SIMILAR PATTERNS OF AMINO ACIDS FOR 3OU6_A_SAMA300
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rmg | RHAMNOGALACTURONASEA (Aspergillusaculeatus) |
PF00295(Glyco_hydro_28) | 5 | ALA A 148GLY A 114GLY A 170LEU A 176ALA A 127 | None | 1.04A | 3ou6A-1rmgA:undetectable | 3ou6A-1rmgA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp0 | THIAZOLEBIOSYNTHETIC ENZYME (Arabidopsisthaliana) |
PF01946(Thi4) | 5 | GLY A 240GLY A 48SER A 49MET A 259ALA A 195 | AHZ A 600 (-3.5A)AHZ A 600 (-3.4A)AHZ A 600 (-3.5A)AHZ A 600 (-3.3A)None | 1.10A | 3ou6A-1rp0A:2.6 | 3ou6A-1rp0A:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sbp | SULFATE-BINDINGPROTEIN (Salmonellaenterica) |
PF13531(SBP_bac_11) | 5 | ALA A 173GLY A 132GLY A 44SER A 45ALA A 191 | SO4 A 311 (-3.4A)SO4 A 311 (-3.1A)SO4 A 311 (-3.5A)SO4 A 311 (-4.4A)None | 0.92A | 3ou6A-1sbpA:undetectable | 3ou6A-1sbpA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sbp | SULFATE-BINDINGPROTEIN (Salmonellaenterica) |
PF13531(SBP_bac_11) | 5 | TYR A 10ALA A 173GLY A 132GLY A 44ALA A 191 | SO4 A 311 (-4.8A)SO4 A 311 (-3.4A)SO4 A 311 (-3.1A)SO4 A 311 (-3.5A)None | 1.10A | 3ou6A-1sbpA:undetectable | 3ou6A-1sbpA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlq | HYPOTHETICAL PROTEINYPJQ (Bacillussubtilis) |
PF04608(PgpA) | 6 | ALA A 152GLY A 114GLY A 119ASP A 122LEU A 121ALA A 154 | None | 1.36A | 3ou6A-1tlqA:undetectable | 3ou6A-1tlqA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 2 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ALA B 232GLY B 185GLY B 336SER B 335ALA B 82 | None | 1.06A | 3ou6A-1tqyB:undetectable | 3ou6A-1tqyB:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v0z | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 5 | ALA A 360GLY A 370MET A 383ASP A 363LEU A 362 | None | 1.10A | 3ou6A-1v0zA:undetectable | 3ou6A-1v0zA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | ALA A 46GLY A 48SER A 69MET A 72ASP A 93 | SAM A 302 (-3.4A)SAM A 302 (-3.6A)SAM A 302 (-4.7A)SAM A 302 (-3.9A)SAM A 302 (-3.4A) | 0.64A | 3ou6A-1ve3A:17.3 | 3ou6A-1ve3A:27.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | ALA A 112GLY A 109SER A 106LEU A 507ALA A 71 | NoneNoneFAD A1561 ( 4.5A)NoneNone | 1.01A | 3ou6A-1w1kA:undetectable | 3ou6A-1w1kA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzn | SAM-DEPENDENTMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | TYR A 5ALA A 49GLY A 51MET A 75ASP A 96 | SAH A1001 (-3.5A)SAH A1001 (-3.4A)SAH A1001 (-3.1A)SAH A1001 (-4.4A)SAH A1001 (-3.3A) | 0.96A | 3ou6A-1wznA:19.0 | 3ou6A-1wznA:28.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8c | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Clostridiumacetobutylicum) |
PF13649(Methyltransf_25) | 5 | ALA A 46GLY A 48SER A 69MET A 72ASP A 93 | None | 0.64A | 3ou6A-1y8cA:18.2 | 3ou6A-1y8cA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zbs | HYPOTHETICAL PROTEINPG1100 (Porphyromonasgingivalis) |
PF01869(BcrAD_BadFG) | 5 | LEU A 274ALA A 95GLY A 67GLY A 100ALA A 75 | None | 1.14A | 3ou6A-1zbsA:undetectable | 3ou6A-1zbsA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ak3 | ADENYLATE KINASEISOENZYME-3 (Bos taurus) |
