A 255
GLY A 300
LEU A 302
ALA A 292
None
1.07A 3ou6B-2r5fA:
undetectable
3ou6B-2r5fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE


(Escherichia
coli)
PF01266
(DAO)
5 ALA A  16
GLY A  18
GLY A  11
SER A  10
MET A  30
None
None
FAD  A1373 (-3.4A)
None
None
1.05A 3ou6B-2uzzA:
2.3
3ou6B-2uzzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803)
PF00190
(Cupin_1)
5 TYR A 350
GLY A 269
GLY A 348
SER A 257
HIS A 285
ACT  A1395 (-4.4A)
None
None
None
MN  A1006 ( 3.5A)
1.13A 3ou6B-2vqaA:
undetectable
3ou6B-2vqaA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE


(Zymomonas
mobilis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A  63
GLY A  59
GLY A  65
ALA A 426
HIS A  20
None
1.15A 3ou6B-2wvgA:
undetectable
3ou6B-2wvgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN


(Aeropyrum
pernix)
PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
5 LEU A  17
ALA A  30
GLY A  26
GLY A  43
ALA A  32
None
1.09A 3ou6B-2yv2A:
3.9
3ou6B-2yv2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Geobacillus
kaustophilus)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 GLY A  96
GLY A 243
LEU A 305
ALA A 229
HIS A 246
None
1.03A 3ou6B-2z01A:
undetectable
3ou6B-2z01A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2n VIRGINIAMYCIN B
LYASE


(Staphylococcus
aureus)
no annotation 5 LEU A 196
ALA A 153
GLY A 149
SER A 150
LEU A 154
None
1.00A 3ou6B-2z2nA:
undetectable
3ou6B-2z2nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea)
PF00182
(Glyco_hydro_19)
5 ALA A 289
GLY A 261
SER A 266
MET A 264
LEU A 282
None
1.07A 3ou6B-2z37A:
undetectable
3ou6B-2z37A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea)
PF00182
(Glyco_hydro_19)
5 TYR A 258
ALA A 289
SER A 266
MET A 264
LEU A 282
None
1.11A 3ou6B-2z37A:
undetectable
3ou6B-2z37A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN


(Thermus
thermophilus)
PF00753
(Lactamase_B)
5 ALA A 172
GLY A 174
GLY A  99
ALA A 191
HIS A  75
None
None
None
None
ZN  A 319 (-3.2A)
1.15A 3ou6B-2zo4A:
undetectable
3ou6B-2zo4A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA


(Cavia porcellus)
PF00042
(Globin)
5 ALA B  27
GLY B  29
GLY B  64
LEU B  68
HIS B 117
None
1.10A 3ou6B-3a0gB:
undetectable
3ou6B-3a0gB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3br8 PROBABLE
ACYLPHOSPHATASE


(Bacillus
subtilis)
PF00708
(Acylphosphatase)
5 ALA A  31
GLY A  48
GLY A  82
MET A   1
ALA A  25
None
1.16A 3ou6B-3br8A:
undetectable
3ou6B-3br8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum)
PF00230
(MIP)
5 LEU A  69
ALA A  53
GLY A  51
GLY A  57
ALA A  30
GOL  A 663 (-4.1A)
None
None
None
None
1.06A 3ou6B-3c02A:
undetectable
3ou6B-3c02A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czx PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE AMIDASE


(Neisseria
meningitidis)
PF01520
(Amidase_3)
5 LEU A  60
ALA A 136
GLY A 140
LEU A 133
ALA A  91
None
1.08A 3ou6B-3czxA:
undetectable
3ou6B-3czxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtn PUTATIVE
METHYLTRANSFERASE
MM_2633


(Methanosarcina
mazei)
PF13649
(Methyltransf_25)
5 GLY A  52
SER A  75
MET A  78
ALA A 114
HIS A 119
None
0.61A 3ou6B-3dtnA:
17.6
3ou6B-3dtnA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492


(Rhodopseudomonas
palustris)
PF08241
(Methyltransf_11)
5 LEU A  14
TYR A  17
GLY A  53
GLY A  73
SER A  74
SAM  A 221 (-4.4A)
SAM  A 221 (-3.8A)
SAM  A 221 (-3.2A)
SAM  A 221 (-3.2A)
SAM  A 221 (-4.6A)
0.74A 3ou6B-3e23A:
19.0
3ou6B-3e23A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 ALA A 551
GLY A 495
GLY A 527
LEU A 573
ALA A 498
None
0.91A 3ou6B-3eqnA:
undetectable
3ou6B-3eqnA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME


(Saccharomyces
cerevisiae)
PF01946
(Thi4)
5 GLY A 290
GLY A  74
SER A  75
MET A 309
ALA A 243
AHZ  A1100 (-3.5A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.6A)
AHZ  A1100 (-3.3A)
None
1.05A 3ou6B-3fpzA:
2.2
3ou6B-3fpzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1