PF00406(ADK)PF05191(ADK_lid) | 5 | LEU A 39GLY A 89SER A 35LEU A 77ALA A 97 | NoneAMP A 226 (-4.7A)NoneNoneNone | 1.14A | 3ou6A-2ak3A:undetectable | 3ou6A-2ak3A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | TYR A 9GLY A 52TRP A 56SER A 73MET A 76 | SAI A1300 (-3.8A)SAI A1300 (-3.5A)NoneSAI A1300 (-4.7A)SAI A1300 ( 4.2A) | 0.73A | 3ou6A-2avnA:19.2 | 3ou6A-2avnA:26.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | LEU A 620ALA A 632GLY A 608GLY A 630ALA A 634 | None | 1.00A | 3ou6A-2ecfA:undetectable | 3ou6A-2ecfA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibn | INOSITOL OXYGENASE (Homo sapiens) |
PF05153(MIOX) | 5 | LEU A 79ALA A 130GLY A 133LEU A 83ALA A 138 | None | 1.11A | 3ou6A-2ibnA:undetectable | 3ou6A-2ibnA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jpd | DNA EXCISION REPAIRPROTEIN ERCC-1 (Homo sapiens) |
PF03834(Rad10) | 5 | LEU A 209TYR A 212GLY A 133LEU A 139ALA A 165 | None | 1.14A | 3ou6A-2jpdA:undetectable | 3ou6A-2jpdA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ox4 | PUTATIVE MANDELATERACEMASE (Zymomonasmobilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 38GLY A 290GLY A 92LEU A 53ALA A 41 | None | 1.14A | 3ou6A-2ox4A:undetectable | 3ou6A-2ox4A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcq | PUTATIVEDIHYDRODIPICOLINATESYNTHASE (Thermusthermophilus) |
PF00701(DHDPS) | 5 | LEU A 36ALA A 84GLY A 68LEU A 92ALA A 86 | None | 1.01A | 3ou6A-2pcqA:undetectable | 3ou6A-2pcqA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2px0 | FLAGELLARBIOSYNTHESIS PROTEINFLHF (Bacillussubtilis) |
PF00448(SRP54) | 5 | LEU A 288GLY A 187GLY A 182SER A 183ALA A 193 | NoneGNP A 1 ( 3.2A)NoneNoneNone | 1.12A | 3ou6A-2px0A:undetectable | 3ou6A-2px0A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qny | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Mycobacteriumtuberculosis) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | LEU A 308TYR A 310ALA A 113GLY A 303GLY A 305 | NoneNoneNoneNoneDFD A 760 (-3.6A) | 1.10A | 3ou6A-2qnyA:undetectable | 3ou6A-2qnyA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 206ALA A 380GLY A 228GLY A 383ALA A 154 | None | 1.11A | 3ou6A-2qo3A:undetectable | 3ou6A-2qo3A:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 5 | LEU A 455ALA A 467GLY A 443GLY A 465ALA A 469 | None | 0.84A | 3ou6A-2qzpA:2.6 | 3ou6A-2qzpA:17.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r5f | TRANSCRIPTIONALREGULATOR, PUTATIVE (Pseudomonassyringae groupgenomosp. 3) |
PF04198(Sugar-bind) | 5 | ALA A 296GLY A 255GLY A 300LEU A 302ALA A 292 | None | 1.10A | 3ou6A-2r5fA:undetectable | 3ou6A-2r5fA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uzz | N-METHYL-L-TRYPTOPHAN OXIDASE (Escherichiacoli) |
PF01266(DAO) | 5 | ALA A 16GLY A 18GLY A 11SER A 10MET A 30 | NoneNoneFAD A1373 (-3.4A)NoneNone | 1.06A | 3ou6A-2uzzA:2.6 | 3ou6A-2uzzA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2weu | TRYPTOPHAN5-HALOGENASE (Streptomycesrugosporus) |
PF04820(Trp_halogenase) | 5 | LEU A 285GLY A 292GLY A 45ASP A 171ALA A 322 | None | 1.05A | 3ou6A-2weuA:undetectable | 3ou6A-2weuA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | ALA A 378GLY A 605ASP A 582LEU A 586ALA A 627 | None | 1.05A | 3ou6A-2xr1A:undetectable | 3ou6A-2xr1A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv2 | SUCCINYL-COASYNTHETASE ALPHACHAIN (Aeropyrumpernix) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | LEU A 17ALA A 30GLY A 26GLY A 43ALA A 32 | None | 1.08A | 3ou6A-2yv2A:3.3 | 3ou6A-2yv2A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2n | VIRGINIAMYCIN BLYASE (Staphylococcusaureus) |
no annotation | 5 | LEU A 196ALA A 153GLY A 149SER A 150LEU A 154 | None | 1.00A | 3ou6A-2z2nA:undetectable | 3ou6A-2z2nA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2x | TK-SUBTILISIN (Thermococcuskodakarensis) |
PF00082(Peptidase_S8) | 5 | GLY A 283GLY A 385ASP A 372LEU A 373ALA A 292 | NoneNone CA A1001 (-3.1A)NoneNone | 0.88A | 3ou6A-2z2xA:2.3 | 3ou6A-2z2xA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2z | TK-SUBTILISINPRECURSOR (Thermococcuskodakarensis) |
PF00082(Peptidase_S8) | 5 | GLY A 283GLY A 385ASP A 372LEU A 373ALA A 292 | NoneNone CA A1006 (-2.8A)NoneNone | 0.83A | 3ou6A-2z2zA:undetectable | 3ou6A-2z2zA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z37 | CHITINASE (Brassica juncea) |
PF00182(Glyco_hydro_19) | 5 | ALA A 289GLY A 261SER A 266MET A 264LEU A 282 | None | 1.04A | 3ou6A-2z37A:undetectable | 3ou6A-2z37A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z37 | CHITINASE (Brassica juncea) |
PF00182(Glyco_hydro_19) | 5 | TYR A 258ALA A 289SER A 266MET A 264LEU A 282 | None | 1.08A | 3ou6A-2z37A:undetectable | 3ou6A-2z37A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3afl | OLIGO ALGINATE LYASE (Agrobacteriumfabrum) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 5 | ALA A 376SER A 382ASP A 387LEU A 388ALA A 318 | None | 1.06A | 3ou6A-3aflA:undetectable | 3ou6A-3aflA:14.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bkw | S-ADENOSYLMETHIONINEDEPENDENTMETHYLTRANSFERASE (Mesorhizobiumjaponicum) |
PF08241(Methyltransf_11) | 5 | GLY A 52SER A 74MET A 77ASP A 96LEU A 97 | None | 0.75A | 3ou6A-3bkwA:17.0 | 3ou6A-3bkwA:25.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bxo | N,N-DIMETHYLTRANSFERASE (Streptomycesvenezuelae) |
PF13649(Methyltransf_25) | 5 | ALA A 46GLY A 48SER A 69MET A 72ASP A 89 | SAM A 238 (-3.2A)SAM A 238 ( 3.7A)SAM A 238 (-4.6A)SAM A 238 (-4.2A)SAM A 238 (-3.0A) | 0.61A | 3ou6A-3bxoA:16.3 | 3ou6A-3bxoA:25.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c02 | AQUAGLYCEROPORIN (Plasmodiumfalciparum) |
PF00230(MIP) | 5 | LEU A 69ALA A 53GLY A 51GLY A 57ALA A 30 | GOL A 663 (-4.1A)NoneNoneNoneNone | 1.06A | 3ou6A-3c02A:undetectable | 3ou6A-3c02A:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3czx | PUTATIVEN-ACETYLMURAMOYL-L-ALANINE AMIDASE (Neisseriameningitidis) |
PF01520(Amidase_3) | 5 | LEU A 60ALA A 136GLY A 140LEU A 133ALA A 91 | None | 1.10A | 3ou6A-3czxA:undetectable | 3ou6A-3czxA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d54 | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE 1 (Thermotogamaritima) |