(Arabidopsis
thaliana)
PF00282
(Pyridoxal_deC)
5 ALA A 246
GLY A 249
TRP A 287
GLY A 211
HIS A 242
LLP  A 277 ( 3.3A)
None
None
None
None
1.02A 3ou6B-3hbxA:
undetectable
3ou6B-3hbxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
5 GLY A 163
GLY A 261
SER A 262
ALA A 168
TRP A 169
None
1.12A 3ou6B-3hutA:
undetectable
3ou6B-3hutA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
5 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
AOO  A 457 (-4.7A)
None
None
None
None
1.15A 3ou6B-3lscA:
undetectable
3ou6B-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA A 423
GLY A 421
GLY A 426
MET A 128
ALA A 449
None
1.05A 3ou6B-3m49A:
undetectable
3ou6B-3m49A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P


(Drosophila
melanogaster)
PF11701
(UNC45-central)
5 LEU A 472
GLY A 495
GLY A 490
LEU A 488
ALA A 511
None
0.83A 3ou6B-3nowA:
undetectable
3ou6B-3nowA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P


(Drosophila
melanogaster)
PF11701
(UNC45-central)
5 LEU A 472
GLY A 495
GLY A 490
LEU A 488
ALA A 512
None
1.13A 3ou6B-3nowA:
undetectable
3ou6B-3nowA:
14.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE


(Streptomyces
luridus)
PF13649
(Methyltransf_25)
12 LEU A  12
TYR A  15
ALA A  54
GLY A  56
TRP A  60
GLY A  76
SER A  77
MET A  80
LEU A  99
ALA A 114
TRP A 116
HIS A 119
SAM  A 300 ( 3.9A)
SAM  A 300 ( 3.5A)
SAM  A 300 (-3.4A)
SAM  A 300 (-3.1A)
None
SAM  A 300 (-3.3A)
SAM  A 300 (-4.5A)
SAM  A 300 (-4.0A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.6A)
None
SO4  A 301 (-4.0A)
0.10A 3ou6B-3ou6A:
39.1
3ou6B-3ou6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
5 TYR A  14
ALA A  58
GLY A  60
SER A  81
MET A  84
SAH  A 263 ( 3.9A)
SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
0.75A 3ou6B-3px2A:
17.4
3ou6B-3px2A:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 LEU A 159
ALA A 118
GLY A  63
GLY A 120
SER A  65
None
1.10A 3ou6B-3q98A:
undetectable
3ou6B-3q98A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445


(Oleispira
antarctica)
PF03009
(GDPD)
5 LEU A 155
GLY A 168
SER A 148
LEU A 182
ALA A 173
None
None
G3P  A 301 ( 4.4A)
None
None
1.08A 3ou6B-3qvqA:
undetectable
3ou6B-3qvqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 306
GLY A 182
LEU A 299
ALA A 157
TRP A 155
None
1.12A 3ou6B-3uogA:
4.9
3ou6B-3uogA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw1 PUTATIVE REGULATORY
PROTEIN


(Salmonella
enterica)
PF00440
(TetR_N)
5 LEU A 109
ALA A  17
LEU A  54
ALA A  12
HIS A  61
None
1.08A 3ou6B-3vw1A:
undetectable
3ou6B-3vw1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
NO3  A 401 (-4.4A)
None
None
None
None
1.00A 3ou6B-3w15A:
undetectable
3ou6B-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Escherichia
coli;
Archaeoglobus
fulgidus)
PF13416
(SBP_bac_8)
5 ALA A 162
GLY A 165
GLY A 191
ALA A 168
TRP A 158
None
1.07A 3ou6B-3waiA:
undetectable
3ou6B-3waiA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii)
PF00267
(Porin_1)
5 GLY A 191
GLY A 175
SER A 193
LEU A 149
ALA A 179
LDA  A1370 ( 4.6A)
LDA  A1383 ( 4.2A)
None
LDA  A1365 ( 4.3A)
None
1.04A 3ou6B-4d65A:
undetectable
3ou6B-4d65A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
5 LEU A 394
ALA A 350
GLY A 349
GLY A 344
LEU A 352
None
1.14A 3ou6B-4emiA:
undetectable
3ou6B-4emiA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 LEU A 365
TYR A 364
ALA A 421
GLY A 437
LEU A 446
None
1.11A 3ou6B-4fl3A:
undetectable
3ou6B-4fl3A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 397
TYR A 403
GLY A 352
LEU A 326
ALA A 426
None
0.93A 3ou6B-4na3A:
undetectable
3ou6B-4na3A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
5 GLY A 183
GLY A 213
SER A 185
LEU A 276
ALA A 209
None
1.15A 3ou6B-4q05A:
3.0
3ou6B-4q05A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A  81
GLY A  83
TRP A 407
LEU A  72
ALA A  55
None
1.02A 3ou6B-4q9dA:
3.7
3ou6B-4q9dA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A  83
TRP A 407
GLY A  79
LEU A  72
ALA A  55
None
0.78A 3ou6B-4q9dA:
3.7
3ou6B-4q9dA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 LEU A 833
ALA A 796
GLY A 801
LEU A 630
HIS A 836
None
1.10A 3ou6B-4qmeA:
undetectable
3ou6B-4qmeA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU


(Pseudomonas
fluorescens)
PF01734
(Patatin)
5 ALA A  95
GLY A  90
GLY A  61
SER A  60
ALA A 261
None
1.12A 3ou6B-4qmkA:
undetectable
3ou6B-4qmkA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6


(Homo sapiens;
Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF17205
(PSI_integrin)
6 GLY A 157
GLY A 175
SER A 176
LEU B 265
ALA A 109
HIS A 113
None
1.46A 3ou6B-4um8A:
undetectable
3ou6B-4um8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdt FAD:PROTEIN FMN
TRANSFERASE


(Treponema
pallidum)
PF02424
(ApbE)
5 LEU A  45
ALA A 164
GLY A 166
LEU A  52
ALA A 162
None
FAD  A 401 (-2.6A)
None
FAD  A 401 ( 3.9A)
FAD  A 401 ( 3.2A)
1.15A 3ou6B-4xdtA:
undetectable
3ou6B-4xdtA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqy PUTATIVE
DEHYDROGENASE


(Sulfitobacter
sp. NAS-14.1)
PF13561
(adh_short_C2)
5 ALA A 143
GLY A 156
GLY A 149
ALA A 140
HIS A 192
None
1.12A 3ou6B-4yqyA:
5.8
3ou6B-4yqyA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135


(Acanthamoeba
polyphaga
mimivirus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
6 LEU A  25
GLY A 625
TRP A 618
LEU A  35
ALA A 232
HIS A  23
None
1.34A 3ou6B-4z26A:
2.3
3ou6B-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135


(Acanthamoeba
polyphaga
mimivirus)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
6 LEU A  25
TYR A  24
GLY A 625
TRP A 618
LEU A  35
ALA A 232
None
1.49A 3ou6B-4z26A:
2.3
3ou6B-4z26A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3n PUTATIVE DRUG/SODIUM
ANTIPORTER


(Escherichia
coli)
PF01554
(MatE)
5 LEU A 314
GLY A 260
GLY A  93
SER A  94
ALA A  83
None
None
None
None
OLC  A 507 ( 3.9A)
1.14A 3ou6B-4z3nA:
undetectable
3ou6B-4z3nA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE


(Streptomyces
platensis)
PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C)
5 LEU A 101
GLY A  51
GLY A  57
LEU A  59
ALA A  46
None
SO4  A 704 (-3.3A)
None
None
None
1.02A 3ou6B-5bp8A:
undetectable
3ou6B-5bp8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2u NANOBODY

(Camelus
dromedarius)
PF07686
(V-set)
5 LEU B  17
TYR B  90
GLY B 117
GLY B   7
ALA B  93
None
1.14A 3ou6B-5c2uB:
undetectable
3ou6B-5c2uB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE


(Chromohalobacter
salexigens)
PF00120
(Gln-synt_C)
5 ALA A 239
TRP A  96
SER A 152
LEU A 148
ALA A 234
None
1.07A 3ou6B-5dm3A:
undetectable
3ou6B-5dm3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE


(Schistosoma
mansoni)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 LEU A 206
ALA A 193
GLY A 195
GLY A 103
LEU A  40
None
1.08A 3ou6B-5eytA:
undetectable
3ou6B-5eytA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0q BETA-GLUCURONIDASE

(Acidobacterium
capsulatum)
PF03662
(Glyco_hydro_79n)
5 LEU A 307
ALA A 394
GLY A 469
LEU A 356
ALA A 383
None
0.92A 3ou6B-5g0qA:
undetectable
3ou6B-5g0qA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF01547
(SBP_bac_1)
5 LEU A 449
GLY A 348
GLY A 170
SER A 175
ALA A 429
None
1.05A 3ou6B-5g5zA:
undetectable
3ou6B-5g5zA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE


(Lactobacillus
brevis)
no annotation 5 ALA C 248
GLY C 251
TRP C 289
GLY C 213
HIS C 244
PLP  C 501 (-3.1A)
None
None
None
None
1.03A 3ou6B-5gp4C:
undetectable
3ou6B-5gp4C:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE


(Methanohalophilus
portucalensis)
PF13649
(Methyltransf_25)
5 ALA A  67
GLY A  69
GLY A  89
SER A  90
MET A  93
SAH  A 301 (-3.9A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.4A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
0.46A 3ou6B-5h02A:
17.0
3ou6B-5h02A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
5 LEU A 225
TYR A 157
GLY A 153
GLY A 177
SER A 178
None
1.04A 3ou6B-5h42A:
undetectable
3ou6B-5h42A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxs SODIUM,CALCIUM
EXCHANGER


(Methanocaldococcus
jannaschii)
PF01699
(Na_Ca_ex)
5 LEU A 254
ALA A 244
GLY A 248
SER A 249
ALA A 239
None
1.10A 3ou6B-5hxsA:
undetectable
3ou6B-5hxsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je3 METHYL TRANSFERASE

(Burkholderia
glumae)
PF13847
(Methyltransf_31)
5 ALA A  47
GLY A  49
SER A  71
MET A  74
ALA A 111
SAH  A 301 (-3.2A)
SAH  A 301 (-3.6A)
SAH  A 301 ( 4.8A)
SAH  A 301 ( 4.5A)
SAH  A 301 (-3.8A)
0.44A 3ou6B-5je3A:
16.5
3ou6B-5je3A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE


(Bacillus
subtilis)
no annotation 5 ALA H 356
GLY H 113
GLY H 352
MET H  53
ALA H   9
None
1.12A 3ou6B-5lp7H:
undetectable
3ou6B-5lp7H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Sulfolobus
solfataricus)
no annotation 5 LEU A 238
TYR A 241
ALA A 201
GLY A 205
GLY A 208
None
0.94A 3ou6B-5n2pA:
undetectable
3ou6B-5n2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii)
no annotation 5 GLY A 193
GLY A 177
SER A 195
LEU A 152
ALA A 181
None
1.01A 3ou6B-5nxnA:
undetectable
3ou6B-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-)
no annotation 5 TYR A 375
ALA A 419
GLY A 430
ALA A  32
TRP A 436
None
None
None
None
GOL  A 501 ( 4.4A)
1.11A 3ou6B-5oieA:
undetectable
3ou6B-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 LEU A 603
ALA A 615
GLY A 591
GLY A 613
ALA A 617
None
0.94A 3ou6B-5oljA:
undetectable
3ou6B-5oljA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU


(Vibrio cholerae)
no annotation 5 LEU A 138
ALA A 219
GLY A 231
GLY A 233
LEU A 217
None
1.15A 3ou6B-5onuA:
undetectable
3ou6B-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE


(Vigna
unguiculata)
PF01150
(GDA1_CD39)
5 LEU F  94
ALA F  87
GLY F  14
SER F  49
LEU F 103
None
None
PO4  F 502 (-3.4A)
None
None
0.99A 3ou6B-5u7xF:
undetectable
3ou6B-5u7xF:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN


(Xanthomonas
citri)
PF13531
(SBP_bac_11)
5 ALA A 225
GLY A 184
GLY A  95
SER A  96
ALA A 243
SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
SO4  A 401 (-4.4A)
None
0.89A 3ou6B-5um2A:
undetectable
3ou6B-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um2 ABC TRANSPORTER
SULFATE BINDING
PROTEIN


(Xanthomonas
citri)
PF13531
(SBP_bac_11)
5 TYR A  60
ALA A 225
GLY A 184
GLY A  95
ALA A 243
SO4  A 401 (-4.7A)
SO4  A 401 (-3.4A)
SO4  A 401 (-3.3A)
SO4  A 401 (-3.6A)
None
1.09A 3ou6B-5um2A:
undetectable
3ou6B-5um2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4


(Pseudoxanthomonas
mexicana)
no annotation 5 ALA A 635
GLY A 611
GLY A 633
LEU A 681
ALA A 637
None
1.10A 3ou6B-5yp3A:
undetectable
3ou6B-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4


(Pseudoxanthomonas
mexicana)
no annotation 5 LEU A 623
ALA A 635
GLY A 611
GLY A 633
ALA A 637
None
0.92A 3ou6B-5yp3A:
undetectable
3ou6B-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 5 LEU A1177
ALA A1230
GLY A1226
GLY A1217
MET A1221
None
1.16A 3ou6B-6bq1A:
undetectable
3ou6B-6bq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE


(Saccharomyces
cerevisiae)
no annotation 5 ALA A  90
GLY A  93
GLY A 120
LEU A 116
ALA A  57
None
None
NA  A 404 (-4.0A)
None
None
1.15A 3ou6B-6c2hA:
2.3
3ou6B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-)
no annotation 5 ALA A 262
GLY A 255
SER A 278
LEU A 133
ALA A 227
None
EDO  A 505 ( 4.9A)
None
None
None
1.08A 3ou6B-6gu8A:
undetectable
3ou6B-6gu8A:
undetectable