PF13507(GATase_5) | 5 | LEU D 92GLY D 49GLY D 84LEU D 183ALA D 141 | NoneCYG D 86 ( 3.5A)NoneNoneCYG D 86 ( 4.6A) | 0.96A | 3ou6A-3d54D:undetectable | 3ou6A-3d54D:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dtn | PUTATIVEMETHYLTRANSFERASEMM_2633 (Methanosarcinamazei) |
PF13649(Methyltransf_25) | 5 | GLY A 52SER A 75MET A 78ASP A 98ALA A 114 | None | 0.89A | 3ou6A-3dtnA:17.7 | 3ou6A-3dtnA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e23 | UNCHARACTERIZEDPROTEIN RPA2492 (Rhodopseudomonaspalustris) |
PF08241(Methyltransf_11) | 5 | LEU A 14TYR A 17GLY A 53GLY A 73SER A 74 | SAM A 221 (-4.4A)SAM A 221 (-3.8A)SAM A 221 (-3.2A)SAM A 221 (-3.2A)SAM A 221 (-4.6A) | 0.77A | 3ou6A-3e23A:19.0 | 3ou6A-3e23A:27.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpz | THIAZOLEBIOSYNTHETIC ENZYME (Saccharomycescerevisiae) |
PF01946(Thi4) | 5 | GLY A 290GLY A 74SER A 75MET A 309ALA A 243 | AHZ A1100 (-3.5A)AHZ A1100 (-3.6A)AHZ A1100 (-3.6A)AHZ A1100 (-3.3A)None | 1.07A | 3ou6A-3fpzA:undetectable | 3ou6A-3fpzA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l8d | METHYLTRANSFERASE (Bacillusthuringiensis) |
PF08241(Methyltransf_11) | 5 | GLY A 63SER A 84MET A 87ASP A 106LEU A 107 | None | 1.05A | 3ou6A-3l8dA:14.4 | 3ou6A-3l8dA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ALA A 423GLY A 421GLY A 426MET A 128ALA A 449 | None | 1.06A | 3ou6A-3m49A:undetectable | 3ou6A-3m49A:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3now | UNC-45 PROTEIN,SD10334P (Drosophilamelanogaster) |
PF11701(UNC45-central) | 5 | LEU A 472GLY A 495GLY A 490LEU A 488ALA A 511 | None | 0.82A | 3ou6A-3nowA:undetectable | 3ou6A-3nowA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obz | PHYTANOYL-COADIOXYGENASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF05721(PhyH) | 6 | LEU A 278ALA A 106GLY A 104GLY A 74SER A 73LEU A 284 | None | 1.49A | 3ou6A-3obzA:undetectable | 3ou6A-3obzA:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ou6 | SAM-DEPENDENTMETHYLTRANSFERASE (Streptomycesluridus) |
PF13649(Methyltransf_25) | 12 | LEU A 12TYR A 15ALA A 54GLY A 56TRP A 60GLY A 76SER A 77MET A 80ASP A 98LEU A 99ALA A 114TRP A 116 | SAM A 300 ( 3.9A)SAM A 300 ( 3.5A)SAM A 300 (-3.4A)SAM A 300 (-3.1A)NoneSAM A 300 (-3.3A)SAM A 300 (-4.5A)SAM A 300 (-4.0A)SAM A 300 (-4.0A)SAM A 300 (-3.9A)SAM A 300 (-3.6A)None | 0.02A | 3ou6A-3ou6A:41.7 | 3ou6A-3ou6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3px2 | N-METHYLTRANSFERASE (Streptomycesfradiae) |
PF13649(Methyltransf_25) | 6 | TYR A 14ALA A 58GLY A 60SER A 81MET A 84ASP A 101 | SAH A 263 ( 3.9A)SAH A 263 (-3.5A)SAH A 263 (-3.3A)SAH A 263 (-4.7A)SAH A 263 (-4.5A)SAH A 263 (-3.5A) | 0.95A | 3ou6A-3px2A:17.3 | 3ou6A-3px2A:28.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q98 | TRANSCARBAMYLASE (Escherichiacoli) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | LEU A 159ALA A 118GLY A 63GLY A 120SER A 65 | None | 1.11A | 3ou6A-3q98A:2.4 | 3ou6A-3q98A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qvq | PHOSPHODIESTERASEOLEI02445 (Oleispiraantarctica) |
PF03009(GDPD) | 5 | LEU A 155GLY A 168SER A 148LEU A 182ALA A 173 | NoneNoneG3P A 301 ( 4.4A)NoneNone | 1.08A | 3ou6A-3qvqA:undetectable | 3ou6A-3qvqA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uog | ALCOHOLDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 306GLY A 182LEU A 299ALA A 157TRP A 155 | None | 1.13A | 3ou6A-3uogA:4.8 | 3ou6A-3uogA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w15 | PEROXISOMALTARGETING SIGNAL 2RECEPTOR (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | LEU A 216ALA A 223GLY A 240GLY A 220SER A 219 | NO3 A 401 (-4.4A)NoneNoneNoneNone | 0.99A | 3ou6A-3w15A:undetectable | 3ou6A-3w15A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wai | MALTOSE-BINDINGPERIPLASMIC PROTEIN,TRANSMEMBRANEOLIGOSACCHARYLTRANSFERASE (Escherichiacoli;Archaeoglobusfulgidus) |
PF13416(SBP_bac_8) | 5 | ALA A 162GLY A 165GLY A 191ALA A 168TRP A 158 | None | 1.08A | 3ou6A-3waiA:undetectable | 3ou6A-3waiA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d65 | PORIN 2 (Providenciastuartii) |
PF00267(Porin_1) | 5 | GLY A 191GLY A 175SER A 193LEU A 149ALA A 179 | LDA A1370 ( 4.6A)LDA A1383 ( 4.2A)NoneLDA A1365 ( 4.3A)None | 1.03A | 3ou6A-4d65A:undetectable | 3ou6A-4d65A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emi | TODA (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | LEU A 394ALA A 350GLY A 349GLY A 344LEU A 352 | None | 1.12A | 3ou6A-4emiA:2.5 | 3ou6A-4emiA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl3 | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 5 | LEU A 365TYR A 364ALA A 421GLY A 437LEU A 446 | None | 1.13A | 3ou6A-4fl3A:undetectable | 3ou6A-4fl3A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4na3 | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 397TYR A 403GLY A 352LEU A 326ALA A 426 | None | 0.93A | 3ou6A-4na3A:undetectable | 3ou6A-4na3A:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q05 | ESTERASE E25 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 5 | GLY A 183GLY A 213SER A 185LEU A 276ALA A 209 | None | 1.13A | 3ou6A-4q05A:2.9 | 3ou6A-4q05A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ALA A 81GLY A 83TRP A 407LEU A 72ALA A 55 | None | 1.06A | 3ou6A-4q9dA:2.1 | 3ou6A-4q9dA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9d | BENZOYLFORMATEDECARBOXYLASE (Mycolicibacteriumsmegmatis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 83TRP A 407GLY A 79LEU A 72ALA A 55 | None | 0.81A | 3ou6A-4q9dA:2.1 | 3ou6A-4q9dA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qdk | MAGNESIUM-PROTOPORPHYRINO-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF07109(Mg-por_mtran_C) | 5 | GLY A 72SER A 93MET A 96ASP A 120LEU A 121 | SAH A 301 (-3.6A)SAH A 301 (-4.6A)SAH A 301 (-4.2A)SAH A 301 (-3.8A)SAH A 301 (-3.6A) | 1.08A | 3ou6A-4qdkA:17.2 | 3ou6A-4qdkA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmk | TYPE III SECRETIONSYSTEM EFFECTORPROTEIN EXOU (Pseudomonasfluorescens) |
PF01734(Patatin) | 5 | ALA A 95GLY A 90GLY A 61SER A 60ALA A 261 | None | 1.12A | 3ou6A-4qmkA:undetectable | 3ou6A-4qmkA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qrl | HYPOTHETICAL PROTEIN (Bacteroidesuniformis) |
PF16585(Lipocalin_8) | 5 | TYR A 118GLY A 26ASP A 115LEU A 121TRP A 32 | None | 1.03A | 3ou6A-4qrlA:undetectable | 3ou6A-4qrlA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdt | FAD:PROTEIN FMNTRANSFERASE (Treponemapallidum) |
PF02424(ApbE) | 5 | LEU A 45ALA A 164GLY A 166LEU A 52ALA A 162 | NoneFAD A 401 (-2.6A)NoneFAD A 401 ( 3.9A)FAD A 401 ( 3.2A) | 1.13A | 3ou6A-4xdtA:undetectable | 3ou6A-4xdtA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z26 | PUTATIVE GMC-TYPEOXIDOREDUCTASE R135 (Acanthamoebapolyphagamimivirus) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 6 | LEU A 25TYR A 24GLY A 625TRP A 618LEU A 35ALA A 232 | None | 1.50A | 3ou6A-4z26A:2.2 | 3ou6A-4z26A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp8 | ENT-COPALYLDIPHOSPHATE SYNTHASE (Streptomycesplatensis) |
PF00432(Prenyltrans)PF13243(SQHop_cyclase_C) | 5 | LEU A 101GLY A 51GLY A 57LEU A 59ALA A 46 | NoneSO4 A 704 (-3.3A)NoneNoneNone | 1.02A | 3ou6A-5bp8A:undetectable | 3ou6A-5bp8A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsz | N-METHYLTRANSFERASE (Streptoalloteichussp. ATCC 53650) |
PF13649(Methyltransf_25) | 5 | ALA A 53GLY A 55SER A 76MET A 79ASP A 96 | SAH A 301 (-3.3A)SAH A 301 ( 3.7A)SAH A 301 (-4.6A)SAH A 301 ( 4.4A)SAH A 301 (-3.7A) | 0.73A | 3ou6A-5bszA:15.5 | 3ou6A-5bszA:26.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2u | NANOBODY (Camelusdromedarius) |
PF07686(V-set) | 5 | LEU B 17TYR B 90GLY B 117GLY B 7ALA B 93 | None | 1.13A | 3ou6A-5c2uB:undetectable | 3ou6A-5c2uB:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dm3 | L-GLUTAMINESYNTHETASE (Chromohalobactersalexigens) |
PF00120(Gln-synt_C) | 5 | ALA A 239TRP A 96SER A 152LEU A 148ALA A 234 | None | 1.07A | 3ou6A-5dm3A:undetectable | 3ou6A-5dm3A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqs | ELONGATION FACTOR1-BETA (Homo sapiens) |
no annotation | 5 | GLY D 80GLY D 4ASP D 5LEU D 6ALA D 33 | None | 1.12A | 3ou6A-5dqsD:undetectable | 3ou6A-5dqsD:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eyt | ADENYLOSUCCINATELYASE (Schistosomamansoni) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | LEU A 206ALA A 193GLY A 195GLY A 103LEU A 40 | None | 1.05A | 3ou6A-5eytA:undetectable | 3ou6A-5eytA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0q | BETA-GLUCURONIDASE (Acidobacteriumcapsulatum) |
PF03662(Glyco_hydro_79n) | 5 | LEU A 307ALA A 394GLY A 469LEU A 356ALA A 383 | None | 0.91A | 3ou6A-5g0qA:undetectable | 3ou6A-5g0qA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5z | ABC TRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01547(SBP_bac_1) | 5 | LEU A 449GLY A 348GLY A 170SER A 175ALA A 429 | None | 1.05A | 3ou6A-5g5zA:undetectable | 3ou6A-5g5zA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gmx | CARBOXYLESTERASE (unculturedbacterium) |
PF00144(Beta-lactamase) | 5 | TYR A 361GLY A 37ASP A 47LEU A 48ALA A 24 | None | 1.09A | 3ou6A-5gmxA:undetectable | 3ou6A-5gmxA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h02 | GLYCINE SARCOSINEN-METHYLTRANSFERASE (Methanohalophilusportucalensis) |
PF13649(Methyltransf_25) | 6 | ALA A 67GLY A 69GLY A 89SER A 90MET A 93ASP A 114 | SAH A 301 (-3.9A)SAH A 301 (-3.3A)SAH A 301 (-3.4A)SAH A 301 ( 4.9A)SAH A 301 (-3.9A)SAH A 301 (-3.7A) | 0.46A | 3ou6A-5h02A:17.4 | 3ou6A-5h02A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h42 | UNCHARACTERIZEDPROTEIN (Lachnoclostridiumphytofermentans) |
PF17167(Glyco_hydro_36) | 5 | LEU A 225TYR A 157GLY A 153GLY A 177SER A 178 | None | 1.03A | 3ou6A-5h42A:undetectable | 3ou6A-5h42A:9.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hct | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | GLY A 205GLY A 275ASP A 279ALA A 234TRP A 236 | NoneNoneACT A 405 (-2.7A)NoneNone | 1.11A | 3ou6A-5hctA:undetectable | 3ou6A-5hctA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxs | SODIUM,CALCIUMEXCHANGER (Methanocaldococcusjannaschii) |
PF01699(Na_Ca_ex) | 5 | LEU A 254ALA A 244GLY A 248SER A 249ALA A 239 | None | 1.12A | 3ou6A-5hxsA:undetectable | 3ou6A-5hxsA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5je3 | METHYL TRANSFERASE (Burkholderiaglumae) |
PF13847(Methyltransf_31) | 6 | ALA A 47GLY A 49SER A 71MET A 74ASP A 95ALA A 111 | SAH A 301 (-3.2A)SAH A 301 (-3.6A)SAH A 301 ( 4.8A)SAH A 301 ( 4.5A)SAH A 301 (-3.7A)SAH A 301 (-3.8A) | 0.65A | 3ou6A-5je3A:16.5 | 3ou6A-5je3A:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lp7 | ACETYL-COAACETYLTRANSFERASE (Bacillussubtilis) |
no annotation | 5 | ALA H 356GLY H 113GLY H 352MET H 53ALA H 9 | None | 1.12A | 3ou6A-5lp7H:undetectable | 3ou6A-5lp7H:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 5 | ALA A 157SER A 150ASP A 147LEU A 146ALA A 120 | None | 1.10A | 3ou6A-5mfbA:undetectable | 3ou6A-5mfbA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mfb | YIII(DQ)4CQI (syntheticconstruct) |
PF00514(Arm) | 5 | ALA A 199SER A 192ASP A 189LEU A 188ALA A 162 | None | 1.09A | 3ou6A-5mfbA:undetectable | 3ou6A-5mfbA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n2p | TRYPTOPHAN SYNTHASEALPHA CHAIN (Sulfolobussolfataricus) |
no annotation | 5 | LEU A 238TYR A 241ALA A 201GLY A 205GLY A 208 | None | 0.96A | 3ou6A-5n2pA:undetectable | 3ou6A-5n2pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nxn | PORIN 1 (Providenciastuartii) |
no annotation | 5 | GLY A 193GLY A 177SER A 195LEU A 152ALA A 181 | None | 1.00A | 3ou6A-5nxnA:undetectable | 3ou6A-5nxnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oie | - (-) |
no annotation | 5 | TYR A 375ALA A 419GLY A 430ALA A 32TRP A 436 | NoneNoneNoneNoneGOL A 501 ( 4.4A) | 1.11A | 3ou6A-5oieA:undetectable | 3ou6A-5oieA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olj | DIPEPTIDYL PEPTIDASEIV (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | LEU A 603ALA A 615GLY A 591GLY A 613ALA A 617 | None | 0.95A | 3ou6A-5oljA:undetectable | 3ou6A-5oljA:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5p60 | ENDOTHIAPEPSIN (Cryphonectriaparasitica) |
PF00026(Asp) | 5 | GLY A 205GLY A 275ASP A 279ALA A 234TRP A 236 | None | 1.13A | 3ou6A-5p60A:undetectable | 3ou6A-5p60A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7x | NOD FACTOR BINDINGLECTIN-NUCLEOTIDEPHOSPHOHYDROLASE (Vignaunguiculata) |
PF01150(GDA1_CD39) | 5 | LEU F 94ALA F 87GLY F 14SER F 49LEU F 103 | NoneNonePO4 F 502 (-3.4A)NoneNone | 1.00A | 3ou6A-5u7xF:undetectable | 3ou6A-5u7xF:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uao | TRYPTOPHANE-5-HALOGENASE (Microbisporasp. ATCCPTA-5024) |
PF04820(Trp_halogenase) | 5 | LEU A 103ALA A 499GLY A 502ASP A 121LEU A 144 | None | 1.10A | 3ou6A-5uaoA:2.4 | 3ou6A-5uaoA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um2 | ABC TRANSPORTERSULFATE BINDINGPROTEIN (Xanthomonascitri) |
PF13531(SBP_bac_11) | 5 | ALA A 225GLY A 184GLY A 95SER A 96ALA A 243 | SO4 A 401 (-3.4A)SO4 A 401 (-3.3A)SO4 A 401 (-3.6A)SO4 A 401 (-4.4A)None | 0.91A | 3ou6A-5um2A:undetectable | 3ou6A-5um2A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um2 | ABC TRANSPORTERSULFATE BINDINGPROTEIN (Xanthomonascitri) |
PF13531(SBP_bac_11) | 5 | TYR A 60ALA A 225GLY A 184GLY A 95ALA A 243 | SO4 A 401 (-4.7A)SO4 A 401 (-3.4A)SO4 A 401 (-3.3A)SO4 A 401 (-3.6A)None | 1.09A | 3ou6A-5um2A:undetectable | 3ou6A-5um2A:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7k | OXAG (Penicilliumoxalicum) |
no annotation | 5 | ALA A 54GLY A 56SER A 84ASP A 109ALA A 126 | SAH A 301 (-3.4A)SAH A 301 (-3.4A)NoneSAH A 301 (-3.6A)SAH A 301 (-3.5A) | 0.71A | 3ou6A-5w7kA:15.6 | 3ou6A-5w7kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7m | GLANDICOLINE BO-METHYLTRANSFERASEROQN (Penicilliumrubens) |
no annotation | 5 | ALA A 54GLY A 56SER A 84ASP A 109ALA A 126 | SAH A 301 (-3.3A)SAH A 301 (-3.3A)NoneSAH A 301 (-3.8A)SAH A 301 (-3.5A) | 0.64A | 3ou6A-5w7mA:15.5 | 3ou6A-5w7mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmj | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Desulfovibriogigas) |
no annotation | 5 | LEU A 579ALA A 536GLY A 538MET A 251ASP A 541 | None | 1.04A | 3ou6A-5xmjA:undetectable | 3ou6A-5xmjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yp3 | DIPEPTIDYLAMINOPEPTIDASE 4 (Pseudoxanthomonasmexicana) |
no annotation | 5 | ALA A 635GLY A 611GLY A 633LEU A 681ALA A 637 | None | 1.11A | 3ou6A-5yp3A:undetectable | 3ou6A-5yp3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yp3 | DIPEPTIDYLAMINOPEPTIDASE 4 (Pseudoxanthomonasmexicana) |
no annotation | 5 | LEU A 623ALA A 635GLY A 611GLY A 633ALA A 637 | None | 0.94A | 3ou6A-5yp3A:undetectable | 3ou6A-5yp3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq1 | PHOSPHATIDYLINOSITOL4-KINASE III ALPHA(PI4KA) (Homo sapiens) |
no annotation | 5 | LEU A1177ALA A1230GLY A1226GLY A1217MET A1221 | None | 1.14A | 3ou6A-6bq1A:undetectable | 3ou6A-6bq1A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f5z | 24-STEROLC-METHYLTRANSFERASE (Haloferaxvolcanii) |
no annotation | 5 | GLY A 48GLY A 70SER A 71MET A 74ASP A 93 | SAH A 301 ( 3.7A)SAH A 301 (-3.6A)NoneSAH A 301 (-4.0A)SAH A 301 (-3.8A) | 0.56A | 3ou6A-6f5zA:18.0 | 3ou6A-6f5zA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fkx | ACETYL XYLANESTERASE (metagenome) |
no annotation | 5 | LEU C 157ALA C 193GLY C 189ASP C 160ALA C 260 | None | 1.10A | 3ou6A-6fkxC:undetectable | 3ou6A-6fkxC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gu8 | - (-) |
no annotation | 5 | ALA A 262GLY A 255SER A 278LEU A 133ALA A 227 | NoneEDO A 505 ( 4.9A)NoneNoneNone | 1.07A | 3ou6A-6gu8A:undetectable | 3ou6A-6gu8A:undetectable |